ATE530561T1 - 3-ether- und 3-thioether-substituierte ciclosporinderivate zur behandlung und prävention einer hepatitis-c-infektion - Google Patents

3-ether- und 3-thioether-substituierte ciclosporinderivate zur behandlung und prävention einer hepatitis-c-infektion

Info

Publication number
ATE530561T1
ATE530561T1 AT05815625T AT05815625T ATE530561T1 AT E530561 T1 ATE530561 T1 AT E530561T1 AT 05815625 T AT05815625 T AT 05815625T AT 05815625 T AT05815625 T AT 05815625T AT E530561 T1 ATE530561 T1 AT E530561T1
Authority
AT
Austria
Prior art keywords
hepatitis
treatment
derivatives
ciclosporine
infection
Prior art date
Application number
AT05815625T
Other languages
English (en)
Inventor
Hans Fliri
David Houck
Original Assignee
Scynexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scynexis Inc filed Critical Scynexis Inc
Application granted granted Critical
Publication of ATE530561T1 publication Critical patent/ATE530561T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
AT05815625T 2004-10-01 2005-09-30 3-ether- und 3-thioether-substituierte ciclosporinderivate zur behandlung und prävention einer hepatitis-c-infektion ATE530561T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61515204P 2004-10-01 2004-10-01
US70762605P 2005-08-11 2005-08-11
PCT/US2005/035533 WO2006039668A2 (en) 2004-10-01 2005-09-30 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis c infection

Publications (1)

Publication Number Publication Date
ATE530561T1 true ATE530561T1 (de) 2011-11-15

Family

ID=36143148

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05815625T ATE530561T1 (de) 2004-10-01 2005-09-30 3-ether- und 3-thioether-substituierte ciclosporinderivate zur behandlung und prävention einer hepatitis-c-infektion

Country Status (20)

Country Link
US (2) US20100167996A1 (de)
EP (1) EP1802650B1 (de)
JP (2) JP5139065B2 (de)
KR (1) KR101309409B1 (de)
CN (1) CN101773661B (de)
AT (1) ATE530561T1 (de)
AU (1) AU2005292162B2 (de)
BR (1) BRPI0516737A (de)
CA (1) CA2583494C (de)
DK (1) DK1802650T3 (de)
ES (1) ES2373450T3 (de)
HK (1) HK1108703A1 (de)
IL (1) IL182315A (de)
MX (1) MX2007003538A (de)
NZ (1) NZ554514A (de)
PL (1) PL1802650T3 (de)
PT (1) PT1802650E (de)
RU (1) RU2399628C2 (de)
SI (1) SI1802650T1 (de)
WO (1) WO2006039668A2 (de)

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EP2509615A1 (de) 2009-12-09 2012-10-17 Scynexis, Inc. Neue cyclische peptide
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CN102834409A (zh) 2009-12-30 2012-12-19 西尼克斯公司 环孢菌素类似物
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US8906853B2 (en) 2012-11-28 2014-12-09 Enanta Pharmaceuticals, Inc. [N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection
US20140205566A1 (en) 2012-11-30 2014-07-24 Novartis Ag Cyclic nucleuoside derivatives and uses thereof
KR20160045136A (ko) 2013-08-26 2016-04-26 이난타 파마슈티칼스, 인코포레이티드 C형 간염을 예방 또는 치료하기 위한 사이클로스포린 유사체
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WO2020037530A1 (en) 2018-08-22 2020-02-27 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Crystalline form of compound and uses thereof in medicine
US20230181680A1 (en) * 2020-04-15 2023-06-15 Farsight Medical Technology (Shanghai) Co., Ltd. Prevention and treatment of organ injuries

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Also Published As

Publication number Publication date
WO2006039668A2 (en) 2006-04-13
DK1802650T3 (da) 2012-02-06
WO2006039668A3 (en) 2007-04-19
US20120264679A1 (en) 2012-10-18
JP2012167113A (ja) 2012-09-06
HK1108703A1 (en) 2008-05-16
AU2005292162A1 (en) 2006-04-13
CN101773661B (zh) 2013-09-25
EP1802650A2 (de) 2007-07-04
CA2583494C (en) 2014-01-21
KR101309409B1 (ko) 2013-09-23
ES2373450T3 (es) 2012-02-03
CA2583494A1 (en) 2006-04-13
JP2008514732A (ja) 2008-05-08
PL1802650T3 (pl) 2012-04-30
SI1802650T1 (sl) 2012-03-30
NZ554514A (en) 2010-10-29
EP1802650B1 (de) 2011-10-26
RU2399628C2 (ru) 2010-09-20
MX2007003538A (es) 2008-01-16
JP5139065B2 (ja) 2013-02-06
KR20070073841A (ko) 2007-07-10
CN101773661A (zh) 2010-07-14
AU2005292162B2 (en) 2011-11-10
IL182315A0 (en) 2007-07-24
WO2006039668B1 (en) 2007-05-31
PT1802650E (pt) 2011-12-30
BRPI0516737A (pt) 2008-04-29
US20100167996A1 (en) 2010-07-01
EP1802650A4 (de) 2008-08-20
IL182315A (en) 2013-08-29
RU2007116119A (ru) 2008-11-10

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