ATE258181T1 - Verfahren zur herstellung von dinatrium pamidronat - Google Patents
Verfahren zur herstellung von dinatrium pamidronatInfo
- Publication number
- ATE258181T1 ATE258181T1 AT02003891T AT02003891T ATE258181T1 AT E258181 T1 ATE258181 T1 AT E258181T1 AT 02003891 T AT02003891 T AT 02003891T AT 02003891 T AT02003891 T AT 02003891T AT E258181 T1 ATE258181 T1 AT E258181T1
- Authority
- AT
- Austria
- Prior art keywords
- pamidronate
- disodium pamidronate
- resulting
- solution
- water
- Prior art date
Links
- WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000004821 distillation Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 229940046231 pamidronate Drugs 0.000 abstract 1
- 229960003978 pamidronic acid Drugs 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Prostheses (AREA)
- Water Treatment By Sorption (AREA)
- Electric Double-Layer Capacitors Or The Like (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- General Factory Administration (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001MI000364A ITMI20010364A1 (it) | 2001-02-23 | 2001-02-23 | Procedimento per la preparazione del pamidronato disodico |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE258181T1 true ATE258181T1 (de) | 2004-02-15 |
Family
ID=11446985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02003891T ATE258181T1 (de) | 2001-02-23 | 2002-02-21 | Verfahren zur herstellung von dinatrium pamidronat |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1236733B1 (de) |
AT (1) | ATE258181T1 (de) |
DE (1) | DE60200171D1 (de) |
IT (1) | ITMI20010364A1 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20012634A1 (it) * | 2001-12-13 | 2003-06-13 | Istituto Biochimico Pavese Pha | Metodo di preparazione del panidronato disodico anidro |
WO2005054260A1 (en) * | 2003-12-04 | 2005-06-16 | Mustafa Nevzat Ilac Sanayii A.S. | Method for producing pure disodium pamidronate |
CN104072538A (zh) * | 2014-07-10 | 2014-10-01 | 陕西汉江药业集团股份有限公司 | 一种双膦酸盐类药物的合成方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000034293A1 (en) * | 1998-12-10 | 2000-06-15 | Aesgen, Inc. | Method for preparation of disodium pamidronate |
KR100343232B1 (ko) * | 1999-12-10 | 2002-07-10 | 김재윤 | 결정성 파미드론산 이나트륨염 수화물과 그의 제조방법 |
-
2001
- 2001-02-23 IT IT2001MI000364A patent/ITMI20010364A1/it unknown
-
2002
- 2002-02-21 EP EP02003891A patent/EP1236733B1/de not_active Expired - Lifetime
- 2002-02-21 AT AT02003891T patent/ATE258181T1/de not_active IP Right Cessation
- 2002-02-21 DE DE60200171T patent/DE60200171D1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE60200171D1 (de) | 2004-02-26 |
EP1236733B1 (de) | 2004-01-21 |
EP1236733A1 (de) | 2002-09-04 |
ITMI20010364A1 (it) | 2002-08-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |