ATE404577T1 - Verfahren zur herstellung von eplerenon - Google Patents

Verfahren zur herstellung von eplerenon

Info

Publication number: ATE404577T1
Authority: AT; Austria
Prior art keywords: eplerenone; producing; producing eplerenone; 7alpha; processes
Prior art date: 2002-03-22

Application number

AT03745535T

Other languages

English (en)

Inventor

Bruce Pearlman

Amphlett Padilla

Jeffrey Havens

Sonja Mackey

Haifeng Wu

Original Assignee

Pharmacia & Upjohn Co Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-22

Filing date

2003-03-21

Publication date

2008-08-15

2003-03-21 Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc

2008-08-15 Application granted granted Critical

2008-08-15 Publication of ATE404577T1 publication Critical patent/ATE404577T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Catalysts (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT03745535T 2002-03-22 2003-03-21 Verfahren zur herstellung von eplerenon ATE404577T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US36678402P	2002-03-22	2002-03-22
US41187402P	2002-09-19	2002-09-19
US42559602P	2002-11-12	2002-11-12

Publications (1)

Publication Number	Publication Date
ATE404577T1 true ATE404577T1 (de)	2008-08-15

Family

ID=28678917

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03745535T ATE404577T1 (de)	2002-03-22	2003-03-21	Verfahren zur herstellung von eplerenon

Country Status (23)

Country	Link
US (2)	US20040024202A1 (de)
EP (2)	EP1490390A2 (de)
JP (2)	JP2005528371A (de)
KR (3)	KR20040097201A (de)
CN (2)	CN1653081A (de)
AT (1)	ATE404577T1 (de)
AU (2)	AU2003259022A1 (de)
BR (2)	BR0308660A (de)
CA (2)	CA2474072A1 (de)
CY (1)	CY1108453T1 (de)
DE (1)	DE60322852D1 (de)
DK (1)	DK1487859T3 (de)
ES (1)	ES2310666T3 (de)
HK (1)	HK1078588A1 (de)
IL (2)	IL164159A0 (de)
MX (2)	MXPA04009178A (de)
MY (1)	MY138479A (de)
PL (2)	PL372460A1 (de)
PT (1)	PT1487859E (de)
RS (2)	RS90504A (de)
SI (1)	SI1487859T1 (de)
TW (2)	TW200401781A (de)
WO (2)	WO2003082895A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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US7235655B2 (en)	2002-03-22	2007-06-26	Pharmacia & Upjohn Company	Processes to prepare eplerenone
CL2004000574A1 (es) *	2003-03-21	2005-02-11	Pharmacia Corp Sa Organizada B	Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion.
HUP0402466A2 (en) *	2004-11-30	2006-07-28	Richter Gedeon Vegyeszet	Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
CN1310941C (zh) *	2005-07-13	2007-04-18	南京大学	依普利酮的合成方法
CN1321128C (zh) *	2005-07-15	2007-06-13	浙江医药股份有限公司新昌制药厂	孕甾－4－烯－7，21－二甲酸，9，11－环氧－17－羟基－3－氧代，γ－内酯，甲酯，(7α,11α,17α)－的制备方法
WO2007025780A2 (en) *	2005-09-02	2007-03-08	Recordati Ireland Limited	Aldosterone receptor antagonists
JP2007297352A (ja) *	2006-05-02	2007-11-15	Toho Earthtech Inc	ヨウ化アルキルの製造方法および２−アルキル置換シクロヘキサノンの製造方法
US20130252288A1 (en) *	2007-07-11	2013-09-26	Stefaan Marie André De Wildeman	Enantioselective reduction
EP2265629B1 (de) *	2008-03-05	2015-06-24	Evestra, Inc.	Bismethylen-17-carbolactone und damit in zusammenhang stehende anwendungen
EP2367808A4 (de) *	2008-11-25	2012-05-09	Evestra Inc	PROGESTATIVE 3-(6,6-ETHYLEN-17b-HYDROXY-3-OXO-17a-PREGNA-4-EN-17a-YL) PROPIONSÄURE-g-LACTONE
CN102464551B (zh) *	2010-11-17	2014-03-26	中国石油化工股份有限公司	异丁烯歧化反应制四甲基乙烯的方法
EP3009443B1 (de)	2014-10-17	2018-09-12	INDUSTRIALE CHIMICA S.r.l.	Verfahren zur herstellung von 7alfa-(methoxycarbonyl)-3-oxo-17alfa-pregn-4,9(11)-dien-21,17-carbolacton, nützliches zwischenprodukt zur synthese von molekülen mit pharmakologischer wirkung
CN105753930A (zh) *	2016-03-30	2016-07-13	北京万全德众医药生物技术有限公司	依普利酮的一种合成方法
CN108003156B (zh) *	2018-01-29	2021-04-20	辽宁科技大学	一种咪唑并吡啶基1,2-乙二酮衍生物的合成方法

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US3413288A (en) *	1965-07-07	1968-11-26	Parke Davis & Co	Process for the production of steroidal c-17 spirolactones
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DE2404947C2 (de) *	1973-02-06	1983-04-21	Roussel-Uclaf, 75007 Paris	Steroidspirolactone, Verfahren zu ihrer Herstellung und deren Verwendung
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JPS59139400A (ja) *	1983-01-31	1984-08-10	Shionogi & Co Ltd	抗アルドステロン活性ステロイド誘導体
FI77669C (fi) *	1983-04-13	1989-04-10	Ciba Geigy Ag	20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat.
EP0263569B1 (de) *	1986-10-10	1992-12-09	Roussel-Uclaf	9-Alpha-Hydroxysteroide, Verfahren zu ihrer Herstellung und Verfahren zur Herstellung der entsprechenden 9(11)-Dehydro-Derivate.
FR2610933B1 (fr) *	1987-02-18	1989-06-09	Roussel Uclaf	Nouveaux 19-nor steroides substitues en position 7, leur preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant
DE3903988A1 (de) *	1989-02-10	1990-08-30	Basf Ag	Oxidierte diphenylheteroalkane, ihre herstellung und verwendung
US5227375A (en) *	1990-02-08	1993-07-13	Endorecherche, Inc.	Aromatase inhibitors
AU680818B2 (en) *	1992-05-21	1997-08-14	Endorecherche Inc.	Improved antiandrogens
US5502222A (en) *	1994-06-01	1996-03-26	Schering Corporation	Process for preparing delta 9,11 and 21-chloro corticosteroids
PT973791E (pt) *	1995-12-11	2007-09-26	Searle Llc	Processo para a preparação de um composto epoxi
ES2186017T3 (es) *	1996-12-11	2003-05-01	Searle & Co	Procedimientos para la preparacion de delta 4,5-esteroides 3-ceto-7alfa-alcoxicarbonil-sustituidos y compuestos intermedios de utilidad en los mismos.
US6887991B1 (en) *	1996-12-11	2005-05-03	G. D. Searle & Company	Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
US7235655B2 (en) *	2002-03-22	2007-06-26	Pharmacia & Upjohn Company	Processes to prepare eplerenone

2003
- 2003-03-21 IL IL16415903A patent/IL164159A0/xx unknown
- 2003-03-21 WO PCT/US2003/007793 patent/WO2003082895A2/en active Application Filing
- 2003-03-21 IL IL16416603A patent/IL164166A0/xx unknown
- 2003-03-21 RS YU90504A patent/RS90504A/sr unknown
- 2003-03-21 MX MXPA04009178A patent/MXPA04009178A/es not_active Application Discontinuation
- 2003-03-21 AT AT03745535T patent/ATE404577T1/de active
- 2003-03-21 KR KR10-2004-7014916A patent/KR20040097201A/ko active IP Right Grant
- 2003-03-21 AU AU2003259022A patent/AU2003259022A1/en not_active Abandoned
- 2003-03-21 JP JP2003580358A patent/JP2005528371A/ja not_active Withdrawn
- 2003-03-21 US US10/392,857 patent/US20040024202A1/en not_active Abandoned
- 2003-03-21 DK DK03745535T patent/DK1487859T3/da active
- 2003-03-21 PL PL03372460A patent/PL372460A1/xx unknown
- 2003-03-21 WO PCT/US2003/007792 patent/WO2003082894A2/en active Application Filing
- 2003-03-21 KR KR1020047014956A patent/KR20050028907A/ko not_active Application Discontinuation
- 2003-03-21 RS YU83104A patent/RS83104A/sr unknown
- 2003-03-21 CA CA002474072A patent/CA2474072A1/en not_active Abandoned
- 2003-03-21 DE DE60322852T patent/DE60322852D1/de not_active Expired - Lifetime
- 2003-03-21 EP EP03716548A patent/EP1490390A2/de not_active Withdrawn
- 2003-03-21 JP JP2003580359A patent/JP2005523306A/ja not_active Ceased
- 2003-03-21 BR BR0308660-7A patent/BR0308660A/pt not_active IP Right Cessation
- 2003-03-21 ES ES03745535T patent/ES2310666T3/es not_active Expired - Lifetime
- 2003-03-21 SI SI200331329T patent/SI1487859T1/sl unknown
- 2003-03-21 EP EP03745535A patent/EP1487859B1/de not_active Expired - Lifetime
- 2003-03-21 TW TW092106344A patent/TW200401781A/zh unknown
- 2003-03-21 BR BR0308466-3A patent/BR0308466A/pt not_active IP Right Cessation
- 2003-03-21 CN CNA038113430A patent/CN1653081A/zh active Pending
- 2003-03-21 AU AU2003220251A patent/AU2003220251A1/en not_active Abandoned
- 2003-03-21 MX MXPA04009216A patent/MXPA04009216A/es unknown
- 2003-03-21 PL PL03373189A patent/PL373189A1/xx unknown
- 2003-03-21 PT PT03745535T patent/PT1487859E/pt unknown
- 2003-03-21 KR KR1020107027095A patent/KR20100131018A/ko not_active Application Discontinuation
- 2003-03-21 CN CNB038065908A patent/CN100473660C/zh not_active Expired - Lifetime
- 2003-03-21 CA CA002480151A patent/CA2480151A1/en not_active Abandoned
- 2003-03-21 TW TW092106310A patent/TWI283245B/zh active
- 2003-03-22 MY MYPI20031014A patent/MY138479A/en unknown
2005
- 2005-11-18 HK HK05110391.9A patent/HK1078588A1/xx not_active IP Right Cessation
2006
- 2006-12-21 US US11/614,538 patent/US20070129332A1/en not_active Abandoned
2008
- 2008-10-24 CY CY20081101205T patent/CY1108453T1/el unknown

Also Published As

Publication number	Publication date
MXPA04009216A (es)	2005-01-25
WO2003082895A2 (en)	2003-10-09
HK1078588A1 (en)	2006-03-17
SI1487859T1 (sl)	2008-10-31
KR20050028907A (ko)	2005-03-23
WO2003082895A3 (en)	2004-04-22
US20070129332A1 (en)	2007-06-07
CN1653081A (zh)	2005-08-10
RS90504A (en)	2006-10-27
ES2310666T3 (es)	2009-01-16
EP1490390A2 (de)	2004-12-29
EP1487859A2 (de)	2004-12-22
US20040024202A1 (en)	2004-02-05
KR20040097201A (ko)	2004-11-17
TW200404079A (en)	2004-03-16
CA2474072A1 (en)	2003-10-09
TW200401781A (en)	2004-02-01
EP1487859B1 (de)	2008-08-13
CN100473660C (zh)	2009-04-01
MXPA04009178A (es)	2004-11-26
BR0308466A (pt)	2005-04-26
BR0308660A (pt)	2005-01-25
PT1487859E (pt)	2008-10-23
DE60322852D1 (de)	2008-09-25
AU2003259022A1 (en)	2003-10-13
TWI283245B (en)	2007-07-01
AU2003220251A1 (en)	2003-10-13
CN1633445A (zh)	2005-06-29
MY138479A (en)	2009-06-30
RS83104A (en)	2006-10-27
PL373189A1 (en)	2005-08-22
IL164166A0 (en)	2005-12-18
CA2480151A1 (en)	2003-10-09
WO2003082894A2 (en)	2003-10-09
PL372460A1 (en)	2005-07-25
CY1108453T1 (el)	2014-04-09
JP2005523306A (ja)	2005-08-04
KR20100131018A (ko)	2010-12-14
IL164159A0 (en)	2005-12-18
JP2005528371A (ja)	2005-09-22
DK1487859T3 (da)	2008-10-06
WO2003082894A3 (en)	2004-04-15

Legal Events

Date

Code

Title

Description

2009-01-15

UEP

Publication of translation of european patent specification

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