ATE298741T1 - Polyaromatische verbindungen zur behandlung von herpes-infektionen - Google Patents
Polyaromatische verbindungen zur behandlung von herpes-infektionenInfo
- Publication number
- ATE298741T1 ATE298741T1 AT01117751T AT01117751T ATE298741T1 AT E298741 T1 ATE298741 T1 AT E298741T1 AT 01117751 T AT01117751 T AT 01117751T AT 01117751 T AT01117751 T AT 01117751T AT E298741 T1 ATE298741 T1 AT E298741T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- polyaromatic compounds
- herpes infections
- herpes
- infections
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
- C07D213/20—Quaternary compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4323297P | 1997-04-10 | 1997-04-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE298741T1 true ATE298741T1 (de) | 2005-07-15 |
Family
ID=21926169
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01117751T ATE298741T1 (de) | 1997-04-10 | 1998-04-01 | Polyaromatische verbindungen zur behandlung von herpes-infektionen |
AT98913241T ATE231839T1 (de) | 1997-04-10 | 1998-04-01 | Polyaromatische antivirale zusammensetzungen |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98913241T ATE231839T1 (de) | 1997-04-10 | 1998-04-01 | Polyaromatische antivirale zusammensetzungen |
Country Status (9)
Country | Link |
---|---|
US (2) | US5958983A (de) |
EP (1) | EP0973735B1 (de) |
JP (1) | JP2001519808A (de) |
AT (2) | ATE298741T1 (de) |
AU (1) | AU6783698A (de) |
DE (2) | DE69811062T2 (de) |
DK (1) | DK0973735T3 (de) |
ES (2) | ES2191292T3 (de) |
WO (1) | WO1998045259A2 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7329670B1 (en) | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
US6335350B1 (en) | 1998-12-09 | 2002-01-01 | American Home Products Corporation | Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses |
IL143182A0 (en) * | 1998-12-09 | 2002-04-21 | American Home Prod | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group |
HUP0104611A3 (en) * | 1998-12-09 | 2002-10-28 | Wyeth Corp | Thiourea inhibitors of herpes viruses and medicaments containing them |
US6262090B1 (en) * | 1998-12-09 | 2001-07-17 | American Home Products Corporation | Aminopyridine-containing thiourea inhibitors of herpes viruses |
WO2000034269A1 (en) * | 1998-12-09 | 2000-06-15 | American Home Products Corporation | Thiourea inhibitors of herpes viruses |
KR20010086091A (ko) * | 1998-12-09 | 2001-09-07 | 이곤 이 버그 | 치환된 페닐렌디아민 그룹을 함유하는 허프스 바이러스의헤테로사이클릭 카복사미드-함유 티오우레아 억제제 |
US6197803B1 (en) | 1998-12-09 | 2001-03-06 | American Home Products Corporation | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group |
HUP0104944A3 (en) * | 1998-12-09 | 2003-03-28 | Wyeth Corp | Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses |
US6201013B1 (en) | 1998-12-09 | 2001-03-13 | American Home Products Corporation | Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substituted phenylenediamine group |
US6166028A (en) | 1998-12-09 | 2000-12-26 | American Home Products Corporation | Diaminopuridine-containing thiourea inhibitors of herpes viruses |
EP1140840B1 (de) * | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | -g(v)-carboxyaryl substituierte diphenyl harnstoffe als raf kinase inhibitoren |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
ATE556713T1 (de) * | 1999-01-13 | 2012-05-15 | Bayer Healthcare Llc | Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer |
AU7353300A (en) * | 1999-09-08 | 2001-04-10 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
AU2003209119A1 (en) | 2002-02-11 | 2003-09-04 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
AU2003209116A1 (en) | 2002-02-11 | 2003-09-04 | Bayer Pharmaceuticals Corporation | Aryl ureas with angiogenesis inhibiting activity |
ATE529406T1 (de) | 2002-02-11 | 2011-11-15 | Bayer Healthcare Llc | Aryl-harnstoffe als kinase inhibitoren |
DE10217518A1 (de) * | 2002-04-19 | 2003-11-06 | Bayer Ag | Lactone |
US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
JP4603531B2 (ja) | 2003-04-30 | 2010-12-22 | ノバルティス アーゲー | スフィンゴシン−1−ホスフェートレセプターモジュレーターとしての、アミノプロパノール誘導体 |
JP4860474B2 (ja) | 2003-05-20 | 2012-01-25 | バイエル、ファーマシューテイカルズ、コーポレイション | Pdgfrによって仲介される病気のためのジアリール尿素 |
WO2005007621A2 (en) * | 2003-05-30 | 2005-01-27 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
KR20070007759A (ko) * | 2003-07-10 | 2007-01-16 | 아칠리온 파르마세우티칼스 인코포레이티드 | 바이러스 복제 억제제로서 유용한 치환된 아릴티오우레아유도체 |
DK1663978T3 (da) | 2003-07-23 | 2008-04-07 | Bayer Pharmaceuticals Corp | Fluorsubstitueret omega-carboxyaryl-diphenylurinstof til behandling og forebyggelse af sygdomme og lidelser |
TW200518742A (en) * | 2003-09-11 | 2005-06-16 | Tibotec Pharm Ltd | Entry inhibitors |
JP5327744B2 (ja) * | 2009-03-13 | 2013-10-30 | 国立大学法人 鹿児島大学 | ジフェニルメタン誘導体を有効成分とする抗ウイルス剤 |
KR20230170813A (ko) | 2018-09-12 | 2023-12-19 | 노파르티스 아게 | 항바이러스 피리도피라진디온 화합물 |
US11667613B2 (en) | 2019-09-26 | 2023-06-06 | Novartis Ag | Antiviral pyrazolopyridinone compounds |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56108759A (en) * | 1980-01-29 | 1981-08-28 | Mitsui Toatsu Chem Inc | Novel bisphenol compound and its preparation |
WO1982003390A1 (en) * | 1981-03-30 | 1982-10-14 | Geigy Ag Ciba | Erivatives of phenoxy-phenyle-isothio-urea,intermediary products based on phenoxy-phenyle-thio-urea,preparation thereof and their utilization against insects |
DE3626309A1 (de) * | 1986-08-02 | 1988-02-18 | Stockhausen Chem Fab Gmbh | Antivirusmittel |
JPH02237922A (ja) * | 1989-01-24 | 1990-09-20 | Green Cross Corp:The | 抗ウィルス剤 |
AU8937491A (en) * | 1990-10-22 | 1992-05-20 | Research Corporation Technologies, Inc. | Aryl and heteroaryl compounds having anti-retrovirus activity |
ATE116637T1 (de) * | 1991-02-05 | 1995-01-15 | Merrell Dow Pharma | Sulfonische stilbenderivate zur behandlung von viruserkrankungen. |
US5569643A (en) * | 1991-03-07 | 1996-10-29 | Nippon Oil Co., Ltd. | Grease composition for constant velocity joint |
EP0590026B1 (de) * | 1991-06-19 | 1999-08-04 | Schering Corporation | Oralaktive antivirale verbindungen |
EP0571083B1 (de) * | 1992-05-18 | 1997-06-18 | Kao Corporation | Entwickleradditiv, Toner und Entwicklerzusammensetzung |
JP3603315B2 (ja) * | 1993-02-19 | 2004-12-22 | 日本製紙株式会社 | 近赤外線吸収剤およびそれを含有した熱線遮蔽材 |
JP3509082B2 (ja) * | 1994-06-23 | 2004-03-22 | 日本製紙株式会社 | 感熱記録体 |
EP0725320B1 (de) * | 1995-01-31 | 2001-06-20 | Mitsubishi Chemical Corporation | Ladungssteuerungsmittel für die Entwicklung elektrostatischer Bilder, und Toner und ladungserzeugendes Material die es enthalten |
-
1998
- 1998-04-01 JP JP54282798A patent/JP2001519808A/ja not_active Withdrawn
- 1998-04-01 US US09/053,177 patent/US5958983A/en not_active Expired - Fee Related
- 1998-04-01 WO PCT/US1998/006152 patent/WO1998045259A2/en active IP Right Grant
- 1998-04-01 EP EP98913241A patent/EP0973735B1/de not_active Expired - Lifetime
- 1998-04-01 DK DK98913241T patent/DK0973735T3/da active
- 1998-04-01 DE DE69811062T patent/DE69811062T2/de not_active Expired - Fee Related
- 1998-04-01 AU AU67836/98A patent/AU6783698A/en not_active Abandoned
- 1998-04-01 AT AT01117751T patent/ATE298741T1/de not_active IP Right Cessation
- 1998-04-01 ES ES98913241T patent/ES2191292T3/es not_active Expired - Lifetime
- 1998-04-01 DE DE69830751T patent/DE69830751T2/de not_active Expired - Fee Related
- 1998-04-01 ES ES01117751T patent/ES2243370T3/es not_active Expired - Lifetime
- 1998-04-01 AT AT98913241T patent/ATE231839T1/de not_active IP Right Cessation
-
1999
- 1999-05-11 US US09/309,645 patent/US6147116A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5958983A (en) | 1999-09-28 |
DE69830751D1 (de) | 2005-08-04 |
DE69830751T2 (de) | 2006-05-18 |
EP0973735B1 (de) | 2003-01-29 |
ES2191292T3 (es) | 2003-09-01 |
DE69811062T2 (de) | 2003-07-17 |
EP0973735A2 (de) | 2000-01-26 |
JP2001519808A (ja) | 2001-10-23 |
WO1998045259A2 (en) | 1998-10-15 |
AU6783698A (en) | 1998-10-30 |
DE69811062D1 (de) | 2003-03-06 |
ES2243370T3 (es) | 2005-12-01 |
DK0973735T3 (da) | 2003-06-23 |
ATE231839T1 (de) | 2003-02-15 |
WO1998045259A3 (en) | 1999-02-25 |
US6147116A (en) | 2000-11-14 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |