ATE451921T1 - Phenylindole zur behandlung von hiv - Google Patents

Phenylindole zur behandlung von hiv

Info

Publication number
ATE451921T1
ATE451921T1 AT02723853T AT02723853T ATE451921T1 AT E451921 T1 ATE451921 T1 AT E451921T1 AT 02723853 T AT02723853 T AT 02723853T AT 02723853 T AT02723853 T AT 02723853T AT E451921 T1 ATE451921 T1 AT E451921T1
Authority
AT
Austria
Prior art keywords
phenylindoles
hiv
treatment
Prior art date
Application number
AT02723853T
Other languages
English (en)
Inventor
Colla Paolo La
Marino Artico
Jean-Pierre Sommadossi
Original Assignee
Idenix Cayman Ltd
Univ Cagliari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idenix Cayman Ltd, Univ Cagliari filed Critical Idenix Cayman Ltd
Application granted granted Critical
Publication of ATE451921T1 publication Critical patent/ATE451921T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
AT02723853T 2001-04-11 2002-04-11 Phenylindole zur behandlung von hiv ATE451921T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28339301P 2001-04-11 2001-04-11
PCT/US2002/011736 WO2002083126A1 (en) 2001-04-11 2002-04-11 Phenylindoles for the treatment of hiv

Publications (1)

Publication Number Publication Date
ATE451921T1 true ATE451921T1 (de) 2010-01-15

Family

ID=23085844

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02723853T ATE451921T1 (de) 2001-04-11 2002-04-11 Phenylindole zur behandlung von hiv

Country Status (10)

Country Link
US (3) US6710068B2 (de)
EP (1) EP1390029B1 (de)
AR (1) AR035857A1 (de)
AT (1) ATE451921T1 (de)
AU (1) AU2002254616B2 (de)
BR (1) BR0208790A (de)
CA (1) CA2444501C (de)
DE (1) DE60234760D1 (de)
TW (1) TWI294875B (de)
WO (1) WO2002083126A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1305313B1 (it) * 1998-07-17 2001-05-04 Colla Paolo 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1.
AR035857A1 (es) * 2001-04-11 2004-07-21 Novirio Pharmaceuticals Ltd Fenilindoles; sus composiciones farmaceuticas y sus usos
EP1545510A4 (de) * 2002-08-07 2006-11-15 Idenix Cayman Ltd Substituierte phenylindole zur behandlung von hiv
ATE442375T1 (de) * 2002-10-31 2009-09-15 Metabasis Therapeutics Inc Cytarabin-monophosphate prodrugs
EP1620407A2 (de) * 2003-04-28 2006-02-01 Idenix (Cayman) Limited Oxopyrimidinverbindungen
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
US7265148B2 (en) * 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
PL1799696T3 (pl) 2004-09-17 2009-04-30 Idenix Pharmaceuticals Inc Fosfoindole jako inhibitory HIV
WO2006041961A1 (en) * 2004-10-05 2006-04-20 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTHAND HUMAN SERVICES Arylthioindole tubulin polymerization inhibitors and methods of treating or preventing cancer using same
ES2314739T3 (es) 2004-10-27 2009-03-16 Janssen Pharmaceutica Nv Derivados de indol como moduladores de receptores de progesterona.
US7524831B2 (en) 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
CA2636007A1 (en) * 2006-01-13 2007-07-26 Wyeth Sulfonyl substituted 1h-indoles as ligands for the 5-hydroxytryptamine receptors
MX2009003410A (es) * 2006-09-29 2009-07-17 Idenix Pharmaceuticals Inc Fosfoindoles enantiomericamente puros como inhibidores de vih.
CA2665007A1 (en) * 2006-10-06 2008-05-08 Merck & Co., Inc. Non-nucleoside reverse transcriptase inhibitors
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
CA2704645A1 (en) * 2007-11-09 2009-05-14 The Salk Institute For Biological Studies Non-nucleoside reverse transcriptase inhibitors
CA2710039C (en) 2007-12-26 2018-07-03 Critical Outcome Technologies, Inc. Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer
CN102007100A (zh) * 2008-02-22 2011-04-06 Irm责任有限公司 作为gpr119活性调控剂的化合物和组合物
CA2730890C (en) 2008-07-17 2018-05-15 Critical Outcome Technologies Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
US8987272B2 (en) 2010-04-01 2015-03-24 Critical Outcome Technologies Inc. Compounds and method for treatment of HIV
EP2606031B1 (de) 2010-08-20 2017-09-27 Amira Pharmaceuticals, Inc. Autotaxin-hemmer und anwendungen davon
EP2508511A1 (de) * 2011-04-07 2012-10-10 Laboratoire Biodim Inhibitoren der Virenreplikation, Verfahren zu deren Herstellung und deren therapeutische Verwendung
US9260416B2 (en) 2011-05-27 2016-02-16 Amira Pharmaceuticals, Inc. Heterocyclic autotaxin inhibitors and uses thereof
EP3046909A4 (de) 2013-09-17 2017-03-29 Pharmakea, Inc. Heterocyclische vinyl-autotaxin-hemmerverbindungen
EP3046905A4 (de) 2013-09-17 2017-03-22 Pharmakea Inc. Vinylautotaxinhemmende verbindungen
EP3049405A4 (de) 2013-09-26 2017-03-08 Pharmakea Inc. Autotaxin-inhibitorverbindungen
CN105793253B (zh) 2013-11-22 2019-08-23 法玛克亚公司 自分泌运动因子抑制剂化合物
US10449210B2 (en) 2014-02-13 2019-10-22 Ligand Pharmaceuticals Inc. Prodrug compounds and their uses
JP2017520545A (ja) 2014-07-02 2017-07-27 リガンド・ファーマシューティカルズ・インコーポレイテッド プロドラッグ化合物およびそれらの使用
AU2016268250B2 (en) 2015-05-27 2020-08-27 Sabre Therapeutics Llc Autotaxin inhibitors and uses thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3304019A1 (de) * 1983-02-07 1984-08-09 Kali-Chemie Pharma Gmbh, 3000 Hannover 3-acyloxy-1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4866084A (en) 1987-07-17 1989-09-12 Harbor Branch Oceanographic Institution, Inc. Topsentin compounds effective against viruses and certain tumors
GB8823693D0 (en) * 1988-10-08 1988-11-16 Hartopp R Injector cleaning apparatus
US5124327A (en) 1991-09-06 1992-06-23 Merck & Co., Inc. HIV reverse transcriptase
WO1993005020A1 (en) * 1991-09-06 1993-03-18 Merck & Co., Inc. Indoles as inhibitors of hiv reverse transcriptase
US5527819A (en) 1991-09-06 1996-06-18 Merck & Co., Inc. Inhibitors of HIV reverse transcriptase
DE4217964A1 (de) 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung
US5633457A (en) * 1992-06-05 1997-05-27 Triangle Special Products Fuel injection cleaning and testing system and apparatus
HUT74614A (en) 1993-02-24 1997-01-28 Merck & Co Inc Nindol derivates suitable for treatment of infection by hiv and pharmaceutical compositions containing them
US5489685A (en) 1994-05-12 1996-02-06 Merck & Co., Ltd. Method of synthesizing furo[2,3-b]pyridine carboxylic acid esters
EP0711768B1 (de) 1994-05-31 2002-02-13 Mitsui Chemicals, Inc. Benzimidazol-derivate
US5734081A (en) 1994-08-05 1998-03-31 Warner-Lambert Company Arylthio compounds
CZ217697A3 (cs) 1995-01-10 1998-03-18 Smithkline Beecham S. P. A. Indolové deriváty, kterých je možno použít pro léčení osteoporózy, způsob jejich přípravy, farmaceutický prostředek obsahující tyto deriváty a použití
GB9614347D0 (en) 1996-07-09 1996-09-04 Smithkline Beecham Spa Novel compounds
US5830894A (en) 1997-02-21 1998-11-03 Viropharma Incorporated Methods for preventing and treating pestivirus infection and associated diseases
US5935982A (en) 1997-02-28 1999-08-10 The University Of North Carolina At Chapel Hill Methods of treating retroviral infection and compounds useful therefor
US20020091148A1 (en) * 2000-09-15 2002-07-11 Bamaung Nwe Y. 3-substituted indole antiproliferative angiogenesis inhibitors
AR035857A1 (es) * 2001-04-11 2004-07-21 Novirio Pharmaceuticals Ltd Fenilindoles; sus composiciones farmaceuticas y sus usos
EP1545510A4 (de) * 2002-08-07 2006-11-15 Idenix Cayman Ltd Substituierte phenylindole zur behandlung von hiv
US7406822B2 (en) * 2005-06-30 2008-08-05 Caterpillar Inc. Particulate trap regeneration system and control strategy
US7481048B2 (en) * 2005-06-30 2009-01-27 Caterpillar Inc. Regeneration assembly

Also Published As

Publication number Publication date
US20020193415A1 (en) 2002-12-19
EP1390029A1 (de) 2004-02-25
US20040180888A1 (en) 2004-09-16
DE60234760D1 (de) 2010-01-28
US6710068B2 (en) 2004-03-23
AU2002254616B2 (en) 2007-09-06
TWI294875B (en) 2008-03-21
BR0208790A (pt) 2004-03-30
CA2444501A1 (en) 2002-10-24
TW200422291A (en) 2004-11-01
AR035857A1 (es) 2004-07-21
US20070293668A1 (en) 2007-12-20
EP1390029B1 (de) 2009-12-16
WO2002083126A1 (en) 2002-10-24
EP1390029A4 (de) 2005-11-30
CA2444501C (en) 2009-11-17

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