ATE311383T1 - Nicht-peptidische bombesin rezeptor antagonisten - Google Patents
Nicht-peptidische bombesin rezeptor antagonistenInfo
- Publication number
- ATE311383T1 ATE311383T1 AT97939359T AT97939359T ATE311383T1 AT E311383 T1 ATE311383 T1 AT E311383T1 AT 97939359 T AT97939359 T AT 97939359T AT 97939359 T AT97939359 T AT 97939359T AT E311383 T1 ATE311383 T1 AT E311383T1
- Authority
- AT
- Austria
- Prior art keywords
- pyridyl
- disorders
- compounds
- imidazole
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2432396P | 1996-08-22 | 1996-08-22 | |
PCT/US1997/013871 WO1998007718A1 (en) | 1996-08-22 | 1997-08-06 | Non-peptide bombesin receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE311383T1 true ATE311383T1 (de) | 2005-12-15 |
Family
ID=21819999
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97939359T ATE311383T1 (de) | 1996-08-22 | 1997-08-06 | Nicht-peptidische bombesin rezeptor antagonisten |
Country Status (17)
Country | Link |
---|---|
US (1) | US6194437B1 (de) |
EP (1) | EP0920424B1 (de) |
JP (1) | JP2001500850A (de) |
AT (1) | ATE311383T1 (de) |
AU (1) | AU733226B2 (de) |
BR (1) | BR9711342A (de) |
CA (1) | CA2255966A1 (de) |
DE (1) | DE69734773T2 (de) |
ES (1) | ES2253782T3 (de) |
IL (1) | IL127194A0 (de) |
IS (1) | IS4937A (de) |
NO (1) | NO312669B1 (de) |
NZ (1) | NZ333038A (de) |
PL (1) | PL331710A1 (de) |
TR (1) | TR199900364T2 (de) |
WO (1) | WO1998007718A1 (de) |
ZA (1) | ZA977526B (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030069231A1 (en) * | 1999-10-12 | 2003-04-10 | Klaus Rudolf | Modified aminoacids, pharmaceuticals containing these compounds and method for their production |
PL341291A1 (en) * | 1997-12-16 | 2001-04-09 | Warner Lambert Co | 1-substituted derivatives of 1-aminomethyl-ccycloalkanes (gabapentin analogues), their production and application of them in treating neurological disorders |
JP2002533338A (ja) * | 1998-12-18 | 2002-10-08 | ワーナー−ランバート・カンパニー | 非ペプチドnk1レセプターアンタゴニスト |
AU3033100A (en) | 1999-01-18 | 2000-08-01 | Boehringer Ingelheim International Gmbh | Substituted imidazoles, their preparation and use |
WO2002040008A2 (en) * | 2000-11-17 | 2002-05-23 | Warner-Lambert Company Llc | Treatment of sexual dysfunction with non peptide bombesin receptor antagonists |
GB2369118A (en) * | 2000-11-17 | 2002-05-22 | Warner Lambert Co | Bombesin receptor antagonists |
IL155814A0 (en) * | 2000-11-17 | 2003-12-23 | Warner Lambert Co | Treatment of sexual dysfunction using bombesin antagonist |
GB2369117A (en) * | 2000-11-17 | 2002-05-22 | Warner Lambert Co | Bombesin receptor antagonists |
WO2002049644A1 (en) * | 2000-12-20 | 2002-06-27 | Warner-Lambert Company Llc | Novel uses of non-peptide bombesin receptor antagonists for treating anxiety and panic disorders |
ES2200617B1 (es) | 2001-01-19 | 2005-05-01 | Almirall Prodesfarma, S.A. | Derivados de urea como antagonistas de integrinas alfa 4. |
DE10123163A1 (de) | 2001-05-09 | 2003-01-16 | Gruenenthal Gmbh | Substituierte Cyclohexan-1,4-diaminderivate |
US20030031627A1 (en) * | 2001-07-31 | 2003-02-13 | Mallinckrodt Inc. | Internal image antibodies for optical imaging and therapy |
AU2003241269A1 (en) * | 2002-02-01 | 2003-09-09 | The Cleveland Clinic Foundation | Neurostimulation for affecting sleep disorders |
EP1501800A1 (de) * | 2002-05-03 | 2005-02-02 | Warner-Lambert Company LLC | Bombesin antagonisten |
US7244743B2 (en) | 2002-06-05 | 2007-07-17 | Solvay Pharmaceuticals Gmbh | Non-peptidic BRS-3 agonists |
EP1539686A1 (de) * | 2002-09-11 | 2005-06-15 | Warner-Lambert Company Llc | Inhibitoren von faktor xa und anderen an der koagulationskaskade beteiligten serinproteasen |
US7595312B2 (en) | 2002-10-25 | 2009-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions |
US6846836B2 (en) * | 2003-04-18 | 2005-01-25 | Bristol-Myers Squibb Company | N-substituted phenylurea inhibitors of mitochondrial F1F0 ATP hydrolase |
GB0403578D0 (en) * | 2004-02-18 | 2004-03-24 | Biofocus Discovery Ltd | Compounds which interact with the G-protein coupled receptor family |
DE102004015723A1 (de) * | 2004-03-29 | 2005-10-20 | Boehringer Ingelheim Pharma | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
US7795385B2 (en) * | 2004-12-17 | 2010-09-14 | Bexar Global, Inc. | Use of bombesin/gastrin-releasing peptide antagonists for the treatment of inflammatory conditions, acute lung injury and bipolar disorder |
JPWO2006115135A1 (ja) | 2005-04-21 | 2008-12-18 | アステラス製薬株式会社 | 過敏性腸症候群治療剤 |
JP5432526B2 (ja) * | 2006-01-06 | 2014-03-05 | サノビオン ファーマシューティカルズ インク | モノアミン再取り込み阻害剤としてのシクロアルキルアミン |
JPWO2015152128A1 (ja) * | 2014-03-31 | 2017-04-13 | 長瀬産業株式会社 | アミノ酸前駆体、アミノ酸およびその製造方法、ならびに該アミノ酸を用いたpet診断用トレーサー |
CN105884674B (zh) * | 2015-01-05 | 2019-07-26 | 南开大学 | 色氨酸衍生物及制备方法和在防治植物病毒、杀菌、杀虫方面的应用 |
GB2561540A (en) | 2017-03-13 | 2018-10-24 | Nodthera Ltd | Chemical compounds |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4000297A (en) | 1971-05-18 | 1976-12-28 | Rotta Research Laboratorium S.P.A. | N-p-chlorobenzoyl tryptophane, salts and compositions thereof |
DE3279123D1 (de) | 1981-10-20 | 1988-11-24 | Mitsui Toatsu Chemicals | Novel pyridazinone derivatives |
FR2546517B1 (fr) | 1983-05-24 | 1987-04-24 | Panmedica | Nouveaux dipeptides du -l-5-hydroxy-tryptophane, procedes pour leur preparation et medicaments les contenant |
EP0288965A2 (de) | 1987-04-29 | 1988-11-02 | Hoechst Aktiengesellschaft | Peptide mit Phospholipase A2- hemmender Wirkung |
US5378803A (en) | 1987-12-11 | 1995-01-03 | Sterling Winthrop Inc. | Azole-fused peptides and processes for preparation thereof |
US5346907A (en) | 1988-04-05 | 1994-09-13 | Abbott Laboratories | Amino acid analog CCK antagonists |
US5153226A (en) * | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
EP0547178A4 (en) | 1990-08-31 | 1994-07-06 | Warner Lambert Co | Novel cholecystokinin antagonists, their preparation and therapeutic use |
US5472978A (en) | 1991-07-05 | 1995-12-05 | Merck Sharp & Dohme Ltd. | Aromatic compounds, pharmaceutical compositions containing them and their use in therapy |
IE72090B1 (en) | 1991-07-05 | 1997-03-12 | Merck Sharp & Dohme | Aromatic compounds pharmaceutical compositions containing them and their use in therapy |
US5495047A (en) | 1991-07-10 | 1996-02-27 | Merck, Sharp & Dohme (Ltd.) | Fused tricyclic compounds, pharmaceutical compositions containing them and their use in therapy |
JPH06509090A (ja) | 1991-07-10 | 1994-10-13 | メルク シヤープ エンド ドーム リミテツド | 芳香族化合物、それらを含む組成物、及び治療におけるそれらの使用 |
FR2687147A1 (fr) * | 1992-02-11 | 1993-08-13 | Union Pharma Scient Appl | Nouveaux derives d'alpha-amino n-pyridyl benzene propanamide, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
CA2134359C (en) | 1992-05-28 | 1997-07-01 | Ernest S. Hamanaka | New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
PT655055E (pt) * | 1992-08-13 | 2001-03-30 | Warner Lambert Co | Antagonistas de taquiquinina |
US5340798A (en) | 1992-10-14 | 1994-08-23 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5534529A (en) | 1993-06-30 | 1996-07-09 | Sankyo Company, Limited | Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses |
JPH07101929A (ja) | 1993-10-01 | 1995-04-18 | Fujisawa Pharmaceut Co Ltd | 尿素誘導体およびその製造法 |
US5470834A (en) | 1993-10-06 | 1995-11-28 | Florida State University | Sulfoximine and suldodiimine matrix metalloproteinase inhibitors |
US5455262A (en) | 1993-10-06 | 1995-10-03 | Florida State University | Mercaptosulfide metalloproteinase inhibitors |
-
1997
- 1997-08-06 NZ NZ333038A patent/NZ333038A/xx unknown
- 1997-08-06 AT AT97939359T patent/ATE311383T1/de not_active IP Right Cessation
- 1997-08-06 DE DE69734773T patent/DE69734773T2/de not_active Expired - Fee Related
- 1997-08-06 EP EP97939359A patent/EP0920424B1/de not_active Expired - Lifetime
- 1997-08-06 BR BR9711342A patent/BR9711342A/pt not_active Application Discontinuation
- 1997-08-06 CA CA002255966A patent/CA2255966A1/en not_active Abandoned
- 1997-08-06 IL IL12719497A patent/IL127194A0/xx unknown
- 1997-08-06 US US09/230,933 patent/US6194437B1/en not_active Expired - Fee Related
- 1997-08-06 WO PCT/US1997/013871 patent/WO1998007718A1/en active IP Right Grant
- 1997-08-06 JP JP10510779A patent/JP2001500850A/ja not_active Abandoned
- 1997-08-06 ES ES97939359T patent/ES2253782T3/es not_active Expired - Lifetime
- 1997-08-06 AU AU41466/97A patent/AU733226B2/en not_active Ceased
- 1997-08-06 PL PL97331710A patent/PL331710A1/xx unknown
- 1997-08-06 TR TR1999/00364T patent/TR199900364T2/xx unknown
- 1997-08-21 ZA ZA9707526A patent/ZA977526B/xx unknown
-
1998
- 1998-12-29 IS IS4937A patent/IS4937A/is unknown
-
1999
- 1999-02-19 NO NO19990788A patent/NO312669B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO990788L (no) | 1999-02-19 |
DE69734773D1 (de) | 2006-01-05 |
IL127194A0 (en) | 1999-09-22 |
CA2255966A1 (en) | 1998-02-26 |
AU4146697A (en) | 1998-03-06 |
DE69734773T2 (de) | 2006-07-20 |
EP0920424A1 (de) | 1999-06-09 |
IS4937A (is) | 1998-12-29 |
BR9711342A (pt) | 1999-08-17 |
ES2253782T3 (es) | 2006-06-01 |
US6194437B1 (en) | 2001-02-27 |
WO1998007718A1 (en) | 1998-02-26 |
ZA977526B (en) | 1998-02-19 |
AU733226B2 (en) | 2001-05-10 |
NO990788D0 (no) | 1999-02-19 |
NZ333038A (en) | 2000-10-27 |
NO312669B1 (no) | 2002-06-17 |
TR199900364T2 (xx) | 1999-05-21 |
EP0920424B1 (de) | 2005-11-30 |
JP2001500850A (ja) | 2001-01-23 |
PL331710A1 (en) | 1999-08-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |