ATE437856T1 - 5-aminoindol-derivate - Google Patents

5-aminoindol-derivate

Info

Publication number
ATE437856T1
ATE437856T1 AT06706180T AT06706180T ATE437856T1 AT E437856 T1 ATE437856 T1 AT E437856T1 AT 06706180 T AT06706180 T AT 06706180T AT 06706180 T AT06706180 T AT 06706180T AT E437856 T1 ATE437856 T1 AT E437856T1
Authority
AT
Austria
Prior art keywords
aminoindole derivatives
aminoindole
derivatives
Prior art date
Application number
AT06706180T
Other languages
English (en)
Inventor
Matthias Heinrich Nettekoven
Jean-Marc Plancher
Olivier Roche
Rosa Maria Rodriguez-Sarmiento
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE437856T1 publication Critical patent/ATE437856T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT06706180T 2005-01-19 2006-01-10 5-aminoindol-derivate ATE437856T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05100312 2005-01-19
PCT/EP2006/000125 WO2006077024A2 (en) 2005-01-19 2006-01-10 5-aminoindole derivatives

Publications (1)

Publication Number Publication Date
ATE437856T1 true ATE437856T1 (de) 2009-08-15

Family

ID=36540146

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06706180T ATE437856T1 (de) 2005-01-19 2006-01-10 5-aminoindol-derivate

Country Status (16)

Country Link
US (2) US7456174B2 (de)
EP (1) EP1841734B1 (de)
JP (1) JP2008527014A (de)
KR (1) KR100902707B1 (de)
CN (1) CN101107227B (de)
AR (1) AR053435A1 (de)
AT (1) ATE437856T1 (de)
AU (1) AU2006207712A1 (de)
BR (1) BRPI0606502A2 (de)
CA (1) CA2594487A1 (de)
DE (1) DE602006008104D1 (de)
ES (1) ES2327776T3 (de)
IL (1) IL184433A0 (de)
MX (1) MX2007008676A (de)
TW (1) TW200637817A (de)
WO (1) WO2006077024A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040096216A (ko) 2003-05-07 2004-11-16 삼성전자주식회사 제빵기
AR048134A1 (es) * 2003-12-15 2006-04-05 Lundbeck & Co As H La combinacion de un inhibidor de la recaptacion de serotonina y un antagonista del receptor de la histamina 3, el agonista inverso o el agonista parcial
CN101326187A (zh) * 2005-12-15 2008-12-17 霍夫曼-拉罗奇有限公司 吡咯并[2,3-c]吡啶衍生物
US7834050B2 (en) * 2006-03-29 2010-11-16 Duke University Small molecule insulin mimetics absent quinones
BRPI0710588A2 (pt) * 2006-04-12 2012-06-19 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, uso dos compostos, e métodos para o tratamento ou prevenção de obesidade, e de diabetes do tipo ii
US7432255B2 (en) 2006-05-16 2008-10-07 Hoffmann-La Roche Inc. 1H-indol-5-yl-piperazin-1-yl-methanone derivatives
US7514433B2 (en) * 2006-08-03 2009-04-07 Hoffmann-La Roche Inc. 1H-indole-6-yl-piperazin-1-yl-methanone derivatives
TW200823204A (en) * 2006-10-17 2008-06-01 Arena Pharm Inc Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto
US7648979B2 (en) * 2007-02-07 2010-01-19 Hoffmann-La Roche Inc. 5-amido-(1H-indol-2-yl)-piperazin-1-yl-methanone derivatives
JP2010520216A (ja) * 2007-03-01 2010-06-10 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒスタミンｈ３受容体のモジュレーターとしてのインドールおよびベンゾチオフェン化合物
CN101796043A (zh) 2007-07-25 2010-08-04 霍夫曼-拉罗奇有限公司 苯并呋喃-和苯并[b]噻吩-2-羧酸酰胺衍生物及其作为阻胺3受体调节剂的应用
CN106905286B (zh) * 2015-12-23 2020-07-24 江苏恩华药业股份有限公司 一种黄酮类化合物衍生物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2705095B1 (fr) 1993-05-12 1995-06-23 Adir Nouveaux indoles substitués, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5756507A (en) * 1995-12-14 1998-05-26 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
SK6652000A3 (en) * 1997-11-11 2002-05-09 Pfizer Prod Inc Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
ES2213693T3 (es) * 2000-03-31 2004-09-01 Ortho-Mcneil Pharmaceutical, Inc. Derivados de indolizina fenil-sustituidos y su uso como ligandos del receptor h3 de la histamina.
EP1268421B1 (de) * 2000-03-31 2009-05-06 Ortho-McNeil Pharmaceutical, Inc. Phenyl-substituierte indole als h3 histaminrezeptorantagonisten
CN1293072C (zh) * 2001-04-20 2007-01-03 惠氏公司 作为5－羟色胺－6配体的杂环基氧基－、－硫代－和－氨基吲哚衍生物
CA2489337C (en) * 2002-06-24 2010-05-25 Schering Corporation Indole derivatives useful as histamine h3 antagonists
WO2005123716A1 (en) * 2004-06-21 2005-12-29 F. Hoffmann-La Roche Ag Indole derivatives as histamine receptor antagonists

Also Published As

Publication number Publication date
ES2327776T3 (es) 2009-11-03
US20090069311A1 (en) 2009-03-12
IL184433A0 (en) 2007-10-31
JP2008527014A (ja) 2008-07-24
AU2006207712A1 (en) 2006-07-27
DE602006008104D1 (de) 2009-09-10
KR100902707B1 (ko) 2009-06-15
MX2007008676A (es) 2007-07-25
WO2006077024A3 (en) 2006-09-08
AR053435A1 (es) 2007-05-09
CN101107227A (zh) 2008-01-16
EP1841734A2 (de) 2007-10-10
KR20070098922A (ko) 2007-10-05
WO2006077024A2 (en) 2006-07-27
BRPI0606502A2 (pt) 2009-06-30
EP1841734B1 (de) 2009-07-29
CN101107227B (zh) 2010-09-22
TW200637817A (en) 2006-11-01
CA2594487A1 (en) 2006-07-27
US20060160855A1 (en) 2006-07-20
US7754736B2 (en) 2010-07-13
US7456174B2 (en) 2008-11-25

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