KR830001940A - 알도즈 환원요소 억제성 퀴놀릴히단토인류 - Google Patents
알도즈 환원요소 억제성 퀴놀릴히단토인류 Download PDFInfo
- Publication number
- KR830001940A KR830001940A KR1019800000213A KR800000213A KR830001940A KR 830001940 A KR830001940 A KR 830001940A KR 1019800000213 A KR1019800000213 A KR 1019800000213A KR 800000213 A KR800000213 A KR 800000213A KR 830001940 A KR830001940 A KR 830001940A
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- KR
- South Korea
- Prior art keywords
- compound
- structural formula
- reacted
- alkyl
- hydrogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 알카리 금속 시아나이드 및 탄산암모늄을 n이 1 또는 2일 때의 다음 구조식(Ⅱ)의 화합물을 반응시키거나 n이 0일 때의 다음 구조식(Ⅲ)의 화합물과 반응시킨 다음 활로겐화 시키고 염기 존재하에 가열시켜 R이 수소인 구조식(Ⅰ)의 화합물을 형성한 다음 임의로 생성물을 비독성 염기와 반응시켜 약제학적으로 무독한 염기성염으로 전환시키고 생성물을 임의로 알킬할라이드 또는 벤질 할라이드와 반응시켜서 이 1 내지 4개의 탄소원자를 가지는 알킬 또는 벤질인 구조식(Ⅰ)의 화합물을 형성시킴을 특징으로 하는 다음 구조식(Ⅰ)의 화합물을 제조하는 방법.상기 구조식에서A는 (a) 또는 (b)X는 산소 또는 항n은 0, 1 또는 2R은 수소, 1 내지 4개의 탄소원자를 가지는 알킬 또는 벤질R1, R2및 R3는 각각 수소, 클로로, 브로모, 플루오로, 1내지 3개의 탄소원자를 가지는 알킬 또는 페닐이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5278 | 1979-01-22 | ||
US06/005,278 US4176185A (en) | 1979-01-22 | 1979-01-22 | Spiro-quinolylhydantoins |
Publications (1)
Publication Number | Publication Date |
---|---|
KR830001940A true KR830001940A (ko) | 1983-05-19 |
Family
ID=21715098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019800000213A KR830001940A (ko) | 1979-01-22 | 1980-01-21 | 알도즈 환원요소 억제성 퀴놀릴히단토인류 |
Country Status (22)
Country | Link |
---|---|
US (1) | US4176185A (ko) |
EP (1) | EP0014079B1 (ko) |
JP (1) | JPS5840959B2 (ko) |
KR (1) | KR830001940A (ko) |
AR (1) | AR222685A1 (ko) |
AT (1) | AT365588B (ko) |
AU (1) | AU514271B2 (ko) |
CA (1) | CA1140928A (ko) |
DE (1) | DE3060079D1 (ko) |
DK (1) | DK156399C (ko) |
EG (1) | EG15085A (ko) |
ES (1) | ES8103090A1 (ko) |
FI (1) | FI69308C (ko) |
GR (1) | GR72408B (ko) |
IE (1) | IE49365B1 (ko) |
IL (1) | IL59177A (ko) |
NO (1) | NO152172C (ko) |
NZ (1) | NZ192650A (ko) |
PH (1) | PH15472A (ko) |
PT (1) | PT70716A (ko) |
YU (1) | YU41692B (ko) |
ZA (1) | ZA80344B (ko) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4176185A (en) * | 1979-01-22 | 1979-11-27 | Pfizer Inc. | Spiro-quinolylhydantoins |
US4490381A (en) * | 1979-11-13 | 1984-12-25 | Imperial Chemical Industries Plc | 1'-Substituted spiro[imidazolidine-4,3'-indoline]2,2',5-triones |
US4248882A (en) * | 1980-02-12 | 1981-02-03 | Pfizer Inc. | Treating diabetes-associated complications with hydantoin amines |
JPS5745185A (en) * | 1980-07-21 | 1982-03-13 | Eisai Co Ltd | Hydantoin derivative and its preparation |
EP0065393B1 (en) * | 1981-05-12 | 1984-12-27 | Imperial Chemical Industries Plc | Pyrrole derivatives |
MX12896A (es) * | 1987-09-04 | 1993-06-01 | Pfizer | Procedimiento para preparar un compuesto de espiro-heteroazolonas |
US5068333A (en) * | 1990-03-07 | 1991-11-26 | Pfizer Inc. | 6-chloro-3,4-dihydro-pyrano [2,3-b]pyridines having the R configuration |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1135915B (de) * | 1961-06-29 | 1962-09-06 | Asta Werke Ag Chem Fab | Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine |
US3876659A (en) * | 1970-09-18 | 1975-04-08 | Sandoz Ag | Spiro tricyclic isoindolines |
US4117230A (en) * | 1976-10-18 | 1978-09-26 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
US4176185A (en) * | 1979-01-22 | 1979-11-27 | Pfizer Inc. | Spiro-quinolylhydantoins |
-
1979
- 1979-01-22 US US06/005,278 patent/US4176185A/en not_active Expired - Lifetime
- 1979-12-28 NO NO794318A patent/NO152172C/no unknown
-
1980
- 1980-01-12 EG EG36/80A patent/EG15085A/xx active
- 1980-01-18 CA CA000343984A patent/CA1140928A/en not_active Expired
- 1980-01-18 AR AR279683A patent/AR222685A1/es active
- 1980-01-18 DE DE8080300170T patent/DE3060079D1/de not_active Expired
- 1980-01-18 NZ NZ192650A patent/NZ192650A/en unknown
- 1980-01-18 YU YU131/80A patent/YU41692B/xx unknown
- 1980-01-18 EP EP80300170A patent/EP0014079B1/en not_active Expired
- 1980-01-18 AT AT0026780A patent/AT365588B/de not_active IP Right Cessation
- 1980-01-21 DK DK024280A patent/DK156399C/da not_active IP Right Cessation
- 1980-01-21 JP JP55005610A patent/JPS5840959B2/ja not_active Expired
- 1980-01-21 PH PH23529A patent/PH15472A/en unknown
- 1980-01-21 KR KR1019800000213A patent/KR830001940A/ko unknown
- 1980-01-21 IL IL59177A patent/IL59177A/xx unknown
- 1980-01-21 ZA ZA00800344A patent/ZA80344B/xx unknown
- 1980-01-21 FI FI800163A patent/FI69308C/fi not_active IP Right Cessation
- 1980-01-21 AU AU54766/80A patent/AU514271B2/en not_active Ceased
- 1980-01-21 IE IE109/80A patent/IE49365B1/en unknown
- 1980-01-21 PT PT70716A patent/PT70716A/pt not_active IP Right Cessation
- 1980-01-22 ES ES487923A patent/ES8103090A1/es not_active Expired
- 1980-11-21 GR GR60999A patent/GR72408B/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATA26780A (de) | 1981-06-15 |
PH15472A (en) | 1983-01-24 |
NO794318L (no) | 1980-07-23 |
EP0014079A1 (en) | 1980-08-06 |
GR72408B (ko) | 1983-11-02 |
JPS55108873A (en) | 1980-08-21 |
ES487923A0 (es) | 1981-02-16 |
NO152172B (no) | 1985-05-06 |
DK24280A (da) | 1980-07-23 |
DK156399C (da) | 1990-01-08 |
FI69308C (fi) | 1986-01-10 |
ES8103090A1 (es) | 1981-02-16 |
EG15085A (en) | 1986-12-30 |
CA1140928A (en) | 1983-02-08 |
DK156399B (da) | 1989-08-14 |
NZ192650A (en) | 1984-04-27 |
JPS5840959B2 (ja) | 1983-09-08 |
PT70716A (en) | 1980-02-01 |
AR222685A1 (es) | 1981-06-15 |
IL59177A0 (en) | 1980-05-30 |
DE3060079D1 (en) | 1982-01-21 |
US4176185A (en) | 1979-11-27 |
FI69308B (fi) | 1985-09-30 |
EP0014079B1 (en) | 1981-11-18 |
YU13180A (en) | 1983-01-21 |
IE800109L (en) | 1980-07-22 |
AU514271B2 (en) | 1981-01-29 |
IL59177A (en) | 1982-11-30 |
AT365588B (de) | 1982-01-25 |
AU5476680A (en) | 1980-07-31 |
NO152172C (no) | 1985-08-14 |
ZA80344B (en) | 1981-02-25 |
YU41692B (en) | 1987-12-31 |
IE49365B1 (en) | 1985-09-18 |
FI800163A (fi) | 1980-07-23 |
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