ATE407949T1 - Charakterisierung der proteinfamilie von soc/crac kalziumkanälen - Google Patents
Charakterisierung der proteinfamilie von soc/crac kalziumkanälenInfo
- Publication number
- ATE407949T1 ATE407949T1 AT99964281T AT99964281T ATE407949T1 AT E407949 T1 ATE407949 T1 AT E407949T1 AT 99964281 T AT99964281 T AT 99964281T AT 99964281 T AT99964281 T AT 99964281T AT E407949 T1 ATE407949 T1 AT E407949T1
- Authority
- AT
- Austria
- Prior art keywords
- soc
- characterization
- polypeptides
- protein family
- calcium channels
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Rheumatology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11422098P | 1998-12-30 | 1998-12-30 | |
US12001899P | 1999-01-29 | 1999-01-29 | |
US14041599P | 1999-06-22 | 1999-06-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE407949T1 true ATE407949T1 (de) | 2008-09-15 |
Family
ID=27381465
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99964281T ATE407949T1 (de) | 1998-12-30 | 1999-12-20 | Charakterisierung der proteinfamilie von soc/crac kalziumkanälen |
Country Status (8)
Country | Link |
---|---|
EP (2) | EP1141017B1 (de) |
JP (1) | JP2002536966A (de) |
AT (1) | ATE407949T1 (de) |
AU (1) | AU776672B2 (de) |
CA (1) | CA2360396A1 (de) |
DE (1) | DE69939553D1 (de) |
HK (1) | HK1041009B (de) |
WO (1) | WO2000040614A2 (de) |
Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60031390D1 (de) | 1999-04-26 | 2006-11-30 | Beth Israel Hospital | Nukleinsäure, die für polypeptide kodieren die eine mutt-domäne enthalten |
DE19953167A1 (de) * | 1999-11-04 | 2001-07-26 | Univ Mainz Johannes Gutenberg | Mit TRP-Proteinen verwandtes Protein MTR1 und dieses codierende DNA-Sequenz |
WO2001062794A2 (en) * | 2000-02-22 | 2001-08-30 | Millennium Pharmaceuticals, Inc. | 18607, a human calcium channel |
EP1143013A1 (de) | 2000-04-03 | 2001-10-10 | Warner-Lambert Company | Verfahren und Zusammenzetzungen zur Screening von ICRAC-Modulatoren |
EP1143017A3 (de) * | 2000-04-03 | 2004-01-28 | Warner-Lambert Company LLC | Methoden und Zusammensetzungen zum Screenen von icrac Modulatoren |
AU2001287639A1 (en) | 2000-07-28 | 2002-02-13 | Ulrich Wissenbach | Trp8, trp9 and trp10, markers for cancer |
AU2001280969A1 (en) * | 2000-07-31 | 2002-02-13 | Millennium Pharmaceuticals, Inc. | 18610, a human transient receptor and uses thereof |
US7087427B2 (en) | 2000-08-03 | 2006-08-08 | University Of Medicine & Dentistry Of New Jersey | Mammalian alpha-kinase proteins, nucleic acids and diagnostic and therapeutic uses thereof |
EP1184457A1 (de) * | 2000-09-05 | 2002-03-06 | Warner-Lambert Company | Identifizierung eines kapazitiven Calcium Kanals in Antigen-präsentierenden Zellen und dessen Verwendung |
EP1186661A1 (de) * | 2000-09-05 | 2002-03-13 | Warner-Lambert Company | Identifizierung eines kapazitativen Calcium Kanals in Antigen-präsentierenden Zellen und dessen Verwendung |
EP1337635B1 (de) * | 2000-11-13 | 2008-06-04 | The Queen's Medical Center | Humane ltrpc7 proteine, dafür kodierende nukleinsäuren und deren verwendungen |
EP1481060A4 (de) | 2001-05-22 | 2005-08-10 | Bristol Myers Squibb Co | Ein neues mitglied der trp-kanal-familie codierendes polynukleotid, trp-plik2, sowie spleissvarianten davon |
WO2003033727A1 (fr) * | 2001-10-12 | 2003-04-24 | Yamanouchi Pharmaceutical Co., Ltd. | Procede de criblage d'un inhibiteur de la mort cellulaire |
US7452675B2 (en) * | 2002-01-25 | 2008-11-18 | The Queen's Medical Center | Methods of screening for TRPM4b modulators |
US7371841B2 (en) | 2002-01-25 | 2008-05-13 | Regents Of The University Of California | Methods of modulating cold sensory perception |
EP1497328A2 (de) * | 2002-04-16 | 2005-01-19 | Bayer HealthCare AG | Regulierung des human transient receptor potential channel |
NZ547633A (en) | 2003-11-06 | 2010-08-27 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugation to ligands |
GB0407175D0 (en) * | 2004-03-30 | 2004-05-05 | Paradigm Therapeutics Ltd | Ion channel |
EP1735341A2 (de) | 2004-04-08 | 2006-12-27 | Janssen Pharmaceutica N.V. | Kälte- und menthol-sensitiver rezeptor 1 vom hunde |
CN102973947A (zh) | 2004-06-01 | 2013-03-20 | 健泰科生物技术公司 | 抗体-药物偶联物和方法 |
US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
WO2006034488A2 (en) | 2004-09-23 | 2006-03-30 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
JP2009533062A (ja) * | 2006-04-10 | 2009-09-17 | ザ・クイーンズ・メディカル・センター | Cracモジュレーターおよび創薬のためのその使用 |
US8431536B2 (en) | 2007-03-05 | 2013-04-30 | The University Of Queensland | Target for breast cancer therapy and/or diagnosis |
EP2145900A1 (de) * | 2008-07-15 | 2010-01-20 | CSL Behring GmbH | Orai1 (CRACM1) ist der Blutplättchen-SOC-Kanal und wesentlich für die pathologischen Thrombusbildung |
IN2012DN03025A (de) | 2009-09-09 | 2015-07-31 | Ct Se Llc | |
NZ602241A (en) | 2010-04-15 | 2015-03-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
CN114246952A (zh) | 2010-06-08 | 2022-03-29 | 基因泰克公司 | 半胱氨酸改造的抗体和偶联物 |
CN103313990B (zh) | 2010-11-17 | 2016-07-20 | 基因泰克公司 | 丙氨酰美登醇抗体偶联物 |
WO2012155019A1 (en) | 2011-05-12 | 2012-11-15 | Genentech, Inc. | Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature pepides |
BR112014009050B1 (pt) | 2011-10-14 | 2022-06-21 | Medimmune Limited | Conjugado anticorpo-fármaco de pirrolbenzodiazepinas, composição farmacêutica que compreende o mesmo, bem como compostos de pirrolbenzodiazepinas |
WO2013130093A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarkers for treatment with anti-tubulin chemotherapeutic compounds |
EP2906253B9 (de) | 2012-10-12 | 2019-04-10 | ADC Therapeutics SA | Pyrrolobenzodiazepin-anti-psma-antikörperkonjugate |
ES2660029T3 (es) | 2012-10-12 | 2018-03-20 | Medimmune Limited | Conjugados de anticuerpo-pirrolobenzodiazepinas |
PL2906296T3 (pl) | 2012-10-12 | 2018-09-28 | Adc Therapeutics Sa | Koniugaty pirolobenzodiazepina-przeciwciało |
WO2014057114A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-anti-psma antibody conjugates |
JP6392763B2 (ja) | 2012-10-12 | 2018-09-19 | エイディーシー・セラピューティクス・エス・アーAdc Therapeutics Sa | ピロロベンゾジアゼピン−抗体結合体 |
EA035405B1 (ru) | 2012-10-12 | 2020-06-08 | Медимьюн Лимитед | Пирролбензодиазепины и их конъюгаты |
JP6392765B2 (ja) | 2012-10-12 | 2018-09-19 | エイディーシー・セラピューティクス・エス・アーAdc Therapeutics Sa | ピロロベンゾジアゼピン−抗体結合体 |
US9562049B2 (en) | 2012-12-21 | 2017-02-07 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
WO2014096365A1 (en) | 2012-12-21 | 2014-06-26 | Spirogen Sàrl | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
TWI680766B (zh) | 2013-03-13 | 2020-01-01 | 英商梅迪繆思有限公司 | 吡咯并苯并二氮呯及其共軛物 |
JP6444902B2 (ja) | 2013-03-13 | 2018-12-26 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピン及びその結合体 |
JP6340019B2 (ja) | 2013-03-13 | 2018-06-06 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピン及びそのコンジュゲート |
AU2014307080B2 (en) | 2013-08-12 | 2018-06-07 | Genentech, Inc. | 1-(chloromethyl)-2,3-dihydro-1H-benzo(E)indole dimer antibody-drug conjugate compounds, and methods of use and treatment |
WO2015052535A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
US10010624B2 (en) | 2013-10-11 | 2018-07-03 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
US9950078B2 (en) | 2013-10-11 | 2018-04-24 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
EP3082876B1 (de) | 2013-12-16 | 2018-01-17 | Genentech, Inc. | 1-(chlormethyl)-2,3-dihydro-1h-benzo[e]indoldimer-antikörper-wirkstoff-konjugatverbindungen und verfahren zur verwendung und behandlung |
JP6895254B2 (ja) | 2013-12-16 | 2021-06-30 | ジェネンテック, インコーポレイテッド | ペプチド模倣化合物及びその抗体−薬物コンジュゲート |
KR102354207B1 (ko) | 2013-12-16 | 2022-01-20 | 제넨테크, 인크. | 펩티드모방체 화합물 및 그의 항체-약물 접합체 |
EP3193940A1 (de) | 2014-09-10 | 2017-07-26 | Medimmune Limited | Pyrrolobenzodiazepine und konjugate daraus |
KR20170052600A (ko) | 2014-09-12 | 2017-05-12 | 제넨테크, 인크. | 시스테인 가공된 항체 및 콘주게이트 |
GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
EP3191134B1 (de) | 2014-09-12 | 2019-11-20 | Genentech, Inc. | Anthracyclindisulfidzwischenprodukte, antikörper-wirkstoff-konjugate und verfahren |
CN107073136A (zh) | 2014-09-17 | 2017-08-18 | 健泰科生物技术公司 | 吡咯并苯并二氮杂卓及其抗体二硫化物偶联物 |
US10780096B2 (en) | 2014-11-25 | 2020-09-22 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
CN107206101B (zh) | 2014-12-03 | 2021-06-25 | 基因泰克公司 | 季铵化合物及其抗体-药物缀合物 |
SG11201706293XA (en) | 2015-02-04 | 2017-09-28 | Hoffmann La Roche | Tau antisense oligomers and uses thereof |
CN115181778A (zh) * | 2015-02-04 | 2022-10-14 | 百时美施贵宝公司 | 选择治疗性分子的方法 |
GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
MA45326A (fr) | 2015-10-20 | 2018-08-29 | Genentech Inc | Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation |
GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
JP6943872B2 (ja) | 2016-03-25 | 2021-10-06 | ジェネンテック, インコーポレイテッド | 多重全抗体及び抗体複合体化薬物定量化アッセイ |
GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
PL3458101T3 (pl) | 2016-05-20 | 2021-05-31 | F. Hoffmann-La Roche Ag | Koniugaty PROTAC-przeciwciało i sposoby ich stosowania |
WO2017205741A1 (en) | 2016-05-27 | 2017-11-30 | Genentech, Inc. | Bioanalytical method for the characterization of site-specific antibody-drug conjugates |
CN109476648B (zh) | 2016-06-06 | 2022-09-13 | 豪夫迈·罗氏有限公司 | 司维司群抗体-药物缀合物和使用方法 |
EP3496763A1 (de) | 2016-08-11 | 2019-06-19 | Genentech, Inc. | Pyrrolobenzodiazepin-prodrugs und antikörperkonjugate davon |
CN110139674B (zh) | 2016-10-05 | 2023-05-16 | 豪夫迈·罗氏有限公司 | 制备抗体药物缀合物的方法 |
GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
UA125198C2 (uk) | 2017-02-08 | 2022-01-26 | Ейдісі Терапьютікс Са | Кон'югати піролобензодіазепін-антитіло |
GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
HUE059828T2 (hu) | 2017-04-18 | 2023-01-28 | Medimmune Ltd | Pirrolobenzodiazepin konjugátumok |
EP3612234B1 (de) | 2017-04-20 | 2024-03-13 | ADC Therapeutics SA | Kombinationstherapie mit anti-axl-antikörper-arzneimittel-konjugat |
US11318211B2 (en) | 2017-06-14 | 2022-05-03 | Adc Therapeutics Sa | Dosage regimes for the administration of an anti-CD19 ADC |
KR102270107B1 (ko) | 2017-08-18 | 2021-06-30 | 메디뮨 리미티드 | 피롤로벤조디아제핀 컨쥬게이트 |
JP2020534300A (ja) | 2017-09-20 | 2020-11-26 | ピーエイチ・ファーマ・カンパニー・リミテッドPh Pharma Co., Ltd. | タイランスタチン類似体 |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
TW202037381A (zh) | 2018-10-24 | 2020-10-16 | 瑞士商赫孚孟拉羅股份公司 | 綴合化學降解誘導劑及使用方法 |
EP3894427A1 (de) | 2018-12-10 | 2021-10-20 | Genentech, Inc. | Photovernetzende peptide zur stellenspezifischen konjugation an fc-haltige proteine |
GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
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US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
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US5672344A (en) | 1987-12-30 | 1997-09-30 | The Regents Of The University Of Michigan | Viral-mediated gene transfer system |
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-
1999
- 1999-12-20 EP EP99964281A patent/EP1141017B1/de not_active Expired - Lifetime
- 1999-12-20 DE DE69939553T patent/DE69939553D1/de not_active Expired - Lifetime
- 1999-12-20 CA CA002360396A patent/CA2360396A1/en not_active Abandoned
- 1999-12-20 AT AT99964281T patent/ATE407949T1/de not_active IP Right Cessation
- 1999-12-20 AU AU20556/00A patent/AU776672B2/en not_active Ceased
- 1999-12-20 WO PCT/US1999/029996 patent/WO2000040614A2/en active IP Right Grant
- 1999-12-20 JP JP2000592322A patent/JP2002536966A/ja active Pending
- 1999-12-20 EP EP08163994A patent/EP2006300A3/de not_active Withdrawn
-
2002
- 2002-04-09 HK HK02102643.5A patent/HK1041009B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2000040614A9 (en) | 2001-08-30 |
EP2006300A3 (de) | 2009-03-11 |
WO2000040614A3 (en) | 2001-02-22 |
EP1141017A2 (de) | 2001-10-10 |
AU776672B2 (en) | 2004-09-16 |
HK1041009B (zh) | 2009-05-08 |
DE69939553D1 (de) | 2008-10-23 |
AU2055600A (en) | 2000-07-24 |
CA2360396A1 (en) | 2000-07-13 |
EP2006300A2 (de) | 2008-12-24 |
JP2002536966A (ja) | 2002-11-05 |
HK1041009A1 (en) | 2002-06-28 |
EP1141017B1 (de) | 2008-09-10 |
WO2000040614A2 (en) | 2000-07-13 |
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