DE60331414D1 - Aggrecanase-1- und -2-peptidsubstrate und verfahren - Google Patents

Aggrecanase-1- und -2-peptidsubstrate und verfahren

Info

Publication number
DE60331414D1
DE60331414D1 DE60331414T DE60331414T DE60331414D1 DE 60331414 D1 DE60331414 D1 DE 60331414D1 DE 60331414 T DE60331414 T DE 60331414T DE 60331414 T DE60331414 T DE 60331414T DE 60331414 D1 DE60331414 D1 DE 60331414D1
Authority
DE
Germany
Prior art keywords
aggrecanase
peptide substrates
metalloproteases
proteases
modulate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60331414T
Other languages
English (en)
Inventor
Anne Fourie
Lars Karlsson
Fawn Coles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc
Application granted granted Critical
Publication of DE60331414D1 publication Critical patent/DE60331414D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Separation, Recovery Or Treatment Of Waste Materials Containing Plastics (AREA)
DE60331414T 2002-01-16 2003-01-15 Aggrecanase-1- und -2-peptidsubstrate und verfahren Expired - Lifetime DE60331414D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/050,200 US20030166037A1 (en) 2002-01-16 2002-01-16 Aggrecanase-1 and -2 peptide substrates and methods
PCT/US2003/001327 WO2003062263A2 (en) 2002-01-16 2003-01-15 Aggrecanase-1 and -2 peptide substrates and methods

Publications (1)

Publication Number Publication Date
DE60331414D1 true DE60331414D1 (de) 2010-04-08

Family

ID=27609064

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60331414T Expired - Lifetime DE60331414D1 (de) 2002-01-16 2003-01-15 Aggrecanase-1- und -2-peptidsubstrate und verfahren

Country Status (8)

Country Link
US (2) US20030166037A1 (de)
EP (1) EP1474509B1 (de)
AT (1) ATE458810T1 (de)
AU (1) AU2003203028A1 (de)
CA (1) CA2473513C (de)
DE (1) DE60331414D1 (de)
ES (1) ES2339758T3 (de)
WO (1) WO2003062263A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003066822A2 (en) * 2002-02-05 2003-08-14 Wyeth Truncated aggrecanase molecules
US6933275B2 (en) * 2002-05-01 2005-08-23 The Board Of Trustees Of The Leland Stanford Junior University Protein kinase C peptides for use in withdrawal
CN101501210A (zh) * 2006-06-09 2009-08-05 苏州圣诺生物医药技术有限公司 分离hiv-1蛋白酶抑制剂的体系和药物组合物
EP2746402A1 (de) * 2013-03-12 2014-06-25 Academisch Medisch Centrum Verfahren zur Prognose von Morbus Alzheimer und Substrate zur Verwendung darin
WO2018152633A1 (en) * 2017-02-22 2018-08-30 Université de Montréal Novel minor histocompatibility antigens and uses thereof
JP7369428B2 (ja) * 2019-08-09 2023-10-26 国立大学法人群馬大学 糖化合物及びその利用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6803188B1 (en) * 1996-01-31 2004-10-12 The Regents Of The University Of California Tandem fluorescent protein constructs
AU8513098A (en) * 1998-07-24 2000-02-14 Du Pont Pharmaceuticals Company Assays and peptide substrate for determining aggrecan degrading metallo proteaseactivity
HUP0302475A2 (hu) * 2000-09-06 2003-11-28 Ortho-Mcneil Pharmaceutical, Inc. Eljárás allergia kezelésére szubsztituált pirazolok alkalmazásával

Also Published As

Publication number Publication date
AU2003203028A1 (en) 2003-09-02
CA2473513A1 (en) 2003-07-31
CA2473513C (en) 2012-03-20
WO2003062263A3 (en) 2004-01-15
US20050164319A1 (en) 2005-07-28
US20030166037A1 (en) 2003-09-04
WO2003062263A2 (en) 2003-07-31
ES2339758T3 (es) 2010-05-25
US7312045B2 (en) 2007-12-25
EP1474509A4 (de) 2005-12-28
EP1474509A2 (de) 2004-11-10
ATE458810T1 (de) 2010-03-15
EP1474509B1 (de) 2010-02-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition