MXPA05011212A - Derivados de indeno como agentes farmaceuticos. - Google Patents
Derivados de indeno como agentes farmaceuticos.Info
- Publication number
- MXPA05011212A MXPA05011212A MXPA05011212A MXPA05011212A MXPA05011212A MX PA05011212 A MXPA05011212 A MX PA05011212A MX PA05011212 A MXPA05011212 A MX PA05011212A MX PA05011212 A MXPA05011212 A MX PA05011212A MX PA05011212 A MXPA05011212 A MX PA05011212A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical agents
- indene derivatives
- indene
- derivatives
- compounds
- Prior art date
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- C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
- C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
- C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- C07C233/21—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/66—Nitrogen atoms
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- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
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- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
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- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
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- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
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Abstract
Se describen en la presente compuestos de la formula (Ia), (ver formula (Ia)) en donde R1, R2, R3, R4a, R5 y R6 se definen en la presente, asi como otros derivados de indeno; tambien se describen las composiciones farmaceuticas que contienen los compuestos y los metodos de uso de los compuestos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US46321603P | 2003-04-15 | 2003-04-15 | |
PCT/CA2004/000566 WO2004092100A1 (en) | 2003-04-15 | 2004-04-15 | Indene derivatives as pharmaceutical agents |
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MXPA05011212A true MXPA05011212A (es) | 2006-03-30 |
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MXPA05011212A MXPA05011212A (es) | 2003-04-15 | 2004-04-15 | Derivados de indeno como agentes farmaceuticos. |
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US (5) | US7601874B2 (es) |
EP (3) | EP2277848B1 (es) |
JP (2) | JP4956182B2 (es) |
KR (1) | KR101239396B1 (es) |
CN (3) | CN102010298A (es) |
AT (1) | ATE498600T1 (es) |
AU (2) | AU2004229598B2 (es) |
BR (1) | BRPI0409376A (es) |
CA (1) | CA2521883C (es) |
DE (1) | DE602004031410D1 (es) |
ES (1) | ES2359916T3 (es) |
HK (1) | HK1155146A1 (es) |
MX (1) | MXPA05011212A (es) |
NO (1) | NO334964B1 (es) |
NZ (1) | NZ542962A (es) |
RU (1) | RU2381209C2 (es) |
WO (1) | WO2004092100A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2277848B1 (en) | 2003-04-15 | 2016-09-14 | Aquinox Pharmaceuticals (Canada) Inc. | Indene derivatives as pharmaceutical agents |
CA2647933A1 (en) * | 2006-03-29 | 2007-11-08 | Schering Corporation | Monocyclic and bicyclic himbacine derivatives useful as thrombin receptor antagonists |
NZ618936A (en) | 2011-07-22 | 2015-07-31 | Venantius Ltd | Indene derivatives for use in the treatment of inflammatory bowel disease |
WO2013174917A1 (en) * | 2012-05-24 | 2013-11-28 | Venantius Limited | Compounds for use in the treatment of autoimmune inflammatory disease |
US9540353B2 (en) | 2013-01-09 | 2017-01-10 | Aquinox Pharmaceuticals (Canada) Inc. | SHIP1 modulators and methods related thereto |
EP2970100A1 (en) | 2013-03-14 | 2016-01-20 | Aquinox Pharmaceuticals (Canada) Inc. | Ship1 modulators and methods related thereto |
US9765085B2 (en) | 2013-03-14 | 2017-09-19 | Aquinox Pharmaceuticals (Canada) Inc. | SHIP1 modulators and methods related thereto |
CA2986790A1 (en) | 2015-06-26 | 2016-12-29 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of the acetate salt of (1s,3s,4r)-4-((3as,4r,5s,7as)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol |
WO2017127753A1 (en) | 2016-01-20 | 2017-07-27 | Aquinox Pharmaceuticals (Canada) Inc. | Synthesis of a substituted indene derivative |
EP3423465A1 (en) | 2016-03-02 | 2019-01-09 | Patheon Austria GmbH & Co KG | Process and intermediates for the production of 17(20)-ene b-seco steroids |
US20180085460A1 (en) | 2016-09-26 | 2018-03-29 | Aquinox Pharmaceuticals (Canada) Inc. | Methods of treating prostatitis |
WO2018126040A1 (en) | 2016-12-28 | 2018-07-05 | Aquinox Pharmaceuticals (Canada) Inc. | Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol |
CN112543753A (zh) | 2018-04-06 | 2021-03-23 | 塔罗制药公司 | 可用于治疗疼痛和炎症的茚衍生物 |
CN112533905A (zh) | 2018-04-06 | 2021-03-19 | 塔罗制药公司 | 可用于治疗疼痛和炎症的茚衍生物 |
EP3774836B1 (en) | 2018-04-06 | 2023-10-04 | Taro Pharmaceuticals Inc. | Hexadecahydro-1h-cyclopenta[a]phenanthrene derivatives useful in treating pain and inflammation |
CN113795273A (zh) | 2019-04-22 | 2021-12-14 | 莎思坦控股有限责任公司 | 基于胶原肽的药物组合物和装置及其生产方法和用途 |
CN110423261B (zh) * | 2019-09-04 | 2021-09-14 | 成都百途医药科技有限公司 | 一种7-酮基石胆酸中间体及其制备工艺、应用 |
CN111056962B (zh) * | 2019-11-28 | 2022-08-05 | 重庆爱旭龙科技有限公司 | 一种诺司普托及其醋酸盐的制备方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
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DE1084718B (de) * | 1958-07-08 | 1960-07-07 | Bayer Ag | Verfahren zur Herstellung von Secosteroiden |
SE345995B (es) * | 1969-01-31 | 1972-06-19 | Bristol Myers Co | |
US3682983A (en) | 1969-11-12 | 1972-08-08 | Klaus Prezewowsky | Preparation of {66 {11 {11 -17 ethinyl steroids |
US3962275A (en) * | 1972-06-05 | 1976-06-08 | Hoffmann-La Roche Inc. | 7-oxa steroids |
US3869467A (en) * | 1972-06-05 | 1975-03-04 | Hoffmann La Roche | 17-{62 -Hydroxy-17-{60 -methyl-5-{60 -androstano{9 3,2-c{9 or{8 2,3-d{9 isoxazoles |
JPH01290624A (ja) * | 1988-05-16 | 1989-11-22 | Shiono Chem Kk | 5,6―セコ―ステロール誘導体血清脂質低下剤 |
JPH07502511A (ja) | 1991-12-20 | 1995-03-16 | グラクソ、インコーポレーテッド | 5‐α‐テストステロンレダクターゼ阻害剤 |
JPH05221901A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール誘導体 |
JPH05221924A (ja) | 1992-02-17 | 1993-08-31 | Shiono Chem Kk | セコステロール化合物 |
US5464866A (en) | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
AP459A (en) | 1992-12-18 | 1996-02-14 | Glaxo Wellcome Inc | Substituted 6-azaandrostenones. |
US5541322A (en) | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
US6046185A (en) | 1996-07-11 | 2000-04-04 | Inflazyme Pharmaceuticals Ltd. | 6,7-oxygenated steroids and uses related thereto |
EP1118654A4 (en) * | 1999-04-16 | 2007-03-07 | Nippon Mitsubishi Oil Corp | TRACTION DRIVE FLUIDS |
EP2277848B1 (en) | 2003-04-15 | 2016-09-14 | Aquinox Pharmaceuticals (Canada) Inc. | Indene derivatives as pharmaceutical agents |
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2004
- 2004-04-15 EP EP10012219.1A patent/EP2277848B1/en not_active Expired - Lifetime
- 2004-04-15 JP JP2006504111A patent/JP4956182B2/ja not_active Expired - Fee Related
- 2004-04-15 US US10/825,084 patent/US7601874B2/en active Active
- 2004-04-15 WO PCT/CA2004/000566 patent/WO2004092100A1/en active Application Filing
- 2004-04-15 NZ NZ542962A patent/NZ542962A/en not_active IP Right Cessation
- 2004-04-15 BR BRPI0409376-3A patent/BRPI0409376A/pt not_active Application Discontinuation
- 2004-04-15 EP EP16001886.7A patent/EP3156387B1/en not_active Expired - Lifetime
- 2004-04-15 CN CN2010105275708A patent/CN102010298A/zh active Pending
- 2004-04-15 ES ES04727484T patent/ES2359916T3/es not_active Expired - Lifetime
- 2004-04-15 CN CNA2004800166073A patent/CN1805915A/zh active Pending
- 2004-04-15 DE DE602004031410T patent/DE602004031410D1/de not_active Expired - Lifetime
- 2004-04-15 MX MXPA05011212A patent/MXPA05011212A/es active IP Right Grant
- 2004-04-15 AU AU2004229598A patent/AU2004229598B2/en not_active Ceased
- 2004-04-15 CN CN201010527611.3A patent/CN102001916B/zh not_active Expired - Fee Related
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- 2004-04-15 KR KR1020057019693A patent/KR101239396B1/ko not_active IP Right Cessation
- 2004-04-15 EP EP04727484A patent/EP1615866B1/en not_active Expired - Lifetime
- 2004-04-15 AT AT04727484T patent/ATE498600T1/de not_active IP Right Cessation
- 2004-04-15 RU RU2005135439/04A patent/RU2381209C2/ru not_active IP Right Cessation
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2005
- 2005-10-18 NO NO20054787A patent/NO334964B1/no not_active IP Right Cessation
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2007
- 2007-01-18 HK HK11109373.5A patent/HK1155146A1/zh not_active IP Right Cessation
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2009
- 2009-09-22 US US12/564,747 patent/US8084503B2/en not_active Expired - Fee Related
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2010
- 2010-02-23 US US12/710,909 patent/US7999010B2/en not_active Expired - Fee Related
- 2010-12-22 JP JP2010286772A patent/JP5529000B2/ja not_active Expired - Fee Related
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2011
- 2011-02-17 AU AU2011200686A patent/AU2011200686B2/en not_active Ceased
- 2011-12-08 US US13/315,038 patent/US8673975B2/en not_active Expired - Lifetime
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2014
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