ATE415959T1 - Herg1-kanal-öffner zur behandlung von herzarrythmien - Google Patents

Herg1-kanal-öffner zur behandlung von herzarrythmien

Info

Publication number
ATE415959T1
ATE415959T1 AT04766708T AT04766708T ATE415959T1 AT E415959 T1 ATE415959 T1 AT E415959T1 AT 04766708 T AT04766708 T AT 04766708T AT 04766708 T AT04766708 T AT 04766708T AT E415959 T1 ATE415959 T1 AT E415959T1
Authority
AT
Austria
Prior art keywords
treatment
channel opener
herg1 channel
arrythmia
heart
Prior art date
Application number
AT04766708T
Other languages
English (en)
Inventor
Soeren Olesen
Morten Grunnet
Palle Christophersen
Dorte Strobaek
Joachim Demnitz
Rie Hansen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE415959T1 publication Critical patent/ATE415959T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
AT04766708T 2003-09-04 2004-09-06 Herg1-kanal-öffner zur behandlung von herzarrythmien ATE415959T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200301264 2003-09-04

Publications (1)

Publication Number Publication Date
ATE415959T1 true ATE415959T1 (de) 2008-12-15

Family

ID=34259076

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04766708T ATE415959T1 (de) 2003-09-04 2004-09-06 Herg1-kanal-öffner zur behandlung von herzarrythmien

Country Status (10)

Country Link
US (2) US7851492B2 (de)
EP (1) EP1663192B1 (de)
JP (2) JP2007504202A (de)
CN (1) CN1845726A (de)
AT (1) ATE415959T1 (de)
AU (1) AU2004269924A1 (de)
CA (1) CA2537746A1 (de)
DE (1) DE602004018162D1 (de)
MX (1) MXPA06002315A (de)
WO (1) WO2005023237A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070293553A1 (en) * 2004-12-17 2007-12-20 Dahl Bjarne H Diphenylurea Derivatives Useful As Potassium Channel Activators
WO2006089871A2 (en) * 2005-02-23 2006-08-31 Neurosearch A/S Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmias
CA2630639A1 (en) * 2005-11-21 2007-05-31 Tap Pharmaceutical Products, Inc. Treatment of qt interval prolongation and diseases associated therewith
US7985761B2 (en) 2006-03-14 2011-07-26 Neurosearch A/S Diphenylurea derivatives and their use as chloride channel blockers or BKCa channel modulators
EP2212303A1 (de) * 2007-11-26 2010-08-04 NeuroSearch AS Als kaliumkanalmodulatoren geeignete, neue benzamidderivate
WO2011119939A2 (en) * 2010-03-25 2011-09-29 The Uab Research Foundation Manipulation of calcium channels to regulate after-depolarization events in cardiac myocytes
ES2787625T3 (es) * 2014-04-17 2020-10-16 Novartis Ag Activadores de hERG policíclicos
CN105343120A (zh) * 2015-11-19 2016-02-24 宁波市医疗中心李惠利医院 Amo-103在制备治疗心律失常药物中的应用
JP7111359B2 (ja) * 2018-02-08 2022-08-02 国立大学法人東北大学 植物のカリウムイオン輸送体の機能制御剤及び植物の育成方法
JP7336133B2 (ja) * 2019-08-07 2023-08-31 国立大学法人東北大学 ジフェニル尿素化合物誘導体

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104890A (en) * 1989-03-28 1992-04-14 Fujisawa Pharmaceutical Company, Ltd. Benzopyran derivatives and processes for preparation thereof
CN1060467A (zh) * 1990-09-25 1992-04-22 武田药品工业株式会社 1，3-苯并嗪衍生物、其生产方法和用途
US5164509A (en) * 1990-11-26 1992-11-17 E. R. Squibb & Sons, Inc. Benzodiazolo analogs
DK41193D0 (da) * 1993-04-07 1993-04-07 Neurosearch As Ionkanalaabnere
US5416097A (en) * 1993-05-19 1995-05-16 Berlex Laboratories, Inc. Potassium channel activators/openers
US5679706A (en) * 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
EP0809492A4 (de) 1995-02-17 2007-01-24 Smithkline Beecham Corp Il-8 rezeptor antagonisten
DE69635751T2 (de) 1995-03-09 2006-10-26 University Of Utah Research Foundation, Salt Lake City "long qt" gene und methode zur diagnose oder prävention des "long qt" syndroms
EP0906273B1 (de) 1996-05-24 2002-10-16 Neurosearch A/S Saure gruppen enthaltende phenylderivate, ihre herstellung und ihre verwendung als chloridkanalblocker
EP0910358A1 (de) 1996-05-24 1999-04-28 Neurosearch A/S Phenylderivate als chloridkanalblocker
DK0977741T3 (da) * 1997-04-22 2003-12-01 Neurosearch As Substituerede phenylderivater, deres fremstilling og anvendelse
US5972894A (en) * 1997-08-07 1999-10-26 Cytran, Inc. Peptides having potassium channel opener activity
CN1162151C (zh) * 1998-01-14 2004-08-18 日本新药株式会社 钾通道激活剂
US6207383B1 (en) 1998-07-27 2001-03-27 University Of Utah Research Foundation Mutations in and genomic structure of HERG—a long QT syndrome gene
AP2001002103A0 (en) 1998-10-22 2001-03-31 Neurosearch As Substituted phenyl derivatives, their preparation and use.
US20030013136A1 (en) 2000-10-30 2003-01-16 Balser Jeffrey R. Human KCR1 regulation of HERG potassium channel block
JP2004535760A (ja) 2000-11-20 2004-12-02 メルク　エンド　カムパニー　インコーポレーテッド ヒトｅｒｇ２カリウムチャンネル
EP1361874A1 (de) * 2001-02-15 2003-11-19 Neurosearch A/S Behandlung von durch übermässigen oder unzureichendem zelltod gekennzeichneten erkrankungen
US20050080112A1 (en) * 2001-06-22 2005-04-14 Madsen Lars Siim Compounds for use in disorders associated with mast cell or basophil acitvity
NZ538513A (en) 2002-09-05 2007-02-23 Neurosearch As Diarylurea derivatives and their use as chloride channel blockers
WO2005023238A1 (en) * 2003-09-04 2005-03-17 Poseidon Pharmaceuticals A/S Erg channel openers for the treatment of hyperexcitability-related neuronal diseases
CA2630639A1 (en) 2005-11-21 2007-05-31 Tap Pharmaceutical Products, Inc. Treatment of qt interval prolongation and diseases associated therewith
US20090047703A1 (en) * 2007-08-17 2009-02-19 University Of Maryland, Baltimore ERG-1 Peptides and Polynucleotides and Their Use in the Treatment and Diagnosis of Disease

Also Published As

Publication number Publication date
CA2537746A1 (en) 2005-03-17
US7851492B2 (en) 2010-12-14
US20060281794A1 (en) 2006-12-14
EP1663192A1 (de) 2006-06-07
JP2011052004A (ja) 2011-03-17
JP2007504202A (ja) 2007-03-01
DE602004018162D1 (de) 2009-01-15
EP1663192B1 (de) 2008-12-03
AU2004269924A1 (en) 2005-03-17
MXPA06002315A (es) 2006-05-22
WO2005023237A1 (en) 2005-03-17
US20110071164A1 (en) 2011-03-24
CN1845726A (zh) 2006-10-11

Similar Documents

Publication Publication Date Title
GB0318447D0 (en) Therapeutic agents
ATE444293T1 (de) Cyclische sulfamide zur inhibierung von gamma- sekretase
NO20055741L (no) Nye kjemiske forbindelser
GB0223038D0 (en) Therapeutic compounds
MXPA05009694A (es) Metodos para mejorar la calidad de la piel.
SI3072978T1 (sl) 1L1RL-1 kot marker za kardiovaskularne bolezni
GB0225474D0 (en) Therapeutic agents
ATE473728T1 (de) Verwendung von fluoreszierenden perlylenverbindungen zur behandlung menschlicher haare
ATE389395T1 (de) Substituierte 2-aminotetraline zur vorbeugenden behandlung von morbus parkinson
WO2005046578A3 (en) Isoquinolinone potassium channel inhibitors
MY147404A (en) Process for preparation of n-benzoyl-staurosporine
ATE415959T1 (de) Herg1-kanal-öffner zur behandlung von herzarrythmien
ATE452134T1 (de) Zur behandlung von auf eine modulation des dopamin-d3-rezeptors ansprechende erkrankungen geeignete 4-piperazinylpyrimidinverbindungen
EA200702583A1 (ru) Использование фенилсемикарбазонов для обработки семян
EP1667685A4 (de) Chinazolin-kaliumkanalhemmer
SE0300850D0 (sv) Chemical compounds
ATE476419T1 (de) Isochinolinon-kaliumkanalinhibitoren
MXPA04005079A (es) Variantes del dominio c2 del factor viii.
SE0200844D0 (sv) Chemical compounds
SE0200843D0 (sv) Chemical compounds
MXPA05003818A (es) Perfilamiento de la expresion genica de muestras ffpe.
UA83821C2 (ru) Производные бензолсульфонамидов, способ их получения и их применение для лечения воспалительных заболеваний и утоления боли
EA200701584A1 (ru) Органические соединения, применяемые для лечения болезни альцгеймера, их применение и способ получения
DE602004030661D1 (de) Verwendung von kahalalide verbindungen zur herstellung eines arzneimittels zur behandlung von psoriasis
ATE536874T1 (de) Dreifache monoamin-wiederaufnahmehemmer zur behandlung von chronischen schmerzen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties