ATE507230T1 - Neues stereospezifisches verfahren zur herstellung von dioxabicyclooctan-verbindungen - Google Patents

Neues stereospezifisches verfahren zur herstellung von dioxabicyclooctan-verbindungen

Info

Publication number
ATE507230T1
ATE507230T1 AT08380318T AT08380318T ATE507230T1 AT E507230 T1 ATE507230 T1 AT E507230T1 AT 08380318 T AT08380318 T AT 08380318T AT 08380318 T AT08380318 T AT 08380318T AT E507230 T1 ATE507230 T1 AT E507230T1
Authority
AT
Austria
Prior art keywords
dioxabicyclooctan
compounds
producing
specific process
new stereo
Prior art date
Application number
AT08380318T
Other languages
English (en)
Inventor
Coy Francisco Pubill
Saladrigas Anna Modolell
Moliner Jose Repolles
Original Assignee
Lacer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer Sa filed Critical Lacer Sa
Application granted granted Critical
Publication of ATE507230T1 publication Critical patent/ATE507230T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
AT08380318T 2008-07-22 2008-11-14 Neues stereospezifisches verfahren zur herstellung von dioxabicyclooctan-verbindungen ATE507230T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08380221A EP2149576A1 (de) 2008-07-22 2008-07-22 Isosorbitnitrate mit vasodilatierender Wirksamkeit

Publications (1)

Publication Number Publication Date
ATE507230T1 true ATE507230T1 (de) 2011-05-15

Family

ID=39800661

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08380318T ATE507230T1 (de) 2008-07-22 2008-11-14 Neues stereospezifisches verfahren zur herstellung von dioxabicyclooctan-verbindungen

Country Status (15)

Country Link
US (2) US8211939B2 (de)
EP (2) EP2149576A1 (de)
JP (1) JP2011528691A (de)
KR (1) KR20110039562A (de)
CN (1) CN102124010B (de)
AR (1) AR072591A1 (de)
AT (1) ATE507230T1 (de)
AU (1) AU2009273233B2 (de)
BR (1) BRPI0916532A2 (de)
CA (1) CA2731574A1 (de)
DE (1) DE602008006545D1 (de)
ES (2) ES2365688T3 (de)
MX (1) MX2011000808A (de)
UY (1) UY32001A (de)
WO (1) WO2010010101A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2149576A1 (de) * 2008-07-22 2010-02-03 Lacer, S.A. Isosorbitnitrate mit vasodilatierender Wirksamkeit
KR20150123324A (ko) * 2013-03-05 2015-11-03 아처 다니엘 미드랜드 캄파니 이소헥시드 모노트리플레이트 및 이의 합성 방법
US10691097B2 (en) 2014-05-09 2020-06-23 The Boeing Company Path repeatable machining for full sized determinant assembly
US10913748B2 (en) * 2018-11-04 2021-02-09 Coeurative, Inc. Compounds useful for treating cardiovascular diseases
US10501471B1 (en) * 2018-11-04 2019-12-10 John F. Schmedtje, Jr. Compounds useful for treating cardiovascular diseases
CN113683623B (zh) * 2021-09-09 2022-08-12 中国人民解放军空军军医大学 一种no供体化合物及其制备方法和用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3028289C2 (de) * 1980-07-25 1986-11-27 Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe 2-O- und 5-O-substituierte 1.4;3.6-Dianhydro-hexit-mononitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
JP2628756B2 (ja) 1988-09-15 1997-07-09 シュバルツファルマ アクチェンゲゼルシャフト 新規有機ニトレート及びそれらの製造方法
US4891373A (en) 1988-11-23 1990-01-02 Pfizer Inc. Aminopropanol derivatives of 1,4:3,6-dianhydrohexitol nitrates, processes for their preparation and their use as medicaments
NL9001955A (nl) 1990-09-05 1992-04-01 Cedona Pharm Bv Nieuwe thiazolidinederivaten.
FR2680173A1 (fr) 1991-08-07 1993-02-12 Hoechst Lab Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires .
DE69321596T2 (de) 1992-07-30 1999-04-22 Cal International Ltd Ester und kombinationen von einem organischen nitrat und einem salicyclat
ES2142773B1 (es) * 1998-10-07 2001-01-01 Lacer Sa Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
ES2258365B1 (es) * 2003-10-03 2007-12-01 Lacer, S.A. Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
EP1941876A1 (de) * 2006-12-28 2008-07-09 Lacer, S.A. Isosorbidmononitrit Derivate zur Behandlung von der Inflammation und okularen Hypertension
EP2149576A1 (de) * 2008-07-22 2010-02-03 Lacer, S.A. Isosorbitnitrate mit vasodilatierender Wirksamkeit

Also Published As

Publication number Publication date
JP2011528691A (ja) 2011-11-24
ES2365688T3 (es) 2011-10-10
DE602008006545D1 (de) 2011-06-09
UY32001A (es) 2010-02-26
ES2341075B1 (es) 2011-03-01
CN102124010B (zh) 2013-12-18
WO2010010101A8 (en) 2011-03-10
CA2731574A1 (en) 2010-01-28
EP2149576A1 (de) 2010-02-03
AR072591A1 (es) 2010-09-08
US20100022638A1 (en) 2010-01-28
MX2011000808A (es) 2011-05-30
AU2009273233A1 (en) 2010-01-28
AU2009273233B2 (en) 2013-03-28
KR20110039562A (ko) 2011-04-19
ES2341075A1 (es) 2010-06-14
US20120189616A1 (en) 2012-07-26
EP2324033A1 (de) 2011-05-25
CN102124010A (zh) 2011-07-13
EP2324033B1 (de) 2012-08-22
US8211939B2 (en) 2012-07-03
WO2010010101A1 (en) 2010-01-28
BRPI0916532A2 (pt) 2015-11-10

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