ATE538109T1 - NEW 2-(2-HYDROXYPHENYL)BENZOTHIADIAZINE SUITABLE FOR THE TREATMENT OF OBESITY AND DIABETES - Google Patents

NEW 2-(2-HYDROXYPHENYL)BENZOTHIADIAZINE SUITABLE FOR THE TREATMENT OF OBESITY AND DIABETES

Info

Publication number
ATE538109T1
ATE538109T1 AT07822643T AT07822643T ATE538109T1 AT E538109 T1 ATE538109 T1 AT E538109T1 AT 07822643 T AT07822643 T AT 07822643T AT 07822643 T AT07822643 T AT 07822643T AT E538109 T1 ATE538109 T1 AT E538109T1
Authority
AT
Austria
Prior art keywords
obesity
diabetes
treatment
benzothiadiazine
hydroxyphenyl
Prior art date
Application number
AT07822643T
Other languages
German (de)
Inventor
Preben Houlberg Olesen
Anders Klarskov Petersen
Flemming Elmelund Nielsen
Lise Brown Christiansen
Holger Claus Hansen
Original Assignee
High Point Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by High Point Pharmaceuticals Llc filed Critical High Point Pharmaceuticals Llc
Application granted granted Critical
Publication of ATE538109T1 publication Critical patent/ATE538109T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
AT07822643T 2006-11-15 2007-11-15 NEW 2-(2-HYDROXYPHENYL)BENZOTHIADIAZINE SUITABLE FOR THE TREATMENT OF OBESITY AND DIABETES ATE538109T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200601488 2006-11-15
PCT/EP2007/062408 WO2008059025A1 (en) 2006-11-15 2007-11-15 Novel 2-(2-hydroxyphenyl) benzothiadiazines useful for treating obesity and diabetes

Publications (1)

Publication Number Publication Date
ATE538109T1 true ATE538109T1 (en) 2012-01-15

Family

ID=39016016

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07822643T ATE538109T1 (en) 2006-11-15 2007-11-15 NEW 2-(2-HYDROXYPHENYL)BENZOTHIADIAZINE SUITABLE FOR THE TREATMENT OF OBESITY AND DIABETES

Country Status (6)

Country Link
US (1) US8022066B2 (en)
EP (1) EP2086951B1 (en)
AT (1) ATE538109T1 (en)
CA (1) CA2669874A1 (en)
ES (1) ES2377322T3 (en)
WO (1) WO2008059025A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008059023A1 (en) 2006-11-15 2008-05-22 High Point Pharmaceuticals, Llc New haloalkylsulfone substituted compounds useful for treating obesity and diabetes
ATE523497T1 (en) 2006-11-15 2011-09-15 High Point Pharmaceuticals Llc NEW 2-(2-HYDROXYPHENYL)BENZIMIDAZOLES SUITABLE FOR THE TREATMENT OF OBESITAS AND DIABETES
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
LT3565806T (en) 2017-01-06 2022-06-10 Rivus Pharmaceuticals, Inc. Novel phenyl derivatives

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WO2008059023A1 (en) 2006-11-15 2008-05-22 High Point Pharmaceuticals, Llc New haloalkylsulfone substituted compounds useful for treating obesity and diabetes

Also Published As

Publication number Publication date
US8022066B2 (en) 2011-09-20
EP2086951A1 (en) 2009-08-12
CA2669874A1 (en) 2008-05-22
EP2086951B1 (en) 2011-12-21
ES2377322T3 (en) 2012-03-26
WO2008059025A1 (en) 2008-05-22
US20090325941A1 (en) 2009-12-31

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