ATE439452T1 - Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen - Google Patents

Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen

Info

Publication number
ATE439452T1
ATE439452T1 AT00928836T AT00928836T ATE439452T1 AT E439452 T1 ATE439452 T1 AT E439452T1 AT 00928836 T AT00928836 T AT 00928836T AT 00928836 T AT00928836 T AT 00928836T AT E439452 T1 ATE439452 T1 AT E439452T1
Authority
AT
Austria
Prior art keywords
semiconductor nanocrystals
detecting analytes
detecting
semiconductor
emits
Prior art date
Application number
AT00928836T
Other languages
English (en)
Inventor
Marcel Bruchez
R Daniels
Stephen Empedocles
Vince Phillips
Edith Wong
Donald Zehnder
Original Assignee
Life Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Life Technologies Corp filed Critical Life Technologies Corp
Application granted granted Critical
Publication of ATE439452T1 publication Critical patent/ATE439452T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
AT00928836T 1999-05-07 2000-05-05 Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen ATE439452T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13308499P 1999-05-07 1999-05-07
PCT/US2000/012227 WO2000068692A1 (en) 1999-05-07 2000-05-05 A method of detecting an analyte using semiconductor nanocrystals

Publications (1)

Publication Number Publication Date
ATE439452T1 true ATE439452T1 (de) 2009-08-15

Family

ID=22456937

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00928836T ATE439452T1 (de) 1999-05-07 2000-05-05 Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen

Country Status (8)

Country Link
US (5) US6274323B1 (de)
EP (1) EP1179185B1 (de)
JP (1) JP2002544488A (de)
AT (1) ATE439452T1 (de)
AU (1) AU4701200A (de)
CA (1) CA2373146A1 (de)
DE (1) DE60042738D1 (de)
WO (1) WO2000068692A1 (de)

Families Citing this family (362)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6607829B1 (en) 1997-11-13 2003-08-19 Massachusetts Institute Of Technology Tellurium-containing nanocrystalline materials
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6582962B1 (en) * 1998-02-27 2003-06-24 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
ATE423314T1 (de) * 1998-06-24 2009-03-15 Illumina Inc Dekodierung von matrixartig-angeordneten sensoren durch mikropartikel
US6617583B1 (en) * 1998-09-18 2003-09-09 Massachusetts Institute Of Technology Inventory control
EP1039291A1 (de) * 1999-03-26 2000-09-27 Sony International (Europe) GmbH Optochemischer Fühler and Herstellungsmethode
US20030207249A1 (en) * 1999-04-15 2003-11-06 Beske Oren E. Connection of cells to substrates using association pairs
US7253435B2 (en) * 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US20030166015A1 (en) * 1999-04-15 2003-09-04 Zarowitz Michael A. Multiplexed analysis of cell-substrate interactions
US20030129654A1 (en) * 1999-04-15 2003-07-10 Ilya Ravkin Coded particles for multiplexed analysis of biological samples
US20030134330A1 (en) * 1999-04-15 2003-07-17 Ilya Ravkin Chemical-library composition and method
US6908737B2 (en) * 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
ATE439452T1 (de) * 1999-05-07 2009-08-15 Life Technologies Corp Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US7192778B2 (en) * 1999-10-06 2007-03-20 Natan Michael J Surface enhanced spectroscopy-active composite nanoparticles
US8497131B2 (en) * 1999-10-06 2013-07-30 Becton, Dickinson And Company Surface enhanced spectroscopy-active composite nanoparticles comprising Raman-active reporter molecules
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
JP2003521252A (ja) 2000-02-07 2003-07-15 イルミナ インコーポレイテッド ユニバーサルプライミングを用いる核酸検出方法
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7361488B2 (en) * 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
AU3806701A (en) 2000-02-07 2001-08-14 Illumina Inc Nucleic acid detection methods using universal priming
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US20020004246A1 (en) * 2000-02-07 2002-01-10 Daniels Robert H. Immunochromatographic methods for detecting an analyte in a sample which employ semiconductor nanocrystals as detectable labels
DE10006432A1 (de) * 2000-02-14 2001-08-16 Ganzimmun Inst Fuer Ganzheitli Verfahren zum Nachweis von Helicobacter pylori in Stuhl- und Speichelproben
WO2001061040A1 (en) * 2000-02-16 2001-08-23 Quantum Dot Corporation Microarray methods utilizing semiconductor nanocrystals
EP1257668B1 (de) 2000-02-16 2008-10-29 Illumina, Inc. Parallele genotypisierung mehrerer patientenproben
US6571028B1 (en) 2000-03-21 2003-05-27 Evident Technologies Optical switch having a saturable absorber
US20020090650A1 (en) * 2000-04-06 2002-07-11 Quantum Dot Corporation Two-dimensional spectral imaging system
US6734420B2 (en) 2000-04-06 2004-05-11 Quantum Dot Corporation Differentiable spectral bar code methods and systems
WO2001083823A1 (en) * 2000-04-28 2001-11-08 Quantum Dot Corporation Methods and compositions for polynucleotide analysis using generic capture sequences
US20050192430A1 (en) * 2000-05-24 2005-09-01 Rosenthal Sandra J. Linker arms for nanocrystals and compounds thereof
US6689338B2 (en) * 2000-06-01 2004-02-10 The Board Of Regents For Oklahoma State University Bioconjugates of nanoparticles as radiopharmaceuticals
US20050013775A1 (en) * 2000-06-01 2005-01-20 Kotov Nicholas A. Bioconjugates of nanoparticles as radiopharmaceuticals
US6611640B2 (en) 2000-10-03 2003-08-26 Evident Technologies Optical dispersion compensator
EP2085781B2 (de) * 2000-10-06 2020-03-11 Life Technologies Corporation Zellen mit spektralen Signaturen und Verfahren zur Herstellung und Verwendung davon
US20050059031A1 (en) * 2000-10-06 2005-03-17 Quantum Dot Corporation Method for enhancing transport of semiconductor nanocrystals across biological membranes
JP2004537712A (ja) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
US6939604B1 (en) * 2000-10-19 2005-09-06 Arch Development Corporation Doped semiconductor nanocrystals
US7171030B2 (en) * 2000-11-30 2007-01-30 University Of Medicine & Denistry Of New Jersey Systems for analyzing microtissue arrays
FI20002623A (fi) * 2000-11-30 2002-05-31 Inno Trac Diagnostics Oy Bioanalyyttinen määritysmenetelmä
US6697548B2 (en) 2000-12-18 2004-02-24 Evident Technologies Fabry-perot opitcal switch having a saturable absorber
US6861263B2 (en) 2001-01-26 2005-03-01 Surromed, Inc. Surface-enhanced spectroscopy-active sandwich nanoparticles
US20020110180A1 (en) * 2001-02-09 2002-08-15 Barney Alfred A. Temperature-sensing composition
US6710911B2 (en) 2001-03-02 2004-03-23 Evident Technologies Optical wavelength converter
ES2340251T3 (es) * 2001-03-09 2010-06-01 L'universite De Reims Champagne-Ardenne Nanocristales solubles en agua no isotopicos ultrasensibles.
US7521019B2 (en) * 2001-04-11 2009-04-21 Lifescan, Inc. Sensor device and methods for manufacture
US6379622B1 (en) * 2001-04-11 2002-04-30 Motorola, Inc. Sensor incorporating a quantum dot as a reference
US6694158B2 (en) 2001-04-11 2004-02-17 Motorola, Inc. System using a portable detection device for detection of an analyte through body tissue
WO2002084271A2 (en) * 2001-04-16 2002-10-24 The Regents Of The University Of California Methods and sensors for luminescent and optoelectronic detection and analysis of polynucleotides
US7572642B2 (en) * 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
US20020164271A1 (en) * 2001-05-02 2002-11-07 Ho Winston Z. Wavelength-coded bead for bioassay and signature recogniton
DE10122836A1 (de) * 2001-05-11 2002-11-28 November Ag Molekulare Medizin Faser, Faden und Verfahren zur Markierung und Identifizierung
GB0113772D0 (en) * 2001-06-06 2001-07-25 Dynal Biotech Asa Process
MXPA03011558A (es) * 2001-06-12 2004-03-26 Wellstat Therapeutics Corp Compuestos para el tratamiento de desordenes metabolicos.
US7095959B2 (en) 2001-06-20 2006-08-22 Evident Technologies Optical time division multiplexing/demultiplexing system
US20030013109A1 (en) * 2001-06-21 2003-01-16 Ballinger Clinton T. Hairpin sensors using quenchable fluorescing agents
US20030148544A1 (en) * 2001-06-28 2003-08-07 Advanced Research And Technology Institute, Inc. Methods of preparing multicolor quantum dot tagged beads and conjugates thereof
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
CN100386627C (zh) * 2001-07-03 2008-05-07 包刚 过滤型蛋白芯片
JP2003028797A (ja) * 2001-07-11 2003-01-29 Hitachi Software Eng Co Ltd 蛍光読み取り装置
US7110640B2 (en) 2001-07-19 2006-09-19 Evident Technologies Reconfigurable optical add/drop filter
EP1432825A4 (de) * 2001-08-31 2005-02-09 Minerva Biotechnologies Corp Mit affinitätstags modifizierte partikel
US6542229B1 (en) 2001-09-12 2003-04-01 Peter J. Kalal Sensors, methods of manufacture and sensing methods
US20030219800A1 (en) * 2001-10-18 2003-11-27 Beske Oren E. Multiplexed cell transfection using coded carriers
US6838289B2 (en) * 2001-11-14 2005-01-04 Beckman Coulter, Inc. Analyte detection system
DE10156612A1 (de) * 2001-11-20 2003-05-28 Markus Klotz Verfahren zum Bestimmen von Substanzen in einer flüssigen oder gasförmigen Probe
US20050118589A1 (en) * 2001-11-21 2005-06-02 Vann Charles S. Digital array
US20030143604A1 (en) * 2001-11-30 2003-07-31 Storhoff James J. Real-time monitoring of PCR amplification using nanoparticle probes
WO2003054234A1 (en) * 2001-12-19 2003-07-03 Roche Diagnostics Corporation Pcr based high throughput polypeptide screening
US20040171076A1 (en) * 2001-12-20 2004-09-02 Dejneka Matthew J. Detectable micro to nano sized structures, methods of manufacture and use
US7241629B2 (en) * 2001-12-20 2007-07-10 Corning Incorporated Detectable labels, methods of manufacture and use
DE10200499A1 (de) * 2002-01-03 2003-07-10 Zeiss Carl Jena Gmbh Verfahren und/oder Anordnung zur Identifikation von fluoreszierenden, lumineszierenden und/oder absorbierenden Substanzen auf und/oder in Probenträgern
US20040026684A1 (en) * 2002-04-02 2004-02-12 Nanosys, Inc. Nanowire heterostructures for encoding information
CA2523626A1 (en) * 2002-04-26 2003-11-06 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
US8211657B2 (en) * 2002-04-29 2012-07-03 The Board Of Trustees Of The University Of Arkansas Capillary-column-based bioseparator/bioreactor with an optical/electrochemical detector for detection of microbial pathogens
WO2004039830A2 (en) * 2002-05-07 2004-05-13 Regents Of The University Of California Bioactivation of particles
AU2003243281A1 (en) 2002-05-17 2003-12-02 Applera Corporation Optical instrument includung excitation source
EP2775291B1 (de) 2002-05-17 2016-01-13 Life Technologies Corporation Vorrichtung zur Unterscheidung mehrerer Fluoreszenzsignale anhand ihrer Anregungswellenlänge
US20040126773A1 (en) * 2002-05-23 2004-07-01 Beske Oren E. Assays with coded sensor particles to sense assay conditions
DE10224825A1 (de) * 2002-06-05 2003-12-24 Eppendorf Ag Verfahren zur Analyse von Biomolekülen
US6730515B2 (en) * 2002-06-11 2004-05-04 Eastman Kodak Company Micro-array calibration means
US20030232340A1 (en) * 2002-06-13 2003-12-18 David Anderson Nanoporous particle with a retained target
DE10231684A1 (de) * 2002-07-12 2004-02-12 Micronas Holding Gmbh Verfahren zur Bestimmung der Zahl von Rezeptoren auf einem Träger sowie Biosensor herstellbar nach diesem Verfahren
GB2391230A (en) * 2002-07-26 2004-02-04 Smartbead Technologies Ltd Multiparameter assays using coded supports
US7810380B2 (en) 2003-03-25 2010-10-12 Tearlab Research, Inc. Systems and methods for collecting tear film and measuring tear film osmolarity
US8020433B2 (en) * 2003-03-25 2011-09-20 Tearlab Research, Inc. Systems and methods for a sample fluid collection device
AU2003262719A1 (en) * 2002-08-14 2004-03-03 Encap Technologies, Inc. Microencapsulated and nanoencapsulated particles, moisture barrier resins, and processes for manufacturing same
US7939170B2 (en) * 2002-08-15 2011-05-10 The Rockefeller University Water soluble metal and semiconductor nanoparticle complexes
CA2498194A1 (en) * 2002-09-04 2004-04-29 Board Of Regents, University Of Texas System Composition, method and use of bi-functional biomaterials
JP5065572B2 (ja) * 2002-09-06 2012-11-07 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 流体の移動を検証するための方法
WO2004038037A2 (en) 2002-09-20 2004-05-06 Intel Corporation Controlled alignment of nano-barcodes encoding specific information for scanning probe microscopy (spm) reading
US7361821B2 (en) 2002-09-20 2008-04-22 Intel Corporation Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading
US7176036B2 (en) * 2002-09-20 2007-02-13 Arrowhead Center, Inc. Electroactive microspheres and methods
CA2502246A1 (en) * 2002-10-15 2004-04-29 Abmetrix, Inc. Sets of digital antibodies directed against short epitopes, and methods using same
US9740817B1 (en) 2002-10-18 2017-08-22 Dennis Sunga Fernandez Apparatus for biological sensing and alerting of pharmaco-genomic mutation
US7192780B2 (en) * 2002-10-23 2007-03-20 Evident Technologies Fluorescent lifetime biological detection and imaging using water-stable semiconductor nanocrystals
US20040101822A1 (en) * 2002-11-26 2004-05-27 Ulrich Wiesner Fluorescent silica-based nanoparticles
JP2004184312A (ja) * 2002-12-05 2004-07-02 Yokogawa Electric Corp 生体高分子検出方法およびバイオチップ
CA2513985C (en) 2003-01-21 2012-05-29 Illumina Inc. Chemical reaction monitor
JP4073323B2 (ja) * 2003-01-23 2008-04-09 日立ソフトウエアエンジニアリング株式会社 機能性ビーズ、その読み取り方法および読み取り装置
US20040150217A1 (en) * 2003-01-23 2004-08-05 Heffelfinger David M. Identifying indicia and focusing target
US20040175842A1 (en) * 2003-03-04 2004-09-09 Roitman Daniel B. Near-field and far-field encoding of microbeads for bioassays
US20040175843A1 (en) * 2003-03-04 2004-09-09 Roitman Daniel B. Near-field and far-field encoding and shaping of microbeads for bioassays
US7917298B1 (en) * 2003-04-17 2011-03-29 Nanosys, Inc. Nanocrystal taggants
US20050026181A1 (en) * 2003-04-29 2005-02-03 Genvault Corporation Bio bar-code
US20040219533A1 (en) * 2003-04-29 2004-11-04 Jim Davis Biological bar code
US8859000B2 (en) * 2003-05-05 2014-10-14 The Research Foundation Of State University Of New York Synthesis of nanoparticles by an emulsion-gas contacting process
US9063145B2 (en) 2003-07-23 2015-06-23 Cellular Technology Limited Multivalent opsonophagocytic assay using bead array and imaging
US7598093B2 (en) 2003-07-23 2009-10-06 Ctl Analyzers, Llc Nanoparticle and microparticle based detection of cellular products
AU2004267802B2 (en) * 2003-08-18 2011-03-17 Tethys Bioscience, Inc. Methods for reducing complexity of a sample using small epitope antibodies
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
US20050208468A1 (en) * 2003-09-15 2005-09-22 Beske Oren E Assays with primary cells
US7488451B2 (en) * 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
US20050069900A1 (en) * 2003-09-25 2005-03-31 Cytyc Corporation Analyte sample detection
JP2007517500A (ja) * 2003-10-15 2007-07-05 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 電子、光学、磁性、半導体、および生物工学用途の足場としての多機能生体物質
JP2007516843A (ja) * 2003-10-20 2007-06-28 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 分子相互作用を検出するためのナノスケール変換システム
AU2003285133A1 (en) * 2003-11-05 2005-06-24 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Biofunctionalized quantum dots for biological imaging
EP1687024B1 (de) * 2003-11-05 2011-10-19 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Kohlenhydrat-antigen-nanoteilchen-konjugate und ihre verwendungen als antimetastatische mittel bei der behandlung von krebs
CA2549190A1 (en) 2003-12-11 2005-06-30 Board Of Regents, The University Of Texas System Method and system for the analysis of saliva using a sensor array
US20050147963A1 (en) * 2003-12-29 2005-07-07 Intel Corporation Composite organic-inorganic nanoparticles and methods for use thereof
US20050191665A1 (en) * 2003-12-29 2005-09-01 Xing Su Composite organic-inorganic nanoclusters
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US20050191687A1 (en) * 2004-02-27 2005-09-01 Tianxin Wang Method for multiplexed analyte detection
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US7745001B2 (en) * 2004-03-23 2010-06-29 University Of New Orleans Research And Technology Foundation, Inc. Synthesis of nanoassemblies containing luminescent quantum dots and magnetic nanoparticles
US20080032420A1 (en) * 2004-03-30 2008-02-07 Lambert James L Surface Enhanced Raman Scattering and Multiplexed Diagnostic Assays
WO2006071247A2 (en) * 2004-03-30 2006-07-06 California Institute Of Technology Diagnostic assays including multiplexed lateral flow immunoassays with quantum dots
US20050221504A1 (en) * 2004-04-01 2005-10-06 Petruno Patrick T Optoelectronic rapid diagnostic test system
US20070143035A1 (en) * 2005-12-19 2007-06-21 Petruno Patrick T Diagnostic test reader with disabling unit
US8128871B2 (en) 2005-04-22 2012-03-06 Alverix, Inc. Lateral flow assay systems and methods
US7521259B2 (en) * 2004-04-01 2009-04-21 Alverix, Inc. Assay test strips with multiple labels and reading same
US20070185679A1 (en) * 2004-04-01 2007-08-09 Petruno Patrick T Indicating status of a diagnostic test system
US7280204B2 (en) * 2004-04-08 2007-10-09 Purdue Research Foundation Multi-spectral detector and analysis system
EP1584914A1 (de) * 2004-04-08 2005-10-12 Sony Deutschland GmbH Ellipsometrie-Verfahren zum Nachweis eines Substrat-gebundenden Hybrids aus mindestens zwei Spezies
WO2006093516A2 (en) * 2004-06-22 2006-09-08 The Regents Of The University Of California Peptide-coated nanoparticles with graded shell compositions
US20060154380A1 (en) * 2004-06-23 2006-07-13 Shunji Egusa Synthesis of ordered arrays from gold clusters
US20060194198A1 (en) * 2004-06-29 2006-08-31 Carlo Licata Use of fibrous protein fibers for chemical sensing and radiation detection
KR100724314B1 (ko) 2004-07-22 2007-06-04 주식회사 엘지생명과학 생체감지물질이 고정된 광결정구 및 이의 제조방법 및이용방법
US7229690B2 (en) * 2004-07-26 2007-06-12 Massachusetts Institute Of Technology Microspheres including nanoparticles
US20060024744A1 (en) * 2004-07-28 2006-02-02 Mills Rhonda A Methods for substantially simultaneous evaluation of a sample containing a cellular target and a soluble analyte
WO2006098752A2 (en) * 2004-07-29 2006-09-21 Kim Laboratories Ultrasensitive sensor and rapid detection of analytes
US7405002B2 (en) 2004-08-04 2008-07-29 Agency For Science, Technology And Research Coated water-soluble nanoparticles comprising semiconductor core and silica coating
US20060240227A1 (en) * 2004-09-23 2006-10-26 Zhijun Zhang Nanocrystal coated surfaces
US7534489B2 (en) * 2004-09-24 2009-05-19 Agency For Science, Technology And Research Coated composites of magnetic material and quantum dots
US7682782B2 (en) * 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
US20060240590A1 (en) * 2004-11-09 2006-10-26 The Research Foundation Of State University Of New York Controlled synthesis of nanowires, nanodiscs, and nanostructured materials using liquid crystalline templates
US8202479B1 (en) * 2004-11-09 2012-06-19 Applied Biosystems, Llc Light collection system
JP2008524600A (ja) * 2004-12-16 2008-07-10 インヴィトロジェン コーポレーション 多重化アッセイの較正及び定量化用の量子ドットコード化ビーズセット、及びその使用方法
US20060148103A1 (en) * 2004-12-30 2006-07-06 Yin-Peng Chen Highly sensitive biological assays
US8569042B2 (en) * 2005-02-23 2013-10-29 Alcatel Lucent DNA structures on ferroelectrics and semiconductors
EP1853732A2 (de) * 2005-02-28 2007-11-14 Gen-Probe Incorporated Präparate und verfahren zur probenmessung durch eine umschaltbare nukleinsäuren-sonde
US20100116664A1 (en) * 2005-03-08 2010-05-13 Ignatius Michael J Monitoring and manipulating cellular transmembrane potentials using nanostructures
CA2601003A1 (en) * 2005-03-10 2006-09-14 Universite De Sherbrooke Quantum dot template for fast and simultaneous detection of different infectious agents
US7608237B2 (en) * 2005-03-28 2009-10-27 The Research Foundation Of State University Of New York Synthesis of nanostructured materials using liquid crystalline templates
US20080166706A1 (en) * 2005-03-30 2008-07-10 Jin Zhang Novel gold nanoparticle aggregates and their applications
US20070026391A1 (en) * 2005-04-11 2007-02-01 Ghc Technologies, Inc. Methods and compositions for identifying chemical or biological agents using multiplexed labeling and colocalization detection
US10041941B2 (en) * 2005-04-22 2018-08-07 Alverix, Inc. Assay test strips with multiple labels and reading same
AU2006239315B2 (en) 2005-04-28 2012-03-01 Ventana Medical Systems, Inc. Enzymes conjugated to antiobodies via a PEG heterobifuctional linker
AU2006239154A1 (en) * 2005-04-28 2006-11-02 Ventana Medical Systems, Inc Nanoparticle conjugates
US8084001B2 (en) * 2005-05-02 2011-12-27 Cornell Research Foundation, Inc. Photoluminescent silica-based sensors and methods of use
US8377398B2 (en) 2005-05-31 2013-02-19 The Board Of Regents Of The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
JP5331476B2 (ja) 2005-06-15 2013-10-30 カリダ・ジェノミックス・インコーポレイテッド 遺伝子解析および化学解析用の単分子アレイ
US8232092B2 (en) * 2005-08-09 2012-07-31 Maxwell Sensors, Inc. Apparatus and method for digital magnetic beads analysis
US7871770B2 (en) 2005-08-09 2011-01-18 Maxwell Sensors, Inc. Light transmitted assay beads
US20090201504A1 (en) * 2005-08-09 2009-08-13 Maxwell Sensors, Inc. Hydrodynamic focusing for analyzing rectangular microbeads
US7858307B2 (en) * 2005-08-09 2010-12-28 Maxwell Sensors, Inc. Light transmitted assay beads
US20070043510A1 (en) * 2005-08-19 2007-02-22 Beckman Coulter, Inc. Assay system
EP2546360A1 (de) 2005-10-07 2013-01-16 Callida Genomics, Inc. Selbstangeordnete einzelne Molekülarrays und Verwendungen davon
WO2007120265A2 (en) * 2005-11-14 2007-10-25 Applera Corporation Coded molecules for detecting target analytes
US20090298197A1 (en) * 2005-11-15 2009-12-03 Oxonica Materials Inc. Sers-based methods for detection of bioagents
US8632730B2 (en) * 2005-11-22 2014-01-21 Alverix, Inc. Assaying test strips having different capture reagents
US7772009B2 (en) * 2005-11-22 2010-08-10 SCR Research, LLC Room temperature phosphorescence apparatus and methods
ES2804129T3 (es) * 2005-11-23 2021-02-03 Ventana Med Syst Inc Conjugado anticuerpo-enzima
US20070122914A1 (en) * 2005-11-30 2007-05-31 Curry Bo U Obtaining measurements of light transmitted through an assay test strip
JP4654414B2 (ja) * 2005-12-01 2011-03-23 独立行政法人産業技術総合研究所 免疫化学的検出方法、及びその検出用試薬キット
US8409863B2 (en) 2005-12-14 2013-04-02 Becton, Dickinson And Company Nanoparticulate chemical sensors using SERS
JP5537034B2 (ja) 2005-12-23 2014-07-02 ナノストリング テクノロジーズ，インコーポレーテッド ナノレポーターならびにその作製方法および使用方法
US7723100B2 (en) 2006-01-13 2010-05-25 Becton, Dickinson And Company Polymer coated SERS nanotag
US7226752B1 (en) 2006-01-19 2007-06-05 Avago Technologies General Ip (Singapore) Pte. Ltd. Methods for detecting an analyte in a sample
ES2601391T3 (es) * 2006-01-27 2017-02-15 Becton Dickinson And Company Inmunoensayo de flujo lateral con modalidad de detección encapsulada
US20090325318A1 (en) * 2006-02-02 2009-12-31 Keith Carron Supra nanoparticle assemblies and methods of making and using the assemblies
WO2008057127A2 (en) 2006-02-06 2008-05-15 Massachusetts Institute Of Technology Self-assembly of macromolecules on multilayered polymer surfaces
WO2007095279A2 (en) * 2006-02-14 2007-08-23 University Of Florida Research Foundation, Inc. Dual nanoparticle assay for detection and separation of biological species
CA2571904A1 (en) * 2006-02-15 2007-08-15 Fio Corporation System and method of detecting pathogens
US20070188736A1 (en) * 2006-02-16 2007-08-16 Fouquet Julie E Obtaining measurement and baseline signals for evaluating assay test strips
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
EP1994180A4 (de) 2006-02-24 2009-11-25 Callida Genomics Inc Genomsequenzierung auf dna-arrays mit hohem durchsatz
SG10201405158QA (en) * 2006-02-24 2014-10-30 Callida Genomics Inc High throughput genome sequencing on dna arrays
EP1996942A1 (de) * 2006-03-10 2008-12-03 Tethys Bioscience, Inc. Multiplex-protein-fraktionierung
US7807265B2 (en) * 2006-05-12 2010-10-05 University Of Central Florida Research Foundation, Inc. Partially passivated quantum dots, process for making, and sensors therefrom
WO2007137060A2 (en) * 2006-05-16 2007-11-29 Applied Biosystems Systems, methods, and apparatus for single molecule sequencing
WO2007138851A1 (ja) * 2006-05-26 2007-12-06 Konica Minolta Medical & Graphic, Inc. III－Ｖ型半導体／ＳｉＯ2型ナノ粒子、及び生体物質標識剤
US20100130367A1 (en) * 2006-07-11 2010-05-27 Drexel University Methods of Quantitatively Assessing Inflammation with Biosensing Nanoparticles
EP2044402B2 (de) * 2006-07-24 2016-11-30 Becton Dickinson and Company Vorrichtung und Verfahren zur Durchführung eines Assays mittels magnetischer Partikeln.
US7764361B2 (en) * 2006-07-27 2010-07-27 Northwestern University Systems and methods to analyze multiplexed bead-based assays using backscattered light
US8110407B2 (en) * 2006-09-14 2012-02-07 Konica Minolta Medical & Graphic, Inc. Fluorescent semiconductor microparticle assembly, fluorescent labeling agent assembly for biological substance, and bioimaging method and biological substance analysis method using the assemblies
US8219170B2 (en) * 2006-09-20 2012-07-10 Nellcor Puritan Bennett Llc System and method for practicing spectrophotometry using light emitting nanostructure devices
US7910302B2 (en) 2006-10-27 2011-03-22 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
ES2663080T3 (es) * 2006-11-01 2018-04-11 Ventana Medical Systems, Inc. Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso
US20090111705A1 (en) 2006-11-09 2009-04-30 Complete Genomics, Inc. Selection of dna adaptor orientation by hybrid capture
CA2580589C (en) 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
US8244021B2 (en) * 2006-12-20 2012-08-14 Ventana Medical Systems, Inc. Quantitative, multispectral image analysis of tissue specimens stained with quantum dots
EP2109900A1 (de) * 2007-01-08 2009-10-21 Plextronics, Inc. Photovoltaische quantenpunktvorrichtung
JP2010518862A (ja) * 2007-02-21 2010-06-03 ライフ テクノロジーズ コーポレーション 単一分子核酸配列決定のための材料および方法
US8360321B2 (en) 2007-04-02 2013-01-29 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
JP4357544B2 (ja) * 2007-05-15 2009-11-04 シャープ株式会社 １３族窒化物蛍光体およびその製造方法
US8597729B2 (en) 2007-06-22 2013-12-03 Fio Corporation Systems and methods for manufacturing quantum dot-doped polymer microbeads
US8551786B2 (en) 2007-07-09 2013-10-08 Fio Corporation Systems and methods for enhancing fluorescent detection of target molecules in a test sample
US20090045360A1 (en) * 2007-08-13 2009-02-19 Xerox Corporation Quantum dot-based luminescent marking material
US8480927B2 (en) * 2007-08-17 2013-07-09 Massachusetts Institute Of Technology Light emitting material
EP2209549A4 (de) 2007-10-12 2014-03-05 Fio Corp Strömungsfokussierungsverfahren und system zur bildung von konzentrierten volumina von mikrokügelchen und weiterhin gebildete mikrokügelchen
CN101910410A (zh) * 2007-10-23 2010-12-08 斯特拉托斯基因公司 通过间隔进行高通量核酸测序
WO2009054244A1 (ja) * 2007-10-26 2009-04-30 Konica Minolta Medical & Graphic, Inc. 半導体ナノ粒子蛍光体の集合体および単一分子観察方法
US20110091903A1 (en) * 2007-11-20 2011-04-21 Bommarito G Marco Method of analyzing a sample for a bacterium using diacetylene-containing polymer sensor
JP2009128136A (ja) * 2007-11-22 2009-06-11 Fujifilm Corp 蛍光検出方法
WO2009072441A1 (ja) * 2007-12-05 2009-06-11 Konica Minolta Medical & Graphic, Inc. 検出方法および検出キット
CA2711499C (en) 2008-01-10 2018-09-25 Research Development Foundation Vaccines and diagnostics for the ehrlichioses
JP4980944B2 (ja) 2008-02-12 2012-07-18 富士フイルム株式会社 免疫学的測定方法
WO2009145813A1 (en) * 2008-03-04 2009-12-03 Qd Vision, Inc. Particles including nanoparticles, uses thereof, and methods
EP2279268A4 (de) 2008-04-04 2011-12-07 Life Technologies Corp Scanning-system und verfahren zur bildgebung und sequenzierung
WO2010002540A2 (en) 2008-06-05 2010-01-07 Life Technologies Corporation Activation and monitoring of cellular transmembrane potentials
WO2009155704A1 (en) 2008-06-25 2009-12-30 Fio Corporation Bio-threat alert system
EP2303771B1 (de) * 2008-06-30 2018-05-30 Life Technologies Corporation Verfahren zum isolieren und reinigen von nanoteilchen aus einem komplexen medium
EP2307309B1 (de) 2008-07-02 2015-11-11 Life Technologies Corporation VERFAHREN ZUR HERSTELLUNG VON STABILE InP/ZnS KERN/SCHICHT ARTIGE HALBLEITERNANOKRISTALLE UND DADURCH HERGESTELLTE PRODUKTEN
CA2733609C (en) 2008-08-14 2018-03-06 Nanostring Technologies, Inc. Stable nanoreporters
CN105759021A (zh) 2008-08-29 2016-07-13 Fio公司 用于检测生物和环境检测样品的一次性手持式诊断检测设备和相关***与方法
US20110207155A1 (en) * 2008-10-13 2011-08-25 Xeptagen Spa Method for the preparation of immunoconjugates and use thereof
WO2010046821A1 (en) * 2008-10-23 2010-04-29 Koninklijke Philips Electronics N.V. Colour management for biological samples
RU2578023C2 (ru) 2009-01-13 2016-03-20 Эф-Ай-Оу Корпорейшн Портативный диагностический прибор и способ его применения с электронным устройством и диагностическим картриджем при диагностическом экспресс-исследовании
US10290387B2 (en) * 2009-01-20 2019-05-14 University Of Utah Research Foundation Modification of colloidal nanocrystals
JP5486018B2 (ja) * 2009-01-20 2014-05-07 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション コロイドナノ結晶の合成後修正
JP2012515927A (ja) * 2009-01-23 2012-07-12 ドレクセル・ユニバーシティー 炎症を検出するための量子ドットを用いた装置および方法
WO2011031876A1 (en) 2009-09-09 2011-03-17 Qd Vision, Inc. Formulations including nanoparticles
KR101865888B1 (ko) 2009-09-09 2018-06-08 삼성전자주식회사 나노입자들을 포함하는 입자, 그의 용도, 및 방법
DE102009041967A1 (de) * 2009-09-17 2011-03-24 Lre Medical Gmbh Vorrichtung zur Analyse von Körperflüssigkeiten
AU2010306862B2 (en) 2009-10-13 2015-08-27 Nanostring Technologies, Inc. Protein detection via nanoreporters
WO2011072228A1 (en) * 2009-12-11 2011-06-16 Massachusetts Institute Of Technology Spectral imaging of photoluminescent materials
JP5838169B2 (ja) 2009-12-31 2016-01-06 ヴェンタナ メディカル システムズ， インク． 一意的に特異的核酸プローブを生成するための方法
CA2785529C (en) 2010-02-11 2019-01-08 Nanostring Technologies, Inc. Compositions and methods for the detection of small rnas
WO2011106583A1 (en) 2010-02-26 2011-09-01 Ventana Medical Systems, Inc. Polytag probes
EP2539466A4 (de) 2010-02-26 2013-08-07 Ventana Med Syst Inc Zytogene analyse von metaphasen-chromosomen
EP2630255B1 (de) 2010-10-22 2014-09-10 Roche Diagnostics GmbH Ein konjugat zwischen einer thiophilen festphase und einem oligonukleotid mit einem thiooxonukleotid
US10308983B2 (en) 2011-02-04 2019-06-04 The Trustees of The University of Pennsylvnia Method for detecting chromosome structure and gene expression simultaneously in single cells
CN103534359B (zh) 2011-03-14 2016-07-06 文塔纳医疗***公司 分析染色体易位的方法及其***
US9758834B2 (en) 2011-03-28 2017-09-12 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
CN103649335B (zh) 2011-05-04 2015-11-25 Htg分子诊断有限公司 定量核酸酶保护测定（qnpa）和测序（qnps）的改进
US9556281B2 (en) 2011-08-15 2017-01-31 The University Of Chicago Compositions and methods related to antibodies to staphylococcal protein A
WO2013057586A1 (en) 2011-10-19 2013-04-25 Oslo Universitetssykehus Hf Compositions and methods for producing soluble t - cell receptors
WO2013108126A2 (en) 2012-01-16 2013-07-25 University Of Oslo Methyltransferases and uses thereof
CN104703622B (zh) 2012-04-26 2017-05-24 芝加哥大学 与金黄色葡萄球菌疾病期间抵消凝固酶活性的抗体相关的组合物和方法
WO2013167387A1 (en) 2012-05-10 2013-11-14 Ventana Medical Systems, Inc. Uniquely specific probes for pten, pik3ca, met, top2a, and mdm2
EP2872646B1 (de) 2012-07-12 2017-08-30 Institut National de la Sante et de la Recherche Medicale (INSERM) Verfahren zur vorhersage der überlebenszeit und behandlungsreaktion eines patienten mit einem soliden tumor mit einer signatur aus 21 genen
WO2014048942A1 (en) 2012-09-25 2014-04-03 Ventana Medical Systems, Inc. Probes for pten, pik3ca, met, and top2a, and method for using the probes
EP2932268A4 (de) 2012-12-17 2016-10-19 Leukodx Ltd Systeme und verfahren zum erkennen eines biologischen zustands
US10610861B2 (en) 2012-12-17 2020-04-07 Accellix Ltd. Systems, compositions and methods for detecting a biological condition
US9759722B2 (en) * 2012-12-17 2017-09-12 Leukodx Ltd. Systems and methods for determining a chemical state
US11366061B2 (en) 2013-01-24 2022-06-21 Grace Bio-Labs, Inc. Protein microarray assay imager
WO2014134508A1 (en) * 2013-03-01 2014-09-04 Rarecyte, Inc. Monochromatic dot ensembles
ES2935257T3 (es) 2013-03-15 2023-03-03 Univ Chicago Métodos y composiciones relacionadas con la actividad de las células T
WO2015036405A1 (en) 2013-09-10 2015-03-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating basal cell carcinoma
US10378044B1 (en) * 2013-10-01 2019-08-13 FemtoDx Methods for increasing the molecular specificity of a nanosensor
US20160265036A1 (en) 2013-11-05 2016-09-15 Htg Molecular Diagnostics, Inc. Methods for detecting nucleic acids
JP6825915B2 (ja) 2014-02-24 2021-02-03 ヴェンタナ メディカル システムズ， インク． 標識された２’−ｏ−メチルｒｎａオリゴヌクレオチドプローブ及びシグナル増幅系を使用する自動ｒｎａ検出
US10323271B2 (en) * 2014-03-20 2019-06-18 Konica Minolta, Inc. Probe reagent and fish using probe reagent
KR20170072188A (ko) 2014-09-23 2017-06-26 티어랩 리서치, 인코포레이티드 미세 유체 눈물 포집 및 관심 대상인 분석물의 측방 유동 분석의 통합을 위한 시스템 및 방법
EP3009147A1 (de) 2014-10-16 2016-04-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur Behandlung von resistenten Glioblastomen
JP2018502567A (ja) 2015-01-12 2018-02-01 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 膵臓癌の診断方法
US9909972B2 (en) * 2016-02-08 2018-03-06 MANTA Instruments, Inc. Multi-camera apparatus for observation of microscopic movements and counting of particles in colloids and its calibration
SG10202107053QA (en) 2015-07-17 2021-08-30 Nanostring Technologies Inc Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
SG10202107055SA (en) 2015-07-17 2021-08-30 Nanostring Technologies Inc Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
WO2017029391A1 (en) 2015-08-20 2017-02-23 INSERM (Institut National de la Santé et de la Recherche Médicale) New method for treating cancer
WO2017055325A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of nk cells in a tissue sample
WO2017055326A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of myeloid dendritic cells in a tissue sample
WO2017055324A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of cells of monocytic origin in a tissue sample
WO2017055322A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of neutrophils in a tissue sample
WO2017055320A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of cytotoxic lymphocytes in a tissue sample
WO2017055321A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of fibroblasts in a tissue sample
WO2017055319A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of b cells in a tissue sample
WO2017055327A1 (en) 2015-09-29 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of endothelial cells in a tissue sample
WO2017060397A1 (en) 2015-10-09 2017-04-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of subjects suffering from melanoma metastases
WO2017067944A1 (en) 2015-10-19 2017-04-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of subjects suffering from triple negative breast cancer
CN105353131B (zh) * 2015-10-23 2017-04-19 山东大学 基于双编码和单分子计数的细胞因子多重检测方法
RU2743169C2 (ru) 2015-11-06 2021-02-15 Вентана Медикал Системз, Инк. Репрезентативная диагностика
WO2017081073A1 (en) 2015-11-10 2017-05-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients with decompensated alcoholic cirrhosis
EP3383418B1 (de) 2015-12-04 2021-10-20 Board of Regents, The University of Texas System Slc45a2-peptide für immuntherapie
US10760135B2 (en) 2016-01-13 2020-09-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for predicting pancreatic cancer treatment response
WO2017182834A1 (en) 2016-04-19 2017-10-26 INSERM (Institut National de la Santé et de la Recherche Médicale) New method for treating resistant glioblastoma
US20190292259A1 (en) 2016-05-24 2019-09-26 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd)
US11060147B2 (en) 2016-06-14 2021-07-13 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for predicting acute severe colitis treatment response
WO2018011107A1 (en) 2016-07-11 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of er-alpha 46 in methods and kits for assessing the status of breast cancer
WO2018011166A2 (en) 2016-07-12 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for quantifying the population of myeloid dendritic cells in a tissue sample
NL2017437B1 (en) * 2016-09-08 2018-03-27 Univ Amsterdam Multi-chromatic capped semiconductor nanocrystals
WO2018046736A1 (en) 2016-09-12 2018-03-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from cancer
WO2018046738A1 (en) 2016-09-12 2018-03-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from cancer
WO2018054960A1 (en) 2016-09-21 2018-03-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting and treating resistance to chemotherapy in npm-alk(+) alcl
WO2018055080A1 (en) 2016-09-22 2018-03-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for reprograming immune environment in a subject in need thereof
US10241111B2 (en) 2016-10-21 2019-03-26 AhuraTech LLC Electroluminescent binding assays
AU2017361521B2 (en) 2016-11-21 2020-08-27 Nanostring Technologies, Inc. Chemical compositions and methods of using same
DE102016124692B4 (de) 2016-12-16 2019-05-16 Gna Biosolutions Gmbh Verfahren und System zum Vervielfältigen einer Nukleinsäure
WO2018122245A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting the survival time of patients suffering from cms3 colorectal cancer
WO2018122249A1 (en) 2016-12-28 2018-07-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer
WO2018146239A1 (en) 2017-02-10 2018-08-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Biomarker for outcome in aml patients
WO2018162404A1 (en) 2017-03-06 2018-09-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Biomarker for outcome in aml patients
WO2018172540A1 (en) 2017-03-24 2018-09-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Method to predict the progression of alzheimer's disease
US11230736B2 (en) 2017-03-29 2022-01-25 Inserm (Institut National De La Santé De La Recherche Médicale) Methods for assessing pregnancy outcome
WO2018189215A1 (en) 2017-04-12 2018-10-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting the survival time of a patient suffering from hepatocellular carcinoma
AU2018269715A1 (en) * 2017-05-18 2020-01-16 Intelligent Material Solutions Inc. Diagnostic assays for detecting, quantifying, and/or tracking microbes and other analytes
WO2019038219A1 (en) 2017-08-21 2019-02-28 INSERM (Institut National de la Santé et de la Recherche Médicale) NEW PROGNOSTIC METHOD OF PANCREATIC CANCER
WO2019043138A1 (en) 2017-09-01 2019-03-07 INSERM (Institut National de la Santé et de la Recherche Médicale) METHOD FOR PREDICTING OUTCOME OF CANCER
WO2019092269A1 (en) 2017-11-13 2019-05-16 F. Hoffmann-La Roche Ag Devices for sample analysis using epitachophoresis
WO2019157445A1 (en) 2018-02-12 2019-08-15 Nanostring Technologies, Inc. Biomolecular probes and methods of detecting gene and protein expression
WO2019207030A1 (en) 2018-04-26 2019-10-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting a response with an immune checkpoint inhibitor in a patient suffering from a lung cancer
SG11202011274YA (en) 2018-05-14 2020-12-30 Nanostring Technologies Inc Chemical compositions and methods of using same
WO2019229489A1 (en) 2018-05-31 2019-12-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of mir-146a-5p and mir-186 as biomarkers of osteoarthritis
US11393387B2 (en) 2018-07-05 2022-07-19 AhuraTech LLC Open-circuit electroluminescence
US11428656B2 (en) 2018-07-05 2022-08-30 AhuraTech LLC Electroluminescent methods and system for real-time measurements of physical properties
US11460403B2 (en) 2018-07-05 2022-10-04 AhuraTech LLC Electroluminescent methods and devices for characterization of biological specimens
CN109187484B (zh) * 2018-09-13 2020-12-04 广西师范大学 一种用亲和反应调控碳点催化sers检测生物素的方法
WO2020089432A1 (en) 2018-11-02 2020-05-07 INSERM (Institut National de la Santé et de la Recherche Médicale) New prognostic method of pancreatic cancer
WO2020089428A1 (en) 2018-11-02 2020-05-07 INSERM (Institut National de la Santé et de la Recherche Médicale) New prognostic method of pancreatic cancer
KR20220008253A (ko) 2019-01-03 2022-01-20 엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔 (인쎄름) 암을 앓는 대상에서 cd8+ t 세포 의존성 면역 반응을 향상시키기 위한 방법 및 약학적 조성물
JP2022522265A (ja) 2019-01-16 2022-04-15 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル エリスロフェロンの変異体及びその使用
EP3924520A1 (de) 2019-02-13 2021-12-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren und zusammensetzungen zur behandlung von krebs bei einer krebskranken person
WO2020182932A1 (en) 2019-03-13 2020-09-17 INSERM (Institut National de la Santé et de la Recherche Médicale) New gene signatures for predicting survival time in patients suffering from renal cell carcinoma
US11255850B2 (en) 2019-03-28 2022-02-22 Alentic Microscience Inc. Bead-based analysis of a sample
WO2020193740A1 (en) 2019-03-28 2020-10-01 INSERM (Institut National de la Santé et de la Recherche Médicale) New strategy for treating pancreatic cancer
US10684278B1 (en) * 2019-03-28 2020-06-16 Alentic Microscience Inc. Bead-based analysis of a sample
US11719700B2 (en) 2019-03-28 2023-08-08 Alentic Microscience Inc. Upconversion for microscopy
US11609233B2 (en) 2019-03-28 2023-03-21 Alentic Microscience Inc. Indicator-based analysis of a sample
US20220177978A1 (en) 2019-04-02 2022-06-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
WO2020212586A1 (en) 2019-04-18 2020-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment and prognosis of cancer
JP2022530390A (ja) 2019-04-24 2022-06-29 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 抗精神病剤の応答を予測するための方法
EP3969583A1 (de) 2019-05-14 2022-03-23 F. Hoffmann-La Roche AG Vorrichtungen und verfahren zur probenanalyse
WO2020229521A1 (en) 2019-05-14 2020-11-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for inhibiting or reducing bacterial biofilms on a surface
WO2021001539A1 (en) 2019-07-04 2021-01-07 INSERM (Institut National de la Santé et de la Recherche Médicale) New strategy to detect and treat eosinophilic fasciitis
US11692989B2 (en) 2019-07-11 2023-07-04 Locus Solutions Ipco, Llc Use of soil and other environmental data to recommend customized agronomic programs
WO2021044012A1 (en) 2019-09-05 2021-03-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Method of treatment and pronostic of acute myeloid leukemia
WO2021063968A1 (en) 2019-09-30 2021-04-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Method and composition for diagnosing chronic obstructive pulmonary disease
WO2021074391A1 (en) 2019-10-17 2021-04-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing nasal intestinal type adenocarcinomas
CN112925005B (zh) * 2019-12-05 2023-09-08 中核四0四有限公司 一种二氧化镎样品钚含量的测定方法
US20230113705A1 (en) 2020-02-28 2023-04-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing, prognosing and managing treatment of breast cancer
WO2021186014A1 (en) 2020-03-20 2021-09-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting the survival time of a patient suffering from a cancer
US20230250426A1 (en) 2020-06-10 2023-08-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for treating and prognosing cancer like glioblastoma
EP4168006A1 (de) 2020-06-18 2023-04-26 Institut National de la Santé et de la Recherche Médicale (INSERM) Neue strategie zur behandlung von bauchspeicheldrüsenkrebs
WO2022018163A1 (en) 2020-07-22 2022-01-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting survival time in patients suffering from cancer
WO2022064049A1 (en) 2020-09-28 2022-03-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for diagnosing brucella infection
US20230383350A1 (en) 2020-10-20 2023-11-30 Institut National De La Sante Et De La Recherche Medicale Method for predicting the response to tnf inhibitors
US20240011094A1 (en) 2020-11-06 2024-01-11 Institut National de la Santé et de la Recherche Médicale Methods for diagnosis and treating polycystic ovary syndrome (pcos)
WO2022135753A1 (en) 2020-12-21 2022-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for prognosis the humoral response of a subject prior to vaccination
WO2022136252A1 (en) 2020-12-21 2022-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for prognosis the humoral response of a subject prior to vaccination
WO2022152698A1 (en) 2021-01-12 2022-07-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of npdk-d to evaluate cancer prognosis
WO2022171611A1 (en) 2021-02-09 2022-08-18 INSERM (Institut National de la Santé et de la Recherche Médicale) New method to pronostic lung cancer
WO2022194949A1 (en) 2021-03-17 2022-09-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for diagnosing pancreatic cancer
WO2022207566A1 (en) 2021-03-29 2022-10-06 INSERM (Institut National de la Santé et de la Recherche Médicale) New method to evaluate pancreatic cancer prognosis
WO2022223791A1 (en) 2021-04-23 2022-10-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating cell senescence accumulation related disease
WO2023280790A1 (en) 2021-07-05 2023-01-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Gene signatures for predicting survival time in patients suffering from renal cell carcinoma
WO2023089159A1 (en) 2021-11-22 2023-05-25 INSERM (Institut National de la Santé et de la Recherche Médicale) New strategy targeting stroma/tumor cell crosstalk to treat a cancer
WO2023144303A1 (en) 2022-01-31 2023-08-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Cd38 as a biomarker and biotarget in t-cell lymphomas
WO2023152133A1 (en) 2022-02-08 2023-08-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for diagnosing colorectal cancer
WO2024061930A1 (en) 2022-09-22 2024-03-28 Institut National de la Santé et de la Recherche Médicale New method to treat and diagnose peripheral t-cell lymphoma (ptcl)

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
JPH03279860A (ja) * 1990-03-29 1991-12-11 Mitsui Petrochem Ind Ltd 検査方法及び検査試薬
US5665582A (en) * 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
US5505928A (en) 1991-11-22 1996-04-09 The Regents Of University Of California Preparation of III-V semiconductor nanocrystals
US5674698A (en) * 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
JP3410777B2 (ja) * 1993-09-13 2003-05-26 株式会社東芝 超微粒子無機蛍光体標識特異的結合物質およびこれを用いた検出方法
JP3517031B2 (ja) * 1995-06-09 2004-04-05 日清紡績株式会社 生物学的活性物質の分析法
US5690807A (en) 1995-08-03 1997-11-25 Massachusetts Institute Of Technology Method for producing semiconductor particles
US5861279A (en) * 1996-01-17 1999-01-19 Schering Corporation Baculovirus expression system for human interleukin 5 receptor and method of screening for interleukin 5 antagonists
DE19627290A1 (de) * 1996-07-06 1998-01-08 Boehringer Mannheim Gmbh Bestimmung von Analyten unter Verwendung zweier Markierungen
CA2262018C (en) 1996-07-29 2007-10-02 Nanosphere Llc Nanoparticles having oligonucleotides attached thereto and uses therefor
US5739001A (en) * 1996-10-29 1998-04-14 E. I. Du Pont De Nemours And Company Solid phase cell-based assay
JPH1151935A (ja) * 1997-08-06 1999-02-26 Aisin Seiki Co Ltd 複数種類のターゲット分子の同時検出方法
US6322901B1 (en) 1997-11-13 2001-11-27 Massachusetts Institute Of Technology Highly luminescent color-selective nano-crystalline materials
US6207392B1 (en) * 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6306610B1 (en) * 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
EP0990903B1 (de) * 1998-09-18 2003-03-12 Massachusetts Institute Of Technology Biologische Verwendungen von halbleitenden Nanokristallen
EP1116036B1 (de) 1998-09-18 2004-08-11 Massachusetts Institute Of Technology Wasserlösliche fluoreszierende halbleiternanokristalle
DE19905277A1 (de) * 1999-02-09 2000-08-10 Bayer Ag Verfahren zur Herstellung von 2-Aminomethyl-1,5-pentandiamin
US20010055764A1 (en) * 1999-05-07 2001-12-27 Empedocles Stephen A. Microarray methods utilizing semiconductor nanocrystals
ATE439452T1 (de) * 1999-05-07 2009-08-15 Life Technologies Corp Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen

Also Published As

Publication number Publication date
JP2002544488A (ja) 2002-12-24
DE60042738D1 (de) 2009-09-24
US20040166505A1 (en) 2004-08-26
US20010034034A1 (en) 2001-10-25
US6274323B1 (en) 2001-08-14
EP1179185A1 (de) 2002-02-13
AU4701200A (en) 2000-11-21
US6630307B2 (en) 2003-10-07
CA2373146A1 (en) 2000-11-16
WO2000068692A1 (en) 2000-11-16
US20090176221A1 (en) 2009-07-09
US20120252018A1 (en) 2012-10-04
EP1179185B1 (de) 2009-08-12

Similar Documents

Publication Publication Date Title
ATE439452T1 (de) Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen
WO2001057522A3 (en) Immunochromatographic methods which employ semiconductor nanocrystals
DE60223635D1 (de) Reagenzien, Verfahren und Vorrichtungen zum Nachweis von Analyten
ATE431427T1 (de) Verbessertes verfahren zum nachweis von atp
ATE205602T1 (de) Verfahren und gerät zum nachweis und zur quantifizierung von glukose in körperflüssigkeiten
DK0699768T3 (da) Fremgangsmåder til quenching i opløsning af fluorescens-mærkede oligonnukleotidprober
ATE204333T1 (de) Verfahren zur dämpfung der fluoreszenz von fluoreszenzmarkierten oligonukleotiden in lösung
ATE509120T1 (de) Fusionsproteine zur detektion von analyten
DE69732667D1 (de) Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen
ES2081991T3 (es) Deteccion o cuantificacion de varios analitos utilizando tecnicas de marcacion.
ATE239912T1 (de) Verfahren und vorrichtung zur referenzierung von fluoreszenzintensitätssignalen
FI900602A0 (fi) Bestaemning.
WO2004067162A3 (en) Apparatus for microfluidic processing and reading of biochip arrays
ATE236996T1 (de) Sätze von, mit fluoreszierenden energieübertragungsverbindungen, markierten primern und deren verwendung in mehrkomponentenanalyse
DK1869459T3 (da) Lipofil farve-baserede assays for clostridial-toksin-aktivitet
DE69401717T2 (de) Verfahren zur Aktivierung von polyanionischen,fluoreszierenden Farbstoffen in schwach dielektrischen Medien mit quaternären Oniumverbindungen
DE602004021185D1 (de) Auf bio-barcodes beruhender nachweis von zielanalyten
DE60143888D1 (de) Methode um die sensitivität einer luminesenz assay zu erhöhen
DE60332382D1 (de) Zentrifugalvorrichtung und verfahren zur durchführung von bindungsversuchen
DE60326065D1 (de) Verfahren zum Mischen von Nukleinsäuren in wasserunlöslichen Medien, und dessen Verwendung
TW200517658A (en) A biochip containing splitable reaction confinement and method for producing same and application thereof
DE502004010078D1 (de) Verfahren zur anzeige von zeitabhängigen vorgängen
DE60043618D1 (de) Verfahren zum nachweis einer reaktion zur molekularen erkennung
ATE513058T1 (de) Verdrängungsassay zur detektion von nukleinsäureoligomer-hybridisierungsereignissen
DE50306024D1 (de) Vorrichtung zum Erfassen von in einer Phosphorschicht enthaltenen Bildinformationen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties