ATE485268T1 - Pyrrolidin-derivate als erk-hemmer - Google Patents
Pyrrolidin-derivate als erk-hemmerInfo
- Publication number
- ATE485268T1 ATE485268T1 AT07750497T AT07750497T ATE485268T1 AT E485268 T1 ATE485268 T1 AT E485268T1 AT 07750497 T AT07750497 T AT 07750497T AT 07750497 T AT07750497 T AT 07750497T AT E485268 T1 ATE485268 T1 AT E485268T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrrolidine derivatives
- erk inhibitors
- erk
- inhibitors
- pyrrolidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77404306P | 2006-02-16 | 2006-02-16 | |
PCT/US2007/003665 WO2007097937A1 (en) | 2006-02-16 | 2007-02-13 | Pyrrolidine derivatives as erk inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE485268T1 true ATE485268T1 (de) | 2010-11-15 |
Family
ID=38170991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07750497T ATE485268T1 (de) | 2006-02-16 | 2007-02-13 | Pyrrolidin-derivate als erk-hemmer |
Country Status (17)
Country | Link |
---|---|
US (1) | US7807672B2 (de) |
EP (1) | EP1984331B1 (de) |
JP (1) | JP2009528280A (de) |
KR (1) | KR20080103996A (de) |
CN (1) | CN101415674A (de) |
AR (1) | AR059493A1 (de) |
AT (1) | ATE485268T1 (de) |
AU (1) | AU2007218059A1 (de) |
CA (1) | CA2642762A1 (de) |
DE (1) | DE602007009932D1 (de) |
ES (1) | ES2353437T3 (de) |
HK (1) | HK1117159A1 (de) |
IL (1) | IL193413A0 (de) |
MX (1) | MX2008010635A (de) |
TW (1) | TW200745089A (de) |
WO (1) | WO2007097937A1 (de) |
ZA (1) | ZA200807457B (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8546404B2 (en) * | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
MX2010005960A (es) * | 2007-11-30 | 2010-06-11 | Schering Corp | Biomarcadores de braf. |
NZ587504A (en) | 2008-02-21 | 2012-09-28 | Merck Sharp & Dohme | Benzopyrazole derivatives as ERK inhibitors |
DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
US9229008B2 (en) | 2008-08-19 | 2016-01-05 | Merck Sharp & Dohme Corp. | IL-8 level as a determinant of responsivity of a cancer to treatment |
ES2775000T3 (es) * | 2009-04-02 | 2020-07-23 | Merck Patent Gmbh | Derivados de piperidina y piperazina como inhibidores de autotaxina |
WO2011002067A1 (ja) * | 2009-07-02 | 2011-01-06 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
EP2448942B1 (de) | 2009-07-02 | 2014-09-24 | Merck Sharp & Dohme Corp. | KONDENSIERTE TRIZYKLISCHE VERBINDUNGEN ALS mTOR-HEMMER |
US8658651B2 (en) | 2009-09-30 | 2014-02-25 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
PE20121172A1 (es) * | 2009-10-14 | 2012-09-05 | Merck Sharp & Dohme | Piperidinas sustituidas con actividad en la hdm2 |
US8541404B2 (en) | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
JP2013513628A (ja) | 2009-12-14 | 2013-04-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | スフィンゴシンキナーゼの阻害薬 |
CN101812007B (zh) * | 2010-04-27 | 2011-11-23 | 浙江大学 | 氨基吡咯类化合物及其制备方法 |
EP2608669B1 (de) | 2010-08-23 | 2016-06-22 | Merck Sharp & Dohme Corp. | Neue pyrazolo-[1,5-a-]pyrimidinderivate als mtor-hemmer |
MX339873B (es) | 2011-02-28 | 2016-06-15 | Genentech Inc | Inhibidores de serina/treonina cinasa. |
IN2013MN02170A (de) | 2011-04-21 | 2015-06-12 | Piramal Entpr Ltd | |
US8901142B2 (en) | 2011-07-26 | 2014-12-02 | Merck Sharp & Dohme Corp. | Fused tricyclic compounds as mTOR inhibitors |
GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
CN103958502B (zh) | 2011-08-04 | 2016-02-10 | 阵列生物制药公司 | 作为丝氨酸/苏氨酸激酶抑制剂的喹唑啉化合物 |
WO2013062923A1 (en) | 2011-10-28 | 2013-05-02 | Merck Sharp & Dohme Corp. | MACROCYCLES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF |
EP2793890B1 (de) | 2011-12-21 | 2016-09-07 | Merck Sharp & Dohme Corp. | Substituierte piperidine als hmd2-hemmer |
WO2013109142A1 (en) | 2012-01-16 | 2013-07-25 | Stichting Het Nederlands Kanker Instituut | Combined pdk and mapk/erk pathway inhibition in neoplasia |
ES2857649T3 (es) | 2012-03-01 | 2021-09-29 | Array Biopharma Inc | Inhibidores de serina/treonina cinasa |
AR092253A1 (es) | 2012-08-27 | 2015-04-08 | Array Biopharma Inc | Inhibidores de serina/treonina cinasa |
BR112015013611A2 (pt) | 2012-12-20 | 2017-11-14 | Merck Sharp & Dohme | composto, e, composição farmacêutica |
WO2015041534A1 (en) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | P90rsk in combination with raf/erk/mek |
WO2015041533A1 (en) | 2013-09-20 | 2015-03-26 | Stichting Het Nederlands Kanker Instituut | Rock in combination with mapk-pathway |
LT3052096T (lt) | 2013-10-03 | 2018-04-10 | Kura Oncology, Inc. | Erk inhibitoriai ir jų panaudojimo būdai |
CN103922928A (zh) * | 2013-10-31 | 2014-07-16 | 北京利和知信科技有限公司 | 适用于制备烯烃聚合催化剂的环取代醚酸酯化合物 |
WO2015074081A1 (en) | 2013-11-18 | 2015-05-21 | Bair Kenneth W | Benzopiperazine compositions as bet bromodomain inhibitors |
CN110627770A (zh) | 2013-11-18 | 2019-12-31 | 福马疗法公司 | 作为bet溴域抑制剂的四氢喹啉组成物 |
US20170027940A1 (en) | 2014-04-10 | 2017-02-02 | Stichting Het Nederlands Kanker Instituut | Method for treating cancer |
WO2015178770A1 (en) | 2014-05-19 | 2015-11-26 | Stichting Het Nederlands Kanker Instituut | Compositions for cancer treatment |
US10864179B2 (en) | 2015-10-01 | 2020-12-15 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Histone deacetylase inhibitors for the use in the treatment of drug resistant melanoma |
WO2017099591A1 (en) | 2015-12-07 | 2017-06-15 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Treatment of inhibitor resistant braf-mutant cancers |
WO2017204626A1 (en) | 2016-05-24 | 2017-11-30 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Combination therapy - combined map2k4/map3k1 and mek/erk inhibition |
US11485729B2 (en) * | 2018-01-23 | 2022-11-01 | Shenzhen Targetrx, Inc. | Substituted pyridazinone compound |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2306108A (en) | 1995-10-13 | 1997-04-30 | Merck & Co Inc | Treatment of Raf-mediated cancers with imidazole derivatives |
JP2000508335A (ja) | 1996-05-30 | 2000-07-04 | メルク エンド カンパニー インコーポレーテッド | 癌の治療方法 |
GB2323845A (en) | 1997-03-31 | 1998-10-07 | Merck & Co Inc | MEK inhibiting lactones |
JP2001510168A (ja) | 1997-07-18 | 2001-07-31 | ノボ ノルディスク アクティーゼルスカブ | FVIIa媒介性細胞内シグナル伝達経路に関連する反対条件の処理のためのFVIIa又はFVIIaiの使用 |
GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
HUP0202332A2 (en) | 2000-02-05 | 2002-10-28 | Vertex Pharma | Pyrazole compositions useful as inhibitors of erk |
AU2001236720A1 (en) | 2000-02-05 | 2001-08-14 | Bemis, Guy | Compositions useful as inhibitors of erk |
AU2001247372A1 (en) | 2000-03-15 | 2001-09-24 | Warner Lambert Company | 5-amide substituted diarylamines as mex inhibitors |
TWI310684B (en) | 2000-03-27 | 2009-06-11 | Bristol Myers Squibb Co | Synergistic pharmaceutical kits for treating cancer |
US7211594B2 (en) | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
US20050009876A1 (en) | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
ATE294797T1 (de) | 2000-09-15 | 2005-05-15 | Vertex Pharma | Pyrazolverbindungen als protein-kinasehemmer |
AU2001290940A1 (en) | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Isoxazoles and their use as inhibitors of erk |
PL210066B1 (pl) | 2000-12-21 | 2011-11-30 | Vertex Pharma | Związek pirazolowy, kompozycja zawierająca ten związek i jego zastosowania |
MY130778A (en) * | 2001-02-09 | 2007-07-31 | Vertex Pharma | Heterocyclic inhibitiors of erk2 and uses thereof |
ATE449763T1 (de) | 2001-04-16 | 2009-12-15 | Eisai R&D Man Co Ltd | 1h-indazolverbindungen die jnk hemmen |
JP2004532234A (ja) | 2001-04-27 | 2004-10-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | トリアゾール由来キナーゼインヒビターおよびその使用 |
MXPA03009847A (es) | 2001-04-27 | 2004-02-12 | Vertex Pharma | Inhibidores de cinasa derivados de pirazol. |
AU2002321910A1 (en) | 2001-08-03 | 2003-02-17 | Vertex Pharmaceuticals Incorporated | Pyrazole-derived kinase inhibitors and uses thereof |
US6875789B2 (en) | 2001-08-03 | 2005-04-05 | Vertex Pharmaceuticals Incorporated | Pyrazole-derived kinase inhibitors and uses thereof |
US7253199B2 (en) | 2001-10-23 | 2007-08-07 | Applied Research Systems Ars Holding N.V. | Azole derivatives and pharmaceutical compositions containing them |
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
EP1506189A1 (de) | 2002-04-26 | 2005-02-16 | Vertex Pharmaceuticals Incorporated | Pyrrol-derivate als inhibitoren von erk2 und deren verwendung |
WO2003099212A2 (en) | 2002-05-24 | 2003-12-04 | The University Of Utah Research Foundation | Mitogen activated protein kinase inhibitor compositions for lymphoma therapy |
IL164209A0 (en) | 2002-05-31 | 2005-12-18 | Eisai Co Ltd | Pyrazole derivatives and pharmaceutical compositions containing the same |
US7196092B2 (en) | 2002-09-04 | 2007-03-27 | Schering Corporation | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors |
US7205308B2 (en) | 2002-09-04 | 2007-04-17 | Schering Corporation | Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors |
AR041291A1 (es) | 2002-09-19 | 2005-05-11 | Schering Corp | Imidazopiridinas como inhibidores de quinasa dependientes de ciclina |
JP4808154B2 (ja) | 2003-03-13 | 2011-11-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼインヒビターとして有用な組成物 |
WO2005002673A1 (en) | 2003-07-03 | 2005-01-13 | Astex Therapeutics Limited | Raf kinase inhibitors |
AU2004293035A1 (en) | 2003-11-19 | 2005-06-09 | Signal Pharmaceuticals, Llc | Methods of treating diseases and disorders by targeting multiple kinases |
MXPA06007095A (es) | 2003-12-22 | 2006-09-04 | Gilead Sciences Inc | Conjugados de fosfonato inhibidores de cinasa. |
WO2005100342A1 (en) | 2004-03-26 | 2005-10-27 | Vertex Pharmaceuticals, Incorporated | Pyridine inhibitors of erk2 and uses thereof |
WO2005100338A1 (en) | 2004-04-13 | 2005-10-27 | Astex Therapeutics Limited | 5-morpholinylmethylthiophenyl pharmaceutial compounds as p38 map kinase modulators |
EP1753738B1 (de) | 2004-05-14 | 2014-07-09 | Vertex Pharmaceuticals Inc. | Pyrrolverbindungen als Hemmer von ERK-Proteinkinasen und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
MXPA06013208A (es) | 2004-05-14 | 2007-01-16 | Vertex Pharma | Profarmacos de pirrolipirimidina como inhibidotes de la proteina cinasa erk. |
WO2006040569A1 (en) | 2004-10-14 | 2006-04-20 | Astex Therapeutics Limited | Thiophene amide compounds for use in the treatment or prophylaxis of cancers |
EP1833820A1 (de) | 2004-12-23 | 2007-09-19 | Vertex Pharmaceuticals Incorporated | Selektive inhibitoren der erk-proteinkinase und anwendungen davon |
CN100377868C (zh) | 2005-03-24 | 2008-04-02 | 中国科学院物理研究所 | 用于磁性/非磁性/磁性多层薄膜的核心复合膜及其用途 |
WO2006136008A1 (en) | 2005-05-24 | 2006-12-28 | University Health Network | Salicylic acid hydrazones as inhibitors of the erk mapkinase pathway and for the treatment of cancer |
US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
RS51981B (en) | 2005-12-13 | 2012-02-29 | Schering Corporation | POLYCYCLIC INDASOL DERIVATIVES WHICH ARE ERK INHIBITORS |
US8546404B2 (en) | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
CA2649628A1 (en) | 2006-04-20 | 2007-11-01 | Takeda Pharmaceutical Company Limited | Pharmaceutical product |
US7601852B2 (en) | 2006-05-11 | 2009-10-13 | Kosan Biosciences Incorporated | Macrocyclic kinase inhibitors |
AU2007269836A1 (en) | 2006-06-30 | 2008-01-10 | Albany Molecular Research, Inc. | Substituted piperidines that increase P53 activity and the uses thereof |
US7671832B2 (en) | 2006-07-10 | 2010-03-02 | Philips Lumileds Lighting Company, Llc | Multi-colored LED backlight with color-compensated clusters near edge |
CA2874756C (en) | 2007-03-28 | 2018-05-29 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
AU2008262038A1 (en) | 2007-06-08 | 2008-12-18 | AbbVie Deutschland GmbH & Co. KG | 5-heteroaryl substituted indazoles as kinase inhibitors |
MX2009014208A (es) | 2007-06-18 | 2010-01-28 | Schering Corp | Compuestos heterociclicos y usos de los mismos como inhibidores de erk. |
NZ587504A (en) | 2008-02-21 | 2012-09-28 | Merck Sharp & Dohme | Benzopyrazole derivatives as ERK inhibitors |
-
2007
- 2007-02-13 ES ES07750497T patent/ES2353437T3/es active Active
- 2007-02-13 AT AT07750497T patent/ATE485268T1/de not_active IP Right Cessation
- 2007-02-13 AU AU2007218059A patent/AU2007218059A1/en not_active Abandoned
- 2007-02-13 DE DE602007009932T patent/DE602007009932D1/de active Active
- 2007-02-13 EP EP07750497A patent/EP1984331B1/de active Active
- 2007-02-13 US US11/705,709 patent/US7807672B2/en not_active Expired - Fee Related
- 2007-02-13 WO PCT/US2007/003665 patent/WO2007097937A1/en active Application Filing
- 2007-02-13 CA CA002642762A patent/CA2642762A1/en not_active Abandoned
- 2007-02-13 MX MX2008010635A patent/MX2008010635A/es unknown
- 2007-02-13 KR KR1020087022312A patent/KR20080103996A/ko not_active Application Discontinuation
- 2007-02-13 CN CNA2007800113120A patent/CN101415674A/zh active Pending
- 2007-02-13 JP JP2008555293A patent/JP2009528280A/ja not_active Withdrawn
- 2007-02-14 AR ARP070100620A patent/AR059493A1/es unknown
- 2007-02-15 TW TW096105603A patent/TW200745089A/zh unknown
-
2008
- 2008-08-12 IL IL193413A patent/IL193413A0/en unknown
- 2008-08-29 ZA ZA200807457A patent/ZA200807457B/xx unknown
- 2008-11-03 HK HK08112047.0A patent/HK1117159A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AR059493A1 (es) | 2008-04-09 |
HK1117159A1 (en) | 2009-01-09 |
MX2008010635A (es) | 2008-10-28 |
TW200745089A (en) | 2007-12-16 |
EP1984331A1 (de) | 2008-10-29 |
EP1984331B1 (de) | 2010-10-20 |
ZA200807457B (en) | 2009-09-30 |
JP2009528280A (ja) | 2009-08-06 |
DE602007009932D1 (de) | 2010-12-02 |
CN101415674A (zh) | 2009-04-22 |
KR20080103996A (ko) | 2008-11-28 |
US7807672B2 (en) | 2010-10-05 |
IL193413A0 (en) | 2009-05-04 |
AU2007218059A1 (en) | 2007-08-30 |
US20070232610A1 (en) | 2007-10-04 |
CA2642762A1 (en) | 2007-08-30 |
WO2007097937A1 (en) | 2007-08-30 |
ES2353437T3 (es) | 2011-03-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE485268T1 (de) | Pyrrolidin-derivate als erk-hemmer | |
ATE527240T1 (de) | Polyzyklische indazol-derivate als erk-hemmer | |
ATE400271T1 (de) | Aryl-pyridinderivate als 11-beta-hsd1-hemmer | |
ATE510825T1 (de) | Acylaminopyrazole als fgfr-inhibitoren | |
ATE420076T1 (de) | Indozolonderivate als 11b-hsd1-inhibitoren | |
DK2041138T3 (da) | Pyrroltriazinkinase-inhibitorer | |
DK2024375T3 (da) | Cyclopropyl-kondenserede indolobenzazepin-HCV-NS5B-hæmmere | |
CR10831A (es) | INHIBIDORES ESPIRO CETONA DE ACETIL-CoA CARBOXILASA | |
ATE467623T1 (de) | Diazepan-acetamidderivate als selektive 11-hsd1- hemmer | |
ATE452631T1 (de) | N-2-adamantanyl-2-phenoxy-acetamid-derivate als 11-betahydroxysteroid-dehydrogenase-hemmer | |
ATE452635T1 (de) | Heteroaryl-substituierte piperidin-derivate als l-cpt1-hemmer | |
ATE475649T1 (de) | Pyridincarboxamide als 11-beta-hsd1-inhibitoren | |
ATE475662T1 (de) | Dihydropyrazolopyrimidinonderivate | |
DK1989206T3 (da) | E1-aktiveringsenzymhæmmere | |
HK1130671A1 (en) | Prolyl hydroxylase inhibitors | |
DE602007008837D1 (de) | Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine | |
ATE483711T1 (de) | Spiroindolinonderivate | |
ATE446090T1 (de) | Thiadiazolidinone als gsk3-inhibitoren | |
ATE469905T1 (de) | Pyridopyrimidinonderivate | |
ATE512135T1 (de) | Spiroindolinonderivate | |
DK2035394T3 (da) | 2-pyrazincarboxamidderivater | |
ATE521595T1 (de) | Cyclohexylaminisochinolonderivate als rho-kinase- inhibitor | |
ATE517101T1 (de) | Als mmp-inhibitoren verwendete hydantoinderivate | |
ATE501138T1 (de) | Thiophenderivate als chk-1-inhibitoren | |
DK2074108T3 (da) | Renin-inhibitorer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |