ATE406176T1 - Il-1-inhibitor in kombinationstherapie zur behandlung il-1-vermittelter krankheiten - Google Patents
Il-1-inhibitor in kombinationstherapie zur behandlung il-1-vermittelter krankheitenInfo
- Publication number
- ATE406176T1 ATE406176T1 AT97954087T AT97954087T ATE406176T1 AT E406176 T1 ATE406176 T1 AT E406176T1 AT 97954087 T AT97954087 T AT 97954087T AT 97954087 T AT97954087 T AT 97954087T AT E406176 T1 ATE406176 T1 AT E406176T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitor
- treatment
- combination therapy
- mediated diseases
- methotrexate
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3279096P | 1996-12-06 | 1996-12-06 | |
US3635397P | 1997-01-23 | 1997-01-23 | |
US3931197P | 1997-02-07 | 1997-02-07 | |
US5202597P | 1997-07-09 | 1997-07-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE406176T1 true ATE406176T1 (de) | 2008-09-15 |
Family
ID=27488035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97954087T ATE406176T1 (de) | 1996-12-06 | 1997-12-08 | Il-1-inhibitor in kombinationstherapie zur behandlung il-1-vermittelter krankheiten |
Country Status (10)
Country | Link |
---|---|
US (3) | US20030072756A1 (de) |
EP (2) | EP0949931B1 (de) |
JP (3) | JP4771563B2 (de) |
AT (1) | ATE406176T1 (de) |
AU (1) | AU736876B2 (de) |
CA (1) | CA2273852C (de) |
DE (1) | DE69738948D1 (de) |
ES (2) | ES2615357T3 (de) |
HK (1) | HK1023501A1 (de) |
WO (1) | WO1998024477A1 (de) |
Families Citing this family (49)
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US7091181B2 (en) | 1994-12-12 | 2006-08-15 | Omeros Corporation | Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors |
ES2615357T3 (es) * | 1996-12-06 | 2017-06-06 | Amgen Inc. | Terapia de combinación usando un inhibidor de IL-1 para tratar enfermedades mediadas por IL-1 |
US6294170B1 (en) | 1997-08-08 | 2001-09-25 | Amgen Inc. | Composition and method for treating inflammatory diseases |
US6927044B2 (en) * | 1998-09-25 | 2005-08-09 | Regeneron Pharmaceuticals, Inc. | IL-1 receptor based cytokine traps |
US7067144B2 (en) | 1998-10-20 | 2006-06-27 | Omeros Corporation | Compositions and methods for systemic inhibition of cartilage degradation |
US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
PL219605B1 (pl) | 1998-10-23 | 2015-06-30 | Kirin Amgen Inc | Dimeryczne mimetyki peptydów trombopoetynowych wiążące się z receptorem MP1 i wykazujące aktywność trombopoetyczną |
US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
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AU6376700A (en) * | 1999-07-28 | 2001-02-19 | Schering Corporation | Combined use of interleukin 10 and methotrexate for immuno-modulatory therapy |
EP1095661A1 (de) * | 1999-11-01 | 2001-05-02 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Vorbeugung und Behandlung von Infektionen assoziiert mit Biomaterialien |
US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
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DE10132308A1 (de) * | 2001-07-06 | 2003-01-30 | Aventis Behring Gmbh | Kombinationspräparat zur Therapie von immunologischen Erkrankungen |
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US7429378B2 (en) | 2003-05-13 | 2008-09-30 | Depuy Spine, Inc. | Transdiscal administration of high affinity anti-MMP inhibitors |
US8273347B2 (en) | 2003-05-13 | 2012-09-25 | Depuy Spine, Inc. | Autologous treatment of degenerated disc with cells |
US7344716B2 (en) | 2003-05-13 | 2008-03-18 | Depuy Spine, Inc. | Transdiscal administration of specific inhibitors of pro-inflammatory cytokines |
US7553827B2 (en) | 2003-08-13 | 2009-06-30 | Depuy Spine, Inc. | Transdiscal administration of cycline compounds |
US8361467B2 (en) | 2003-07-30 | 2013-01-29 | Depuy Spine, Inc. | Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints |
US8895540B2 (en) | 2003-11-26 | 2014-11-25 | DePuy Synthes Products, LLC | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor |
WO2006035876A1 (ja) * | 2004-09-29 | 2006-04-06 | Kowa Co., Ltd. | 関節リウマチの予防及び/又は治療薬 |
BRPI0518622A2 (pt) * | 2004-12-02 | 2008-12-02 | Domantis Ltd | usos de antagonistas de receptor do tipo 1 de interleucina-1(il-1r1) para a fabricaÇço de um medicamento para o tratamento de uma doenÇa respiratària; composiÇço farmacÊutica que compreende um antagonista do il-1r1 e um veÍculo fisiologicamente aceitÁvel e dispositivo de liberaÇço de medicamento |
WO2006076673A2 (en) * | 2005-01-14 | 2006-07-20 | Regeneron Pharmaceuticals, Inc. | Use of il-i antagonists to treat polymyalgia rheumatica and giant cell arteritis |
WO2006104172A1 (ja) * | 2005-03-29 | 2006-10-05 | Kowa Co., Ltd. | 関節リウマチの予防及び/又は治療薬 |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
EP1920772A4 (de) * | 2005-08-31 | 2010-11-17 | Kowa Co | Prophylaktisches und/oder therapeutisches verfahren für rheumatoide arthritis |
JPWO2007049732A1 (ja) * | 2005-10-28 | 2009-04-30 | 興和株式会社 | 関節リウマチの予防及び/又は治療法 |
US20080311111A1 (en) * | 2005-12-01 | 2008-12-18 | Drew Philip D | Competitive Domain Antibody Formats That Bind Interleukin 1 Receptor Type 1 |
WO2008001499A1 (fr) * | 2006-06-29 | 2008-01-03 | Kowa Co., Ltd. | Agent prophylactique et/ou thérapeutique pour le traitement de la polyarthrite rhumatoïde |
WO2009025763A2 (en) * | 2007-08-16 | 2009-02-26 | Schepens Eye Research Institute | Therapeutic compositions for treatment of inflammation of ocular and adnexal tissues |
US8986696B2 (en) | 2007-12-21 | 2015-03-24 | Depuy Mitek, Inc. | Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints |
US10106587B2 (en) | 2008-02-27 | 2018-10-23 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
US8753690B2 (en) * | 2008-02-27 | 2014-06-17 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
US20110045522A1 (en) * | 2009-08-20 | 2011-02-24 | Danchen Gao | Methods for diagnosing diabetes and determining effectiveness of treatments |
AU2010292486B2 (en) | 2009-08-27 | 2014-08-07 | Biomet Biologics, Llc | Implantable device for production of interleukin-1 receptor antagonist |
PL3470421T3 (pl) | 2010-07-29 | 2023-10-23 | Buzzard Pharmaceuticals AB | Chimeryczne antagonisty receptora il-1 typu i |
WO2012078101A1 (en) * | 2010-12-07 | 2012-06-14 | Swedish Orphan Biovitrum Ab (Publ) | Method for the treatment of il-1 mediated diseases |
RU2014107743A (ru) * | 2011-07-29 | 2015-09-10 | Илэвэн Байотерапьютикс, Инк. | Очищенные белки |
JP6450364B2 (ja) | 2013-03-13 | 2019-01-09 | セセン バイオ, インコーポレイテッド | 眼送達のためのキメラサイトカイン製剤 |
US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
US9758806B2 (en) | 2013-03-15 | 2017-09-12 | Biomet Biologics, Llc | Acellular compositions for treating inflammatory disorders |
US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
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-
1997
- 1997-12-08 ES ES08014990.9T patent/ES2615357T3/es not_active Expired - Lifetime
- 1997-12-08 WO PCT/US1997/022720 patent/WO1998024477A1/en active IP Right Grant
- 1997-12-08 EP EP97954087A patent/EP0949931B1/de not_active Expired - Lifetime
- 1997-12-08 ES ES97954087T patent/ES2312179T3/es not_active Expired - Lifetime
- 1997-12-08 CA CA002273852A patent/CA2273852C/en not_active Expired - Lifetime
- 1997-12-08 JP JP52589298A patent/JP4771563B2/ja not_active Expired - Lifetime
- 1997-12-08 EP EP08014990.9A patent/EP2002846B1/de not_active Expired - Lifetime
- 1997-12-08 DE DE69738948T patent/DE69738948D1/de not_active Expired - Lifetime
- 1997-12-08 AU AU57955/98A patent/AU736876B2/en not_active Expired
- 1997-12-08 AT AT97954087T patent/ATE406176T1/de not_active IP Right Cessation
-
2000
- 2000-04-18 HK HK00102322.5A patent/HK1023501A1/xx not_active IP Right Cessation
-
2002
- 2002-10-04 US US10/265,037 patent/US20030072756A1/en not_active Abandoned
-
2003
- 2003-07-16 US US10/621,784 patent/US20040044001A1/en not_active Abandoned
-
2006
- 2006-07-31 JP JP2006209209A patent/JP2006306890A/ja not_active Withdrawn
-
2008
- 2008-08-29 JP JP2008222907A patent/JP2009007380A/ja not_active Withdrawn
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- 2009-02-27 US US12/380,535 patent/US20090203609A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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AU5795598A (en) | 1998-06-29 |
EP0949931B1 (de) | 2008-08-27 |
ES2312179T3 (es) | 2009-02-16 |
JP2002509529A (ja) | 2002-03-26 |
EP2002846B1 (de) | 2017-01-25 |
HK1023501A1 (en) | 2000-09-15 |
US20040044001A1 (en) | 2004-03-04 |
CA2273852C (en) | 2009-09-29 |
US20030072756A1 (en) | 2003-04-17 |
AU736876B2 (en) | 2001-08-02 |
WO1998024477A1 (en) | 1998-06-11 |
DE69738948D1 (de) | 2008-10-09 |
EP2002846A2 (de) | 2008-12-17 |
CA2273852A1 (en) | 1998-06-11 |
ES2615357T3 (es) | 2017-06-06 |
JP2009007380A (ja) | 2009-01-15 |
EP0949931A1 (de) | 1999-10-20 |
JP2006306890A (ja) | 2006-11-09 |
EP2002846A3 (de) | 2009-01-14 |
JP4771563B2 (ja) | 2011-09-14 |
US20090203609A1 (en) | 2009-08-13 |
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