ATE444293T1 - Cyclische sulfamide zur inhibierung von gamma- sekretase - Google Patents
Cyclische sulfamide zur inhibierung von gamma- sekretaseInfo
- Publication number
- ATE444293T1 ATE444293T1 AT03809796T AT03809796T ATE444293T1 AT E444293 T1 ATE444293 T1 AT E444293T1 AT 03809796 T AT03809796 T AT 03809796T AT 03809796 T AT03809796 T AT 03809796T AT E444293 T1 ATE444293 T1 AT E444293T1
- Authority
- AT
- Austria
- Prior art keywords
- gamma secretase
- inhibiting gamma
- cyclic sulfamides
- sulfamides
- cyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0225475.3A GB0225475D0 (en) | 2002-11-01 | 2002-11-01 | Therapeutic agents |
PCT/GB2003/004728 WO2004039800A1 (en) | 2002-11-01 | 2003-10-31 | Cyclic sulfamides for inhibition of gamma-secretase |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE444293T1 true ATE444293T1 (de) | 2009-10-15 |
Family
ID=9947010
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03809796T ATE444293T1 (de) | 2002-11-01 | 2003-10-31 | Cyclische sulfamide zur inhibierung von gamma- sekretase |
Country Status (9)
Country | Link |
---|---|
US (1) | US7427621B2 (de) |
EP (1) | EP1611129B1 (de) |
JP (1) | JP2006508092A (de) |
AT (1) | ATE444293T1 (de) |
AU (1) | AU2003276439B2 (de) |
CA (1) | CA2503884C (de) |
DE (1) | DE60329533D1 (de) |
GB (1) | GB0225475D0 (de) |
WO (1) | WO2004039800A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100927304B1 (ko) | 2001-12-27 | 2009-11-18 | 다이이찌 세이야꾸 가부시기가이샤 | β-아밀로이드 단백 생산·분비 저해제 |
KR20060066057A (ko) | 2003-06-30 | 2006-06-15 | 다이이찌 세이야꾸 가부시기가이샤 | 복소환 메틸 설폰 유도체 |
CA2539042A1 (en) * | 2003-09-24 | 2005-04-07 | Merck Sharp & Dohme Limited | Gamma-secretase inhibitors |
ES2382814T3 (es) | 2005-05-17 | 2012-06-13 | Merck Sharp & Dohme Ltd. | Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer |
US8242103B2 (en) | 2005-05-19 | 2012-08-14 | Merck Sharp & Dohme Limited | Sulphamides for treatment of cancer |
EP1996182A4 (de) | 2006-02-27 | 2009-08-12 | Univ Johns Hopkins | Krebsbehandlung mit gamma-sekretasehemmern |
WO2008076556A2 (en) | 2006-11-15 | 2008-06-26 | Massachusetts Eye & Ear Infirmary | Generation of inner ear cells |
EP2121633A2 (de) | 2007-02-12 | 2009-11-25 | Merck & Co., Inc. | Piperazinderivate zur behandlung von alzheimer-krankheit und verwandten leiden |
WO2009128057A2 (en) | 2008-04-18 | 2009-10-22 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al | Psycho-pharmaceuticals |
GB0813694D0 (en) * | 2008-07-25 | 2008-09-03 | Glaxo Group Ltd | Compounds |
CA2743436C (en) | 2008-11-24 | 2017-10-31 | Massachusetts Eye & Ear Infirmary | Pathways to generate hair cells |
US8691825B2 (en) | 2009-04-01 | 2014-04-08 | Merck Sharp & Dohme Corp. | Inhibitors of AKT activity |
WO2011046771A1 (en) | 2009-10-14 | 2011-04-21 | Schering Corporation | SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF |
WO2011163330A1 (en) | 2010-06-24 | 2011-12-29 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
CA2805265A1 (en) | 2010-08-02 | 2012-02-09 | Merck Sharp & Dohme Corp. | Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina) |
WO2012024170A2 (en) | 2010-08-17 | 2012-02-23 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
US8946216B2 (en) | 2010-09-01 | 2015-02-03 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as ERK inhibitors |
EP2615916B1 (de) | 2010-09-16 | 2017-01-04 | Merck Sharp & Dohme Corp. | Kondensierte pyrazolderivate als neue erk-hemmer |
WO2012058210A1 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) |
WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
US9023865B2 (en) | 2011-10-27 | 2015-05-05 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
US20150299696A1 (en) | 2012-05-02 | 2015-10-22 | Sirna Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
AU2013312358B2 (en) | 2012-09-07 | 2018-08-09 | Massachusetts Eye & Ear Infirmary | Treating hearing loss |
WO2014052563A2 (en) | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
MX363243B (es) | 2012-11-28 | 2019-03-14 | Merck Sharp & Dohme | Composiciones para tratar cáncer y usos de dichas composiciones. |
RU2690663C2 (ru) | 2012-12-20 | 2019-06-05 | Мерк Шарп И Доум Корп. | Замещенные имидазопиридины в качестве ингибиторов hdm2 |
US9540377B2 (en) | 2013-01-30 | 2017-01-10 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as HDM2 inhibitors |
US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
WO2016022776A2 (en) | 2014-08-06 | 2016-02-11 | Massachusetts Eye And Ear Infirmary | Increasing atoh1 life to drive sensorineural hair cell differentiantion |
WO2017096233A1 (en) | 2015-12-04 | 2017-06-08 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss by inhibition of casein kinase 1 |
AU2017212655B2 (en) | 2016-01-29 | 2024-01-18 | Decibel Therapeutics, Inc. | Expansion and differentiation of inner ear supporting cells and methods of use thereof |
WO2017200762A2 (en) | 2016-05-16 | 2017-11-23 | The General Hospital Corporation | Human airway stem cells in lung epithelial engineering |
JP6904612B2 (ja) | 2016-12-16 | 2021-07-21 | パイプライン セラピューティクス, インコーポレイテッド | 蝸牛シナプス障害を処置する方法 |
US10947234B2 (en) | 2017-11-08 | 2021-03-16 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
EP3833668A4 (de) | 2018-08-07 | 2022-05-11 | Merck Sharp & Dohme Corp. | Prmt5-inhibitoren |
WO2020033284A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
AU2020408148A1 (en) | 2019-12-17 | 2022-06-16 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
WO2024049931A1 (en) | 2022-09-02 | 2024-03-07 | Merck Sharp & Dohme Llc | Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5703129A (en) | 1996-09-30 | 1997-12-30 | Bristol-Myers Squibb Company | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production |
CA2276278C (en) | 1997-02-27 | 2009-04-07 | Takeda Chemical Industries, Ltd. | Amine compounds, their production and use |
JP2003528076A (ja) | 2000-03-20 | 2003-09-24 | メルク シャープ エンド ドーム リミテッド | スルホンアミド置換架橋ビシクロアルキル誘導体 |
CA2427206C (en) * | 2000-11-02 | 2011-06-28 | Merck Sharp & Dohme Limited | Sulfamides as gamma-secretase inhibitors |
WO2003093252A1 (en) * | 2002-05-01 | 2003-11-13 | Merck Sharp & Dohme Limited | Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase |
-
2002
- 2002-11-01 GB GBGB0225475.3A patent/GB0225475D0/en not_active Ceased
-
2003
- 2003-10-31 US US10/533,272 patent/US7427621B2/en not_active Expired - Fee Related
- 2003-10-31 EP EP03809796A patent/EP1611129B1/de not_active Expired - Lifetime
- 2003-10-31 WO PCT/GB2003/004728 patent/WO2004039800A1/en active Application Filing
- 2003-10-31 AT AT03809796T patent/ATE444293T1/de not_active IP Right Cessation
- 2003-10-31 JP JP2004547819A patent/JP2006508092A/ja active Pending
- 2003-10-31 AU AU2003276439A patent/AU2003276439B2/en not_active Ceased
- 2003-10-31 CA CA2503884A patent/CA2503884C/en not_active Expired - Fee Related
- 2003-10-31 DE DE60329533T patent/DE60329533D1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2503884C (en) | 2011-07-05 |
DE60329533D1 (de) | 2009-11-12 |
GB0225475D0 (en) | 2002-12-11 |
AU2003276439A1 (en) | 2004-05-25 |
EP1611129A1 (de) | 2006-01-04 |
WO2004039800A1 (en) | 2004-05-13 |
JP2006508092A (ja) | 2006-03-09 |
CA2503884A1 (en) | 2004-05-13 |
EP1611129B1 (de) | 2009-09-30 |
AU2003276439B2 (en) | 2009-12-24 |
US7427621B2 (en) | 2008-09-23 |
US20060135570A1 (en) | 2006-06-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |