ATE314057T1 - Smilagenin und anzurogenin-d zur behandlung der alzheimerischen krankheit - Google Patents
Smilagenin und anzurogenin-d zur behandlung der alzheimerischen krankheitInfo
- Publication number
- ATE314057T1 ATE314057T1 AT99913462T AT99913462T ATE314057T1 AT E314057 T1 ATE314057 T1 AT E314057T1 AT 99913462 T AT99913462 T AT 99913462T AT 99913462 T AT99913462 T AT 99913462T AT E314057 T1 ATE314057 T1 AT E314057T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- anzrogenin
- smilagenin
- alzheimer
- disease
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
- G01N33/944—Acetylcholine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9806513.9A GB9806513D0 (en) | 1998-03-26 | 1998-03-26 | Membrane-bound receptors |
GBGB9905275.5A GB9905275D0 (en) | 1999-03-08 | 1999-03-08 | Treatment of conditions associated with membrane-bound receptors and their function |
PCT/GB1999/000960 WO1999048482A2 (en) | 1998-03-26 | 1999-03-26 | Smilagenin and anzurogenin-d for the treatment of alzheimer's disease |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE314057T1 true ATE314057T1 (de) | 2006-01-15 |
Family
ID=26313369
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99913462T ATE314057T1 (de) | 1998-03-26 | 1999-03-26 | Smilagenin und anzurogenin-d zur behandlung der alzheimerischen krankheit |
AT99913453T ATE337788T1 (de) | 1998-03-26 | 1999-03-26 | Steroidale saponine zur behandlung der alzheimerischen krankheit |
AT06017380T ATE507834T1 (de) | 1998-03-26 | 1999-03-26 | Sarsasapogenin und smilagenin zur behandlung kognitiver störungen |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99913453T ATE337788T1 (de) | 1998-03-26 | 1999-03-26 | Steroidale saponine zur behandlung der alzheimerischen krankheit |
AT06017380T ATE507834T1 (de) | 1998-03-26 | 1999-03-26 | Sarsasapogenin und smilagenin zur behandlung kognitiver störungen |
Country Status (28)
Country | Link |
---|---|
US (2) | US6812213B2 (de) |
EP (3) | EP1066033B1 (de) |
JP (4) | JP2003524581A (de) |
KR (6) | KR101092050B1 (de) |
CN (3) | CN1209112C (de) |
AT (3) | ATE314057T1 (de) |
AU (2) | AU748138B2 (de) |
BR (2) | BR9909110A (de) |
CA (2) | CA2325633C (de) |
CY (1) | CY1105653T1 (de) |
DE (3) | DE69929177T2 (de) |
DK (2) | DK1066042T3 (de) |
ES (2) | ES2257042T3 (de) |
GB (1) | GB2335599B (de) |
HK (3) | HK1033742A1 (de) |
HR (2) | HRP20000638A2 (de) |
HU (2) | HUP0103654A2 (de) |
ID (2) | ID26989A (de) |
IL (4) | IL138664A0 (de) |
IS (2) | IS5637A (de) |
MX (1) | MXPA00009437A (de) |
NO (4) | NO20004804L (de) |
NZ (1) | NZ507355A (de) |
PL (3) | PL207723B1 (de) |
PT (1) | PT1066042E (de) |
RU (1) | RU2297228C2 (de) |
TR (2) | TR200002774T2 (de) |
WO (2) | WO1999048507A2 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6277978B1 (en) | 1995-12-22 | 2001-08-21 | University Of Utah Research Foundation | KVLQT1—a long QT syndrome gene |
US20030118673A1 (en) * | 1998-03-26 | 2003-06-26 | Zongqin Xia | Smilagenin and anzurogenin-D for the treatment of alzheimer's disease |
GB9923076D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
AU781810B2 (en) * | 1998-03-26 | 2005-06-16 | Phytopharm Plc. | Steroidal sapogenins and their derivatives for treating Alzheimer's disease |
ID26989A (id) * | 1998-03-26 | 2001-02-22 | Phytopharm Plc | Smilagenin dan anzurogenin-d untuk pengobatan penyakit alzheimer |
GB2347676A (en) * | 1999-03-08 | 2000-09-13 | Phytopharm Plc | Screening method |
US20010024664A1 (en) * | 1999-03-19 | 2001-09-27 | Obukowicz Mark G. | Selective COX-2 inhibition from edible plant extracts |
GB9923078D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
GB9923077D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
GB0000228D0 (en) * | 2000-01-06 | 2000-03-01 | Phytopharm Plc | Fluoro substituted sapogenins and their use |
GB0107822D0 (en) * | 2001-03-28 | 2001-05-23 | Phytopharm Plc | Sapogenin derivatives their synthesis and use methods based upon their use |
NZ547344A (en) * | 2002-03-27 | 2007-11-30 | Phytopharm Plc | Therapeutic methods and uses of sapogenins and their derivatives |
CA2477787C (en) * | 2002-03-27 | 2011-12-20 | Phytopharm Plc | Therapeutic methods and uses of sapogenins and their derivatives |
KR101130212B1 (ko) * | 2002-03-27 | 2012-04-13 | 파이토팜 피엘씨 | 사포게닌 및 그 유도체의 치료 방법 및 사용법 |
US20050130948A1 (en) * | 2002-03-27 | 2005-06-16 | Daryl Rees | Therapeutic methods and uses of sapogenins and their derivatives |
ES2323363T3 (es) * | 2002-03-27 | 2009-07-14 | Phytopharm Plc | Usos terapeuticos de sapogeninas. |
WO2004037845A1 (en) * | 2002-10-28 | 2004-05-06 | Phytopharm Plc | Stereospecific reduction of sapogen-3-ones |
US20080182801A1 (en) | 2003-12-22 | 2008-07-31 | Btg International Limited | Core 2 glcnac-t inhibitors |
GB0513881D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors III |
GB0329667D0 (en) * | 2003-12-22 | 2004-01-28 | King S College London | Core 2 GlcNAc-T inhibitor |
GB0409567D0 (en) * | 2004-04-28 | 2004-06-02 | Phytopharm Plc | Chemical compounds |
JP2008516972A (ja) * | 2004-10-14 | 2008-05-22 | ジョージタウン ユニバーシティー | 神経保護作用を有するスピロステノールの薬学的組成物 |
GB0424528D0 (en) | 2004-11-05 | 2004-12-08 | Phytopharm Plc | Chemical compounds |
GB0512726D0 (en) * | 2005-06-22 | 2005-07-27 | Btg Int Ltd | Multiple sclerosis therapy and diagnosis |
GB0513883D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Diagnosis of Atherosclerosis |
GB0513888D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
KR100779179B1 (ko) * | 2006-05-19 | 2007-11-28 | 충북대학교 산학협력단 | 토복령의 메탄올 추출물을 함유하는 뇌신경 보호 또는퇴행성뇌질환 예방 또는 치료제 |
JP2009256243A (ja) * | 2008-04-17 | 2009-11-05 | Noevir Co Ltd | 保湿剤、抗老化剤、抗酸化剤、皮膚外用剤及び機能性経口組成物 |
EP2285821B1 (de) | 2008-06-17 | 2014-12-17 | Pawan Kumar Goel | Neuartiges verfahren zur extraktion von furostanol-saponinen aus bockshornkleesamen |
KR101027384B1 (ko) * | 2009-06-29 | 2011-04-11 | 에이디엠이십일 주식회사 | 플랫와이퍼블레이드와 와이퍼아암의 연결장치 |
US20120034193A1 (en) | 2009-01-24 | 2012-02-09 | Daryl Rees | Treatment of neurotrophic factor mediated disorders |
EP2595621A1 (de) * | 2010-07-20 | 2013-05-29 | Phytopharm PLC | Behandlung von l-dpa-, dopaminagonisten- und/oder dopaminverstärker-induzierten erkrankungen |
TWI422378B (zh) * | 2010-11-18 | 2014-01-11 | Univ Chung Shan Medical | 使用薯蕷皂素來改善與停經期症候群有關聯的認知缺陷 |
CN102389438A (zh) * | 2011-06-30 | 2012-03-28 | 北京师范大学 | 黄芪甲苷的应用 |
US20150126464A1 (en) * | 2013-01-21 | 2015-05-07 | Resilio Company Limited | Therapeutic drug and therapeutic method for neurological diseases including alzheimer's disease associated with 1,25d3-marrs |
KR101777920B1 (ko) * | 2015-07-27 | 2017-09-14 | 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 | 진세노사이드 f1을 포함하는 아밀로이드 플라크 제거용 조성물 |
CN105168785A (zh) * | 2015-10-08 | 2015-12-23 | 湖北民族学院 | 一种治疗阿尔茨海默病的中药制剂及制备方法 |
EP3572085A1 (de) | 2018-05-25 | 2019-11-27 | Neuro-Sys | Synergistische kombinationszusammensetzung mit einem steroidalen saponin, einer ersten polyphenolverbindung und gegebenenfalls einer zweiten polyphenolverbindung |
CN108514603B (zh) * | 2018-06-28 | 2021-12-28 | 佳木斯大学 | 一种治疗强直型帕金森病的中药组合物及其制备方法 |
KR102028730B1 (ko) | 2019-05-22 | 2019-10-04 | (주)클래시스 | 집속초음파 기술을 이용한 지모 추출물의 제조방법 및 이로부터 수득된 지모 추출물 |
CN110859849A (zh) * | 2019-12-11 | 2020-03-06 | 大连医科大学 | 薯蓣皂苷在制备帕金森病保护药物中的应用 |
US11788574B2 (en) | 2021-08-13 | 2023-10-17 | Rimgard Sweden AB | Anti-theft locking bolt assembly |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE794362A (fr) * | 1972-01-22 | 1973-07-23 | Merck Patent Gmbh | Sulfates hydrosolubles de sterine |
US3929769A (en) * | 1972-05-19 | 1975-12-30 | Ciba Geigy Corp | Process for the manufacture of steroid epoxides |
CA985172A (en) | 1972-10-06 | 1976-03-09 | Dushan M. Dvornik | Compositions and methods for reducing blood cholesterol |
DE2416978A1 (de) * | 1974-04-08 | 1975-10-09 | Degussa | Arzneimittel mit dem hauptsapogenin der helleborus-arten als wirkstoff |
LU81256A1 (fr) | 1979-05-15 | 1980-12-16 | Oreal | Composition cosmetique capillaire notamment pour le lavage et/ou le demelage des cheveux,a base d'un extrait de plantes contenant des saponosides |
JPS5855500A (ja) * | 1981-09-25 | 1983-04-01 | Tokiwa Yakuhin Kogyo Kk | 16−デヒドロプレグネノロンの製造法 |
US4602005A (en) * | 1982-05-17 | 1986-07-22 | Medical Research Foundation Of Oregon | Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis |
US4602003A (en) * | 1982-05-17 | 1986-07-22 | Medical Research Foundation Of Oregon | Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia |
US4562250A (en) * | 1982-09-13 | 1985-12-31 | Regents Of The University Of Minnesota | Steroidal glycosides produced by Yucca tissue culture |
US4546097A (en) * | 1983-11-04 | 1985-10-08 | The United States Of America As Represented By The Department Of Health And Human Services | Saponin-based polyether polyols, pharmaceutical compositions and a method of using same |
US4680289A (en) | 1985-06-05 | 1987-07-14 | Progenics, Inc. | Treatment of obesity and diabetes using sapogenins |
US5017562A (en) | 1987-02-11 | 1991-05-21 | Regents Of The University Of Minnesota | Crystalline saponin-containing complex |
DE3838716A1 (de) * | 1988-11-15 | 1990-05-17 | Kanoldt Arzneimittel Gmbh | Arzneimittelzubereitung aus esterderivaten des hecogenins und dessen verwendung zur behandlung von benigner prostatahyperplasie |
SG50585A1 (en) * | 1990-01-18 | 1998-07-20 | Cura Nominees Pty Ltd | Glycoalkaloids |
US5252729A (en) * | 1991-10-23 | 1993-10-12 | Schering Corporation | Extraction of compounds from plant materials using supercritical fluids |
US5244887A (en) * | 1992-02-14 | 1993-09-14 | Straub Carl D | Stanols to reduce cholesterol absorption from foods and methods of preparation and use thereof |
RU94046294A (ru) * | 1992-06-26 | 1996-10-10 | Пфайзер Инк. (US) | Стероидные гликозиды для лечения гиперхолестеринэмии |
DE4303214A1 (de) * | 1993-02-04 | 1994-08-11 | Wolfgang Marks | Behandlung von Erkrankungen viraler, viroidaler oder onkogener Genese durch Steroid-Saponine oder deren Aglykone |
WO1994018994A1 (en) * | 1993-02-23 | 1994-09-01 | Pharmakon Usa, Inc. | Therapeutic herbal composition |
CN1092992A (zh) * | 1993-03-29 | 1994-10-05 | 中国科学院沈阳应用生态研究所 | 提高脑功能的药物及其制备方法 |
CN1052636C (zh) * | 1993-03-29 | 2000-05-24 | 中国科学院沈阳应用生态研究所 | 文冠果子的醇提取物在制备治疗智力低下的药物中的应用 |
PL311278A1 (en) * | 1993-04-28 | 1996-02-05 | Pfizer | Crystalline glycosidal spirostantil monohydrate |
CN1033754C (zh) * | 1993-05-31 | 1997-01-08 | 上海第二医科大学 | 知母皂甙元作为制备β肾上腺素和M胆碱受体双向调节药的用途及其制法 |
US5589182A (en) * | 1993-12-06 | 1996-12-31 | Tashiro; Renki | Compositions and method of treating cardio-, cerebro-vascular and alzheimer's diseases and depression |
AU7948494A (en) * | 1993-12-28 | 1995-07-17 | Pfizer Inc. | Steroidal glycosides |
CA2180148A1 (en) * | 1993-12-28 | 1995-07-06 | Michael Paul Deninno | Hypocholesterolemic agents |
US5856535A (en) * | 1994-08-18 | 1999-01-05 | Magainin Pharmaceuticals, Inc. | Aminosterol ester compounds |
US5840740A (en) * | 1995-06-07 | 1998-11-24 | Magainin Pharmaceuticals Inc. | Aminosterol compounds and a method of treating infection using the aminosterol compounds |
KR970705574A (ko) * | 1994-08-30 | 1997-10-09 | 스피겔 알렌 제이 | 스피로스타닐 글리코시드 결정(spirostanyl glycosidal crystals) |
EP0782451A1 (de) * | 1994-09-20 | 1997-07-09 | Pfizer Inc. | Kombinationen eines hemmers der cholesterinabsorption und eines hemmers der cholesterinsynthese |
WO1996038466A1 (en) * | 1995-05-29 | 1996-12-05 | Pfizer Inc. | Steroidal glycosides |
US5763430A (en) * | 1995-06-07 | 1998-06-09 | Magainin Pharmaceuticals Inc. | Method of treating a viral infection by administering a steroid compound |
US5840936A (en) * | 1995-06-07 | 1998-11-24 | Magainin Pharmaceuticals Inc. | Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE) |
US5847172A (en) * | 1995-06-07 | 1998-12-08 | Magainin Pharmaceuticals Inc. | Certain aminosterol compounds and pharmaceutical compositions including these compounds |
US6143738A (en) * | 1995-06-07 | 2000-11-07 | Magainin Pharmaceuticals, Inc. | Therapeutic uses for an aminosterol compound |
US5792635A (en) * | 1995-06-07 | 1998-08-11 | Magainin Pharmaceuticals, Inc. | Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine |
US5795885A (en) * | 1995-06-07 | 1998-08-18 | Magainin Pharmaceuticals Inc. | Method of inhibiting profileration of cells by administering an aminosterol compound |
US5804239A (en) | 1996-07-26 | 1998-09-08 | Nouveau Technologies, Inc. | Method and composition for food flavoring |
ES2285772T3 (es) * | 1997-05-15 | 2007-11-16 | University Of Washington | Composicion y metodos para tratar la enfermedad de alzheimer y otras amiloidosis. |
JP4520033B2 (ja) * | 1997-08-28 | 2010-08-04 | エフエックス ライフ サイエンシズ アクチェンゲゼルシャフト | 薬草抽出物の化学的および薬理学的標準化 |
CN1131237C (zh) | 1997-09-26 | 2003-12-17 | 中国人民解放军军事医学科学院放射医学研究所 | 甾体皂甙防治老年性痴呆的用途及新的甾体皂甙 |
JP3873097B2 (ja) * | 1997-11-06 | 2007-01-24 | 独立行政法人理化学研究所 | 抗肥満剤及び脂質代謝改善剤 |
ID26989A (id) * | 1998-03-26 | 2001-02-22 | Phytopharm Plc | Smilagenin dan anzurogenin-d untuk pengobatan penyakit alzheimer |
GB9905275D0 (en) * | 1999-03-08 | 1999-04-28 | Phytopharm Ltd | Treatment of conditions associated with membrane-bound receptors and their function |
US6544566B1 (en) * | 1999-04-23 | 2003-04-08 | Protein Technologies International, Inc. | Composition containing plant sterol, soy protein and isoflavone for reducing LDL cholesterol |
-
1999
- 1999-03-26 ID IDW20002146A patent/ID26989A/id unknown
- 1999-03-26 JP JP2000537532A patent/JP2003524581A/ja active Pending
- 1999-03-26 BR BR9909110-0A patent/BR9909110A/pt not_active Application Discontinuation
- 1999-03-26 CN CNB998060429A patent/CN1209112C/zh not_active Expired - Fee Related
- 1999-03-26 ID IDW20002147A patent/ID26781A/id unknown
- 1999-03-26 KR KR1020097000085A patent/KR101092050B1/ko not_active IP Right Cessation
- 1999-03-26 TR TR2000/02774T patent/TR200002774T2/xx unknown
- 1999-03-26 CA CA002325633A patent/CA2325633C/en not_active Expired - Fee Related
- 1999-03-26 AT AT99913462T patent/ATE314057T1/de active
- 1999-03-26 AT AT99913453T patent/ATE337788T1/de active
- 1999-03-26 DE DE69929177T patent/DE69929177T2/de not_active Expired - Lifetime
- 1999-03-26 DE DE69933016T patent/DE69933016T2/de not_active Expired - Lifetime
- 1999-03-26 AT AT06017380T patent/ATE507834T1/de not_active IP Right Cessation
- 1999-03-26 HU HU0103654A patent/HUP0103654A2/hu unknown
- 1999-03-26 JP JP2000537555A patent/JP3768100B2/ja not_active Expired - Fee Related
- 1999-03-26 CA CA002325634A patent/CA2325634A1/en not_active Abandoned
- 1999-03-26 PL PL380866A patent/PL207723B1/pl unknown
- 1999-03-26 KR KR1020097000581A patent/KR20090009997A/ko not_active Application Discontinuation
- 1999-03-26 KR KR1020067027786A patent/KR20070007214A/ko not_active Application Discontinuation
- 1999-03-26 IL IL13866499A patent/IL138664A0/xx unknown
- 1999-03-26 TR TR2000/02773T patent/TR200002773T2/xx unknown
- 1999-03-26 AU AU31574/99A patent/AU748138B2/en not_active Ceased
- 1999-03-26 EP EP99913462A patent/EP1066033B1/de not_active Expired - Lifetime
- 1999-03-26 DK DK99913453T patent/DK1066042T3/da active
- 1999-03-26 NZ NZ507355A patent/NZ507355A/xx unknown
- 1999-03-26 PL PL99343423A patent/PL195897B1/pl not_active IP Right Cessation
- 1999-03-26 DK DK06017380.4T patent/DK1719512T3/da active
- 1999-03-26 PT PT99913453T patent/PT1066042E/pt unknown
- 1999-03-26 DE DE69943415T patent/DE69943415D1/de not_active Expired - Lifetime
- 1999-03-26 IL IL13866399A patent/IL138663A0/xx not_active IP Right Cessation
- 1999-03-26 CN CNB2005100529656A patent/CN100377714C/zh not_active Expired - Fee Related
- 1999-03-26 MX MXPA00009437A patent/MXPA00009437A/es active IP Right Grant
- 1999-03-26 KR KR1020007010677A patent/KR100632052B1/ko not_active IP Right Cessation
- 1999-03-26 KR KR1020007010698A patent/KR100713311B1/ko not_active IP Right Cessation
- 1999-03-26 KR KR1020077027370A patent/KR20070117001A/ko not_active Application Discontinuation
- 1999-03-26 GB GB9907100A patent/GB2335599B/en not_active Expired - Fee Related
- 1999-03-26 AU AU31581/99A patent/AU3158199A/en not_active Abandoned
- 1999-03-26 WO PCT/GB1999/000951 patent/WO1999048507A2/en active IP Right Grant
- 1999-03-26 EP EP99913453A patent/EP1066042B1/de not_active Expired - Lifetime
- 1999-03-26 WO PCT/GB1999/000960 patent/WO1999048482A2/en not_active Application Discontinuation
- 1999-03-26 CN CNB998061581A patent/CN1198622C/zh not_active Expired - Fee Related
- 1999-03-26 HU HU0101693A patent/HUP0101693A3/hu unknown
- 1999-03-26 BR BR9909109-7A patent/BR9909109A/pt not_active Application Discontinuation
- 1999-03-26 PL PL99343508A patent/PL343508A1/xx unknown
- 1999-03-26 ES ES99913462T patent/ES2257042T3/es not_active Expired - Lifetime
- 1999-03-26 EP EP06017380A patent/EP1719512B1/de not_active Expired - Lifetime
- 1999-03-26 ES ES99913453T patent/ES2272060T3/es not_active Expired - Lifetime
-
2000
- 2000-09-24 IL IL138663A patent/IL138663A/en unknown
- 2000-09-25 IS IS5637A patent/IS5637A/is unknown
- 2000-09-25 IS IS5638A patent/IS5638A/is unknown
- 2000-09-26 HR HR20000638A patent/HRP20000638A2/hr not_active Application Discontinuation
- 2000-09-26 HR HR20000637A patent/HRP20000637A2/hr not_active Application Discontinuation
- 2000-09-26 NO NO20004804A patent/NO20004804L/no not_active Application Discontinuation
- 2000-09-26 NO NO20004803A patent/NO20004803L/no not_active Application Discontinuation
-
2001
- 2001-06-20 HK HK01104289A patent/HK1033742A1/xx not_active IP Right Cessation
- 2001-06-22 HK HK01104373A patent/HK1033903A1/xx not_active IP Right Cessation
-
2002
- 2002-02-15 US US10/077,493 patent/US6812213B2/en not_active Expired - Fee Related
-
2004
- 2004-03-15 JP JP2004073546A patent/JP2004224797A/ja active Pending
- 2004-03-15 JP JP2004073541A patent/JP2004217666A/ja active Pending
- 2004-07-17 US US10/894,425 patent/US20060182817A1/en not_active Abandoned
- 2004-07-29 RU RU2004123463/15A patent/RU2297228C2/ru not_active IP Right Cessation
-
2006
- 2006-04-11 IL IL174991A patent/IL174991A0/en unknown
- 2006-10-10 CY CY20061101448T patent/CY1105653T1/el unknown
- 2006-11-22 HK HK06112803.6A patent/HK1091417A1/xx not_active IP Right Cessation
-
2008
- 2008-09-19 NO NO20083993A patent/NO20083993L/no not_active Application Discontinuation
- 2008-12-16 NO NO20085251A patent/NO20085251L/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE314057T1 (de) | Smilagenin und anzurogenin-d zur behandlung der alzheimerischen krankheit | |
HK1046912A1 (en) | Substituted sapogenins and their use | |
IL180972A0 (en) | 5-beta-sapogenin and psuedosapogenin derivatives and their use in the treatment of dementia | |
GB9923078D0 (en) | Sapogenin derivatives and their use |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1066033 Country of ref document: EP |