ATE346086T1 - Verfahren zur herstellung von n2-(1(s)-carboxy-3- phenylpropyl)-l-lysyl-l-prolin - Google Patents

Verfahren zur herstellung von n2-(1(s)-carboxy-3- phenylpropyl)-l-lysyl-l-prolin

Info

Publication number: ATE346086T1
Authority: AT; Austria
Prior art keywords: lysyl; phenylpropyl; proline; inorganic; compound
Prior art date: 1998-09-22

Application number

AT99944783T

Other languages

English (en)

Inventor

Tadashi Moroshima

Yoshifumi Yanagida

Yoshihide Fuse

Yasuyoshi Ueda

Original Assignee

Kaneka Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-22

Filing date

1999-09-22

Publication date

2006-12-15

1999-09-22 Application filed by Kaneka Corp filed Critical Kaneka Corp

2006-12-15 Application granted granted Critical

2006-12-15 Publication of ATE346086T1 publication Critical patent/ATE346086T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pyrrole Compounds (AREA)

AT99944783T 1998-09-22 1999-09-22 Verfahren zur herstellung von n2-(1(s)-carboxy-3- phenylpropyl)-l-lysyl-l-prolin ATE346086T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP26867698		1998-09-22

Publications (1)

Publication Number	Publication Date
ATE346086T1 true ATE346086T1 (de)	2006-12-15

Family

ID=17461854

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99944783T ATE346086T1 (de)	1998-09-22	1999-09-22	Verfahren zur herstellung von n2-(1(s)-carboxy-3- phenylpropyl)-l-lysyl-l-prolin

Country Status (16)

Country	Link
US (1)	US6271393B1 (de)
EP (1)	EP1035131B1 (de)
JP (1)	JP4307733B2 (de)
KR (1)	KR100625553B1 (de)
CN (1)	CN1200946C (de)
AT (1)	ATE346086T1 (de)
CA (1)	CA2311407A1 (de)
CZ (1)	CZ292494B6 (de)
DE (1)	DE69934084T2 (de)
ES (1)	ES2277446T3 (de)
HU (1)	HUP0100831A3 (de)
IL (1)	IL136271A (de)
PL (1)	PL340685A1 (de)
RU (1)	RU2220152C2 (de)
SI (1)	SI20271A (de)
WO (1)	WO2000017229A1 (de)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0168769A3 (de) *	1984-07-16	1989-02-08	Merck & Co. Inc.	Verfahren zur Herstellung von Carboxyalkyldipeptiden
JPH0653757B2 (ja) *	1985-12-06	1994-07-20	味の素株式会社	プロリン誘導体の芳香族スルホン酸塩
JPH01254651A (ja) *	1988-04-04	1989-10-11	Kanegafuchi Chem Ind Co Ltd	Ｎ↑２−（１−カルボキシ−３−フエニルプロピル）−ｌ−リジン誘導体及び該化合物を用いるリジノプリルの製造法
US5519146A (en) *	1993-01-08	1996-05-21	Kanegafuchi Kagaku Kogyo Kabushiki Kaisha	Process for crystallizing N2 - ((S) -1-ethoxycarbonyl-3-phenylpropyl)-N6 -trifluoroacetyl-L-lysyl-L-proline
DE4331540A1 (de) *	1993-09-17	1995-03-23	Degussa	Verfahren zur Reinigung von 1-[N·2·-((S)-Ethoxycarbonyl)-3-phenylpropyl)-N·6·-trifluoracetyl]-L-lysyl-L-prolin (Lisinopril(Tfa)ethylester)
HU214581B (hu) *	1995-03-14	1998-04-28	Richter Gedeon Vegyészeti Gyár Rt.	N2-(1S)-(1-/Etoxi-karbonil/-3-fenil-propil)-N6-(trifluor-acetil)-(L)-lizil-(L)-prolin-benzil-észter és eljárás előállítására
JP3792777B2 (ja) *	1996-05-10	2006-07-05	株式会社カネカ	１−アルコキシカルボニル−３−フェニルプロピル誘導体の製造方法

1999
- 1999-09-22 SI SI9920011A patent/SI20271A/sl not_active IP Right Cessation
- 1999-09-22 CA CA002311407A patent/CA2311407A1/en not_active Abandoned
- 1999-09-22 EP EP99944783A patent/EP1035131B1/de not_active Expired - Lifetime
- 1999-09-22 DE DE69934084T patent/DE69934084T2/de not_active Expired - Lifetime
- 1999-09-22 JP JP2000574137A patent/JP4307733B2/ja not_active Expired - Fee Related
- 1999-09-22 US US09/554,827 patent/US6271393B1/en not_active Expired - Lifetime
- 1999-09-22 IL IL13627199A patent/IL136271A/xx not_active IP Right Cessation
- 1999-09-22 RU RU2000116019/04A patent/RU2220152C2/ru not_active IP Right Cessation
- 1999-09-22 CN CNB99801639XA patent/CN1200946C/zh not_active Expired - Fee Related
- 1999-09-22 PL PL99340685A patent/PL340685A1/xx unknown
- 1999-09-22 HU HU0100831A patent/HUP0100831A3/hu unknown
- 1999-09-22 AT AT99944783T patent/ATE346086T1/de not_active IP Right Cessation
- 1999-09-22 CZ CZ20001897A patent/CZ292494B6/cs not_active IP Right Cessation
- 1999-09-22 ES ES99944783T patent/ES2277446T3/es not_active Expired - Lifetime
- 1999-09-22 WO PCT/JP1999/005189 patent/WO2000017229A1/ja active IP Right Grant
- 1999-09-22 KR KR1020007005439A patent/KR100625553B1/ko not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69934084D1 (de)	2007-01-04
WO2000017229A1 (fr)	2000-03-30
CN1286695A (zh)	2001-03-07
KR20010032238A (ko)	2001-04-16
ES2277446T3 (es)	2007-07-01
DE69934084T2 (de)	2007-04-05
PL340685A1 (en)	2001-02-26
JP4307733B2 (ja)	2009-08-05
CZ20001897A3 (cs)	2000-10-11
EP1035131A4 (de)	2002-05-02
IL136271A0 (en)	2001-05-20
CA2311407A1 (en)	2000-03-30
CN1200946C (zh)	2005-05-11
EP1035131A1 (de)	2000-09-13
KR100625553B1 (ko)	2006-09-20
HUP0100831A2 (hu)	2001-08-28
EP1035131B1 (de)	2006-11-22
SI20271A (sl)	2000-12-31
IL136271A (en)	2005-06-19
RU2220152C2 (ru)	2003-12-27
HUP0100831A3 (en)	2001-12-28
CZ292494B6 (cs)	2003-10-15
US6271393B1 (en)	2001-08-07

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2007-05-15

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2010-06-15

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