ATE58554T1 - Menschlicher hybridomfusionspartner zur herstellung menschlicher monoklonaler antikoerper. - Google Patents

Menschlicher hybridomfusionspartner zur herstellung menschlicher monoklonaler antikoerper.

Info

Publication number
ATE58554T1
ATE58554T1 AT85306493T AT85306493T ATE58554T1 AT E58554 T1 ATE58554 T1 AT E58554T1 AT 85306493 T AT85306493 T AT 85306493T AT 85306493 T AT85306493 T AT 85306493T AT E58554 T1 ATE58554 T1 AT E58554T1
Authority
AT
Austria
Prior art keywords
human
hybridom
production
monoclonal antibodies
fusion partner
Prior art date
Application number
AT85306493T
Other languages
English (en)
Inventor
Danuta Kozbor
Carlo M Croce
Original Assignee
Wistar Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wistar Inst filed Critical Wistar Inst
Application granted granted Critical
Publication of ATE58554T1 publication Critical patent/ATE58554T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT85306493T 1984-11-20 1985-09-12 Menschlicher hybridomfusionspartner zur herstellung menschlicher monoklonaler antikoerper. ATE58554T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/673,370 US4693975A (en) 1984-11-20 1984-11-20 Human hybridroma fusion partner for production of human monoclonal antibodies
EP85306493A EP0182467B1 (de) 1984-11-20 1985-09-12 Menschlicher Hybridomfusionspartner zur Herstellung menschlicher monoklonaler Antikörper

Publications (1)

Publication Number Publication Date
ATE58554T1 true ATE58554T1 (de) 1990-12-15

Family

ID=24702377

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85306493T ATE58554T1 (de) 1984-11-20 1985-09-12 Menschlicher hybridomfusionspartner zur herstellung menschlicher monoklonaler antikoerper.

Country Status (7)

Country Link
US (1) US4693975A (de)
EP (1) EP0182467B1 (de)
JP (1) JPS61128886A (de)
AT (1) ATE58554T1 (de)
AU (1) AU577745B2 (de)
CA (1) CA1245581A (de)
DE (1) DE3580654D1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1214123A (en) * 1983-01-20 1986-11-18 Masashi Matsui Cell lines for use in the preparation of hybridoma cells
JPH0798000B2 (ja) * 1987-05-23 1995-10-25 萩原 義秀 ガン関連抗原特異的ヒト免疫グロブリン
US5001065A (en) * 1987-05-27 1991-03-19 Cetus Corporation Human cell line and triomas, antibodies, and transformants derived therefrom
JPH0249597A (ja) * 1988-04-27 1990-02-19 Kimiyoshi Tsuji モノクローナル抗体及びその利用方法
CA2002067A1 (en) * 1988-11-09 1990-05-09 Tamotsu Fukuda Parent cell line for producing human hybridomas
US6274552B1 (en) 1993-03-18 2001-08-14 Cytimmune Sciences, Inc. Composition and method for delivery of biologically-active factors
US20010055581A1 (en) * 1994-03-18 2001-12-27 Lawrence Tamarkin Composition and method for delivery of biologically-active factors
US7229841B2 (en) * 2001-04-30 2007-06-12 Cytimmune Sciences, Inc. Colloidal metal compositions and methods
US6407218B1 (en) 1997-11-10 2002-06-18 Cytimmune Sciences, Inc. Method and compositions for enhancing immune response and for the production of in vitro mabs
JP2008504216A (ja) * 2003-12-02 2008-02-14 サイトイミューン サイエンシズ インコーポレイテッド モノクローナル抗体の生成のための方法および組成物
AU2005209318B2 (en) * 2004-01-28 2010-02-11 Cytimmune Sciences, Inc. Functionalized colloidal metal compositions and methods
CN102533966B (zh) 2005-08-01 2014-03-12 俄亥俄州立大学研究基金会 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物
JP2009507918A (ja) 2005-09-12 2009-02-26 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション Ｂｃｌ２関連癌の診断及び療法のための組成物及び方法
EP2502630B1 (de) 2006-01-05 2015-03-11 The Ohio State University Research Foundation Verfahren und Zusammensetzungen auf Mikro-RNA-Basis zur Diagnose, Prognose und Behandlung von Lungenkrebs
AU2007205257B2 (en) 2006-01-05 2013-07-25 The Ohio State University Research Foundation MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors
ES2545119T3 (es) 2006-01-05 2015-09-08 The Ohio State University Research Foundation Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
US7985584B2 (en) 2006-03-20 2011-07-26 The Ohio State University Research Foundation MicroRNA fingerprints during human megakaryocytopoiesis
WO2008008430A2 (en) * 2006-07-13 2008-01-17 The Ohio State University Research Foundation Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases
EP2061907B1 (de) * 2006-09-19 2011-11-23 The Ohio State University Research Foundation Tcl1-expression in durch mir-29 und mir-181 regulierter chronischer lymphozyten-leukämie (cll)
WO2008054828A2 (en) 2006-11-01 2008-05-08 The Ohio State University Research Foundation Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma
EP2109687B1 (de) 2007-01-31 2014-06-04 The Ohio State University Research Foundation Micro-rna-basierte verfahren zur behandlung von akuter myeloischer leukämie (aml)
WO2008153987A2 (en) 2007-06-08 2008-12-18 The Government Of The United States Of America As Represented By The Secretary Of Department Of Health And Human Services Methods for determining hepatocellular carcinoma subtype and detecting hepatic cancer stem cells
CA2690749A1 (en) 2007-06-15 2008-12-24 The Ohio State University Research Foundation Oncogenic all-1 fusion proteins for targeting drosha-mediated microrna processing
WO2009018303A2 (en) 2007-07-31 2009-02-05 The Ohio State University Research Foundation Methods for reverting methylation by targeting dnmt3a and dnmt3b
CN101835902B (zh) 2007-08-03 2014-03-26 俄亥俄州立大学研究基金会 编码ncrna的超保守区域
WO2009020923A1 (en) 2007-08-03 2009-02-12 Musc Foundation For Research Development Human monoclonal antibodies and methods for producing the same
AU2008288806B2 (en) 2007-08-22 2014-11-27 The Ohio State University Research Foundation Methods and compositions for inducing deregulation of EphA7 and Erk phosphorylation in human acute leukemias
US20110014118A1 (en) * 2007-09-21 2011-01-20 Lawrence Tamarkin Nanotherapeutic colloidal metal compositions and methods
US20090104114A1 (en) * 2007-09-21 2009-04-23 Cytimmune Sciences, Inc. Nanotherapeutic Colloidal Metal Compositions and Methods
CN103898069A (zh) 2007-10-26 2014-07-02 俄亥俄州立大学研究基金会 鉴定脆性组氨酸三联体(Fhit)相互作用的方法及其用途
EP2219458B1 (de) * 2007-11-08 2015-07-15 Cytimmune Sciences, Inc. Zusammensetzungen und verfahren für die erzeugung von antikörpern
CN102149827B (zh) 2008-06-11 2014-08-20 由卫生与公众服务部代表的***合众国政府 MiR-26家族作为肝细胞癌和对治疗的应答性的预测性标志物的用途
AU2010321555B2 (en) 2009-11-23 2015-10-15 The Ohio State University Materials and methods useful for affecting tumor cell growth, migration and invasion
US8493081B2 (en) * 2009-12-08 2013-07-23 Magna Closures Inc. Wide activation angle pinch sensor section and sensor hook-on attachment principle
CA2816603A1 (en) 2010-11-12 2012-05-18 The Ohio State University Research Foundation Materials and methods related to microrna-21, mismatch repair, and colorectal cancer
AU2011329066B2 (en) 2010-11-15 2017-03-09 The Ohio State University Research Foundation Controlled release mucoadhesive systems
CN103561750A (zh) 2011-03-07 2014-02-05 俄亥俄州立大学 通过microRNA-155(miR-155)诱导的增变活性使炎症与癌症关联
CA2852066A1 (en) 2011-10-14 2013-04-18 The Ohio State University Methods and materials related to ovarian cancer
AU2012352265B2 (en) 2011-12-13 2017-02-16 Ohio State Innovation Foundation Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
EP2804960A4 (de) 2012-01-20 2015-08-19 Univ Ohio State Brustkrebsbiomarkersignaturen für invasivität und prognose

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2079313A (en) * 1980-07-07 1982-01-20 Nat Res Dev Improvements in or relating to rat myeloma cell lines
CH652145A5 (de) * 1982-01-22 1985-10-31 Sandoz Ag Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen.
US4529694A (en) * 1982-04-16 1985-07-16 The Children's Medical Center Corporation Cell fusion
US4574116A (en) * 1983-01-13 1986-03-04 The Board Of Trustees Of The Leland Stanford Jr. University Methods and cell lines for immortalization and monoclonal antibody production by antigen-stimulated B-lymphocytes
CA1214123A (en) * 1983-01-20 1986-11-18 Masashi Matsui Cell lines for use in the preparation of hybridoma cells
JPS59169489A (ja) * 1983-03-15 1984-09-25 Otsuka Pharmaceut Co Ltd ヒト培養株化細胞
EP0131878A3 (de) * 1983-07-19 1987-08-05 Sloan-Kettering Institute For Cancer Research Verfahren zur Herstellung menschlicher monoklonaler Antikörper
DK172686A (da) * 1985-04-22 1986-10-23 Hybritech Inc Antigen opnaaet ud fra humant vaev, fremgangsmaade til under anvendelse af antigenet at fremstille monoklonale antistoffer til diagnose og behandling af cancer, fremgangsmaade til paavisning af cancer, samt antistoffer mod antigenet

Also Published As

Publication number Publication date
JPS61128886A (ja) 1986-06-16
EP0182467A2 (de) 1986-05-28
DE3580654D1 (de) 1991-01-03
AU577745B2 (en) 1988-09-29
US4693975A (en) 1987-09-15
EP0182467A3 (en) 1987-09-16
EP0182467B1 (de) 1990-11-22
CA1245581A (en) 1988-11-29
AU5007885A (en) 1986-05-29

Similar Documents

Publication Publication Date Title
ATE58554T1 (de) Menschlicher hybridomfusionspartner zur herstellung menschlicher monoklonaler antikoerper.
ATE26464T1 (de) Rekombinante monoklonale antikoerper.
AU542303B2 (en) Antibody production by rat myeloma cells
EP0176355A3 (de) Immunologisches Verfahren unabhängig von Antigenen
JPS5673029A (en) Production of antibody against hepatitis virus and cell system therefor
JPS5695123A (en) Hybrid cell line* antibody and method for manufacturing monoclonal antibody to human prothymocyte cell
SE8300290D0 (sv) Process for the production of human mono-clonal antibodies
EP0440266A3 (de) Menschliche monoklonale Antikörper gegen bakterielle Toxine
PT86792A (pt) Monoclonal antibodies against melanoma-associated antigens hybrid cell lines producing these antibodies and use therefor
SE8106528L (sv) Framstellning av menskliga monoklonala antikroppar medelst menskliga hybridom
AU545181B2 (en) Hybridoma for producing monoclonal antibodies
JPS5753411A (en) Monoclonal antibody against drug, manufacture and somatic cell hybridoma for monoclonal antibody production
AU545222B2 (en) Hybridoma for producing monoconal antibodies
DE3581288D1 (de) Antileishmania monoklonale antikoerper, diese antikoerper ausscheidende hybridomas, von diesen antikoerpern erkannte leishmaniaantigene, verfahren zur herstellung und verwendung von diesen monoklonalen antikoerpern und antigenen.
EP0161638A3 (en) Monoclonal antibody and method for quantitation of immoglobulins using the same
DE3485128D1 (de) Zellinien verwendbar zur herstellung von hybridomazellen.
EP0102601A3 (de) Monoklonaler Antikörper, Verfahren zu seiner Herstellung und Verwendung dieses monoklonalen Antikörpers
ES8503371A1 (es) Procedimiento para preparar nuevos anticuerpos de igg de raton con especificidad anti-interferon de humano
DE3576359D1 (de) Verfahren zur herstellung von tumorspezifische monoklonale antikoerper produzierenden hybridomazellen.
KR860007275A (ko) 모노클로날 항-알파-아밀라제 항체 및 그의 제법
ES8801945A1 (es) Un procedimiento para la obtencion de anticuerpos monoclonales contra peptidos atriales natuureticos.
EP0287397A3 (en) Monoclonal antibody specific to human pancreatic phospholipase a2
DE3580524D1 (de) Monoklonaler antikoerper geeignet zur spezifischen unterscheidung von humanen hepatokarzinomzellen.
ES8609465A1 (es) Procedimiento para preparar nuevos anticuerpos monoclonales de raton con especificidad anti-interferon de humano
EP0287012A3 (de) Monoklonaler Anti-R-Binder-Antikörper, Verfahren zu seiner Herstellung und seine Verwendung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee