ATE425177T1 - Reduziertes fk228 und seine verwendung - Google Patents
Reduziertes fk228 und seine verwendungInfo
- Publication number
- ATE425177T1 ATE425177T1 AT01947940T AT01947940T ATE425177T1 AT E425177 T1 ATE425177 T1 AT E425177T1 AT 01947940 T AT01947940 T AT 01947940T AT 01947940 T AT01947940 T AT 01947940T AT E425177 T1 ATE425177 T1 AT E425177T1
- Authority
- AT
- Austria
- Prior art keywords
- reduced
- salt
- compound
- histone deacetylase
- diseases
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 102000003964 Histone deacetylase Human genes 0.000 abstract 1
- 108090000353 Histone deacetylase Proteins 0.000 abstract 1
- 108700019146 Transgenes Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 abstract 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 abstract 1
- 230000006197 histone deacetylation Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000007420 reactivation Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Glass Compositions (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000216584 | 2000-07-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE425177T1 true ATE425177T1 (de) | 2009-03-15 |
Family
ID=18711825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01947940T ATE425177T1 (de) | 2000-07-17 | 2001-07-09 | Reduziertes fk228 und seine verwendung |
Country Status (7)
Country | Link |
---|---|
US (1) | US7056884B2 (de) |
EP (1) | EP1302476B1 (de) |
JP (1) | JP4810784B2 (de) |
AT (1) | ATE425177T1 (de) |
DE (1) | DE60137932D1 (de) |
ES (1) | ES2321584T3 (de) |
WO (1) | WO2002006307A1 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002020817A1 (en) | 2000-09-01 | 2002-03-14 | Fujisawa Pharmaceutical Co., Ltd. | A method of producing fr901228 |
PL210794B1 (pl) * | 2001-08-21 | 2012-03-30 | Astellas Pharma Inc | Zastosowanie inhibitora deacetylazy histonowej FK228 lub jego soli |
DE60331297D1 (de) | 2002-03-07 | 2010-04-01 | Univ Delaware | Verfahren zur verstärkung der oligonucleotid-vermittelten nucleinsäuresequenzänderung unter verwendung von zusammensetzungen mit einem hydroxyharnstoff |
MXPA04009761A (es) * | 2002-04-05 | 2005-05-27 | Fujisawa Pharmaceutical Co | Dipsipeptido para terapia de cancer renal. |
CA2495354A1 (en) * | 2002-08-20 | 2004-03-04 | Yamanouchi Pharmaceutical Co., Ltd. | An agent for inhibiting articular cartilage extracellular matrix degradation |
JPWO2004074478A1 (ja) * | 2003-02-19 | 2006-06-01 | アステラス製薬株式会社 | ヒストンデアセチラーゼ阻害剤の抗腫瘍効果の予測方法 |
US7375228B2 (en) * | 2003-03-17 | 2008-05-20 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
EP1491188A1 (de) * | 2003-06-25 | 2004-12-29 | G2M Cancer Drugs AG | Topische Verwendung von Valproinsäure zur Behandlung von Hauterkrankungen |
EP2238982B8 (de) * | 2003-06-27 | 2013-01-16 | Astellas Pharma Inc. | Therapiemittel für Weichgewebesarkom |
ES2425083T3 (es) | 2003-09-25 | 2013-10-11 | Astellas Pharma Inc. | Agente antitumoral que comprende FK228 como inhibidor de histona desacetilasa y doxorrubicina como inhibidor de topoisomerasa II |
EP1713460A2 (de) * | 2003-12-10 | 2006-10-25 | Wisconsin Alumni Research Foundation | Fk228-analoga und ihre verwendung als hdac-hemmer |
US20050159470A1 (en) * | 2003-12-19 | 2005-07-21 | Syrrx, Inc. | Histone deacetylase inhibitors |
WO2005066151A2 (en) * | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
US20050187148A1 (en) * | 2004-02-25 | 2005-08-25 | Yoshinori Naoe | Antitumor agent |
US7951780B2 (en) * | 2004-02-25 | 2011-05-31 | Astellas Pharma Inc. | Antitumor agent |
WO2006055621A2 (en) * | 2004-11-17 | 2006-05-26 | The University Of Chicago | Histone deacetylase inhibitors and methods of use |
JP2008524246A (ja) * | 2004-12-16 | 2008-07-10 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
JP2008540574A (ja) * | 2005-05-11 | 2008-11-20 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
GB0511266D0 (en) * | 2005-06-02 | 2005-07-13 | Trust | Chemical compounds |
CN101263121A (zh) * | 2005-07-14 | 2008-09-10 | 塔克达圣地亚哥公司 | 组蛋白脱乙酰基酶抑制剂 |
EP1965824A4 (de) * | 2005-11-18 | 2011-10-19 | Gloucester Pharmaceuticals Inc | Metaboliten-derivate des hdac-inhibitors fk228 |
JP2009525955A (ja) * | 2006-01-13 | 2009-07-16 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
US20100137239A1 (en) | 2006-04-24 | 2010-06-03 | Gloucester Pharmaceuticals | Gemcitabine combination therapy |
WO2007146730A2 (en) | 2006-06-08 | 2007-12-21 | Gloucester Pharmaceuticals | Deacetylase inhibitor therapy |
JP5178731B2 (ja) | 2006-11-22 | 2013-04-10 | カルス セラピューティクス リミテッド | デプシペプチドおよびその治療的使用 |
CN101801994A (zh) * | 2006-12-29 | 2010-08-11 | 格洛斯特制药公司 | 制备Romidepsin |
BRPI0720734A2 (pt) * | 2006-12-29 | 2014-01-07 | Gloucester Pharmaceuticals Inc | Preparação da romidepsina |
US20110269699A1 (en) * | 2008-10-24 | 2011-11-03 | Mitchell Keegan | Cancer therapy |
US20120190817A2 (en) | 2010-07-12 | 2012-07-26 | Celgene Corporation | Romidepsin solid forms and uses thereof |
US8859502B2 (en) | 2010-09-13 | 2014-10-14 | Celgene Corporation | Therapy for MLL-rearranged leukemia |
CA2874936A1 (en) * | 2012-06-06 | 2013-12-12 | Bionor Immuno As | Vaccine |
AU2013202506B2 (en) | 2012-09-07 | 2015-06-18 | Celgene Corporation | Resistance biomarkers for hdac inhibitors |
AU2013202507B9 (en) | 2012-11-14 | 2015-08-13 | Celgene Corporation | Inhibition of drug resistant cancer cells |
CN104450837B (zh) * | 2013-09-18 | 2019-01-01 | 上海医药工业研究院 | 一种用于生产罗米地辛的方法及发酵培养基 |
NZ630311A (en) | 2013-12-27 | 2016-03-31 | Celgene Corp | Romidepsin formulations and uses thereof |
CN109796521B (zh) * | 2017-11-17 | 2022-04-19 | 上海医药工业研究院 | 一种罗米地辛醋酸盐晶型及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8817743D0 (en) * | 1988-07-26 | 1988-09-01 | Fujisawa Pharmaceutical Co | Fr901228 substance & preparation thereof |
ATE162850T1 (de) * | 1993-09-10 | 1998-02-15 | Kyowa Hakko Kogyo Kk | Phospholipase c inhibitierendes peptid |
-
2001
- 2001-07-09 JP JP2002512207A patent/JP4810784B2/ja not_active Expired - Lifetime
- 2001-07-09 AT AT01947940T patent/ATE425177T1/de active
- 2001-07-09 EP EP01947940A patent/EP1302476B1/de not_active Expired - Lifetime
- 2001-07-09 ES ES01947940T patent/ES2321584T3/es not_active Expired - Lifetime
- 2001-07-09 DE DE60137932T patent/DE60137932D1/de not_active Expired - Lifetime
- 2001-07-09 WO PCT/JP2001/005954 patent/WO2002006307A1/ja active Application Filing
- 2001-07-09 US US10/333,063 patent/US7056884B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2321584T3 (es) | 2009-06-09 |
DE60137932D1 (de) | 2009-04-23 |
EP1302476A4 (de) | 2006-06-28 |
JP4810784B2 (ja) | 2011-11-09 |
EP1302476B1 (de) | 2009-03-11 |
US7056884B2 (en) | 2006-06-06 |
US20040053820A1 (en) | 2004-03-18 |
WO2002006307A1 (fr) | 2002-01-24 |
EP1302476A1 (de) | 2003-04-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
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