ATE509023T1 - Spirochromanon-derivate als acetyl-koenzym-a- carboxylase-hemmer - Google Patents
Spirochromanon-derivate als acetyl-koenzym-a- carboxylase-hemmerInfo
- Publication number
- ATE509023T1 ATE509023T1 AT06787451T AT06787451T ATE509023T1 AT E509023 T1 ATE509023 T1 AT E509023T1 AT 06787451 T AT06787451 T AT 06787451T AT 06787451 T AT06787451 T AT 06787451T AT E509023 T1 ATE509023 T1 AT E509023T1
- Authority
- AT
- Austria
- Prior art keywords
- acetyl coenzyme
- carboxylase inhibitors
- spirochromanone
- derivatives
- spirochromanone derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70038205P | 2005-07-19 | 2005-07-19 | |
PCT/US2006/027543 WO2007011809A1 (en) | 2005-07-19 | 2006-07-14 | Spirochromanone derivatives as acetyl coenzyme a carboxylase (acc) inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE509023T1 true ATE509023T1 (de) | 2011-05-15 |
Family
ID=37317248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06787451T ATE509023T1 (de) | 2005-07-19 | 2006-07-14 | Spirochromanon-derivate als acetyl-koenzym-a- carboxylase-hemmer |
Country Status (20)
Country | Link |
---|---|
US (2) | US7935712B2 (de) |
EP (1) | EP1910375B1 (de) |
JP (1) | JP5076159B2 (de) |
KR (1) | KR20080036041A (de) |
CN (1) | CN101238132A (de) |
AR (1) | AR054842A1 (de) |
AT (1) | ATE509023T1 (de) |
AU (1) | AU2006270145B2 (de) |
BR (1) | BRPI0613427A2 (de) |
CA (1) | CA2614963C (de) |
DO (1) | DOP2006000170A (de) |
IL (1) | IL188417A0 (de) |
MX (1) | MX2008000966A (de) |
NO (1) | NO20080865L (de) |
NZ (1) | NZ564591A (de) |
PE (1) | PE20070527A1 (de) |
RU (1) | RU2422446C2 (de) |
TW (1) | TW200728307A (de) |
WO (2) | WO2007011809A1 (de) |
ZA (1) | ZA200711119B (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE509023T1 (de) * | 2005-07-19 | 2011-05-15 | Merck Sharp & Dohme | Spirochromanon-derivate als acetyl-koenzym-a- carboxylase-hemmer |
BRPI0715160A2 (pt) | 2006-08-08 | 2013-06-11 | Sanofi Aventis | imidazolidina-2,4-dionas substituÍdas por arilamimoaril-alquil-, processo para preparÁ-las, medicamentos compeendendo estes compostos, e seu uso |
MX2009005604A (es) * | 2006-11-29 | 2009-06-08 | Pfizer Prod Inc | Inhibidores espiro cetona de acetil-coa carboxilasa. |
PE20081559A1 (es) | 2007-01-12 | 2008-11-20 | Merck & Co Inc | DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA |
WO2008088692A2 (en) * | 2007-01-12 | 2008-07-24 | Merck & Co., Inc. | Spirochromanon derivatives |
JPWO2008102749A1 (ja) | 2007-02-20 | 2010-05-27 | 武田薬品工業株式会社 | 複素環化合物 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
JP2011521940A (ja) * | 2008-05-28 | 2011-07-28 | ファイザー・インク | ピラゾロスピロケトンアセチルCoAカルボキシラーゼ阻害剤 |
WO2009144554A1 (en) * | 2008-05-28 | 2009-12-03 | Pfizer, Inc. | Pyrazolospiroketone acetyl-c0a carboxylase inhibitors |
US8524730B2 (en) | 2008-07-04 | 2013-09-03 | Msd K.K. | Spirochromanone carboxylic acids |
TW201014822A (en) | 2008-07-09 | 2010-04-16 | Sanofi Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
AU2009271634A1 (en) * | 2008-07-14 | 2010-01-21 | Cropsolution, Inc. | Modulators of acetyl-coenzyme a carboxylase and methods of use thereof |
US8324385B2 (en) * | 2008-10-30 | 2012-12-04 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
US20100113473A1 (en) * | 2008-10-30 | 2010-05-06 | Player Mark R | Aryl amide compound as an acetyl coenzyme a carboxylase inhibitor |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
TW201038572A (en) * | 2009-03-25 | 2010-11-01 | Gruenenthal Gmbh | Substituted spiro-amide compounds |
CN102482312A (zh) | 2009-08-26 | 2012-05-30 | 赛诺菲 | 新颖的杂芳族氟代糖苷结晶水合物、含有这些化合物的药物和它们的用途 |
CA2778316A1 (en) * | 2009-11-10 | 2011-05-19 | Pfizer Inc. | N-2 pyrazolospiroketone acetyl-coa carboxylase inhibitors |
ES2444543T3 (es) * | 2009-11-10 | 2014-02-25 | Pfizer Inc | Inhibidores de la N1-pirazoloespirocetona acetil-CoA carboxilasa |
EP3159331A1 (de) | 2010-05-05 | 2017-04-26 | Infinity Pharmaceuticals, Inc. | Tetrazolone als fettsäuresynthasehemmer |
WO2011140296A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
WO2011140425A1 (en) | 2010-05-06 | 2011-11-10 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
PT2621493T (pt) | 2010-09-30 | 2016-11-14 | Pfizer | Inibidores de n1-pirazolospirocetona acetil-coa carboxilase |
CN103189377B (zh) | 2010-10-29 | 2015-02-25 | 辉瑞大药厂 | N1/n2-内酰胺乙酰辅酶a羧化酶抑制剂 |
DK2670752T3 (en) | 2011-02-02 | 2016-07-04 | Vertex Pharma | PYRROLOPYRAZINE SPIROCYCLIC PIPERIDINAMIDE AS ION CHANNEL MODULATORS |
JP5940562B2 (ja) * | 2011-02-18 | 2016-06-29 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | イオンチャネルのモジュレーターとしてのクロマン−スピロ環式ピペリジンアミド |
EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
ES2618929T3 (es) | 2011-03-14 | 2017-06-22 | Vertex Pharmaceuticals Incorporated | Morfolina-Spiro piperidina amida cíclica como moduladores del canal iónico |
PT2699576E (pt) | 2011-04-22 | 2016-03-09 | Pfizer | Derivados de pirazoloespirocetona para utilização como inibidores de acetil-coa carboxilase |
WO2012161119A1 (ja) * | 2011-05-20 | 2012-11-29 | 興和株式会社 | 新規なスピロピペリジン誘導体及びこれを含有する医薬 |
EP3670496A3 (de) | 2013-10-17 | 2020-09-30 | Shionogi&Co., Ltd. | Acc2 hemmer |
WO2018112204A1 (en) * | 2016-12-14 | 2018-06-21 | Cephalon, Inc. | Spiropiperidine derivatives |
JP7142375B2 (ja) * | 2017-06-30 | 2022-09-27 | クイクスゲン インコーポレイテッド | 新規なスピロラクトン化合物及び医薬組成物 |
WO2019099457A1 (en) * | 2017-11-14 | 2019-05-23 | Quixgen, Inc. | Benzodioxinone compounds |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2535338A1 (de) * | 1975-08-07 | 1977-02-17 | Bayer Ag | Chromanone-(4) |
DE2814983A1 (de) | 1978-04-07 | 1979-10-18 | Bayer Ag | Neue chromanon-derivate |
IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
US5206240A (en) * | 1989-12-08 | 1993-04-27 | Merck & Co., Inc. | Nitrogen-containing spirocycles |
ES2119174T3 (es) | 1993-01-28 | 1998-10-01 | Merck & Co Inc | Azaciclos espiro-sustituidos como antagonistas de los receptores de las taquiquininas. |
US5563716A (en) * | 1994-01-24 | 1996-10-08 | Victor Company Of Japan, Ltd. | Video signal reproducing method and apparatus |
CA2189634A1 (en) | 1994-05-06 | 1995-11-16 | John J. Baldwin | Combinatorial dihydrobenzopyran library |
JP2001516330A (ja) | 1995-06-06 | 2001-09-25 | メルク エンド カンパニー インコーポレーテッド | アルファ1aアドレナリンレセプターアンタゴニスト |
GB9601724D0 (en) * | 1996-01-29 | 1996-03-27 | Merck Sharp & Dohme | Therapeutic agents |
JP3961793B2 (ja) * | 2001-08-08 | 2007-08-22 | 大日本スクリーン製造株式会社 | 基板洗浄方法 |
JP2003059871A (ja) * | 2001-08-10 | 2003-02-28 | Sekisui Chem Co Ltd | Icチップの製造方法 |
JP2003094912A (ja) * | 2001-09-26 | 2003-04-03 | Bridgestone Corp | ランフラットタイヤ及びその製造方法 |
DE60301491T2 (de) * | 2002-02-27 | 2006-05-18 | Pfizer Products Inc., Groton | Acc-hemmer |
JP4004898B2 (ja) * | 2002-08-30 | 2007-11-07 | 成和樹脂工業株式会社 | クランプ用カバー |
WO2004092179A1 (ja) | 2003-04-14 | 2004-10-28 | Nippon Soda Co. Ltd. | スピロ誘導体、製造法および抗酸化薬 |
JP2005119987A (ja) | 2003-10-15 | 2005-05-12 | Ajinomoto Co Inc | アシルスルホンアミド誘導体 |
EP1824842A4 (de) | 2004-11-18 | 2009-08-26 | Incyte Corp | Hemmer von 11- hydroxyl steroid dehydrogenase typ 1 und anwendungsverfahren |
ATE509023T1 (de) * | 2005-07-19 | 2011-05-15 | Merck Sharp & Dohme | Spirochromanon-derivate als acetyl-koenzym-a- carboxylase-hemmer |
WO2008088692A2 (en) * | 2007-01-12 | 2008-07-24 | Merck & Co., Inc. | Spirochromanon derivatives |
PE20081559A1 (es) * | 2007-01-12 | 2008-11-20 | Merck & Co Inc | DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA |
-
2006
- 2006-07-14 AT AT06787451T patent/ATE509023T1/de not_active IP Right Cessation
- 2006-07-14 JP JP2008522850A patent/JP5076159B2/ja not_active Expired - Fee Related
- 2006-07-14 WO PCT/US2006/027543 patent/WO2007011809A1/en active Application Filing
- 2006-07-14 KR KR1020087001366A patent/KR20080036041A/ko not_active Application Discontinuation
- 2006-07-14 WO PCT/US2006/027546 patent/WO2007011811A1/en active Application Filing
- 2006-07-14 EP EP06787451A patent/EP1910375B1/de not_active Not-in-force
- 2006-07-14 RU RU2008106243/04A patent/RU2422446C2/ru not_active IP Right Cessation
- 2006-07-14 AU AU2006270145A patent/AU2006270145B2/en not_active Ceased
- 2006-07-14 CN CNA2006800263744A patent/CN101238132A/zh active Pending
- 2006-07-14 MX MX2008000966A patent/MX2008000966A/es not_active Application Discontinuation
- 2006-07-14 CA CA2614963A patent/CA2614963C/en not_active Expired - Fee Related
- 2006-07-14 NZ NZ564591A patent/NZ564591A/en not_active IP Right Cessation
- 2006-07-14 US US11/988,588 patent/US7935712B2/en active Active
- 2006-07-14 BR BRPI0613427-0A patent/BRPI0613427A2/pt not_active IP Right Cessation
- 2006-07-14 US US11/487,029 patent/US7410976B2/en active Active
- 2006-07-17 AR ARP060103054A patent/AR054842A1/es not_active Application Discontinuation
- 2006-07-17 PE PE2006000853A patent/PE20070527A1/es not_active Application Discontinuation
- 2006-07-18 DO DO2006000170A patent/DOP2006000170A/es unknown
- 2006-07-18 TW TW095126220A patent/TW200728307A/zh unknown
-
2007
- 2007-12-20 ZA ZA200711119A patent/ZA200711119B/xx unknown
- 2007-12-25 IL IL188417A patent/IL188417A0/en unknown
-
2008
- 2008-02-18 NO NO20080865A patent/NO20080865L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2006270145A1 (en) | 2007-01-25 |
DOP2006000170A (es) | 2007-03-31 |
AU2006270145B2 (en) | 2011-04-14 |
KR20080036041A (ko) | 2008-04-24 |
US7935712B2 (en) | 2011-05-03 |
NO20080865L (no) | 2008-04-18 |
JP5076159B2 (ja) | 2012-11-21 |
MX2008000966A (es) | 2008-03-26 |
US20090131464A1 (en) | 2009-05-21 |
CA2614963A1 (en) | 2007-01-25 |
EP1910375B1 (de) | 2011-05-11 |
WO2007011809A1 (en) | 2007-01-25 |
JP2009502785A (ja) | 2009-01-29 |
RU2422446C2 (ru) | 2011-06-27 |
BRPI0613427A2 (pt) | 2012-10-30 |
WO2007011811A1 (en) | 2007-01-25 |
CN101238132A (zh) | 2008-08-06 |
NZ564591A (en) | 2010-01-29 |
ZA200711119B (en) | 2009-12-30 |
US7410976B2 (en) | 2008-08-12 |
EP1910375A1 (de) | 2008-04-16 |
AR054842A1 (es) | 2007-07-18 |
PE20070527A1 (es) | 2007-06-14 |
RU2008106243A (ru) | 2009-08-27 |
CA2614963C (en) | 2014-10-07 |
IL188417A0 (en) | 2008-11-03 |
US20070021453A1 (en) | 2007-01-25 |
TW200728307A (en) | 2007-08-01 |
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