ATE465159T1 - (s)-(-)-1-(4-fluorisochinolin-5-yl)sulfonyl-2- methyl-1,4-homopiperazinhydrochlorid- dihydrat - Google Patents

(s)-(-)-1-(4-fluorisochinolin-5-yl)sulfonyl-2- methyl-1,4-homopiperazinhydrochlorid- dihydrat

Info

Publication number
ATE465159T1
ATE465159T1 AT05811715T AT05811715T ATE465159T1 AT E465159 T1 ATE465159 T1 AT E465159T1 AT 05811715 T AT05811715 T AT 05811715T AT 05811715 T AT05811715 T AT 05811715T AT E465159 T1 ATE465159 T1 AT E465159T1
Authority
AT
Austria
Prior art keywords
sulfonyl
methyl
fluorisoquinoline
homopiperazine hydrochloride
dihydrate
Prior art date
Application number
AT05811715T
Other languages
English (en)
Inventor
Takeshi Ohshima
Hiroyoshi Hidaka
Masami Shiratsuchi
Kazuhiro Onogi
Toshiaki Oda
Original Assignee
Kowa Co
Western Therapeutics Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36498130&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE465159(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kowa Co, Western Therapeutics Inst Inc filed Critical Kowa Co
Application granted granted Critical
Publication of ATE465159T1 publication Critical patent/ATE465159T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT05811715T 2004-11-29 2005-11-29 (s)-(-)-1-(4-fluorisochinolin-5-yl)sulfonyl-2- methyl-1,4-homopiperazinhydrochlorid- dihydrat ATE465159T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004344271 2004-11-29
PCT/JP2005/021844 WO2006057397A1 (ja) 2004-11-29 2005-11-29 （ｓ）－（－）－１－（４－フルオロイソキノリン－５－イル）スルホニル－２－メチル－１，４－ホモピペラジン塩酸塩・二水和物

Publications (1)

Publication Number Publication Date
ATE465159T1 true ATE465159T1 (de) 2010-05-15

Family

ID=36498130

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05811715T ATE465159T1 (de) 2004-11-29 2005-11-29 (s)-(-)-1-(4-fluorisochinolin-5-yl)sulfonyl-2- methyl-1,4-homopiperazinhydrochlorid- dihydrat

Country Status (24)

Country Link
US (1) US7858615B2 (de)
EP (1) EP1818329B1 (de)
JP (1) JP4016060B2 (de)
KR (1) KR101253369B1 (de)
CN (1) CN101068806B (de)
AT (1) ATE465159T1 (de)
AU (1) AU2005308060B2 (de)
BR (1) BRPI0517909B8 (de)
CA (1) CA2589237C (de)
CY (1) CY1112406T1 (de)
DE (1) DE602005020835D1 (de)
DK (1) DK1818329T3 (de)
EA (1) EA011283B1 (de)
ES (1) ES2345562T3 (de)
HK (1) HK1112898A1 (de)
MX (1) MX2007006322A (de)
MY (1) MY139797A (de)
NO (1) NO339021B1 (de)
NZ (1) NZ555560A (de)
PL (1) PL1818329T3 (de)
PT (1) PT1818329E (de)
TW (1) TWI354670B (de)
WO (1) WO2006057397A1 (de)
ZA (1) ZA200704201B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006290827A (ja) * 2005-04-13 2006-10-26 Kowa Co 緑内障予防又は治療剤
WO2007026664A1 (ja) 2005-08-30 2007-03-08 Asahi Kasei Pharma Corporation スルホンアミド化合物
WO2008105058A1 (ja) 2007-02-27 2008-09-04 Asahi Kasei Pharma Corporation スルホンアミド化合物
US7964613B2 (en) 2007-02-28 2011-06-21 Asahi Kasei Pharma Corporation Sulfonamide compound
US8232292B2 (en) * 2007-07-02 2012-07-31 Asahi Kasei Pharma Corporation Sulfonamide compound and crystal thereof
UA102128C2 (en) * 2008-12-05 2013-06-10 Х. Луннбек А/С Nalmefene hydrochloride dihydrate
EP2818463A1 (de) 2010-08-26 2014-12-31 Kowa Co., Ltd. Herstellungsverfahren für 1,4-diazepan derivate
CN105050600B (zh) * 2013-04-24 2018-09-28 国立大学法人九州大学 眼底疾病治疗剂
JP6244038B2 (ja) * 2014-09-25 2017-12-06 興和株式会社 医薬製剤
WO2016111688A1 (en) * 2015-01-08 2016-07-14 Hewlett-Packard Development Company, L.P. Mobile printers
CN107216311B (zh) * 2016-03-21 2019-09-03 山东诚创医药技术开发有限公司 (s)-4-[(4-氟代异喹啉-5-基)磺酰基]-3-甲基-1,4-二氮杂环庚烷盐酸盐的精制方法
CN106496189A (zh) * 2016-10-10 2017-03-15 江苏礼华生物技术有限公司 盐酸Ripasudil晶型
CN107164328A (zh) * 2017-06-30 2017-09-15 太仓卡斯特姆新材料有限公司 一种高稳定性mcf‑7乳腺癌细胞的复苏方法
CA3120751A1 (en) 2018-12-17 2020-06-25 D. Western Therapeutics Institute, Inc. New form of isoquinoline sulfonamide
JP7398137B2 (ja) * 2019-06-21 2023-12-14 コアンチョウ オキュサン オフサルミック バイオテクノロジー カンパニー リミテッド Ｒｏｃｋプロテインキナーゼ阻害薬としてのイソキノリンの誘導体及びその使用
CN114644618A (zh) 2020-12-21 2022-06-21 广州润尔眼科生物科技有限公司 一种作为rock蛋白激酶抑制剂的异喹啉酮型化合物的盐型及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3734531B2 (ja) * 1995-06-29 2006-01-11 旭化成ファーマ株式会社 １−（５−イソキノリンスルホニル）ホモピペラジン塩酸塩３水和物
EP0870767B1 (de) * 1995-07-03 2000-02-16 Asahi Kasei Kogyo Kabushiki Kaisha 1-(5-isochinolinsulfonyl)homopiperazin hydrochlorid
DK0885888T3 (da) * 1996-02-02 2003-11-24 Western Therapeutics Inst D Isoquinolinderivater og lægemidler
AU9646198A (en) * 1997-10-22 1999-05-10 Nippon Shinyaku Co. Ltd. Isoquinoline derivative and drug

Also Published As

Publication number Publication date
DK1818329T3 (da) 2010-07-19
KR20070084127A (ko) 2007-08-24
CA2589237A1 (en) 2006-06-01
KR101253369B1 (ko) 2013-04-11
PL1818329T3 (pl) 2010-10-29
CN101068806A (zh) 2007-11-07
DE602005020835D1 (de) 2010-06-02
MX2007006322A (es) 2007-06-19
TW200630359A (en) 2006-09-01
CN101068806B (zh) 2012-02-01
ES2345562T3 (es) 2010-09-27
EA011283B1 (ru) 2009-02-27
BRPI0517909B8 (pt) 2021-05-25
TWI354670B (en) 2011-12-21
CA2589237C (en) 2013-05-14
JP4016060B2 (ja) 2007-12-05
NO20072382L (no) 2007-08-23
MY139797A (en) 2009-10-30
PT1818329E (pt) 2010-06-22
BRPI0517909B1 (pt) 2018-11-21
US7858615B2 (en) 2010-12-28
HK1112898A1 (de) 2008-09-19
US20080021018A1 (en) 2008-01-24
EP1818329A1 (de) 2007-08-15
WO2006057397A1 (ja) 2006-06-01
JPWO2006057397A1 (ja) 2008-06-05
EP1818329A4 (de) 2009-08-05
BRPI0517909A (pt) 2008-10-21
EA200701156A1 (ru) 2007-10-26
NO339021B1 (no) 2016-11-07
AU2005308060A1 (en) 2006-06-01
ZA200704201B (en) 2008-09-25
AU2005308060B2 (en) 2011-02-17
EP1818329B1 (de) 2010-04-21
NZ555560A (en) 2008-10-31
CY1112406T1 (el) 2015-12-09

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