ATE427360T1 - Endomannosidasen zur modifzierung der glykoproteine in eukaryoten - Google Patents
Endomannosidasen zur modifzierung der glykoproteine in eukaryotenInfo
- Publication number
- ATE427360T1 ATE427360T1 AT04713369T AT04713369T ATE427360T1 AT E427360 T1 ATE427360 T1 AT E427360T1 AT 04713369 T AT04713369 T AT 04713369T AT 04713369 T AT04713369 T AT 04713369T AT E427360 T1 ATE427360 T1 AT E427360T1
- Authority
- AT
- Austria
- Prior art keywords
- eukaryotes
- endomannosidases
- modifying
- methods
- glycoproteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/2488—Mannanases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0113—Glycoprotein endo-alpha-1,2-mannosidase (3.2.1.130)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/371,877 US7449308B2 (en) | 2000-06-28 | 2003-02-20 | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
US10/695,243 US7332299B2 (en) | 2003-02-20 | 2003-10-27 | Endomannosidases in the modification of glycoproteins in eukaryotes |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE427360T1 true ATE427360T1 (de) | 2009-04-15 |
Family
ID=32911944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04713369T ATE427360T1 (de) | 2003-02-20 | 2004-02-20 | Endomannosidasen zur modifzierung der glykoproteine in eukaryoten |
Country Status (8)
Country | Link |
---|---|
US (3) | US7332299B2 (de) |
EP (1) | EP1597379B3 (de) |
JP (2) | JP4787737B2 (de) |
AT (1) | ATE427360T1 (de) |
AU (1) | AU2004213860B2 (de) |
CA (1) | CA2516527A1 (de) |
DE (1) | DE602004020321D1 (de) |
WO (1) | WO2004074497A2 (de) |
Families Citing this family (45)
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US20060029604A1 (en) * | 2000-06-28 | 2006-02-09 | Gerngross Tillman U | Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform |
US7863020B2 (en) * | 2000-06-28 | 2011-01-04 | Glycofi, Inc. | Production of sialylated N-glycans in lower eukaryotes |
US20060034828A1 (en) * | 2000-06-28 | 2006-02-16 | Gerngross Tillman U | Immunoglobulins comprising predominantly a GlcNAcMAN5GLCNAC2 glycoform |
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JP2009507040A (ja) * | 2005-09-02 | 2009-02-19 | グライコフィ, インコーポレイテッド | 主としてglcnacman3glcnac2糖形態を含む免疫グロブリン |
JP2009507482A (ja) * | 2005-09-09 | 2009-02-26 | グライコフィ, インコーポレイテッド | 主にman7glcnac2、man8glcnac2グリコフォームを含むイムノグロブリン |
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CN101535340B (zh) * | 2006-05-19 | 2013-05-01 | 格利科菲公司 | ***组合物 |
WO2007136752A2 (en) | 2006-05-19 | 2007-11-29 | Glycofi, Inc. | Erythropoietin compositions |
AU2008227024A1 (en) * | 2007-03-07 | 2008-09-18 | Glycofi, Inc. | Production of glycoproteins with modified fucosylation |
AU2009279062B2 (en) * | 2008-08-08 | 2014-01-16 | Universiteit Gent | Cells producing glycoproteins having altered glycosylation patterns and methods and use thereof |
CA2751730A1 (en) | 2009-02-25 | 2010-09-02 | Merck Sharp & Dohme Corp. | Metabolic engineering of a galactose assimilation pathway in the glycoengineered yeast pichia pastoris |
KR101786121B1 (ko) * | 2009-03-16 | 2017-10-16 | 디에스엠 아이피 어셋츠 비.브이. | 라비린툴로바이코타문 미생물에서의 단백질 생산 |
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EP2494050A4 (de) * | 2009-10-30 | 2013-10-30 | Merck Sharp & Dohme | In glycoengineerter pichia pastoris hergestellter granulozytenkolonienstimulierender faktor |
EP2519642B1 (de) * | 2009-12-28 | 2017-10-25 | DSM IP Assets B.V. | Auf xylose wachsende rekombinante thraustochytride sowie zusammensetzungen, herstellungsverfahren und verwendungen davon |
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WO2011082189A1 (en) * | 2009-12-28 | 2011-07-07 | Martek Biosciences Corporation | Production of hemagglutinin-neuraminidase protein in microalgae |
JP5976549B2 (ja) | 2010-02-24 | 2016-08-24 | メルク・シャープ・エンド・ドーム・コーポレイション | ピチア・パストリスにおいて産生される治療用糖タンパク質上のn−グリコシル化部位占拠を増加させるための方法 |
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WO2013174927A1 (en) | 2012-05-23 | 2013-11-28 | Novartis International Pharmaceutical Limited | Production of fucosylated glycoproteins |
WO2014064203A1 (en) | 2012-10-26 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Lyve-1 antagonists for preventing or treating a pathological condition associated with lymphangiogenesis |
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SG11201700446XA (en) | 2014-07-21 | 2017-02-27 | Glykos Finland Oy | Production of glycoproteins with mammalian-like n-glycans in filamentous fungi |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
WO2024017998A1 (en) | 2022-07-21 | 2024-01-25 | Technische Universität Dresden | M-csf for use in the prophylaxis and/or treatment of viral infections in states of immunosuppression |
EP4309666A1 (de) | 2022-07-21 | 2024-01-24 | Technische Universität Dresden | M-csf zur verwendung bei der prophylaxe und/oder behandlung viraler infektionen bei immunsuppressionszuständen |
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2003
- 2003-10-27 US US10/695,243 patent/US7332299B2/en not_active Expired - Lifetime
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2004
- 2004-02-20 AU AU2004213860A patent/AU2004213860B2/en not_active Ceased
- 2004-02-20 WO PCT/US2004/005131 patent/WO2004074497A2/en active Application Filing
- 2004-02-20 JP JP2006503759A patent/JP4787737B2/ja not_active Expired - Fee Related
- 2004-02-20 CA CA002516527A patent/CA2516527A1/en not_active Abandoned
- 2004-02-20 DE DE602004020321T patent/DE602004020321D1/de not_active Expired - Lifetime
- 2004-02-20 AT AT04713369T patent/ATE427360T1/de not_active IP Right Cessation
- 2004-02-20 EP EP04713369.9A patent/EP1597379B3/de not_active Expired - Lifetime
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CA2516527A1 (en) | 2004-09-02 |
EP1597379B3 (de) | 2021-06-23 |
JP4787737B2 (ja) | 2011-10-05 |
AU2004213860A1 (en) | 2004-09-02 |
EP1597379B1 (de) | 2009-04-01 |
US20120064568A1 (en) | 2012-03-15 |
EP1597379A2 (de) | 2005-11-23 |
US20040171826A1 (en) | 2004-09-02 |
JP2006518598A (ja) | 2006-08-17 |
US20090130709A1 (en) | 2009-05-21 |
WO2004074497A2 (en) | 2004-09-02 |
JP5280399B2 (ja) | 2013-09-04 |
DE602004020321D1 (de) | 2009-05-14 |
EP1597379B2 (de) | 2016-08-03 |
US7332299B2 (en) | 2008-02-19 |
JP2010187693A (ja) | 2010-09-02 |
AU2004213860B2 (en) | 2009-04-02 |
US8986949B2 (en) | 2015-03-24 |
WO2004074497A3 (en) | 2004-12-02 |
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