ATE330224T1 - Funktionelles protein array - Google Patents
Funktionelles protein arrayInfo
- Publication number
- ATE330224T1 ATE330224T1 AT01956692T AT01956692T ATE330224T1 AT E330224 T1 ATE330224 T1 AT E330224T1 AT 01956692 T AT01956692 T AT 01956692T AT 01956692 T AT01956692 T AT 01956692T AT E330224 T1 ATE330224 T1 AT E330224T1
- Authority
- AT
- Austria
- Prior art keywords
- protein array
- functional protein
- proteins
- immobilised
- mrna
- Prior art date
Links
- 238000003498 protein array Methods 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000004671 cell-free system Anatomy 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0020016A GB0020016D0 (en) | 2000-08-15 | 2000-08-15 | Functional protein arrays |
| GB0029309A GB0029309D0 (en) | 2000-12-01 | 2000-12-01 | Functional protein arrays |
| GB0106610A GB0106610D0 (en) | 2001-03-16 | 2001-03-16 | Functional protein arrays |
| GB0113883A GB0113883D0 (en) | 2001-06-07 | 2001-06-07 | Functional protein arrays |
| GB0117232A GB0117232D0 (en) | 2001-07-14 | 2001-07-14 | Functional protein arrays |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE330224T1 true ATE330224T1 (de) | 2006-07-15 |
Family
ID=27515975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01956692T ATE330224T1 (de) | 2000-08-15 | 2001-08-15 | Funktionelles protein array |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7674752B2 (de) |
| EP (1) | EP1309861B1 (de) |
| JP (1) | JP4719403B2 (de) |
| AT (1) | ATE330224T1 (de) |
| AU (2) | AU7861301A (de) |
| CA (1) | CA2419490C (de) |
| CY (1) | CY1105271T1 (de) |
| DE (1) | DE60120713T2 (de) |
| DK (1) | DK1309861T3 (de) |
| ES (1) | ES2266224T3 (de) |
| PT (1) | PT1309861E (de) |
| WO (1) | WO2002014860A1 (de) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4880188B2 (ja) * | 2001-01-23 | 2012-02-22 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 核酸プログラム型タンパク質アレイ |
| WO2002088324A2 (en) * | 2001-05-02 | 2002-11-07 | Sigma-Genosys, Ltd. | Methods for determining secondary modifications of molecules using arrays |
| US7687437B2 (en) | 2001-07-13 | 2010-03-30 | Nanosphere, Inc. | Method for immobilizing molecules onto surfaces |
| DE10145226A1 (de) * | 2001-09-13 | 2003-04-10 | Lifebits Ag | Herstellung von trägergebundenen Molekülen |
| US7105347B2 (en) | 2002-07-30 | 2006-09-12 | Corning Incorporated | Method and device for protein delivery into cells |
| JP2004105070A (ja) * | 2002-09-18 | 2004-04-08 | Inst Of Physical & Chemical Res | 無細胞タンパク質合成系を用いたリガンド結合タンパク質の製造方法及びその使用 |
| US7691580B2 (en) | 2003-01-29 | 2010-04-06 | Corning Incorporated | Reverse protein delivery into cells on coded microparticles |
| WO2005015212A1 (en) * | 2003-08-07 | 2005-02-17 | Cellfree Sciences Co., Ltd. | Reagent for producing a protein chip |
| US20050260653A1 (en) * | 2004-04-14 | 2005-11-24 | Joshua Labaer | Nucleic-acid programmable protein arrays |
| WO2006002934A1 (en) * | 2004-06-30 | 2006-01-12 | Rina Netzwerk Rna Technologien Gmbh | Blueprint biochips |
| US20090054255A1 (en) * | 2004-07-01 | 2009-02-26 | The Regents Of The University Of California | Microfluidic devices and methods |
| JPWO2006052016A1 (ja) * | 2004-11-12 | 2008-05-29 | 独立行政法人科学技術振興機構 | タンパク質合成法、固相固定化ｍＲＮＡ及びタンパク質合成装置 |
| US20060234265A1 (en) * | 2005-03-21 | 2006-10-19 | Jim Richey | Microarrays having multi-functional, compartmentalized analysis areas and methods of use |
| US20070003954A1 (en) * | 2005-05-12 | 2007-01-04 | The Board Of Regents Of The University Of Texas System | Protein and antibody profiling using small molecule microarrays |
| GB0511717D0 (en) * | 2005-06-09 | 2005-07-13 | Babraham Inst | Repeatable protein arrays |
| EP1757942A1 (de) * | 2005-08-26 | 2007-02-28 | Max-Delbrück-Centrum | Array für den Nachweis von Protein-Protein Interaktionen und Methode zu dessen Herstellung |
| US8148302B2 (en) * | 2005-10-19 | 2012-04-03 | The United States Of America As Represented By The Department Of Health And Human Services | In situ assembling of protein microarrays |
| WO2007061981A2 (en) | 2005-11-21 | 2007-05-31 | Lumera Corporation | Surface plasmon resonance spectrometer with an actuator-driven angle scanning mechanism |
| US7463358B2 (en) * | 2005-12-06 | 2008-12-09 | Lumera Corporation | Highly stable surface plasmon resonance plates, microarrays, and methods |
| US8178316B2 (en) * | 2006-06-29 | 2012-05-15 | President And Fellows Of Harvard College | Evaluating proteins |
| JP5187932B2 (ja) * | 2006-11-01 | 2013-04-24 | 独立行政法人科学技術振興機構 | 生体分子アッセイチップ |
| US9085798B2 (en) | 2009-04-30 | 2015-07-21 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| JP5991916B2 (ja) * | 2009-05-29 | 2016-09-14 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | 自己免疫性ｔ細胞の単離および処理のためのペプトイドリガンド |
| AU2010256880B2 (en) * | 2009-06-02 | 2015-01-22 | Opko Health, Inc. | Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases |
| TW201124726A (en) * | 2009-10-16 | 2011-07-16 | Univ Texas | Compositions and methods for producing coded peptoid libraries |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| PT2556171E (pt) | 2010-04-05 | 2015-12-21 | Prognosys Biosciences Inc | Ensaios biológicos codificados espacialmente |
| CN105418764A (zh) | 2010-08-27 | 2016-03-23 | 国立大学法人东京大学 | 蛋白质或胜肽的印刷方法、及蛋白质或胜肽阵列、功能性蛋白质或功能性胜肽的鉴定方法 |
| DE102011010307A1 (de) | 2011-02-03 | 2012-08-09 | Albert-Ludwigs-Universität Freiburg | Vorrichtung und Verfahren zur Erzeugung von Protein-Mikroarrays |
| US20120258871A1 (en) | 2011-04-08 | 2012-10-11 | Prognosys Biosciences, Inc. | Peptide constructs and assay systems |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| JP2014527036A (ja) | 2011-06-27 | 2014-10-09 | ザ ジャクソン ラボラトリー | 癌および自己免疫疾患の処置のための方法および組成物 |
| AU2012300319B8 (en) | 2011-08-26 | 2017-07-27 | Alan Marc Kleinfeld | Development and use of fluorescent probes of unbound bilirubin |
| US8987174B2 (en) | 2011-10-28 | 2015-03-24 | Prognosys Biosciences, Inc. | Methods for manufacturing molecular arrays |
| US9701959B2 (en) | 2012-02-02 | 2017-07-11 | Invenra Inc. | High throughput screen for biologically active polypeptides |
| JP6015894B2 (ja) * | 2012-03-19 | 2016-10-26 | 国立大学法人埼玉大学 | タンパク質アレイの製造方法及びタンパク質アレイ |
| CN111233978A (zh) | 2013-03-15 | 2020-06-05 | 普罗格诺西斯生物科学公司 | 用于检测肽/mhc/tcr结合的方法 |
| EP2971280B1 (de) | 2013-03-15 | 2018-08-29 | Arizona Board of Regents on behalf of Arizona State University | Biosensor-mikroarrayzusammensetzungen und verfahren |
| US9879313B2 (en) | 2013-06-25 | 2018-01-30 | Prognosys Biosciences, Inc. | Methods and systems for determining spatial patterns of biological targets in a sample |
| JP6521255B2 (ja) * | 2013-08-30 | 2019-05-29 | 国立大学法人 東京大学 | タンパク質アレイ又はペプチドアレイの製造方法、機能性タンパク質又は機能性ペプチドの同定方法、タンパク質アレイ又はペプチドアレイ、及び、機能性タンパク質又は機能性ペプチド同定キット |
| WO2015070037A2 (en) | 2013-11-08 | 2015-05-14 | Prognosys Biosciences, Inc. | Polynucleotide conjugates and methods for analyte detection |
| US10584390B2 (en) | 2014-08-06 | 2020-03-10 | The Texas A&M University System | Tritrichomonas foetus nucleic acid detection methods |
| CN113186256A (zh) | 2015-04-10 | 2021-07-30 | 空间转录公司 | 生物样本的空间区别、多重核酸分析 |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| KR20220041211A (ko) | 2019-08-09 | 2022-03-31 | 넛크래커 테라퓨틱스 인코포레이티드 | 치료학적 조성물로부터 물질을 제거하기 위한 제조 방법 및 장치 |
| EP4025711A2 (de) | 2019-11-08 | 2022-07-13 | 10X Genomics, Inc. | Erhöhung der spezifität einer analytbindung |
| WO2021091611A1 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Spatially-tagged analyte capture agents for analyte multiplexing |
| FI3891300T3 (fi) | 2019-12-23 | 2023-05-10 | 10X Genomics Inc | Menetelmät spatiaalista analyysiä varten rna-templatoitua ligaatiota käyttäen |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
| US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
| US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
| US11835462B2 (en) | 2020-02-11 | 2023-12-05 | 10X Genomics, Inc. | Methods and compositions for partitioning a biological sample |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| US11926863B1 (en) | 2020-02-27 | 2024-03-12 | 10X Genomics, Inc. | Solid state single cell method for analyzing fixed biological cells |
| US11768175B1 (en) | 2020-03-04 | 2023-09-26 | 10X Genomics, Inc. | Electrophoretic methods for spatial analysis |
| ES2965354T3 (es) | 2020-04-22 | 2024-04-12 | 10X Genomics Inc | Métodos para análisis espacial que usan eliminación de ARN elegido como diana |
| AU2021275906A1 (en) | 2020-05-22 | 2022-12-22 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
| WO2021236929A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
| WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
| EP4025692A2 (de) | 2020-06-02 | 2022-07-13 | 10X Genomics, Inc. | Nukleinsäure-bibliotheksverfahren |
| CN116249785A (zh) | 2020-06-02 | 2023-06-09 | 10X基因组学有限公司 | 用于抗原-受体的空间转录组学 |
| WO2021252499A1 (en) | 2020-06-08 | 2021-12-16 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
| EP4165207A1 (de) | 2020-06-10 | 2023-04-19 | 10X Genomics, Inc. | Verfahren zur bestimmung einer position eines analyten in einer biologischen probe |
| AU2021294334A1 (en) | 2020-06-25 | 2023-02-02 | 10X Genomics, Inc. | Spatial analysis of DNA methylation |
| US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
| US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
| WO2022140028A1 (en) | 2020-12-21 | 2022-06-30 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
| EP4301870A1 (de) | 2021-03-18 | 2024-01-10 | 10X Genomics, Inc. | Multiplex-erfassung von gen- und proteinexpression aus einer biologischen probe |
| WO2023034489A1 (en) | 2021-09-01 | 2023-03-09 | 10X Genomics, Inc. | Methods, compositions, and kits for blocking a capture probe on a spatial array |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843701A (en) * | 1990-08-02 | 1998-12-01 | Nexstar Pharmaceticals, Inc. | Systematic polypeptide evolution by reverse translation |
| JPH1025299A (ja) * | 1996-07-12 | 1998-01-27 | Nec Corp | 整列ペプチド、及びそれを用いたタンパク質の結合・相互作用部位検出方法 |
| ATE332368T1 (de) | 1997-01-21 | 2006-07-15 | Gen Hospital Corp | Selektion von proteinen mittels rns-protein fusionen |
| US6207370B1 (en) * | 1997-09-02 | 2001-03-27 | Sequenom, Inc. | Diagnostics based on mass spectrometric detection of translated target polypeptides |
| US6087102A (en) | 1998-01-07 | 2000-07-11 | Clontech Laboratories, Inc. | Polymeric arrays and methods for their use in binding assays |
| US6406921B1 (en) | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
| AU775997B2 (en) | 1998-12-02 | 2004-08-19 | Bristol-Myers Squibb Company | DNA-protein fusions and uses thereof |
| SG121902A1 (en) * | 2000-01-11 | 2006-05-26 | Maxygen Inc | Integrated systems for diversity generation and screening |
| JP4880188B2 (ja) | 2001-01-23 | 2012-02-22 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 核酸プログラム型タンパク質アレイ |
-
2001
- 2001-08-15 CA CA2419490A patent/CA2419490C/en not_active Expired - Fee Related
- 2001-08-15 DE DE60120713T patent/DE60120713T2/de not_active Expired - Lifetime
- 2001-08-15 EP EP01956692A patent/EP1309861B1/de not_active Expired - Lifetime
- 2001-08-15 AU AU7861301A patent/AU7861301A/xx active Pending
- 2001-08-15 AU AU2001278613A patent/AU2001278613B2/en not_active Ceased
- 2001-08-15 US US10/344,607 patent/US7674752B2/en not_active Expired - Fee Related
- 2001-08-15 AT AT01956692T patent/ATE330224T1/de not_active IP Right Cessation
- 2001-08-15 JP JP2002519938A patent/JP4719403B2/ja not_active Expired - Fee Related
- 2001-08-15 ES ES01956692T patent/ES2266224T3/es not_active Expired - Lifetime
- 2001-08-15 DK DK01956692T patent/DK1309861T3/da active
- 2001-08-15 PT PT01956692T patent/PT1309861E/pt unknown
- 2001-08-15 WO PCT/GB2001/003657 patent/WO2002014860A1/en active IP Right Grant
-
2006
- 2006-08-30 CY CY20061101233T patent/CY1105271T1/el unknown
-
2009
- 2009-01-09 US US12/351,465 patent/US20110245093A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110245093A1 (en) | 2011-10-06 |
| WO2002014860A8 (en) | 2002-06-06 |
| JP4719403B2 (ja) | 2011-07-06 |
| ES2266224T3 (es) | 2007-03-01 |
| AU2001278613B2 (en) | 2006-09-07 |
| US7674752B2 (en) | 2010-03-09 |
| WO2002014860A1 (en) | 2002-02-21 |
| US20040161748A1 (en) | 2004-08-19 |
| PT1309861E (pt) | 2006-10-31 |
| EP1309861B1 (de) | 2006-06-14 |
| CA2419490C (en) | 2010-01-26 |
| EP1309861A1 (de) | 2003-05-14 |
| DE60120713D1 (de) | 2006-07-27 |
| AU7861301A (en) | 2002-02-25 |
| CA2419490A1 (en) | 2002-02-21 |
| DK1309861T3 (da) | 2006-10-23 |
| CY1105271T1 (el) | 2010-03-03 |
| DE60120713T2 (de) | 2007-06-06 |
| JP2004506898A (ja) | 2004-03-04 |
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Legal Events
| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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| REN | Ceased due to non-payment of the annual fee |