ATE449057T1 - Resolvine: biotemplate zur durchführung therapeutischer anwendungen - Google Patents
Resolvine: biotemplate zur durchführung therapeutischer anwendungenInfo
- Publication number
- ATE449057T1 ATE449057T1 AT03785253T AT03785253T ATE449057T1 AT E449057 T1 ATE449057 T1 AT E449057T1 AT 03785253 T AT03785253 T AT 03785253T AT 03785253 T AT03785253 T AT 03785253T AT E449057 T1 ATE449057 T1 AT E449057T1
- Authority
- AT
- Austria
- Prior art keywords
- dha
- epa
- present
- compounds
- tri
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 abstract 4
- 229960005135 eicosapentaenoic acid Drugs 0.000 abstract 4
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 abstract 4
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical class CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 2
- 102000010907 Cyclooxygenase 2 Human genes 0.000 abstract 2
- 108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 235000020669 docosahexaenoic acid Nutrition 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 abstract 1
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 235000005911 diet Nutrition 0.000 abstract 1
- 230000000378 dietary effect Effects 0.000 abstract 1
- 229940090949 docosahexaenoic acid Drugs 0.000 abstract 1
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 230000005012 migration Effects 0.000 abstract 1
- 238000013508 migration Methods 0.000 abstract 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 abstract 1
- 230000001766 physiological effect Effects 0.000 abstract 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40279802P | 2002-08-12 | 2002-08-12 | |
| PCT/US2003/025336 WO2004014835A2 (en) | 2002-08-12 | 2003-08-12 | Resolvins: biotemplates for therapeutic interventions |
| US10/639,714 US7585856B2 (en) | 2002-08-12 | 2003-08-12 | Resolvins: Biotemplates for novel therapeutic interventions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE449057T1 true ATE449057T1 (de) | 2009-12-15 |
Family
ID=31720623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03785253T ATE449057T1 (de) | 2002-08-12 | 2003-08-12 | Resolvine: biotemplate zur durchführung therapeutischer anwendungen |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7585856B2 (de) |
| EP (3) | EP1537067B1 (de) |
| JP (7) | JP4845378B2 (de) |
| AT (1) | ATE449057T1 (de) |
| AU (2) | AU2003258194B2 (de) |
| CA (1) | CA2495260C (de) |
| DE (1) | DE60330154D1 (de) |
| DK (1) | DK2216318T3 (de) |
| ES (1) | ES2700133T3 (de) |
| HU (1) | HUE041471T2 (de) |
| SI (1) | SI2216318T1 (de) |
| WO (1) | WO2004014835A2 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3846801A (en) | 2000-02-16 | 2001-08-27 | Brigham & Womens Hospital | Aspirin-triggered lipid mediators |
| EP1268393A2 (de) | 2000-03-20 | 2003-01-02 | Trustees Of Boston University | Lipoxinanaloge und verfahren zur behandlung von periodontalen erkrankungen |
| US7582785B2 (en) * | 2002-04-01 | 2009-09-01 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7902257B2 (en) | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7759395B2 (en) * | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| ES2700133T3 (es) * | 2002-08-12 | 2019-02-14 | Brigham & Womens Hospital | Resolvinas: modelos biológicos para intervenciones terapéuticas |
| WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| WO2005105025A1 (en) * | 2004-04-14 | 2005-11-10 | Boston University | Methods and compositions for preventing or treating periodontal diseases |
| US7884131B2 (en) * | 2004-11-19 | 2011-02-08 | Martek Biosciences, Corporation | Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same |
| US7893106B2 (en) * | 2004-11-19 | 2011-02-22 | Martek Biosciences, Corporation | Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same |
| US20090318394A1 (en) * | 2004-11-19 | 2009-12-24 | Julie Nauroth | Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same |
| US20060293288A1 (en) * | 2005-01-07 | 2006-12-28 | Serhan Charles N | Use of resolvins to treat gastrointestinal diseases |
| WO2007041440A2 (en) * | 2005-10-03 | 2007-04-12 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers |
| US8636986B2 (en) * | 2005-11-18 | 2014-01-28 | The Forsyth Institute | Treatment and prevention of bone loss using resolvins |
| EP1983977A4 (de) * | 2006-01-31 | 2011-11-30 | Martek Biosciences Corp | Oxylipine aus stearidonsäure und gamma-linolensäure sowie verfahren zu ihrer herstellung und verwendung |
| US20070254897A1 (en) * | 2006-04-28 | 2007-11-01 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of cardiovascular disease |
| RU2009101324A (ru) * | 2006-07-19 | 2010-07-27 | Ризолвикс Фармасьютикалз, Инк. (Us) | Композиции и способы лечения воспаления слизистой оболочки |
| WO2008063772A2 (en) * | 2006-10-13 | 2008-05-29 | The Brigham And Women's Hospital Inc. | Resolvin d series and protectin d1 mitigate acute kidney injury |
| WO2008058274A2 (en) * | 2006-11-09 | 2008-05-15 | Children's Medical Center Corporation | Use of resolvins and docosatrienes and analogues thereof for the treatment of angiogenesis and ocular neovascularization |
| US20100048705A1 (en) * | 2006-11-09 | 2010-02-25 | Children's Medical Center Corporation | Methods of treating and preventing neovascularization with omega-3 polyunsaturated fatty acids |
| EP2120920A4 (de) * | 2007-02-20 | 2011-06-15 | Martek Biosciences Corp | Oxylipine aus langkettigen mehrfach ungesättigten fettsäuren sowie verfahren zu ihrer herstellung und verwendung |
| US20110027841A1 (en) * | 2007-12-21 | 2011-02-03 | Martek Biosciences Corporation | Method for preparation of oxylipins |
| US20110237495A1 (en) * | 2008-05-21 | 2011-09-29 | The Brigham And Women's Hospital, Inc. Corporate Sponsored Research And Licensing | Functional metabolomics coupled microfluidic chemotaxis device and identification of novel cell mediators |
| ES2569371T3 (es) | 2008-09-16 | 2016-05-10 | The Brigham And Women's Hospital Inc. | Compuestos del ácido 7,14-dihidroxidocosahexaenoico |
| EP2415748A4 (de) | 2009-02-20 | 2013-08-07 | Univ Tokyo | Neue entzündungshemmende verbindungen |
| WO2012170791A2 (en) * | 2011-06-10 | 2012-12-13 | The Brigham And Women's Hospital, Inc. | Docosahexaenoyl ethanolamides |
| EP2887923B1 (de) | 2012-08-24 | 2023-04-05 | Sun Pharmaceutical Industries Limited | Ophthalmische formulierung eines polyoxyllipids oder einer polyoxylfettsäure und behandlung von augenleiden |
| US9463177B2 (en) | 2012-09-10 | 2016-10-11 | The Regents Of The University Of California | Compounds and methods for modulating vascular injury |
| CN103588670A (zh) * | 2013-10-28 | 2014-02-19 | 史克勇 | 一种癌痛药物 |
| CN103601649A (zh) * | 2013-10-28 | 2014-02-26 | 史克勇 | 新型化合物 |
| CN103588671A (zh) * | 2013-10-28 | 2014-02-19 | 史克勇 | 癌性疼痛治疗药物 |
| CN103588673A (zh) * | 2013-10-29 | 2014-02-19 | 史克勇 | 癌痛药物 |
| FR3029836B1 (fr) * | 2014-12-11 | 2016-12-23 | Saint Gobain | Feuillete d'une feuille de materiau polymere epais et d'une feuille de verre mince |
| WO2016149582A1 (en) | 2015-03-18 | 2016-09-22 | The Forsyth Institute | Methods for stabilizing atherosclerotic plaques using lipoxins, resolvins, and analogs thereof |
| ES2607715B1 (es) * | 2015-10-01 | 2018-01-17 | Solutex Na, Lcc | Proceso para la preparación y estabilización de emulsiones con omega-3 mediante redes cristalinas isométricas de derivados de celulosa |
| DK3373976T3 (da) | 2015-11-10 | 2024-04-02 | Sun Pharmaceutical Ind Ltd | Topiske formuleringer og anvendelser deraf |
| US11903998B2 (en) | 2016-05-27 | 2024-02-20 | Forsyth Dental Infirmary For Children | Compositions and methods of treating cancer using lipid agonists and receptors thereof |
| JP2022504834A (ja) | 2018-10-09 | 2022-01-13 | ユニバーシティ オブ ロチェスター | 外陰膣障害の治療 |
| JP7220940B2 (ja) * | 2020-02-18 | 2023-02-13 | 国立大学法人北海道大学 | レゾルビンｅ２の安定等価体 |
| WO2023137554A1 (en) * | 2022-01-20 | 2023-07-27 | Benderdour Mohamed | Resolvin analogs compounds, methods and uses thereof |
| WO2023168245A2 (en) | 2022-03-03 | 2023-09-07 | Thetis Pharmaceuticals Llc | Cyclodextrin complexes of specialized proresolving mediators |
Family Cites Families (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4201211A (en) * | 1977-07-12 | 1980-05-06 | Alza Corporation | Therapeutic system for administering clonidine transdermally |
| GB2033745B (en) | 1978-05-26 | 1983-08-17 | Wellcome Found | Fatty acid and derivatives thereof for use in treatment or prophylaxis of thromboembolic conditions |
| US4442099A (en) * | 1981-11-27 | 1984-04-10 | Research Corporation | Leukotriene analogues |
| US4567290A (en) * | 1981-11-27 | 1986-01-28 | Research Corporation | Leukotriene analogues |
| US4576758A (en) * | 1984-06-01 | 1986-03-18 | The Upjohn Company | Anti-inflammatory lipoxin B analogs |
| US4759880A (en) * | 1984-09-27 | 1988-07-26 | Research Corporation | Alkanoarachidonic acids |
| GB8507058D0 (en) * | 1985-03-19 | 1985-04-24 | Efamol Ltd | Pharmaceutical & dietary compositions |
| US4710521A (en) * | 1986-07-25 | 1987-12-01 | The Celotex Corporation | Catalyst mixtures for polyisocyanurate foam |
| US4810424A (en) | 1987-10-09 | 1989-03-07 | The State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University | Method for the recovery of 12-(S)-hydroxyeicosapentaenoic acid from the red alga murrayella periclados |
| US5136501A (en) * | 1989-05-26 | 1992-08-04 | Reuters Limited | Anonymous matching system |
| JPH06505959A (ja) * | 1990-05-07 | 1994-07-07 | ボッコー バリー アイ | 安定な脱臭油及びその医薬組成物の方法及び製剤 |
| US5650435A (en) * | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| US5087790A (en) * | 1991-06-12 | 1992-02-11 | University Of Southern California | Method for olefination of carbonyl compounds using titanocene derivatives |
| EP0591303B1 (de) * | 1991-06-24 | 2000-12-06 | Women's And Children's Hospital | Verfahren und zusammensetzungen zur behandlung von malaria und anderen erkrankungen |
| US5177046A (en) * | 1991-09-20 | 1993-01-05 | Air Products And Chemicals, Inc. | Amine-boron adducts as reduced odor catalyst compositions for the production of polyurethanes |
| JPH05186342A (ja) | 1992-01-10 | 1993-07-27 | Fujirebio Inc | 免疫調節作用を併せもつ抗炎症剤 |
| US5409955A (en) | 1993-05-13 | 1995-04-25 | Bockow; Barry I. | Compositions and methods for inhibiting uterine contractility |
| US6048897A (en) * | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
| US5441951A (en) * | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
| US6887901B1 (en) * | 1993-06-15 | 2005-05-03 | Brigham & Women's Hospital, Inc. | Lipoxin compounds and their use in treating cell proliferative disorders |
| US5411988A (en) * | 1993-10-27 | 1995-05-02 | Bockow; Barry I. | Compositions and methods for inhibiting inflammation and adhesion formation |
| US5814599A (en) | 1995-08-04 | 1998-09-29 | Massachusetts Insitiute Of Technology | Transdermal delivery of encapsulated drugs |
| US6030917A (en) * | 1996-07-23 | 2000-02-29 | Symyx Technologies, Inc. | Combinatorial synthesis and analysis of organometallic compounds and catalysts |
| US5752238A (en) * | 1994-11-03 | 1998-05-12 | Intel Corporation | Consumer-driven electronic information pricing mechanism |
| US5594732A (en) * | 1995-03-03 | 1997-01-14 | Intecom, Incorporated | Bridging and signalling subsystems and methods for private and hybrid communications systems including multimedia systems |
| US5845265A (en) * | 1995-04-26 | 1998-12-01 | Mercexchange, L.L.C. | Consignment nodes |
| US5756789A (en) * | 1995-06-08 | 1998-05-26 | Texaco, Inc. | Synthesis of metal--containing aluminophosphates with layered structure |
| CA2182851A1 (en) | 1995-08-15 | 1997-02-16 | August Masaru Watanabe | Method for treating substance abuse withdrawal |
| US5709855A (en) | 1995-09-22 | 1998-01-20 | Bockow; Barry I. | Compositions of spirulina algae and omega fatty acids for treatment of inflammation and pain |
| US5870717A (en) * | 1995-11-13 | 1999-02-09 | International Business Machines Corporation | System for ordering items over computer network using an electronic catalog |
| TR199802049T2 (xx) * | 1996-04-12 | 1999-01-18 | G.D.Searle & Co. | COX-2 Inhibit�rlerinin �nilac� olarak s�bstit�e edilmi� benzens�lfonamid t�revleri. |
| US5878400A (en) * | 1996-06-17 | 1999-03-02 | Trilogy Development Group, Inc. | Method and apparatus for pricing products in multi-level product and organizational groups |
| US5842040A (en) * | 1996-06-18 | 1998-11-24 | Storage Technology Corporation | Policy caching method and apparatus for use in a communication device based on contents of one data unit in a subset of related data units |
| DE69739048D1 (de) * | 1996-06-28 | 2008-11-27 | Univ Southern California | Verfahren zur synthese von aminen und aminosäuren mit organoborverbindungen |
| US5890138A (en) * | 1996-08-26 | 1999-03-30 | Bid.Com International Inc. | Computer auction system |
| US5861399A (en) | 1996-07-17 | 1999-01-19 | Heart Care Partners | Methods and compositions for the rapid and enduring relief of inadequate myocardial function |
| US5896379A (en) * | 1996-08-26 | 1999-04-20 | Motorola, Inc. | Network node for packet switching with selective data processing and method therefor |
| US5912006A (en) | 1996-08-28 | 1999-06-15 | Eboc, Inc. | Compositions and methods for alleviating discomforting menstrual pain |
| US5946467A (en) * | 1996-09-20 | 1999-08-31 | Novell, Inc. | Application-level, persistent packeting apparatus and method |
| US20020055539A1 (en) | 1996-10-02 | 2002-05-09 | Bockow Barry I. | Compositions and methods for treating cardiovascular conditions |
| US6201022B1 (en) | 1997-03-27 | 2001-03-13 | Myorx, Inc. | Methods for treating neurotransmitter-mediated pain syndromes by topically administering an omega fatty acid |
| US6008205A (en) * | 1997-04-04 | 1999-12-28 | The Brigham & Women's Hospital, Inc. | Polyisoprenyl phosphate stable analogs for regulation of neutrophil responses |
| AU6959898A (en) * | 1997-04-11 | 1998-11-11 | David J. Grainger | Compounds and therapies for the prevention of vascular and non-vascular pathol ogies |
| US6428990B1 (en) | 1997-04-11 | 2002-08-06 | Abbott Laboratories | Human desaturase gene and uses thereof |
| US5878423A (en) * | 1997-04-21 | 1999-03-02 | Bellsouth Corporation | Dynamically processing an index to create an ordered set of questions |
| US6030715A (en) * | 1997-10-09 | 2000-02-29 | The University Of Southern California | Azlactone-related dopants in the emissive layer of an OLED |
| US6259699B1 (en) * | 1997-12-30 | 2001-07-10 | Nexabit Networks, Llc | System architecture for and method of processing packets and/or cells in a common switch |
| JP3196714B2 (ja) * | 1998-03-05 | 2001-08-06 | 日本電気株式会社 | トリプルウェル構造の半導体集積回路の製造方法 |
| JP2002513750A (ja) | 1998-05-07 | 2002-05-14 | エラン コーポレーシヨン ピーエルシー | 溶媒／助溶剤を含まないマイクロエマルジョン及びエマルジョンプレ濃縮物のドラッグデリバリーシステム |
| US6377937B1 (en) * | 1998-05-28 | 2002-04-23 | Paskowitz Associates | Method and system for more effective communication of characteristics data for products and services |
| US6069109A (en) * | 1998-07-01 | 2000-05-30 | Union Carbide Chemicals & Plastics Technology Corporation | Process for the production of half-sandwich transition metal based catalyst precursors |
| US6336138B1 (en) * | 1998-08-25 | 2002-01-01 | Hewlett-Packard Company | Template-driven approach for generating models on network services |
| AU1321700A (en) * | 1998-10-23 | 2000-05-15 | University Of Southern California | Combinatorial approach to chiral reagents or catalysts having amine or amino alcohol ligands |
| US6336105B1 (en) * | 1998-11-16 | 2002-01-01 | Trade Access Inc. | System and method for representing data and providing electronic non-repudiation in a negotiations system |
| DE19855426A1 (de) | 1998-12-02 | 2000-06-08 | Wolfgang Langhoff | Mittel zur Therapie und Prophylaxe von rheumatisch-arthritischen Erkrankungen und zur Prophylaxe von cardiovaskulären Erkrankungen |
| US6272474B1 (en) * | 1999-02-08 | 2001-08-07 | Crisostomo B. Garcia | Method for monitoring and trading stocks via the internet displaying bid/ask trade bars |
| US6397212B1 (en) * | 1999-03-04 | 2002-05-28 | Peter Biffar | Self-learning and self-personalizing knowledge search engine that delivers holistic results |
| CA2645558C (en) * | 1999-03-18 | 2012-05-15 | Brigham And Women's Hospital | Regulation of phospholipase d activity |
| DK1163204T3 (da) * | 1999-03-18 | 2005-12-19 | Brigham & Womens Hospital | Lipoxinforbindelser og deres anvendelse |
| CA2367160A1 (en) * | 1999-03-18 | 2000-09-21 | Charles N. Serhan | Leukotriene b4 receptor transgenic mammals |
| AU775140B2 (en) * | 1999-03-18 | 2004-07-22 | Brigham And Women's Hospital | Use of lipoxin compounds for inhibiting of TNF-(alfa) initiated neutrophil response |
| US6427132B1 (en) * | 1999-08-31 | 2002-07-30 | Accenture Llp | System, method and article of manufacture for demonstrating E-commerce capabilities via a simulation on a network |
| US6415270B1 (en) * | 1999-09-03 | 2002-07-02 | Omnihub, Inc. | Multiple auction coordination method and system |
| AU3846801A (en) | 2000-02-16 | 2001-08-27 | Brigham & Womens Hospital | Aspirin-triggered lipid mediators |
| EP1268393A2 (de) * | 2000-03-20 | 2003-01-02 | Trustees Of Boston University | Lipoxinanaloge und verfahren zur behandlung von periodontalen erkrankungen |
| ATE412448T1 (de) * | 2001-03-02 | 2008-11-15 | Brigham & Womens Hospital | Lipoxin analoge als neue inhibitoren der angiogenese |
| US20040044028A1 (en) * | 2001-03-30 | 2004-03-04 | Obukowicz Mark G. | Combinations of omega-3 fatty acids and cyclooxygenase-2 inhibitors for treatment or prevention of cardiovascular disease and treatment or prevention of cancer |
| WO2003039533A1 (en) * | 2001-11-06 | 2003-05-15 | The Brigham And Women's Hospital, Inc. | Lipoxins and aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
| EP1458373A1 (de) * | 2001-12-18 | 2004-09-22 | The Brigham and Women's Hospital | Verwendung von lipoxin analoga zur steigerung der zellverteidigung gegen durch gramnegative bakterien hervorgerufene infektionen |
| WO2003053423A2 (en) | 2001-12-18 | 2003-07-03 | The Brigham And Women's Hospital | Inhibition or prevention of infection by bacteria with epa, dha or analogs |
| US7582785B2 (en) | 2002-04-01 | 2009-09-01 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| ES2527753T3 (es) * | 2002-04-01 | 2015-01-29 | University Of Southern California | Eicosanoides trihidroxi poliinsaturados |
| AU2003238240A1 (en) | 2002-06-17 | 2003-12-31 | Resolvyx Pharmaceuticals | ANALOGUES OF LIPID MEDIATORS DERIVED FROM OMEGA-3 PUFAs AND METHODS OF USE |
| US7759395B2 (en) | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| ES2700133T3 (es) * | 2002-08-12 | 2019-02-14 | Brigham & Womens Hospital | Resolvinas: modelos biológicos para intervenciones terapéuticas |
| WO2004078143A2 (en) | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| US20050075398A1 (en) * | 2003-08-05 | 2005-04-07 | Bazan Nicolas G. | Neuroprotectin D1 protects against cellular apoptosis, stroke damage, alzheimer's disease and retinal diseases |
| WO2005105025A1 (en) * | 2004-04-14 | 2005-11-10 | Boston University | Methods and compositions for preventing or treating periodontal diseases |
| US20060293288A1 (en) | 2005-01-07 | 2006-12-28 | Serhan Charles N | Use of resolvins to treat gastrointestinal diseases |
-
2003
- 2003-08-12 ES ES09009237T patent/ES2700133T3/es not_active Expired - Lifetime
- 2003-08-12 EP EP03785253A patent/EP1537067B1/de not_active Expired - Lifetime
- 2003-08-12 HU HUE09009237A patent/HUE041471T2/hu unknown
- 2003-08-12 DK DK09009237.0T patent/DK2216318T3/en active
- 2003-08-12 DE DE60330154T patent/DE60330154D1/de not_active Expired - Lifetime
- 2003-08-12 US US10/639,714 patent/US7585856B2/en not_active Expired - Lifetime
- 2003-08-12 EP EP18199438.5A patent/EP3584235A3/de not_active Withdrawn
- 2003-08-12 EP EP09009237.0A patent/EP2216318B1/de not_active Expired - Lifetime
- 2003-08-12 CA CA2495260A patent/CA2495260C/en not_active Expired - Lifetime
- 2003-08-12 WO PCT/US2003/025336 patent/WO2004014835A2/en active Application Filing
- 2003-08-12 AT AT03785253T patent/ATE449057T1/de not_active IP Right Cessation
- 2003-08-12 SI SI200332587T patent/SI2216318T1/sl unknown
- 2003-08-12 AU AU2003258194A patent/AU2003258194B2/en not_active Expired
- 2003-08-12 JP JP2004528101A patent/JP4845378B2/ja not_active Expired - Lifetime
-
2009
- 2009-07-08 US US12/499,528 patent/US20100016432A1/en not_active Abandoned
-
2010
- 2010-01-22 JP JP2010012499A patent/JP5410314B2/ja not_active Expired - Lifetime
- 2010-02-10 AU AU2010200473A patent/AU2010200473A1/en not_active Abandoned
- 2010-12-16 US US12/970,924 patent/US20130217771A1/en not_active Abandoned
-
2012
- 2012-11-29 JP JP2012261696A patent/JP6097536B2/ja not_active Expired - Lifetime
-
2014
- 2014-10-24 JP JP2014217081A patent/JP2015025010A/ja not_active Withdrawn
-
2016
- 2016-04-26 JP JP2016088009A patent/JP6559092B2/ja not_active Expired - Lifetime
-
2019
- 2019-03-29 JP JP2019067658A patent/JP2019112464A/ja not_active Withdrawn
- 2019-03-29 JP JP2019067659A patent/JP2019112465A/ja not_active Withdrawn
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE449057T1 (de) | Resolvine: biotemplate zur durchführung therapeutischer anwendungen | |
| WO2005089744A3 (en) | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma | |
| WO2006078457A3 (en) | Use of resolvins to treat gastrointestinal diseases | |
| Fialkow | Omega-3 fatty acid formulations in cardiovascular disease: dietary supplements are not substitutes for prescription products | |
| EP1392276B1 (de) | Verstärkte wirkung mehrfach ungesättigter fettsäuren | |
| KR940018091A (ko) | 불포화 지방산을 포함하는 처방 | |
| BR0112073A (pt) | Combinações terapêuticas de ácidos graxos | |
| ID22744A (id) | Metoda dan komposisi untuk mengurangi pengaruh dari nekrotisasi enterkolitis | |
| Martins de Lima et al. | Mechanisms by which fatty acids regulate leucocyte function | |
| BRPI0408006A (pt) | uso de ácidos graxos Èmega -3 no tratamento de pacientes diabéticos | |
| BRPI0415744A (pt) | lipìdios contendo ácidos graxos Èmega-3 e Èmega-6 | |
| KR20000049016A (ko) | 에이코사펜타엔산 및/또는 스테아리돈산을 포함하여 이루어지는약제학적 제제 | |
| PT1310249E (pt) | Utilizacao de acidos gordos poli-insaturados para prevencao primaria de eventos cardiovasculares graves | |
| JPH04342525A (ja) | ホスホリパーゼａ２抑制用薬剤の製造方法 | |
| WO2007070611A3 (en) | Nutritional supplement containing long-chain polyunsaturated fatty acids | |
| DK1152755T3 (da) | Essentielle fedtsyrer til forebyggelse af cardiovaskulære tilfælde | |
| HUP0303019A2 (hu) | Esszenciális N-3 zsírsavakat tartalmazó gyógyszerkészítmények alkalmazása a szívgyengeség és szívelégtelenség terápiájában | |
| JP2014512351A5 (de) | ||
| EP1698685A4 (de) | Fettzusammensetzung | |
| JP2014231513A5 (de) | ||
| Brunborg et al. | Effects of short-term oral administration of dietary marine oils in patients with inflammatory bowel disease and joint pain: a pilot study comparing seal oil and cod liver oil | |
| Stańdo et al. | Omega‐3 polyunsaturated fatty acids as an adjunct to non‐surgical treatment of periodontitis | |
| Hr | Omega-3-Fatty Acids: Cardiovascular Disease | |
| NO20014341L (no) | Opplösning av flerumettede fettsyrer og derivater derav ved dannelse av inklusjonssammensetninger med <gamma>-syklodekstrin ogbruk derav i farmasöytiske, kosmetiske eller matsammensetninger | |
| WO2005053669A8 (fr) | Utilisation des acides gras polyinsatures omega 3 dans l'apnee du sommeil |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |