ATE397077T1 - Substraten und nachweise zur wirksamkeit von beta-secretase - Google Patents

Substraten und nachweise zur wirksamkeit von beta-secretase

Info

Publication number
ATE397077T1
ATE397077T1 AT01955899T AT01955899T ATE397077T1 AT E397077 T1 ATE397077 T1 AT E397077T1 AT 01955899 T AT01955899 T AT 01955899T AT 01955899 T AT01955899 T AT 01955899T AT E397077 T1 ATE397077 T1 AT E397077T1
Authority
AT
Austria
Prior art keywords
substrates
secretase
evidence
beta
effectiveness
Prior art date
Application number
AT01955899T
Other languages
English (en)
Inventor
Riqian Yan
Alfredo Tomasselli
Mark Gurney
Thomas Emmons
Michael Bienkowski
Robert Heinrikson
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Application granted granted Critical
Publication of ATE397077T1 publication Critical patent/ATE397077T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01955899T 2000-07-19 2001-07-19 Substraten und nachweise zur wirksamkeit von beta-secretase ATE397077T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21979500P 2000-07-19 2000-07-19
US27525101P 2001-03-12 2001-03-12

Publications (1)

Publication Number Publication Date
ATE397077T1 true ATE397077T1 (de) 2008-06-15

Family

ID=26914256

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01955899T ATE397077T1 (de) 2000-07-19 2001-07-19 Substraten und nachweise zur wirksamkeit von beta-secretase

Country Status (11)

Country Link
US (8) US7205120B2 (de)
EP (1) EP1301604B1 (de)
JP (1) JP2004504018A (de)
AT (1) ATE397077T1 (de)
AU (1) AU2001277950A1 (de)
CA (1) CA2410898A1 (de)
DE (1) DE60134230D1 (de)
IL (1) IL153943A0 (de)
IS (1) IS6678A (de)
TW (2) TW200628612A (de)
WO (1) WO2002006306A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19983100T1 (de) 1998-04-06 2001-05-31 Imation Corp Herstellung eines umgekehrten optischen Masters für Datenspeicherplatten
US7196163B2 (en) 2001-05-22 2007-03-27 Merk & Co., Inc. Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity
IL150600A (en) * 2001-07-19 2005-09-25 Akzo Nobel Nv Process for the preparation of compounds containing one or more amide bonds using an excess of an activated carboxylic component and scavenging the residual activated carboxylic component
IL150601A (en) * 2001-07-19 2010-06-30 Organon Nv Process for rapid synthesis of peptides within a solution using the back of an activated carboxyl component and destruction of the residual activated carboxyl component
WO2003087842A1 (en) * 2002-04-18 2003-10-23 Esbatech Ag Method for the identification of modulators of a secretase activity
JP2004000060A (ja) * 2002-05-31 2004-01-08 Otsuka Pharmaceut Co Ltd アミロイドβ産生に影響を与える化合物のスクリーニング方法
US20040175768A1 (en) * 2002-11-14 2004-09-09 Kushon Stuart A. Methods of biosensing using fluorescent polymers and quencher-tether-ligand bioconjugates
US20050112696A1 (en) * 2003-11-25 2005-05-26 The University Of Texas Southwestern Medical Center Compositions, methods and assays related to secretase cleavage specificity
US20060098887A1 (en) * 2004-05-19 2006-05-11 Hazem El-Bakry Mehthod for image conversion
US20060223849A1 (en) * 2005-03-14 2006-10-05 Mjalli Adnan M Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors
DE102005051978A1 (de) * 2005-10-31 2007-05-10 Forschungszentrum Borstel Zentrum für Medizin und Biowissenschaften Verfahren zur Bestimmung der Spaltbarkeit von Substraten
JP4848986B2 (ja) * 2007-03-22 2011-12-28 富士ゼロックス株式会社 光導波路及びその製造方法
US8548257B2 (en) * 2009-01-05 2013-10-01 Apple Inc. Distinguishing between faces and non-faces
MX346500B (es) 2010-11-10 2017-03-22 Genentech Inc * Metodos y composiciones para inmunoterapia para enfermedad neural.
JP2013158281A (ja) * 2012-02-03 2013-08-19 Shionogi & Co Ltd 新規ｂａｃｅ１活性測定方法
JP6993228B2 (ja) 2014-11-19 2022-03-03 ジェネンテック， インコーポレイテッド 抗トランスフェリン受容体／抗ｂａｃｅ１多重特異性抗体および使用方法
EP3845565A3 (de) 2014-11-19 2021-09-08 Genentech, Inc. Antikörper gegen bace1 und verwendung davon zur immuntherapie bei neuronalen erkrankungen

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292652A (en) 1990-10-05 1994-03-08 Athena Neurosciences, Inc. Amyloidin protease and uses thereof
US5798224A (en) * 1992-12-29 1998-08-25 Doheny Eye Institute Nucleic acids encoding protocadherin
JP4052605B2 (ja) * 1994-05-18 2008-02-27 タカラバイオ株式会社 α−１，３／４−フコシダーゼ遺伝子
WO1996040885A2 (en) * 1995-06-07 1996-12-19 Athena Neurosciences, Inc. β-SECRETASE, ANTIBODIES TO β-SECRETASE, AND ASSAYS FOR DETECTING β-SECRETASE INHIBITION
US6803188B1 (en) * 1996-01-31 2004-10-12 The Regents Of The University Of California Tandem fluorescent protein constructs
GB9701684D0 (en) 1997-01-28 1997-03-19 Smithkline Beecham Plc Novel compounds
WO1999040930A1 (en) * 1998-02-12 1999-08-19 Center For Blood Research, Inc. Specific inhibitors of nfat activation by calcineurin and their use in treating immune-related diseases
US7090976B2 (en) * 1999-11-10 2006-08-15 Rigel Pharmaceuticals, Inc. Methods and compositions comprising Renilla GFP
CA2330242A1 (fr) * 1998-06-05 1999-12-16 Aventis Pharma S.A. Polypeptides possedant une activite de type beta-secretase
DE69920473T2 (de) * 1998-07-21 2006-02-23 Cytovia, Inc., San Diego Neue fluoreszenzfarbstoffe und ihre anwendung in fluoreszenznachweisverfahren ganzer zellen für kaspasen, peptidasen, proteasen und andere enzyme sowie deren verwendung
US6835565B1 (en) 1998-09-24 2004-12-28 Pharmacia & Upjohn Company Alzheimer's disease secretase
US6313268B1 (en) * 1998-10-16 2001-11-06 Vivian Y. H. Hook Secretases related to Alzheimer's dementia
AU4000900A (en) 1999-02-10 2000-08-29 Elan Pharmaceuticals, Inc. Beta-secretase enzyme compositions and methods
WO2000058479A1 (en) 1999-03-26 2000-10-05 Amgen Inc. Beta secretase genes and polypeptides
AU5773500A (en) * 1999-06-28 2001-01-31 Board Of Trustees Of The University Of Illinois, The Inhibitors of memapsin 2 and use thereof
US7429639B2 (en) * 1999-09-29 2008-09-30 Ludwig Institute For Cancer Research SSX-2 peptides presented by HLA class II molecules
GB9925136D0 (en) * 1999-10-22 1999-12-22 Smithkline Beecham Plc Novel treatment
CN1414976A (zh) * 1999-12-08 2003-04-30 明德塞特生物制药(美国)公司 作为免疫原的嵌合肽及其抗体,以及利用嵌合肽或抗体进行免疫的方法
JP2003528071A (ja) * 2000-03-23 2003-09-24 エラン ファーマスーティカルズ インコーポレイテッド アルツハイマー病治療用組成物および方法
US20030096864A1 (en) * 2000-06-30 2003-05-22 Fang Lawrence Y. Compounds to treat alzheimer's disease
ATE413884T1 (de) 2001-05-22 2008-11-15 Merck & Co Inc Beta-secretase-substrat und seine verwendung

Also Published As

Publication number Publication date
JP2004504018A (ja) 2004-02-12
IL153943A0 (en) 2003-07-31
WO2002006306A3 (en) 2002-07-25
WO2002006306A2 (en) 2002-01-24
US7803739B2 (en) 2010-09-28
TW200628612A (en) 2006-08-16
US20040253706A1 (en) 2004-12-16
AU2001277950A1 (en) 2002-01-30
US20040254342A1 (en) 2004-12-16
IS6678A (is) 2003-01-14
EP1301604A2 (de) 2003-04-16
TWI316960B (en) 2009-11-11
US20050096457A1 (en) 2005-05-05
US20080299596A1 (en) 2008-12-04
US7888291B2 (en) 2011-02-15
DE60134230D1 (de) 2008-07-10
EP1301604B1 (de) 2008-05-28
US20040254341A1 (en) 2004-12-16
US20040241792A1 (en) 2004-12-02
US20030017991A1 (en) 2003-01-23
US20080090260A1 (en) 2008-04-17
US7205120B2 (en) 2007-04-17
CA2410898A1 (en) 2002-01-24

Similar Documents

Publication Publication Date Title
ATE397077T1 (de) Substraten und nachweise zur wirksamkeit von beta-secretase
AR036196A1 (es) Agentes de contraste multimericos dirigidos a base de peptidos
ATE350470T1 (de) Durch thrombin spaltbare chimäre proteine
ATE308550T1 (de) Verwendungen von sulfatierten fuko- oligosacchariden zum pflanzenschutz
DE69637307D1 (de) Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer
DE60331778D1 (de) Metalloproteaseaktivierung von myostatin und verfahren zur modulation der myostatinaktivität
DE69534588D1 (de) Protocadherin-proteine und verwendungen davon
ATE270280T1 (de) Substituierte dipeptide zur förderung der sekretion von wachstumshormon
HK1054394A1 (en) Diaryl peptides as ns3-serine protease inhibitors of hepatits c virus
ATE423216T1 (de) Neue fructosylpeptidoxidase und deren nutzung
ATE335485T1 (de) Quinolin-enthaltende alpha-ketoamid-basierte inhibitoren von cystein- und serin protease
ATE227739T1 (de) Hybridprotein zur hemmung der mastzelldegranulation und dessen verwendung
ATE382060T1 (de) Moleküle und verfahren zur inhibierung der freisetzung von kim-1
HK1025511A1 (en) Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors
EA200201138A1 (ru) Пептид, модулирующий рецептор тромбопоэтина
ATE353336T1 (de) Neues peptid mit angiotensinkonvertase hemmender wirkung
DE60025830D1 (de) Fusions-polypeptide zur gewebegeneration und wundheilung zur gezielten matrixanwendung
NO20052552D0 (no) Loselige Notch-baserte substrater for gamma-sekretase og fremgangsmater og blandinger for anvendelse av samme.
ATE323763T1 (de) Dna & protein bindende miniatur proteine
DE69938130D1 (de) Neue peptide
DE69738600D1 (de) Neuroaktive peptide
DE69615185T2 (de) Faktor ix bindende peptide abgeleitet von faktor vii und ihre verwendung als inhibitoren der blutgerinnung
DE60331414D1 (de) Aggrecanase-1- und -2-peptidsubstrate und verfahren
DE60326048D1 (de) Kristallstruktur des angiotensin-konvertierenden enzyms (ace) und ihre verwendung
DE69812597D1 (de) Peptide zur Inhibition von HPV E7 Proteinen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties