ATE507839T1 - Kombinationstherapie - Google Patents
KombinationstherapieInfo
- Publication number
- ATE507839T1 ATE507839T1 AT02719260T AT02719260T ATE507839T1 AT E507839 T1 ATE507839 T1 AT E507839T1 AT 02719260 T AT02719260 T AT 02719260T AT 02719260 T AT02719260 T AT 02719260T AT E507839 T1 ATE507839 T1 AT E507839T1
- Authority
- AT
- Austria
- Prior art keywords
- cells expressing
- combination therapy
- depletion
- treatment
- disorders characterized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28080501P | 2001-04-02 | 2001-04-02 | |
PCT/US2002/008057 WO2002078766A2 (en) | 2001-04-02 | 2002-03-14 | Combination therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE507839T1 true ATE507839T1 (de) | 2011-05-15 |
Family
ID=23074728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02719260T ATE507839T1 (de) | 2001-04-02 | 2002-03-14 | Kombinationstherapie |
Country Status (11)
Country | Link |
---|---|
US (5) | US20020197256A1 (de) |
EP (2) | EP2359849A1 (de) |
JP (2) | JP4679035B2 (de) |
AT (1) | ATE507839T1 (de) |
AU (2) | AU2002250352C1 (de) |
CA (1) | CA2440831C (de) |
DE (1) | DE60239931D1 (de) |
ES (1) | ES2364816T3 (de) |
HK (1) | HK1062636A1 (de) |
IL (3) | IL157946A0 (de) |
WO (1) | WO2002078766A2 (de) |
Families Citing this family (78)
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US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
EP1158985B1 (de) | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | GAMMA CARBOXYARYLSUBSTITUIERTE DIPHENYLHARNSTOFFVERBINDUNGEN ALS p38 KINASEHEMMER |
US7183387B1 (en) | 1999-01-15 | 2007-02-27 | Genentech, Inc. | Polypeptide variants with altered effector function |
US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
AU777970C (en) | 1999-05-07 | 2006-08-17 | F. Hoffman-La Roche Ag | Treatment of autoimmune diseases with antagonists which bind to B cell surface markers |
JP2003528805A (ja) * | 1999-07-12 | 2003-09-30 | ジェネンテック・インコーポレーテッド | Cd20に結合するアンタゴニストを用いた異種抗原に対する免疫応答のブロッキング |
DE60028830T2 (de) * | 2000-02-16 | 2007-01-18 | Genentech, Inc., South San Francisco | Anti-april antikörper und hybridomazellen |
JP2002016181A (ja) * | 2000-04-25 | 2002-01-18 | Torex Semiconductor Ltd | 半導体装置、その製造方法、及び電着フレーム |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
ATE507839T1 (de) * | 2001-04-02 | 2011-05-15 | Genentech Inc | Kombinationstherapie |
FR2828104B1 (fr) * | 2001-08-01 | 2005-06-24 | Chu Montpellier | Utilisation d'inhibiteurs du facteur de croissance epidermique liant l'heparine ou d'inhibiteurs de ses recepteurs pour la preparation de medicaments utiles pour traiter le myelome |
MXPA04003798A (es) * | 2001-10-25 | 2004-07-30 | Genentech Inc | Composiciones de glicoproteina. |
SI1478358T1 (sl) | 2002-02-11 | 2013-09-30 | Bayer Healthcare Llc | Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi |
SI1572744T1 (sl) * | 2002-12-16 | 2010-09-30 | Genentech Inc | Imunoglobulinske variante in njihove uporabe |
WO2004060317A2 (en) * | 2002-12-31 | 2004-07-22 | Genta Incorporated | Combination of gallium compounds with nonchemotherapeutic anticancer agents in the treatment of neoplasia |
UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
US20040202658A1 (en) | 2003-04-09 | 2004-10-14 | Genentech, Inc. | Therapy of autoimmune disease in a patient with an inadequate response to TNF-alpha inhibitor |
AU2004252067B2 (en) * | 2003-05-09 | 2012-04-12 | Duke University | CD20-specific antibodies and methods of employing same |
DK1636585T3 (da) | 2003-05-20 | 2008-05-26 | Bayer Pharmaceuticals Corp | Diarylurinstoffer med kinasehæmmende aktivitet |
AR044388A1 (es) * | 2003-05-20 | 2005-09-07 | Applied Molecular Evolution | Moleculas de union a cd20 |
JP2007526220A (ja) | 2003-06-05 | 2007-09-13 | ジェネンテック・インコーポレーテッド | B細胞疾患の併用療法 |
JP2007500844A (ja) * | 2003-07-29 | 2007-01-18 | ジェネンテック・インコーポレーテッド | ヒト抗cd20抗体のアッセイとその用途 |
US20050053602A1 (en) * | 2003-08-29 | 2005-03-10 | Genentech, Inc. | Therapy of ocular disorders |
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US8277810B2 (en) | 2003-11-04 | 2012-10-02 | Novartis Vaccines & Diagnostics, Inc. | Antagonist anti-CD40 antibodies |
TR201809892T4 (tr) | 2003-11-05 | 2018-07-23 | Roche Glycart Ag | Fc reseptörüne bağlanma afinitesi ve artırılmış efektör fonksiyonu bulunan antijen bağlayan moleküller. |
MXPA06006865A (es) * | 2003-12-19 | 2006-08-23 | Genentech Inc | Deteccion de cd20 en rechazo de transplante. |
US20050186206A1 (en) * | 2003-12-19 | 2005-08-25 | Genentech, Inc. | Detection of CD20 in therapy of autoimmune diseases |
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US20050271658A1 (en) * | 2004-05-05 | 2005-12-08 | Genentech, Inc. | Preventing autoimmune disease |
AU2005251764A1 (en) * | 2004-06-04 | 2005-12-22 | Genentech, Inc. | Method for treating lupus |
AR049200A1 (es) * | 2004-06-04 | 2006-07-05 | Genentech Inc | Metodo para tratar esclerosis multiple con una composicion que contiene un anticuerpo cd20 |
CA2573359A1 (en) * | 2004-07-22 | 2006-02-02 | Genentech, Inc. | Method of treating sjogren's syndrome |
CN101001873B (zh) | 2004-08-04 | 2013-03-13 | 曼璀克生物科技有限责任公司 | Fc区变体 |
US8017151B2 (en) * | 2004-09-07 | 2011-09-13 | Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center | Amphiphilic polymer-protein conjugates and methods of use thereof |
US8168222B2 (en) | 2004-09-07 | 2012-05-01 | Board Of Regents Of The University Of Nebraska | Amphiphilic polymer-protein conjugates and methods of use thereof |
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ES2460517T3 (es) | 2005-07-25 | 2014-05-13 | Emergent Product Development Seattle, Llc | Reducción de células b mediante el uso de moléculas de unión específica a cd37 y de unión específica a cd20 |
MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
JP6088723B2 (ja) | 2005-11-23 | 2017-03-01 | ジェネンテック, インコーポレイテッド | B細胞アッセイに関する組成物及び方法。 |
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ES2554527T3 (es) * | 2006-01-24 | 2015-12-21 | Biocompatibles Uk Limited | Proceso para rellenar partículas poliméricas con un fármaco |
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KR101571027B1 (ko) | 2006-06-12 | 2015-11-23 | 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 | 효과기 기능을 갖는 단일쇄 다가 결합 단백질 |
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AR078161A1 (es) | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
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CA2824278C (en) * | 2010-12-20 | 2022-09-20 | The Rockefeller University | Modulating agonistic tnfr antibodies |
ES2692268T3 (es) | 2011-03-29 | 2018-12-03 | Roche Glycart Ag | Variantes de Fc de anticuerpo |
EP3495387B1 (de) | 2012-07-13 | 2021-09-01 | Roche Glycart AG | Bispezifische anti-vegf-/anti-ang-2-antikörper und deren verwendung bei der behandlung von vaskulären okulären erkrankungen |
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CN114470001A (zh) * | 2018-04-18 | 2022-05-13 | 浙江大学 | 人羊膜上皮细胞在自身免疫性疾病中的治疗用途 |
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-
2002
- 2002-03-14 AT AT02719260T patent/ATE507839T1/de active
- 2002-03-14 AU AU2002250352A patent/AU2002250352C1/en not_active Expired
- 2002-03-14 EP EP10176041A patent/EP2359849A1/de not_active Withdrawn
- 2002-03-14 DE DE60239931T patent/DE60239931D1/de not_active Expired - Lifetime
- 2002-03-14 ES ES02719260T patent/ES2364816T3/es not_active Expired - Lifetime
- 2002-03-14 EP EP02719260A patent/EP1383532B1/de not_active Revoked
- 2002-03-14 JP JP2002577030A patent/JP4679035B2/ja not_active Expired - Lifetime
- 2002-03-14 WO PCT/US2002/008057 patent/WO2002078766A2/en active Application Filing
- 2002-03-14 US US10/099,818 patent/US20020197256A1/en not_active Abandoned
- 2002-03-14 CA CA2440831A patent/CA2440831C/en not_active Expired - Lifetime
- 2002-03-14 IL IL15794602A patent/IL157946A0/xx unknown
-
2003
- 2003-09-16 IL IL157946A patent/IL157946A/en active IP Right Grant
-
2004
- 2004-07-09 HK HK04105003.0A patent/HK1062636A1/xx not_active IP Right Cessation
-
2006
- 2006-09-29 US US11/537,559 patent/US20070178091A1/en not_active Abandoned
-
2008
- 2008-06-26 AU AU2008202838A patent/AU2008202838A1/en not_active Abandoned
-
2009
- 2009-10-28 JP JP2009247791A patent/JP5587589B2/ja not_active Expired - Lifetime
-
2010
- 2010-02-18 IL IL204031A patent/IL204031A/en active IP Right Grant
-
2011
- 2011-02-01 US US13/019,183 patent/US20110123531A1/en not_active Abandoned
-
2013
- 2013-11-05 US US14/072,703 patent/US20140065160A1/en not_active Abandoned
-
2016
- 2016-09-26 US US15/276,591 patent/US20170233482A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL157946A0 (en) | 2004-03-28 |
WO2002078766A2 (en) | 2002-10-10 |
WO2002078766A3 (en) | 2003-05-22 |
CA2440831C (en) | 2013-05-28 |
AU2002250352C1 (en) | 2009-04-30 |
AU2002250352B2 (en) | 2008-04-03 |
HK1062636A1 (en) | 2004-11-19 |
EP2359849A1 (de) | 2011-08-24 |
EP1383532A4 (de) | 2004-10-06 |
US20170233482A1 (en) | 2017-08-17 |
US20140065160A1 (en) | 2014-03-06 |
EP1383532A2 (de) | 2004-01-28 |
US20070178091A1 (en) | 2007-08-02 |
ES2364816T3 (es) | 2011-09-14 |
JP4679035B2 (ja) | 2011-04-27 |
AU2008202838A1 (en) | 2008-07-24 |
US20110123531A1 (en) | 2011-05-26 |
CA2440831A1 (en) | 2002-10-10 |
US20020197256A1 (en) | 2002-12-26 |
IL157946A (en) | 2013-11-28 |
IL204031A (en) | 2015-05-31 |
JP2005508844A (ja) | 2005-04-07 |
JP5587589B2 (ja) | 2014-09-10 |
DE60239931D1 (de) | 2011-06-16 |
EP1383532B1 (de) | 2011-05-04 |
JP2010077134A (ja) | 2010-04-08 |
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