ATE529109T1 - Hemmung der p38 kinase aktivität durch substituierte heterocyclische harnstoffe - Google Patents

Hemmung der p38 kinase aktivität durch substituierte heterocyclische harnstoffe

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Publication number
ATE529109T1
ATE529109T1 AT98964709T AT98964709T ATE529109T1 AT E529109 T1 ATE529109 T1 AT E529109T1 AT 98964709 T AT98964709 T AT 98964709T AT 98964709 T AT98964709 T AT 98964709T AT E529109 T1 ATE529109 T1 AT E529109T1
Authority
AT
Austria
Prior art keywords
inhibition
kinase activity
substituted heterocyclic
heterocyclic ureas
ureas
Prior art date
Application number
AT98964709T
Other languages
English (en)
Inventor
Jacques Dumas
Uday Khire
Timothy Lowinger
Holger Paulsen
Bernd Riedl
William Scott
Roger Smith
Jill Wood
Holia Hatoum-Mokdad
Jeffrey Johnson
Wendy Lee
Aniko Redman
Original Assignee
Bayer Healthcare Llc
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Publication date
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Publication of ATE529109T1 publication Critical patent/ATE529109T1/de

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
AT98964709T 1997-12-22 1998-12-22 Hemmung der p38 kinase aktivität durch substituierte heterocyclische harnstoffe ATE529109T1 (de)

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PCT/US1998/026080 WO1999032111A1 (en) 1997-12-22 1998-12-22 INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS

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EP1041982A4 (de) 2006-06-14
JP4403482B2 (ja) 2010-01-27
MXPA00006233A (es) 2002-09-18
EP1041982B1 (de) 2011-10-19
ES2154253T1 (es) 2001-04-01
AU739642B2 (en) 2001-10-18
DE1041982T1 (de) 2001-06-07
IL136738A0 (en) 2001-06-14
AU1997199A (en) 1999-07-12
IL170201A (en) 2006-12-31
JP2001526223A (ja) 2001-12-18
CA2315720A1 (en) 1999-07-01
EP1041982A1 (de) 2000-10-11
ES2154253T3 (es) 2012-01-27
WO1999032111A1 (en) 1999-07-01
IL136738A (en) 2007-06-17

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