MX2015007909A - Tratamiento de trastornos del ritmo circadiano. - Google Patents

Tratamiento de trastornos del ritmo circadiano.

Info

Publication number
MX2015007909A
MX2015007909A MX2015007909A MX2015007909A MX2015007909A MX 2015007909 A MX2015007909 A MX 2015007909A MX 2015007909 A MX2015007909 A MX 2015007909A MX 2015007909 A MX2015007909 A MX 2015007909A MX 2015007909 A MX2015007909 A MX 2015007909A
Authority
MX
Mexico
Prior art keywords
treatment
circadian rhythm
rhythm disorders
patients
circadian
Prior art date
Application number
MX2015007909A
Other languages
English (en)
Inventor
Marlene Michelle Dressman
John Joseph Feeney
Louis William Licamele
Michael H Polymeropoulos
Original Assignee
Vanda Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50979184&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2015007909(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/751,011 external-priority patent/US8785492B2/en
Application filed by Vanda Pharmaceuticals Inc filed Critical Vanda Pharmaceuticals Inc
Publication of MX2015007909A publication Critical patent/MX2015007909A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/305—Mercury compounds
    • A61K31/31—Mercury compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/493—Physical analysis of biological material of liquid biological material urine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2864—Sleep disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Primary Health Care (AREA)
  • Medical Informatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Las modalidades de la invención se refieren al uso de un agonista de melatonina en el tratamiento de ritmos circadianos de curso libre en los pacientes, incluidos pacientes con deficiencia de percepción de la luz, por ejemplo, pacientes ciegos, y a métodos para medir el ritmo circadiano.
MX2015007909A 2012-12-18 2013-12-18 Tratamiento de trastornos del ritmo circadiano. MX2015007909A (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261738987P 2012-12-18 2012-12-18
US201261738985P 2012-12-18 2012-12-18
US201361755896P 2013-01-23 2013-01-23
US13/751,011 US8785492B2 (en) 2012-01-26 2013-01-25 Treatment of circadian rhythm disorders
PCT/US2013/023315 WO2013112951A2 (en) 2012-01-26 2013-01-25 Treatment of circadian rhythm disorders
US201361903354P 2013-11-12 2013-11-12
PCT/US2013/076311 WO2014100292A1 (en) 2012-12-18 2013-12-18 Treatment of circadian rhythm disorders

Publications (1)

Publication Number Publication Date
MX2015007909A true MX2015007909A (es) 2016-04-25

Family

ID=50979184

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2015007909A MX2015007909A (es) 2012-12-18 2013-12-18 Tratamiento de trastornos del ritmo circadiano.
MX2019006218A MX2019006218A (es) 2012-12-18 2015-06-18 Tratamiento de trastornos del ritmo circadiano.
MX2020012689A MX2020012689A (es) 2012-12-18 2015-06-18 Tratamiento de trastornos del ritmo circadiano.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2019006218A MX2019006218A (es) 2012-12-18 2015-06-18 Tratamiento de trastornos del ritmo circadiano.
MX2020012689A MX2020012689A (es) 2012-12-18 2015-06-18 Tratamiento de trastornos del ritmo circadiano.

Country Status (15)

Country Link
US (2) US9730910B2 (es)
EP (2) EP2934509B1 (es)
JP (4) JP6144358B2 (es)
KR (4) KR20150093236A (es)
CN (2) CN105142630A (es)
AU (5) AU2013361459A1 (es)
BR (1) BR112015014619A2 (es)
CA (2) CA2893542C (es)
CL (1) CL2015001700A1 (es)
ES (1) ES2805376T3 (es)
IL (2) IL266159B1 (es)
MX (3) MX2015007909A (es)
RU (1) RU2748386C2 (es)
WO (1) WO2014100292A1 (es)
ZA (1) ZA201504579B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE034876T2 (hu) 2012-01-26 2018-03-28 Vanda Pharmaceuticals Inc Cirkadián ritmussal kapcsolatos rendellenességek kezelése
US11918557B2 (en) 2012-01-26 2024-03-05 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
CN105142630A (zh) * 2012-12-18 2015-12-09 万达制药公司 昼夜节律紊乱的治疗
WO2015117048A1 (en) * 2014-01-31 2015-08-06 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
US10065952B2 (en) 2015-10-30 2018-09-04 Neurocrine Biosciences, Inc. Valbenazine salts and polymorphs thereof
HRP20220621T1 (hr) 2015-12-23 2022-06-24 Neurocrine Biosciences, Inc. Postupak sinteze za proizvodnju (s)-(2r,3r,11br)-3-izobutil-9,10-dimetoksi-2,3,4,6,7,11b-heksahidro-1h-pirido[2,1-a]izokinolin-2-il 2-amino-3-metilbutanoat di(4-metilbenzensulfonata)
KR20230170135A (ko) 2017-01-27 2023-12-18 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
WO2019028245A1 (en) 2017-08-02 2019-02-07 Vanda Pharmaceuticals Inc. USE OF TASIMELTÉON FOR THE TREATMENT OF AFFECTIVE DISORDERS
IL309802A (en) 2017-09-21 2024-02-01 Neurocrine Biosciences Inc High dose valbenazine formulation and related preparations, methods and kits
US10993941B2 (en) 2017-10-10 2021-05-04 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
CN116492340A (zh) 2017-10-10 2023-07-28 纽罗克里生物科学有限公司 施用某些vmat2抑制剂的方法
CA3104693A1 (en) 2018-08-15 2020-02-20 Neurocrine Biosciences, Inc. Methods for the administration of certain vmat2 inhibitors
EP4186502A1 (en) * 2019-02-13 2023-05-31 Vanda Pharmaceuticals Inc. Method of improving sleep
JP6722911B1 (ja) * 2019-04-18 2020-07-15 株式会社こどもみらい 個人別の概日リズムに基づく生活時刻の提示システム
JP7348613B2 (ja) * 2019-04-18 2023-09-21 株式会社こどもみらい 個人別の概日リズムに基づく生活時刻の提示システム
KR20220027977A (ko) * 2019-06-29 2022-03-08 반다 파마슈티칼즈, 인코퍼레이티드. 수면 이상 치료에서의 타시멜테온 용도
US10940141B1 (en) 2019-08-23 2021-03-09 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL50699A0 (en) 1975-10-28 1976-12-31 Ici America Inc Triazole derivatives
DE3466215D1 (en) 1983-05-18 1987-10-22 Univ Monash The use of melatonin for the manufacture of a medicament
IL79264A0 (en) 1986-06-27 1986-09-30 Univ Ramot Tryptamine derivatives,pharmaceutical compositions containing them and their use in an assay for melatonin receptors
US4997845A (en) 1987-02-02 1991-03-05 Eli Lilly And Company β-alkylmelatonins as ovulation inhibitors
US5093352A (en) 1988-11-14 1992-03-03 Whitby Research, Inc. Antidepressant agents
US5151446A (en) 1989-09-25 1992-09-29 Northwestern University Substituted 2-amidotetralins as melatonin agonists and antagonists
FR2658818B1 (fr) 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
IT1251544B (it) 1991-05-13 1995-05-17 Gabriele Biella Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico
US6180657B1 (en) 1993-11-18 2001-01-30 Eli Lilly And Company Melatonin derivatives for use in treating desynchronization disorders
US5403851A (en) 1994-04-05 1995-04-04 Interneuron Pharmaceuticals, Inc. Substituted tryptamines, phenalkylamines and related compounds
GB9416884D0 (en) 1994-08-20 1994-10-12 Danbiosyst Uk Drug delivery compositions
SK284521B6 (sk) 1995-02-01 2005-05-05 Neurim Pharmaceuticals (1991) Ltd. Použitie melatonínu na prípravu farmaceutického prostriedku
EP0862429A4 (en) * 1995-10-24 2003-05-28 Gruenenthal Gmbh METHOD FOR ADJUSTING THE CIRCADIAN RHYTHM OF A MAMMAL
IL129999A (en) 1996-12-10 2004-06-20 Bristol Myers Squibb Co Melatonergic agents which are benzodioxole, benzopuran, dihydrobenzopuran and benzodioxane
US5776969A (en) 1997-02-27 1998-07-07 Eli Lilly And Company Treatment of sleep disorders
AUPO588297A0 (en) 1997-03-26 1997-04-24 Luminis Pty Limited Mediation in melatonin production
US6348485B1 (en) 1998-06-09 2002-02-19 Takeda Chemical Industries, Ltd. Method for treating or preventing sleep disorders
US6562858B2 (en) 1999-05-17 2003-05-13 St. Elizabeth's Medical Center Of Boston, Inc. Method for treating depression
WO2001002392A1 (en) 1999-06-30 2001-01-11 Bristol-Myers Squibb Company Heterocyclic aminopyrrolidine derivatives as melatonergic agents
JP5067998B2 (ja) 2001-10-30 2012-11-07 ノバルティス アーゲー イロペリドンおよび星形ポリマーのデポー製剤
GB0216416D0 (en) 2002-07-15 2002-08-21 Novartis Ag Organic compounds
IL155666A (en) * 2003-04-29 2013-12-31 Neurim Pharma 1991 Insomnia treatment
JP2005080603A (ja) 2003-09-10 2005-03-31 Kumamoto Technology & Industry Foundation 生体リズム障害の度合の判断方法
WO2005063240A1 (en) 2003-12-22 2005-07-14 The Brigham And Women's Hospital, Inc. Methods and compositions for treatment of hypertension
WO2005063297A2 (en) 2003-12-24 2005-07-14 Sepracor Inc. Melatonin combination therapy for improving sleep quality
NZ565763A (en) 2005-07-29 2010-12-24 Vanda Pharmaceuticals Inc Method of improving wakefulness
US7754902B2 (en) 2006-05-18 2010-07-13 Vanda Pharmaceuticals, Inc. Ruthenium(II) catalysts for use in stereoselective cyclopropanations
KR20090024140A (ko) 2006-05-22 2009-03-06 반다 파마슈티칼즈, 인코퍼레이티드. 우울증 질환에 대한 치료
RU2488392C2 (ru) 2006-05-22 2013-07-27 Ванда Фармасьютиклз, Инк. Лечение агонистом мелатонина
JP5590676B2 (ja) 2007-09-13 2014-09-17 ヴァンダ ファーマシューティカルズ インコーポレイテッド Ｐｅｒ３ｖｎｔｒ遺伝子型に基づく睡眠パラメータ及び睡眠誘導化合物に対する応答の予測
WO2009084023A2 (en) 2007-10-19 2009-07-09 Glenmark Generics Limited Amorphous ramelteon and process for the preparation thereof
JP5558016B2 (ja) * 2009-03-17 2014-07-23 株式会社 資生堂 概日リズム調整剤
WO2011009102A1 (en) 2009-07-16 2011-01-20 Vanda Pharmaceuticals Inc. Use of a melatonin agonist for the treatment of sleep disorders including primary insomnia
HUE034876T2 (hu) 2012-01-26 2018-03-28 Vanda Pharmaceuticals Inc Cirkadián ritmussal kapcsolatos rendellenességek kezelése
CN105142630A (zh) * 2012-12-18 2015-12-09 万达制药公司 昼夜节律紊乱的治疗

Also Published As

Publication number Publication date
ES2805376T3 (es) 2021-02-11
IL266159B1 (en) 2024-03-01
KR102269761B1 (ko) 2021-06-28
WO2014100292A1 (en) 2014-06-26
JP2017165742A (ja) 2017-09-21
JP2018138554A (ja) 2018-09-06
CN110200958A (zh) 2019-09-06
CA3158157A1 (en) 2014-06-26
AU2021203925B2 (en) 2022-06-30
CN105142630A (zh) 2015-12-09
AU2022228094A1 (en) 2022-09-29
EP2934509A1 (en) 2015-10-28
AU2019219847A1 (en) 2019-09-12
KR20190100429A (ko) 2019-08-28
KR102148990B1 (ko) 2020-08-27
EP3767297A1 (en) 2021-01-20
NZ709065A (en) 2020-12-18
KR20150093236A (ko) 2015-08-17
RU2748386C2 (ru) 2021-05-25
IL239246A0 (en) 2015-07-30
CA2893542C (en) 2022-07-19
MX2019006218A (es) 2019-09-06
AU2021203925A1 (en) 2021-07-08
MX2020012689A (es) 2021-02-15
KR20170058464A (ko) 2017-05-26
IL266159A (en) 2019-06-30
JP6826216B2 (ja) 2021-02-03
US9730910B2 (en) 2017-08-15
CA2893542A1 (en) 2014-06-26
NZ749282A (en) 2020-12-18
BR112015014619A2 (pt) 2017-07-11
JP2016506410A (ja) 2016-03-03
CL2015001700A1 (es) 2015-12-28
AU2013361459A1 (en) 2015-07-02
AU2018208633A1 (en) 2018-08-09
JP6317503B2 (ja) 2018-04-25
JP2020090512A (ja) 2020-06-11
JP6144358B2 (ja) 2017-06-07
EP2934509B1 (en) 2020-05-27
RU2015129349A (ru) 2017-01-26
US20150025086A1 (en) 2015-01-22
KR20200102545A (ko) 2020-08-31
ZA201504579B (en) 2023-05-31
US20170304256A1 (en) 2017-10-26
IL239246B (en) 2019-05-30

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