KR830001940A - 알도즈 환원요소 억제성 퀴놀릴히단토인류 - Google Patents

알도즈 환원요소 억제성 퀴놀릴히단토인류 Download PDF

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Publication number
KR830001940A
KR830001940A KR1019800000213A KR800000213A KR830001940A KR 830001940 A KR830001940 A KR 830001940A KR 1019800000213 A KR1019800000213 A KR 1019800000213A KR 800000213 A KR800000213 A KR 800000213A KR 830001940 A KR830001940 A KR 830001940A
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KR
South Korea
Prior art keywords
compound
structural formula
reacted
alkyl
hydrogen
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KR1019800000213A
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English (en)
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코렌슈눌 로드니
Original Assignee
폴 밀러
화이자 인크
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Application filed by 폴 밀러, 화이자 인크 filed Critical 폴 밀러
Publication of KR830001940A publication Critical patent/KR830001940A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

알도즈 환원요소 억제성 퀴놀릴히단토인류
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 알카리 금속 시아나이드 및 탄산암모늄을 n이 1 또는 2일 때의 다음 구조식(Ⅱ)의 화합물을 반응시키거나 n이 0일 때의 다음 구조식(Ⅲ)의 화합물과 반응시킨 다음 활로겐화 시키고 염기 존재하에 가열시켜 R이 수소인 구조식(Ⅰ)의 화합물을 형성한 다음 임의로 생성물을 비독성 염기와 반응시켜 약제학적으로 무독한 염기성염으로 전환시키고 생성물을 임의로 알킬할라이드 또는 벤질 할라이드와 반응시켜서 이 1 내지 4개의 탄소원자를 가지는 알킬 또는 벤질인 구조식(Ⅰ)의 화합물을 형성시킴을 특징으로 하는 다음 구조식(Ⅰ)의 화합물을 제조하는 방법.
    상기 구조식에서
    A는 (a) 또는 (b)
    X는 산소 또는 항
    n은 0, 1 또는 2
    R은 수소, 1 내지 4개의 탄소원자를 가지는 알킬 또는 벤질
    R1, R2및 R3는 각각 수소, 클로로, 브로모, 플루오로, 1내지 3개의 탄소원자를 가지는 알킬 또는 페닐이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800000213A 1979-01-22 1980-01-21 알도즈 환원요소 억제성 퀴놀릴히단토인류 KR830001940A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5278 1979-01-22
US06/005,278 US4176185A (en) 1979-01-22 1979-01-22 Spiro-quinolylhydantoins

Publications (1)

Publication Number Publication Date
KR830001940A true KR830001940A (ko) 1983-05-19

Family

ID=21715098

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800000213A KR830001940A (ko) 1979-01-22 1980-01-21 알도즈 환원요소 억제성 퀴놀릴히단토인류

Country Status (22)

Country Link
US (1) US4176185A (ko)
EP (1) EP0014079B1 (ko)
JP (1) JPS5840959B2 (ko)
KR (1) KR830001940A (ko)
AR (1) AR222685A1 (ko)
AT (1) AT365588B (ko)
AU (1) AU514271B2 (ko)
CA (1) CA1140928A (ko)
DE (1) DE3060079D1 (ko)
DK (1) DK156399C (ko)
EG (1) EG15085A (ko)
ES (1) ES8103090A1 (ko)
FI (1) FI69308C (ko)
GR (1) GR72408B (ko)
IE (1) IE49365B1 (ko)
IL (1) IL59177A (ko)
NO (1) NO152172C (ko)
NZ (1) NZ192650A (ko)
PH (1) PH15472A (ko)
PT (1) PT70716A (ko)
YU (1) YU41692B (ko)
ZA (1) ZA80344B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4176185A (en) * 1979-01-22 1979-11-27 Pfizer Inc. Spiro-quinolylhydantoins
US4490381A (en) * 1979-11-13 1984-12-25 Imperial Chemical Industries Plc 1'-Substituted spiro[imidazolidine-4,3'-indoline]2,2',5-triones
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
EP0065393B1 (en) * 1981-05-12 1984-12-27 Imperial Chemical Industries Plc Pyrrole derivatives
MX12896A (es) * 1987-09-04 1993-06-01 Pfizer Procedimiento para preparar un compuesto de espiro-heteroazolonas
US5068333A (en) * 1990-03-07 1991-11-26 Pfizer Inc. 6-chloro-3,4-dihydro-pyrano [2,3-b]pyridines having the R configuration

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1135915B (de) * 1961-06-29 1962-09-06 Asta Werke Ag Chem Fab Verfahren zur Herstellung neuer, antikonvulsiv wirksamer Spirohydantoine
US3876659A (en) * 1970-09-18 1975-04-08 Sandoz Ag Spiro tricyclic isoindolines
US4117230A (en) * 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4176185A (en) * 1979-01-22 1979-11-27 Pfizer Inc. Spiro-quinolylhydantoins

Also Published As

Publication number Publication date
ATA26780A (de) 1981-06-15
PH15472A (en) 1983-01-24
NO794318L (no) 1980-07-23
EP0014079A1 (en) 1980-08-06
GR72408B (ko) 1983-11-02
JPS55108873A (en) 1980-08-21
ES487923A0 (es) 1981-02-16
NO152172B (no) 1985-05-06
DK24280A (da) 1980-07-23
DK156399C (da) 1990-01-08
FI69308C (fi) 1986-01-10
ES8103090A1 (es) 1981-02-16
EG15085A (en) 1986-12-30
CA1140928A (en) 1983-02-08
DK156399B (da) 1989-08-14
NZ192650A (en) 1984-04-27
JPS5840959B2 (ja) 1983-09-08
PT70716A (en) 1980-02-01
AR222685A1 (es) 1981-06-15
IL59177A0 (en) 1980-05-30
DE3060079D1 (en) 1982-01-21
US4176185A (en) 1979-11-27
FI69308B (fi) 1985-09-30
EP0014079B1 (en) 1981-11-18
YU13180A (en) 1983-01-21
IE800109L (en) 1980-07-22
AU514271B2 (en) 1981-01-29
IL59177A (en) 1982-11-30
AT365588B (de) 1982-01-25
AU5476680A (en) 1980-07-31
NO152172C (no) 1985-08-14
ZA80344B (en) 1981-02-25
YU41692B (en) 1987-12-31
IE49365B1 (en) 1985-09-18
FI800163A (fi) 1980-07-23

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