ATE542810T1 - Verfahren zur herstellung von 3,5-di-omikron-acyl-2-fluor-2-c-methyl-d-ribono gamma-lacton - Google Patents

Verfahren zur herstellung von 3,5-di-omikron-acyl-2-fluor-2-c-methyl-d-ribono gamma-lacton

Info

Publication number
ATE542810T1
ATE542810T1 AT07857390T AT07857390T ATE542810T1 AT E542810 T1 ATE542810 T1 AT E542810T1 AT 07857390 T AT07857390 T AT 07857390T AT 07857390 T AT07857390 T AT 07857390T AT E542810 T1 ATE542810 T1 AT E542810T1
Authority
AT
Austria
Prior art keywords
methyl
ribono
lactone
acyl
omikron
Prior art date
Application number
AT07857390T
Other languages
English (en)
Inventor
Miall Cedilote
Thomas P Cleary
Hans Iding
Pingsheng Zhang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE542810T1 publication Critical patent/ATE542810T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
AT07857390T 2006-12-18 2007-12-11 Verfahren zur herstellung von 3,5-di-omikron-acyl-2-fluor-2-c-methyl-d-ribono gamma-lacton ATE542810T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87561706P 2006-12-18 2006-12-18
PCT/EP2007/063703 WO2008074693A2 (en) 2006-12-18 2007-12-11 Process for preparing 3,5-di-omicron-acyl-2-fluoro-2-c-methyl-d-ribono-gamma-lactone

Publications (1)

Publication Number Publication Date
ATE542810T1 true ATE542810T1 (de) 2012-02-15

Family

ID=39433788

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07857390T ATE542810T1 (de) 2006-12-18 2007-12-11 Verfahren zur herstellung von 3,5-di-omikron-acyl-2-fluor-2-c-methyl-d-ribono gamma-lacton

Country Status (13)

Country Link
US (1) US7838693B2 (de)
EP (1) EP2094679B1 (de)
JP (1) JP5148627B2 (de)
KR (1) KR101118413B1 (de)
CN (1) CN101573349B (de)
AT (1) ATE542810T1 (de)
AU (1) AU2007336365B2 (de)
BR (1) BRPI0720835A2 (de)
CA (1) CA2671856C (de)
ES (1) ES2379696T3 (de)
IL (1) IL198801A (de)
MX (1) MX2009006156A (de)
WO (1) WO2008074693A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103724301A (zh) 2012-10-10 2014-04-16 上海特化医药科技有限公司 (2r)-2-脱氧-2,2-二取代-1,4-核糖内酯及其制备方法和用途
CN104918924B (zh) * 2013-01-14 2018-05-11 吉利德制药有限责任公司 制备氟代内酯衍生物的方法
AR094466A1 (es) * 2013-01-14 2015-08-05 Hoffmann La Roche Proceso para la obtención de un derivado de fluorlactona
JP6394588B2 (ja) * 2013-02-28 2018-09-26 セントラル硝子株式会社 （２Ｒ）−２−フルオロ−２−Ｃ−メチル−Ｄ−リボノ−γ−ラクトンの製造方法
JP6476591B2 (ja) * 2013-06-05 2019-03-06 セントラル硝子株式会社 （２Ｒ）−２−フルオロ−２−Ｃ−メチル−Ｄ−リボノ−γ−ラクトン類の製造方法
CN105085445B (zh) * 2015-08-11 2016-09-07 海门慧聚药业有限公司 索非布韦中间体的制备

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1243434A4 (de) * 2000-11-30 2006-05-24 Daicel Chem Übertragungsblatt
EP2308861B1 (de) * 2002-03-08 2017-03-01 Eisai R&D Management Co., Ltd. Macrocyclische verbindungen verwendbar als arzneitmitteln
ES2726998T3 (es) * 2003-05-30 2019-10-11 Gilead Pharmasset Llc Análogos de nucleósidos fluorados modificados
WO2006012440A2 (en) * 2004-07-21 2006-02-02 Pharmasset, Inc. Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives
PT3109244T (pt) * 2004-09-14 2019-06-04 Gilead Pharmasset Llc ¿preparação de ribofuranosil pirimidinas e purinas 2¿-fluoro-2¿-alquil substituídas ou outras opcionalmente substituídas e os seus derivados

Also Published As

Publication number Publication date
JP2010513377A (ja) 2010-04-30
WO2008074693A3 (en) 2008-10-30
AU2007336365A1 (en) 2008-06-26
EP2094679B1 (de) 2012-01-25
US7838693B2 (en) 2010-11-23
CN101573349B (zh) 2013-07-10
CN101573349A (zh) 2009-11-04
US20080145901A1 (en) 2008-06-19
AU2007336365B2 (en) 2013-03-07
IL198801A (en) 2013-08-29
BRPI0720835A2 (pt) 2015-09-29
KR20090080562A (ko) 2009-07-24
WO2008074693A2 (en) 2008-06-26
CA2671856A1 (en) 2008-06-26
JP5148627B2 (ja) 2013-02-20
EP2094679A2 (de) 2009-09-02
CA2671856C (en) 2015-02-10
MX2009006156A (es) 2009-06-19
IL198801A0 (en) 2010-02-17
ES2379696T3 (es) 2012-04-30
KR101118413B1 (ko) 2012-03-07

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