ATE428731T1 - Therapeutische antiköper mit reduzierten nebenwirkungen - Google Patents
Therapeutische antiköper mit reduzierten nebenwirkungenInfo
- Publication number
- ATE428731T1 ATE428731T1 AT03765177T AT03765177T ATE428731T1 AT E428731 T1 ATE428731 T1 AT E428731T1 AT 03765177 T AT03765177 T AT 03765177T AT 03765177 T AT03765177 T AT 03765177T AT E428731 T1 ATE428731 T1 AT E428731T1
- Authority
- AT
- Austria
- Prior art keywords
- side effects
- therapeutic antibodies
- reduced side
- therapeutic
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39793402P | 2002-07-23 | 2002-07-23 | |
PCT/GB2003/003156 WO2004009638A1 (en) | 2002-07-23 | 2003-07-23 | Therapeutic antibodies with reduced side effects |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE428731T1 true ATE428731T1 (de) | 2009-05-15 |
Family
ID=30771146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03765177T ATE428731T1 (de) | 2002-07-23 | 2003-07-23 | Therapeutische antiköper mit reduzierten nebenwirkungen |
Country Status (8)
Country | Link |
---|---|
US (2) | US20040109855A1 (de) |
EP (1) | EP1523503B1 (de) |
JP (1) | JP4583170B2 (de) |
AT (1) | ATE428731T1 (de) |
AU (1) | AU2003260686B2 (de) |
DE (1) | DE60327205D1 (de) |
ES (1) | ES2323457T3 (de) |
WO (1) | WO2004009638A1 (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2423850C (en) | 2000-10-09 | 2017-07-04 | Isis Innovation Limited | Therapeutic antibodies |
EP2178914A2 (de) | 2007-08-15 | 2010-04-28 | Bayer Schering Pharma Aktiengesellschaft | Monospezifische und multispezifische antikörper und anwendungsverfahren |
AU2013202755B2 (en) * | 2007-08-22 | 2016-05-12 | Cytomx Therapeutics, Inc. | Activatable binding polypeptides and methods of identification and use thereof |
EP3492488A1 (de) | 2007-08-22 | 2019-06-05 | The Regents of The University of California | Aktivierbare bindende polypeptide und verfahren zu deren identifikation und anwendung |
AU2016213702C1 (en) * | 2007-08-22 | 2018-11-29 | Cytomx Therapeutics, Inc. | Activatable binding polypeptides and methods of identification and use thereof |
EP3543256A1 (de) | 2009-01-12 | 2019-09-25 | Cytomx Therapeutics Inc. | Modifizierte antikörperzusammensetzungen, verfahren zur herstellung und verwendung davon |
CA2753294A1 (en) | 2009-02-23 | 2010-08-26 | Cytomx Therapeutics, Inc. | Proproteins and methods of use thereof |
JP2015516813A (ja) | 2012-04-27 | 2015-06-18 | シトムクス セラピューティクス,インコーポレイティド | 上皮成長因子受容体を結合する活性化可能抗体及びその使用方法 |
JP6257600B2 (ja) | 2012-05-25 | 2018-01-10 | スローン ケタリング インスティテュート フォア キャンサー リサーチ | Gi症候群及び移植片対宿主病の治療方法 |
WO2013192546A1 (en) | 2012-06-22 | 2013-12-27 | Cytomx Therapeutics, Inc. | Activatable antibodies having non-binding steric moieties and mehtods of using the same |
JP2015521625A (ja) | 2012-06-22 | 2015-07-30 | シトムクス セラピューティクス,インコーポレイティド | 抗−Jagged1/Jagged2交差反応性抗体、活性化可能抗−Jagged抗体及びそれらの使用方法 |
WO2014052462A2 (en) | 2012-09-25 | 2014-04-03 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind interleukin-6 receptor and methods of use thereof |
CN112162094A (zh) | 2013-01-04 | 2021-01-01 | 西托姆克斯治疗公司 | 用于检测生物***中的蛋白酶活性的组合物和方法 |
AU2014274215B2 (en) | 2013-05-28 | 2019-02-28 | Dcb-Usa Llc | Antibody locker for the inactivation of protein drug |
CA2913732A1 (en) | 2013-06-04 | 2014-12-11 | Cytomx Therapeutics, Inc. | Compositions and methods for conjugating activatable antibodies |
WO2015013671A1 (en) | 2013-07-25 | 2015-01-29 | Cytomx Therapeutics, Inc. | Multispecific antibodies, multispecific activatable antibodies and methods of using the same |
US20150087810A1 (en) | 2013-09-25 | 2015-03-26 | Cytomx Therapeutics, Inc. | Matrix Metalloproteinase Substrates And Other Cleavable Moieties And Methods Of Use Thereof |
WO2015066279A2 (en) | 2013-10-30 | 2015-05-07 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof |
US9737623B2 (en) | 2013-12-11 | 2017-08-22 | Cytomx Therapeutics, Inc. | Antibodies that bind activatable antibodies and methods of use thereof |
DK3628328T3 (da) | 2014-01-31 | 2022-12-05 | Cytomx Therapeutics Inc | Matriptase- og u-plasminogen-aktivatorsubstrater og andre spaltelige dele og fremgangsmåder til anvendelse deraf |
EP3172235A2 (de) | 2014-07-25 | 2017-05-31 | Cytomx Therapeutics Inc. | Anti-cd3-antikörper, aktivierbare anti-cd3-antikörper, multispezifische anti-cd3-antikörper, multispezifische aktivierbare anti-cd3-antikörper und verfahren zur verwendung davon |
MA41374A (fr) | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
US10336824B2 (en) | 2015-03-13 | 2019-07-02 | Cytomx Therapeutics, Inc. | Anti-PDL1 antibodies, activatable anti-PDL1 antibodies, and methods of thereof |
AU2016258988A1 (en) | 2015-05-04 | 2017-12-07 | Cytomx Therapeutics, Inc | Anti-ITGa3 antibodies, activatable anti-ITGa3 antibodies, and methods of use thereof |
EP3292149B1 (de) | 2015-05-04 | 2021-12-01 | CytomX Therapeutics, Inc. | Aktivierbare anti-cd71-antikörper, und verfahren zur verwendung davon |
CN115340607A (zh) | 2015-05-04 | 2022-11-15 | 西托姆克斯治疗公司 | 抗cd166抗体、可活化抗cd166抗体及其使用方法 |
KR20180040138A (ko) | 2015-07-13 | 2018-04-19 | 싸이톰스 테라퓨틱스, 인크. | 항pd-1 항체, 활성화 가능한 항pd-1 항체, 및 이들의 사용 방법 |
JP7039582B2 (ja) | 2016-11-03 | 2022-03-22 | ブリストル-マイヤーズ スクイブ カンパニー | 活性化可能な抗ctla-4抗体およびその使用 |
MX2019006624A (es) | 2016-12-09 | 2019-08-01 | Seattle Genetics Inc | Anticuerpos bivalentes enmascarados por helices superenrolladas. |
CN110914302A (zh) | 2017-06-01 | 2020-03-24 | 赛托姆克斯治疗学股份有限公司 | 可活化抗pdl1抗体及其使用方法 |
EA202090247A1 (ru) | 2017-07-14 | 2020-05-12 | Цитомкс Терапьютикс, Инк. | Антитела против cd166 и их применения |
CN111278461A (zh) | 2017-08-16 | 2020-06-12 | 百时美施贵宝公司 | 可前药化抗体、其前药以及使用和制备方法 |
TW201927816A (zh) | 2017-10-14 | 2019-07-16 | 美商Cytomx生物製藥公司 | 抗體、可活化之抗體、雙特異性抗體、和雙特異性可活化之抗體、及其使用方法 |
TW202112354A (zh) | 2019-06-05 | 2021-04-01 | 美商西雅圖遺傳學公司 | 遮蔽抗體調配物 |
US20220306727A1 (en) | 2019-06-05 | 2022-09-29 | Seagen Inc. | Methods of Purifying Masked Antibodies |
US20220251206A1 (en) | 2019-06-11 | 2022-08-11 | Bristol-Myers Squibb Company | Anti-ctla4 antibody prodruggable (probody) at a cdr position |
CA3174786A1 (en) | 2020-04-10 | 2021-10-14 | Sayantan Mitra | Activatable cytokine constructs and related compositions and methods |
CA3211924A1 (en) | 2021-03-16 | 2022-09-22 | Sayantan Mitra | Masked activatable cytokine constructs and related compositions and methods |
EP4370211A1 (de) | 2021-07-14 | 2024-05-22 | Seagen Inc. | Antikörpermaskierende domänen |
WO2023049825A1 (en) | 2021-09-24 | 2023-03-30 | Seagen Inc. | Improved antibody masking domains |
WO2023222580A1 (en) | 2022-05-16 | 2023-11-23 | Byondis B.V. | Novel masked antibodies |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9603507D0 (en) * | 1996-02-20 | 1996-04-17 | Isis Innovation | Antibody variants |
US5990286A (en) * | 1996-12-18 | 1999-11-23 | Techniclone, Inc. | Antibodies with reduced net positive charge |
CA2423850C (en) * | 2000-10-09 | 2017-07-04 | Isis Innovation Limited | Therapeutic antibodies |
US7132511B2 (en) * | 2001-02-19 | 2006-11-07 | Merck Patent Gmbh | Modified anti-EGFR antibodies with reduced immunogenicity |
-
2003
- 2003-07-09 US US10/615,718 patent/US20040109855A1/en not_active Abandoned
- 2003-07-23 DE DE60327205T patent/DE60327205D1/de not_active Expired - Lifetime
- 2003-07-23 JP JP2004522335A patent/JP4583170B2/ja not_active Expired - Lifetime
- 2003-07-23 AT AT03765177T patent/ATE428731T1/de not_active IP Right Cessation
- 2003-07-23 WO PCT/GB2003/003156 patent/WO2004009638A1/en active Application Filing
- 2003-07-23 AU AU2003260686A patent/AU2003260686B2/en not_active Expired
- 2003-07-23 ES ES03765177T patent/ES2323457T3/es not_active Expired - Lifetime
- 2003-07-23 EP EP03765177A patent/EP1523503B1/de not_active Expired - Lifetime
-
2011
- 2011-08-19 US US13/199,127 patent/US20130028893A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE60327205D1 (de) | 2009-05-28 |
AU2003260686B2 (en) | 2009-11-26 |
EP1523503B1 (de) | 2009-04-15 |
ES2323457T3 (es) | 2009-07-16 |
EP1523503A1 (de) | 2005-04-20 |
JP2006506333A (ja) | 2006-02-23 |
WO2004009638A1 (en) | 2004-01-29 |
JP4583170B2 (ja) | 2010-11-17 |
AU2003260686A1 (en) | 2004-02-09 |
US20040109855A1 (en) | 2004-06-10 |
US20130028893A1 (en) | 2013-01-31 |
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Legal Events
Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |