ATE517094T1 - Verfahren zur herstellung von medetomidin und seinen salzen - Google Patents

Verfahren zur herstellung von medetomidin und seinen salzen

Info

Publication number
ATE517094T1
ATE517094T1 AT07822154T AT07822154T ATE517094T1 AT E517094 T1 ATE517094 T1 AT E517094T1 AT 07822154 T AT07822154 T AT 07822154T AT 07822154 T AT07822154 T AT 07822154T AT E517094 T1 ATE517094 T1 AT E517094T1
Authority
AT
Austria
Prior art keywords
salts
medetomidine
producing
transmetalation
dimethylbenzaldehyde
Prior art date
Application number
AT07822154T
Other languages
English (en)
Inventor
Inese Reine
Armands Zandersons
Original Assignee
Grindeks Jsc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grindeks Jsc filed Critical Grindeks Jsc
Application granted granted Critical
Publication of ATE517094T1 publication Critical patent/ATE517094T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT07822154T 2006-11-06 2007-11-02 Verfahren zur herstellung von medetomidin und seinen salzen ATE517094T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06123548A EP1918282A1 (de) 2006-11-06 2006-11-06 Verfahren zur Herstellung von Medetomidine und ihre Salzen
PCT/EP2007/061822 WO2008055852A1 (en) 2006-11-06 2007-11-02 Method for preparing medetomidine and its salts

Publications (1)

Publication Number Publication Date
ATE517094T1 true ATE517094T1 (de) 2011-08-15

Family

ID=37770375

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07822154T ATE517094T1 (de) 2006-11-06 2007-11-02 Verfahren zur herstellung von medetomidin und seinen salzen

Country Status (19)

Country Link
US (1) US7902377B2 (de)
EP (2) EP1918282A1 (de)
JP (1) JP2010508332A (de)
KR (1) KR20090052398A (de)
CN (1) CN101535272B (de)
AT (1) ATE517094T1 (de)
AU (1) AU2007316693B2 (de)
BR (1) BRPI0714992A2 (de)
CA (1) CA2660365C (de)
DK (1) DK2079706T3 (de)
EA (1) EA200900355A1 (de)
ES (1) ES2369746T3 (de)
MX (1) MX2009004649A (de)
NZ (1) NZ575125A (de)
PL (1) PL2079706T3 (de)
PT (1) PT2079706E (de)
SI (1) SI2079706T1 (de)
WO (1) WO2008055852A1 (de)
ZA (1) ZA200902607B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102753532B (zh) * 2009-12-09 2015-05-13 I-技术有限公司 美托咪定的制备方法
CN102452984B (zh) * 2010-10-21 2013-10-23 桑迪亚医药技术（上海）有限责任公司 4-[1-(2,3-二甲基苯基)乙烯基]-1-r1-2-r2咪唑的合成方法
US8962862B2 (en) 2011-07-22 2015-02-24 Cambrex Karlskoga Ab Processes for preparing 4-substituted imidazoles
JP5779297B2 (ja) 2012-05-08 2015-09-16 ロンザ・リミテッド メデトミジンの調製のための方法
SG11201405611SA (en) 2012-05-08 2014-11-27 Lonza Ag Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal
WO2012172119A2 (en) 2012-05-08 2012-12-20 Lonza Ltd Method for the preparation of medetomidine
WO2012172121A1 (en) * 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of medetomidine with chloroacetone
WO2012172122A2 (en) 2012-06-28 2012-12-20 Lonza Ltd Method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal
CN105218453B (zh) * 2012-06-28 2017-04-12 隆萨有限公司 用氯丙酮制备美托咪定的方法
JP5779298B2 (ja) 2012-06-28 2015-09-16 ロンザ・リミテッド クロロアセトンを用いて２−（２，３−ジメチルフェニル）−１−プロパナールを調製するための方法
CN103588711B (zh) * 2013-11-27 2015-04-08 天津炜捷制药有限公司 一种美托咪定中间体的制备方法
CN103664788B (zh) * 2013-12-04 2015-11-25 湖北生物医药产业技术研究院有限公司 制备美托咪啶的方法
CN104447562A (zh) * 2014-03-27 2015-03-25 宁波天衡药业股份有限公司 一种制备盐酸右美托咪定关键中间体的新方法
CN106083724B (zh) * 2016-08-02 2018-06-26 江苏恒瑞医药股份有限公司 一种右美托咪定的制备方法
CN111269192A (zh) * 2020-02-25 2020-06-12 成都睿智化学研究有限公司 一种5-羟甲基四氮唑及其衍生物的合成方法
CN114671811A (zh) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 一种右美托咪定拆分副产物的外消旋化回收方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2069481B (en) 1980-02-13 1983-07-27 Farmos Oy Substituted imidazole derivatives
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
EP1791833A2 (de) * 2004-09-24 2007-06-06 Allergan, Inc. 4-(kondensiertes cyclisches methyl)imidazol-2-thione, die als alpha2-adrenerge agonisten wirken
EP1797043A1 (de) * 2004-09-24 2007-06-20 Allergan, Inc. 4-(phenylmethyl und substituiertes phenylmethyl)imidazol-2-thione, die als spezifische alpha2-adrenerge agonisten wirken

Also Published As

Publication number Publication date
DK2079706T3 (da) 2011-10-03
WO2008055852A8 (en) 2009-05-22
ES2369746T3 (es) 2011-12-05
SI2079706T1 (sl) 2011-11-30
PT2079706E (pt) 2011-10-19
PL2079706T3 (pl) 2011-12-30
JP2010508332A (ja) 2010-03-18
BRPI0714992A2 (pt) 2013-07-30
KR20090052398A (ko) 2009-05-25
US20100048915A1 (en) 2010-02-25
EP2079706B1 (de) 2011-07-20
NZ575125A (en) 2011-02-25
EP1918282A1 (de) 2008-05-07
AU2007316693B2 (en) 2012-02-02
EA200900355A1 (ru) 2009-10-30
AU2007316693A1 (en) 2008-05-15
CN101535272A (zh) 2009-09-16
WO2008055852A1 (en) 2008-05-15
EP2079706A1 (de) 2009-07-22
US7902377B2 (en) 2011-03-08
CA2660365C (en) 2014-03-25
CA2660365A1 (en) 2008-05-15
CN101535272B (zh) 2011-10-05
ZA200902607B (en) 2010-04-28
MX2009004649A (es) 2009-05-21

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