ATE554800T1 - Medizinische vorrichtungen mit porösen regionen zur kontrollierten aussetzung oder verabreichung therapeutischer wirkstoffe - Google Patents

Medizinische vorrichtungen mit porösen regionen zur kontrollierten aussetzung oder verabreichung therapeutischer wirkstoffe

Info

Publication number
ATE554800T1
ATE554800T1 AT07839083T AT07839083T ATE554800T1 AT E554800 T1 ATE554800 T1 AT E554800T1 AT 07839083 T AT07839083 T AT 07839083T AT 07839083 T AT07839083 T AT 07839083T AT E554800 T1 ATE554800 T1 AT E554800T1
Authority
AT
Austria
Prior art keywords
porous regions
medical devices
administration
active ingredients
therapeutic active
Prior art date
Application number
AT07839083T
Other languages
English (en)
Inventor
Barron Tenney
Michael Helmus
Yixin Xu
Original Assignee
Boston Scient Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scient Ltd filed Critical Boston Scient Ltd
Application granted granted Critical
Publication of ATE554800T1 publication Critical patent/ATE554800T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/146Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602Type of release, e.g. controlled, sustained, slow
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0043Catheters; Hollow probes characterised by structural features
    • A61M2025/0057Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT07839083T 2006-10-10 2007-10-01 Medizinische vorrichtungen mit porösen regionen zur kontrollierten aussetzung oder verabreichung therapeutischer wirkstoffe ATE554800T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/545,439 US7666179B2 (en) 2006-10-10 2006-10-10 Medical devices having porous regions for controlled therapeutic agent exposure or delivery
PCT/US2007/021055 WO2008045228A2 (en) 2006-10-10 2007-10-01 Medical devices having porous regions for controlled therapeutic agent exposure or delivery

Publications (1)

Publication Number Publication Date
ATE554800T1 true ATE554800T1 (de) 2012-05-15

Family

ID=39091787

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07839083T ATE554800T1 (de) 2006-10-10 2007-10-01 Medizinische vorrichtungen mit porösen regionen zur kontrollierten aussetzung oder verabreichung therapeutischer wirkstoffe

Country Status (6)

Country Link
US (1) US7666179B2 (de)
EP (1) EP2089070B1 (de)
JP (1) JP2010505591A (de)
AT (1) ATE554800T1 (de)
CA (1) CA2669075A1 (de)
WO (1) WO2008045228A2 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7655001B2 (en) * 2001-03-23 2010-02-02 Petrakis Dennis N Temperature responsive systems
US7445616B2 (en) * 2001-03-23 2008-11-04 Petrakis Dennis N Temperature responsive systems
US20050182443A1 (en) 2004-02-18 2005-08-18 Closure Medical Corporation Adhesive-containing wound closure device and method
US20060009099A1 (en) 2004-07-12 2006-01-12 Closure Medical Corporation Adhesive-containing wound closure device and method
US8597720B2 (en) 2007-01-21 2013-12-03 Hemoteq Ag Medical product for treating stenosis of body passages and for preventing threatening restenosis
US8187255B2 (en) * 2007-02-02 2012-05-29 Boston Scientific Scimed, Inc. Medical devices having nanoporous coatings for controlled therapeutic agent delivery
WO2009006390A2 (en) 2007-07-03 2009-01-08 Charles Stark Draper Laboratory, Inc. Drug-eluting staples prosthesis
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US7833266B2 (en) * 2007-11-28 2010-11-16 Boston Scientific Scimed, Inc. Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
GB0811874D0 (en) * 2008-06-30 2008-07-30 Nemaura Pharma Ltd Patches for reverse iontophoresis
US20110159070A1 (en) * 2008-07-03 2011-06-30 The Regents Of The University Of California Biomaterials and implants for enhanced cartilage formation, and methods for making and using them
US7951193B2 (en) * 2008-07-23 2011-05-31 Boston Scientific Scimed, Inc. Drug-eluting stent
US7727450B1 (en) * 2009-01-20 2010-06-01 Gm Global Technology Operations, Inc. Method of using shape memory polymers
US10369256B2 (en) 2009-07-10 2019-08-06 Boston Scientific Scimed, Inc. Use of nanocrystals for drug delivery from a balloon
WO2011008393A2 (en) 2009-07-17 2011-01-20 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
CN102065372B (zh) * 2009-11-16 2014-10-08 ***通信集团公司 以广播方式传输数据的方法及相关装置
US8992411B2 (en) 2010-02-16 2015-03-31 Ams Research Corporation Bioabsorbable mesh for surgical implants
WO2012031236A1 (en) 2010-09-02 2012-03-08 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
JP5696279B2 (ja) * 2010-12-01 2015-04-08 学校法人自治医科大学 長期徐放型薬剤硬膜外腔留置システム
WO2012116182A1 (en) * 2011-02-23 2012-08-30 Ams Research Corporation Pelvic implant and therapeutic agent system and method
WO2013022458A1 (en) 2011-08-05 2013-02-14 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
FR2986156B1 (fr) * 2012-01-30 2014-07-04 Rhenovia Pharma Dispositif transdermique pour l'administration controlee a un patient d'au moins un principe actif
WO2013116811A1 (en) * 2012-02-03 2013-08-08 The Board Of Regents Of The University Of Texas System Improved processability of polymeric substrates and related methods
US9526640B2 (en) * 2013-08-18 2016-12-27 Boston Scientific Scimed, Inc. Anti-migration micropatterned stent coating
DE102012025143A1 (de) * 2012-11-07 2014-05-08 Heraeus Medical Gmbh Verfahren zur Wirkstofffreisetzung und Wirkstofffreisetzungssysteme
US20150336058A1 (en) * 2013-01-31 2015-11-26 Regents Of The University Of Minnesota Nanoporous filtration membranes
EP2849212B1 (de) * 2013-09-17 2018-05-23 IMEC vzw Schutz von porösen Substraten vor der Behandlung
US20150342760A1 (en) * 2014-06-02 2015-12-03 Boston Scientific Scimed Inc. Anti-migration stent
CN104803348A (zh) * 2015-04-20 2015-07-29 中国科学院光电技术研究所 一种牺牲模板制备高深宽比聚合物纳米柱阵列的方法
US10232154B2 (en) * 2015-07-28 2019-03-19 Boston Scientific Scimed, Inc. Implantable medical devices and related methods of use
EP3481571A4 (de) * 2016-07-05 2020-07-22 Porosteon Development LLC Poröse metallvorrichtungen
US10792024B2 (en) 2016-09-28 2020-10-06 Ethicon, Inc. Scaffolds with channels for joining layers of tissue at discrete points
US10687986B2 (en) 2016-09-29 2020-06-23 Ethicon, Inc. Methods and devices for skin closure
USD848624S1 (en) 2016-09-29 2019-05-14 Ethicon, Inc. Release paper for wound treatment devices
US20180271505A1 (en) 2017-03-23 2018-09-27 Ethicon, Inc. Scaffolds for Joining Layers of Tissue at Discrete Points
US10470935B2 (en) 2017-03-23 2019-11-12 Ethicon, Inc. Skin closure systems and devices of improved flexibility and stretchability for bendable joints
US11504446B2 (en) 2017-04-25 2022-11-22 Ethicon, Inc. Skin closure devices with self-forming exudate drainage channels
US10993708B2 (en) 2018-07-31 2021-05-04 Ethicon, Inc. Skin closure devices with interrupted closure
US20220211913A1 (en) * 2019-05-03 2022-07-07 Syracuse University Shape memory polymer hydrogels for wound healing
US11707351B2 (en) 2019-08-19 2023-07-25 Encompass Technologies, Inc. Embolic protection and access system

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8527369D0 (en) * 1985-11-06 1985-12-11 Smiths Industries Plc Catheters
JPH01285274A (ja) * 1988-05-12 1989-11-16 Olympus Optical Co Ltd 薬剤徐放装置
JPH0723572B2 (ja) * 1988-10-17 1995-03-15 三菱重工業株式会社 形状記憶性ポリマーによる織布
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6106642A (en) * 1998-02-19 2000-08-22 Boston Scientific Limited Process for the improved ductility of nitinol
AU767510B2 (en) * 1999-02-18 2003-11-13 Valeritas, Inc. Electroactive pore
US6491061B1 (en) * 2000-02-25 2002-12-10 University Of New Mexico Stimuli responsive hybrid materials containing molecular actuators and their applications
US6682521B2 (en) * 2000-03-23 2004-01-27 Dennis N. Petrakis Temperature activated systems
JP4657577B2 (ja) * 2001-01-09 2011-03-23 マイクロチップス・インコーポレーテッド 眼への適用および他への適用のための可撓性マイクロチップデバイス
US20030109824A1 (en) * 2001-11-07 2003-06-12 Microvena Corporation Distal protection device with local drug delivery to maintain patency
US7108685B2 (en) * 2002-04-15 2006-09-19 Boston Scientific Scimed, Inc. Patch stabilization of rods for treatment of cardiac muscle
US20040193262A1 (en) * 2003-03-29 2004-09-30 Shadduck John H. Implants for treating ocular hypertension, methods of use and methods of fabrication
US20050013988A1 (en) * 2003-04-16 2005-01-20 Qiang Fu Stimuli responsive mesoporous materials for control of molecular transport
US7356368B2 (en) * 2004-07-21 2008-04-08 Boston Scientific Scimed, Inc. Light-activated anti-infective coatings and devices made thereof
JP2005139183A (ja) * 2004-11-04 2005-06-02 Cellseed Inc 刺激応答性材料の利用方法
US20060129215A1 (en) * 2004-12-09 2006-06-15 Helmus Michael N Medical devices having nanostructured regions for controlled tissue biocompatibility and drug delivery
US20060127442A1 (en) 2004-12-09 2006-06-15 Helmus Michael N Use of supercritical fluids to incorporate biologically active agents into nanoporous medical articles
US20070148251A1 (en) * 2005-12-22 2007-06-28 Hossainy Syed F A Nanoparticle releasing medical devices
US20070224235A1 (en) * 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery

Also Published As

Publication number Publication date
WO2008045228A2 (en) 2008-04-17
EP2089070A2 (de) 2009-08-19
EP2089070B1 (de) 2012-04-25
US20080086113A1 (en) 2008-04-10
WO2008045228A3 (en) 2009-02-12
US7666179B2 (en) 2010-02-23
JP2010505591A (ja) 2010-02-25
CA2669075A1 (en) 2008-04-17

Similar Documents

Publication Publication Date Title
ATE554800T1 (de) Medizinische vorrichtungen mit porösen regionen zur kontrollierten aussetzung oder verabreichung therapeutischer wirkstoffe
BRPI0507048A (pt) uso de baixa dosagem de eritropoetina para estimular células precursoras endoteliais, regenerar órgãos e retardar a progressão de danos em órgão alvo
ATE456369T1 (de) Flibanserin zur behandlung von harninkontinenz und assoziierten erkrankungen
ATE399553T1 (de) Pharmazeutische zusammensetzungen mit dextromethorphan und chinidin zur behandlung von neurologischen erkrankungen
DE602005026078D1 (de) Verwendung von Antioxidantien zur Verhinderung von Oxidation und zur Reduzierung von Wirkstoffzersetzung in wirkstoffhaltigen medizinischen Artikeln
DE602005026866D1 (de) Vewendung von dreidimensionalem kultiviertem gewebe zur behandlung von kongestivem herzversagen
ATE416798T1 (de) Medizinprodukt mit gewebeabhängiger arzneimittelelution
DE602006007093D1 (de) Kombinationstherapie zur Behandlung von Diabetes und dadurch bedingten Leiden sowie zur Behandlung von mittels Erhöhung des GLP-1-Spiegels im Blut verbesserten Leiden
EA200802204A1 (ru) Применение ингибиторов dpp iv
DE60115498D1 (de) Chirurgische vorrichtungen
DE60216139D1 (de) Arylharnstoff-verbindungen in kombination mit anderen zytostatisch oder zytotoxisch wirksamen stoffen zur behandlungen menschlicher krebserkrankungen
CR8380A (es) Metodos para preparar y utilizar compuestos novedosos de celulas madre y sus conjuntos
BRPI0519739A2 (pt) combinaÇço compreendendo um agente fornecendo um sinal, um material de implante e uma droga
BRPI0822625B8 (pt) dispositivo espaçador modular para o tratamento de infecções por próteses
ATE457166T1 (de) Orale zusammensetzungen zur behandlung von diabetes
ECSP045407A (es) Benzazoles sustituidos y el uso del mismo como inhibidores de quinasa raf
MY143795A (en) Tetrahydropyridoindole derivatives
TR201903587T4 (tr) Telomeraz aktivitesinin artırılması için bileşimler.
BRPI0509172A (pt) pelo menos uma entidade quìmica, composição farmacêutica, métodos para tratar um paciente, para inibir pelo menos uma enzima que utiliza atp, e para tratar pelo menos uma doença, uso de pelo menos uma entidade quìmica, e, método para a fabricação de um medicamento
DOP2000000114A (es) Oxazolidinonas substituidas y su uso
CY1109519T1 (el) Κεκορεσμενες και ακορεστες 3-πυριδυλο-βενζοκυκλοαλκυλομεθυλαμινες για τη θεραπεια πονων, καταθλιψεων και καταστασεων φοβου
DE602005021770D1 (de) Indol-1-yl-essigsäurederivate
EA200971053A1 (ru) Способы лечения кожных язв
ATE495767T1 (de) Regelungsverfahren für die eluierung von therapeutischen wirkstoffen
BR112013005673A2 (pt) uso de lipase de ácido lisossomal para tratamento de deficiência de lipase de ácido lisossomal em pacientes