ATE515266T1 - 2-(amino-3,4-dioxo-1-cyclobuten-1- yl)aminoalkylsäure-derivate für die schmerzbehandlung - Google Patents

2-(amino-3,4-dioxo-1-cyclobuten-1- yl)aminoalkylsäure-derivate für die schmerzbehandlung

Info

Publication number: ATE515266T1
Authority: AT; Austria
Prior art keywords: aminoalkylic; cyclobuten; dioxo; amino; acid derivatives
Prior art date: 2001-10-10

Application number

AT02789180T

Other languages

English (en)

Inventor

Michael Brandt

Margaret Zaleska

John Moyer

Original Assignee

Wyeth Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-10

Filing date

2002-10-09

Publication date

2011-07-15

2002-10-09 Application filed by Wyeth Llc filed Critical Wyeth Llc

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE515266T1 publication Critical patent/ATE515266T1/de

Links

239000002253 acid Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT02789180T 2001-10-10 2002-10-09 2-(amino-3,4-dioxo-1-cyclobuten-1- yl)aminoalkylsäure-derivate für die schmerzbehandlung ATE515266T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US32824501P	2001-10-10	2001-10-10
PCT/US2002/032252 WO2003031416A2 (en)	2001-10-10	2002-10-09	[[2-(amino-3,4-dioxo-1cyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain

Publications (1)

Publication Number	Publication Date
ATE515266T1 true ATE515266T1 (de)	2011-07-15

Family

ID=23280159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02789180T ATE515266T1 (de)	2001-10-10	2002-10-09	2-(amino-3,4-dioxo-1-cyclobuten-1- yl)aminoalkylsäure-derivate für die schmerzbehandlung

Country Status (27)

Country	Link
US (2)	US7098200B2 (de)
EP (1)	EP1434588B1 (de)
JP (1)	JP4350512B2 (de)
KR (1)	KR100922703B1 (de)
CN (1)	CN100448449C (de)
AR (1)	AR036764A1 (de)
AT (1)	ATE515266T1 (de)
AU (1)	AU2009201746A1 (de)
BR (1)	BR0213237A (de)
CA (1)	CA2461348C (de)
CY (1)	CY1111909T1 (de)
DK (1)	DK1434588T3 (de)
EA (1)	EA009993B1 (de)
ES (1)	ES2367356T3 (de)
HK (1)	HK1064609A1 (de)
HU (1)	HUP0401773A3 (de)
IL (2)	IL161275A0 (de)
MX (1)	MXPA04003354A (de)
NO (1)	NO20041378L (de)
NZ (1)	NZ532159A (de)
PL (1)	PL368863A1 (de)
PT (1)	PT1434588E (de)
SI (1)	SI1434588T1 (de)
TW (1)	TWI321472B (de)
UA (1)	UA78529C2 (de)
WO (1)	WO2003031416A2 (de)
ZA (1)	ZA200403406B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LT1562567T (lt) *	2002-11-22	2017-08-25	Grünenthal GmbH	Pasirinktų analgetikų ir cox-ii slopiklių derinys
US20050004079A1 (en) *	2003-04-09	2005-01-06	Wyeth	Pharmaceutical compositions for intranasal administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives and methods of use thereof
JP4621659B2 (ja) *	2003-04-09	2011-01-26	ワイス・エルエルシー	［２−（８，９−ジオキソ−２，６−ジアザビシクロ［５．２．０］ノナ−１（７）−エン−２−イル）アルキル］ホスホン酸の誘導体およびｎ−メチル−ｄ−アスパルテート（ｎｍｄａ）受容体アンタゴニストとしてのその使用
US20050142192A1 (en) *	2003-10-15	2005-06-30	Wyeth	Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives
TW200514775A (en)	2003-10-22	2005-05-01	Wyeth Corp	Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof
CA2583114A1 (en) *	2004-10-08	2006-04-20	Wyeth	Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and method of making them
US20090061024A1 (en) *	2007-08-27	2009-03-05	Wyeth	Compositions and methods employing nmda antagonists for achieving an anesthetic-sparing effect
ES2880578T3 (es) *	2009-02-13	2021-11-24	Allergan Inc	Composiciones farmacéuticas que comprenden (3-(1-(1H-imidazol-4-il)etil)-2-metilfenil)metanol
BRPI1009900A2 (pt)	2009-03-19	2016-03-15	Wyeth Llc	métodos para a preparação de ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfônico e seus precursores
WO2013078151A1 (en)	2011-11-21	2013-05-30	Allergan, Inc.	Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases
WO2015149066A1 (en) *	2014-03-28	2015-10-01	University Of Virginia Patent Foundation	General anesthetics that are not neurotoxic

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5168103A (en)	1991-01-22	1992-12-01	American Home Products Corporation	[[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives
US5124319A (en)	1991-10-11	1992-06-23	American Home Products Corporation	Benzimidazole phosphono-amino acids
DK124393D0 (da) *	1993-11-03	1993-11-03	Lundbeck & Co As H	Compounds
AT400440B (de) *	1993-12-06	1995-12-27	Vianova Kunstharz Ag	Verfahren zur herstellung von wasserverdünnbaren lackbindemitteln und deren verwendung
TW427904B (en) *	1995-12-07	2001-04-01	American Home Prod	Neuroprotective agents
UA52698C2 (uk) *	1996-10-04	2003-01-15	Х. Луннбек А/С	Похідні (3-алкоксіізоксазол-4-іл)заміщеної 2-амінокарбонової кислоти та їх сірковмісні аналоги, фармацевтична композиція на їх основі
WO1999006417A1 (en)	1997-08-01	1999-02-11	American Home Products Corporation	Process for the preparation of [2-((8,9)- dioxo-2,6-diazabicyclo [5.2.0]-non-1(7)-en-2-yl)-ethyl] phosphonic acid
US5990307A (en)	1997-08-01	1999-11-23	American Home Products Corporation	Process for the preparation of [2-((8.9)-Dioxo-2,6-Diazabicyclo [5.2.0]-Non-1(7)-en-2yl) Ethyl]Phosphonic acid
US6541669B1 (en)	1998-06-08	2003-04-01	Theravance, Inc.	β2-adrenergic receptor agonists
US6225343B1 (en)	1999-06-16	2001-05-01	Nastech Pharmaceutical Company, Inc.	Compositions and methods comprising morphine gluconate
US20030158254A1 (en)	2002-01-24	2003-08-21	Xenoport, Inc.	Engineering absorption of therapeutic compounds via colonic transporters
US20040082543A1 (en)	2002-10-29	2004-04-29	Pharmacia Corporation	Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain

2002
- 2002-09-10 UA UA20040503402A patent/UA78529C2/uk unknown
- 2002-10-08 AR ARP020103791A patent/AR036764A1/es unknown
- 2002-10-09 MX MXPA04003354A patent/MXPA04003354A/es active IP Right Grant
- 2002-10-09 BR BR0213237-0A patent/BR0213237A/pt not_active Application Discontinuation
- 2002-10-09 HU HU0401773A patent/HUP0401773A3/hu unknown
- 2002-10-09 EA EA200400523A patent/EA009993B1/ru not_active IP Right Cessation
- 2002-10-09 NZ NZ532159A patent/NZ532159A/en not_active IP Right Cessation
- 2002-10-09 WO PCT/US2002/032252 patent/WO2003031416A2/en active Application Filing
- 2002-10-09 AT AT02789180T patent/ATE515266T1/de active
- 2002-10-09 TW TW091123270A patent/TWI321472B/zh not_active IP Right Cessation
- 2002-10-09 US US10/267,159 patent/US7098200B2/en not_active Expired - Fee Related
- 2002-10-09 DK DK02789180.3T patent/DK1434588T3/da active
- 2002-10-09 CA CA2461348A patent/CA2461348C/en not_active Expired - Fee Related
- 2002-10-09 PT PT02789180T patent/PT1434588E/pt unknown
- 2002-10-09 KR KR1020047005298A patent/KR100922703B1/ko not_active IP Right Cessation
- 2002-10-09 JP JP2003534400A patent/JP4350512B2/ja not_active Expired - Fee Related
- 2002-10-09 SI SI200230959T patent/SI1434588T1/sl unknown
- 2002-10-09 EP EP02789180A patent/EP1434588B1/de not_active Expired - Lifetime
- 2002-10-09 CN CNB028202430A patent/CN100448449C/zh not_active Expired - Fee Related
- 2002-10-09 PL PL02368863A patent/PL368863A1/xx not_active IP Right Cessation
- 2002-10-09 ES ES02789180T patent/ES2367356T3/es not_active Expired - Lifetime
- 2002-10-09 IL IL16127502A patent/IL161275A0/xx unknown
2004
- 2004-04-02 NO NO20041378A patent/NO20041378L/no unknown
- 2004-04-04 IL IL161275A patent/IL161275A/en not_active IP Right Cessation
- 2004-05-05 ZA ZA200403406A patent/ZA200403406B/en unknown
- 2004-10-05 HK HK04107633.4A patent/HK1064609A1/xx not_active IP Right Cessation
2006
- 2006-05-12 US US11/433,737 patent/US7759346B2/en not_active Expired - Fee Related
2009
- 2009-05-01 AU AU2009201746A patent/AU2009201746A1/en not_active Ceased
2011
- 2011-08-02 CY CY20111100744T patent/CY1111909T1/el unknown

Also Published As

Publication number	Publication date
JP2005508950A (ja)	2005-04-07
CN100448449C (zh)	2009-01-07
KR20050034604A (ko)	2005-04-14
US20030114444A1 (en)	2003-06-19
BR0213237A (pt)	2004-09-28
JP4350512B2 (ja)	2009-10-21
HUP0401773A3 (en)	2005-06-28
ES2367356T3 (es)	2011-11-02
NZ532159A (en)	2006-02-24
DK1434588T3 (da)	2011-08-15
PT1434588E (pt)	2011-09-05
EA009993B1 (ru)	2008-06-30
MXPA04003354A (es)	2004-09-28
WO2003031416A2 (en)	2003-04-17
ZA200403406B (en)	2007-04-25
EP1434588B1 (de)	2011-07-06
IL161275A0 (en)	2004-09-27
KR100922703B1 (ko)	2009-10-22
IL161275A (en)	2009-09-01
AU2009201746A1 (en)	2009-05-28
CY1111909T1 (el)	2015-11-04
SI1434588T1 (sl)	2011-10-28
WO2003031416A3 (en)	2003-08-14
HK1064609A1 (en)	2005-02-04
US20060205696A1 (en)	2006-09-14
CA2461348A1 (en)	2003-04-17
US7759346B2 (en)	2010-07-20
PL368863A1 (en)	2005-04-04
UA78529C2 (en)	2007-04-10
CN1568189A (zh)	2005-01-19
EA200400523A1 (ru)	2004-08-26
CA2461348C (en)	2011-02-15
EP1434588A2 (de)	2004-07-07
TWI321472B (en)	2010-03-11
NO20041378L (no)	2004-05-28
US7098200B2 (en)	2006-08-29
HUP0401773A2 (hu)	2005-01-28
AR036764A1 (es)	2004-09-29

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2012-01-15

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