ATE500264T1 - Makrozyklische peptide mit wirkung gegen das hepatitis-c-virus - Google Patents
Makrozyklische peptide mit wirkung gegen das hepatitis-c-virusInfo
- Publication number
- ATE500264T1 ATE500264T1 AT04761821T AT04761821T ATE500264T1 AT E500264 T1 ATE500264 T1 AT E500264T1 AT 04761821 T AT04761821 T AT 04761821T AT 04761821 T AT04761821 T AT 04761821T AT E500264 T1 ATE500264 T1 AT E500264T1
- Authority
- AT
- Austria
- Prior art keywords
- virus
- active against
- against hepatitis
- macrocyclic peptides
- peptides active
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50483903P | 2003-09-22 | 2003-09-22 | |
PCT/CA2004/001658 WO2005028501A1 (en) | 2003-09-22 | 2004-09-20 | Macrocyclic peptides active against the hepatitis c virus |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE500264T1 true ATE500264T1 (de) | 2011-03-15 |
Family
ID=34375541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04761821T ATE500264T1 (de) | 2003-09-22 | 2004-09-20 | Makrozyklische peptide mit wirkung gegen das hepatitis-c-virus |
Country Status (22)
Country | Link |
---|---|
US (2) | US7642235B2 (de) |
EP (1) | EP1673385B1 (de) |
JP (2) | JP4704342B2 (de) |
KR (1) | KR20060094083A (de) |
CN (1) | CN1856502A (de) |
AR (1) | AR045938A1 (de) |
AT (1) | ATE500264T1 (de) |
AU (1) | AU2004274051A1 (de) |
BR (1) | BRPI0414571A (de) |
CA (1) | CA2536182C (de) |
DE (1) | DE602004031645D1 (de) |
EA (1) | EA200600498A1 (de) |
EC (1) | ECSP066448A (de) |
ES (1) | ES2361997T3 (de) |
IL (1) | IL174403A0 (de) |
MX (1) | MXPA06003141A (de) |
NO (1) | NO20061767L (de) |
PE (1) | PE20050431A1 (de) |
RS (1) | RS20060197A (de) |
TW (1) | TW200521144A (de) |
UY (1) | UY28525A1 (de) |
WO (1) | WO2005028501A1 (de) |
Families Citing this family (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TR199901602T2 (xx) | 1996-10-18 | 1999-10-21 | Vertex Pharmaceuticals Incorporated | Serin proteazlar�n ve �zel olarak hepatit C vir�s� NS3 proteaz�n�n inhibit�rleri. |
SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
US7119072B2 (en) * | 2002-01-30 | 2006-10-10 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis C virus |
MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
NZ543250A (en) * | 2003-04-02 | 2008-12-24 | Boehringer Ingelheim Int | Pharmaceutical compositions for hepatitis C viral protease inhibitors |
US7148347B2 (en) * | 2003-04-10 | 2006-12-12 | Boehringer Ingelheim International Gmbh | Process for preparing macrocyclic compounds |
US7176208B2 (en) * | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
EP1654261B1 (de) | 2003-05-21 | 2007-11-14 | Boehringer Ingelheim International GmbH | Verbindungen als hepatitis c inhibitoren |
PE20050374A1 (es) | 2003-09-05 | 2005-05-30 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc |
US7642235B2 (en) * | 2003-09-22 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
US7132504B2 (en) * | 2003-11-12 | 2006-11-07 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
JP2007513200A (ja) * | 2003-12-08 | 2007-05-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 超臨界流体処理によるルテニウム副生物の除去 |
EP1730167B1 (de) * | 2004-01-21 | 2011-01-12 | Boehringer Ingelheim International GmbH | Makrocyclische peptide mit wirkung gegen das hepatitis-c-virus |
DE602005019700D1 (de) * | 2004-03-15 | 2010-04-15 | Boehringer Ingelheim Int | E, die sich für die behandlung von hepatitis-c-virusinfektionen eignen |
CA2568008C (en) | 2004-05-25 | 2014-01-28 | Boehringer Ingelheim International Gmbh | Process for preparing acyclic hcv protease inhibitors |
UY29016A1 (es) | 2004-07-20 | 2006-02-24 | Boehringer Ingelheim Int | Analogos de dipeptidos inhibidores de la hepatitis c |
ATE512971T1 (de) | 2004-07-20 | 2011-07-15 | Boehringer Ingelheim Int | Peptidanaloga als hepatitis c-hemmer |
EP1794178A1 (de) * | 2004-09-17 | 2007-06-13 | Boehringer Ingelheim International Gmbh | Verfahren zur herstellung makrocyclischer inhibitoren der hcv-protease |
US7189844B2 (en) | 2004-09-17 | 2007-03-13 | Boehringer Ingelheim International Gmbh | Ring-closing metathesis process in supercritical fluid |
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DE102005002336A1 (de) | 2005-01-17 | 2006-07-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Durchführung von kontinuierlichen Olefin-Ringschluss-Metathesen in komprimiertem Kohlendioxid |
US7323447B2 (en) | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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US7592336B2 (en) | 2005-05-10 | 2009-09-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7608592B2 (en) | 2005-06-30 | 2009-10-27 | Virobay, Inc. | HCV inhibitors |
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US7700552B2 (en) | 2005-07-29 | 2010-04-20 | Medivir Ab | Macrocyclic inhibitors of hepatitis C virus |
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US7964624B1 (en) * | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
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UY28525A1 (es) | 2005-04-29 |
US20050080005A1 (en) | 2005-04-14 |
CA2536182C (en) | 2012-07-24 |
KR20060094083A (ko) | 2006-08-28 |
BRPI0414571A (pt) | 2006-11-07 |
PE20050431A1 (es) | 2005-07-19 |
ECSP066448A (es) | 2006-09-18 |
RS20060197A (en) | 2008-09-29 |
JP2007529411A (ja) | 2007-10-25 |
EP1673385A1 (de) | 2006-06-28 |
TW200521144A (en) | 2005-07-01 |
CN1856502A (zh) | 2006-11-01 |
IL174403A0 (en) | 2006-08-01 |
MXPA06003141A (es) | 2006-06-05 |
EA200600498A1 (ru) | 2006-10-27 |
EP1673385A4 (de) | 2006-10-04 |
EP1673385B1 (de) | 2011-03-02 |
DE602004031645D1 (de) | 2011-04-14 |
CA2536182A1 (en) | 2005-03-31 |
WO2005028501A1 (en) | 2005-03-31 |
ES2361997T3 (es) | 2011-06-27 |
AR045938A1 (es) | 2005-11-16 |
NO20061767L (no) | 2006-06-16 |
JP4704342B2 (ja) | 2011-06-15 |
JP2011006420A (ja) | 2011-01-13 |
AU2004274051A1 (en) | 2005-03-31 |
US20100028300A1 (en) | 2010-02-04 |
US7642235B2 (en) | 2010-01-05 |
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