ATE286913T1 - Antikörper gegen epitope mit homologie zu auto- antigenen, verfahren zur herstellung und deren verwendungen - Google Patents
Antikörper gegen epitope mit homologie zu auto- antigenen, verfahren zur herstellung und deren verwendungenInfo
- Publication number
- ATE286913T1 ATE286913T1 AT95302440T AT95302440T ATE286913T1 AT E286913 T1 ATE286913 T1 AT E286913T1 AT 95302440 T AT95302440 T AT 95302440T AT 95302440 T AT95302440 T AT 95302440T AT E286913 T1 ATE286913 T1 AT E286913T1
- Authority
- AT
- Austria
- Prior art keywords
- antigens
- amabs
- self
- homology
- auto
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 4
- 101710160107 Outer membrane protein A Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Environmental Sciences (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Virology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Food Science & Technology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/226,168 US7119248B1 (en) | 1994-04-12 | 1994-04-12 | Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE286913T1 true ATE286913T1 (de) | 2005-01-15 |
Family
ID=22847844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95302440T ATE286913T1 (de) | 1994-04-12 | 1995-04-12 | Antikörper gegen epitope mit homologie zu auto- antigenen, verfahren zur herstellung und deren verwendungen |
Country Status (8)
Country | Link |
---|---|
US (2) | US7119248B1 (de) |
EP (1) | EP0677533B1 (de) |
JP (3) | JP3797680B2 (de) |
AT (1) | ATE286913T1 (de) |
CA (1) | CA2146693C (de) |
DE (1) | DE69533912T2 (de) |
DK (1) | DK0677533T3 (de) |
ES (1) | ES2236698T3 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7119248B1 (en) * | 1994-04-12 | 2006-10-10 | Miltenyi Biotec Gmbh | Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof |
PT1049717E (pt) * | 1998-01-23 | 2007-05-31 | Hoffmann La Roche | Anticorpos contra a il-12 humana. |
US7026456B1 (en) | 1998-01-23 | 2006-04-11 | Hoffman-La Roche, Inc. | Antibodies against human IL-12 |
ES2586206T3 (es) | 2000-06-19 | 2016-10-13 | Beth Israel Deaconess Medical Center | Composiciones y métodos de anticuerpos monoclonales y policlonales específicos para subpoblaciones de linfocitos T |
WO2003092615A2 (en) * | 2002-05-01 | 2003-11-13 | Beth Israel Deaconess Medical Center | Use of anti-cd1 antibodies for the modulation of immune responses |
EP1606387A4 (de) * | 2003-03-04 | 2008-04-23 | Alexion Pharma Inc | Zur erzeugung konstanter hybridbereiche verwendete vektoren |
JP4545685B2 (ja) * | 2003-04-16 | 2010-09-15 | 小野薬品工業株式会社 | 心臓疾患治療物質のスクリーニング方法および心臓疾患治療医薬組成物 |
WO2007080404A2 (en) * | 2006-01-12 | 2007-07-19 | Asterion Limited | Leptin ligand |
WO2007106448A1 (en) * | 2006-03-10 | 2007-09-20 | Lexicon Genetics Incorporated | Methods for making antibodies in genetically engineered mice |
JP5435878B2 (ja) * | 2008-02-12 | 2014-03-05 | 富士フイルム株式会社 | 断片化抗体を標識物質に固定した標識粒子 |
MX342907B (es) | 2009-05-13 | 2016-10-17 | Genzyme Corp * | El uso de un anticuerpo anti-cd52 monoclonal para el tratamiento de lupus. |
US8617554B2 (en) | 2009-05-13 | 2013-12-31 | Genzyme Corporation | Anti-human CD52 immunoglobulins |
US8790916B2 (en) | 2009-05-14 | 2014-07-29 | Genestream, Inc. | Microfluidic method and system for isolating particles from biological fluid |
US20120204278A1 (en) | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
JP5944312B2 (ja) | 2009-07-08 | 2016-07-05 | カイマブ・リミテッド | 動物モデルおよび治療用分子 |
US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
HUE026229T2 (en) | 2010-02-08 | 2016-06-28 | Regeneron Pharma | Common light chain mouse |
US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
US8695618B2 (en) | 2010-12-22 | 2014-04-15 | Carnegie Mellon University | 3D chemical pattern control in 2D fluidics devices |
EP2739740B1 (de) | 2011-08-05 | 2019-10-02 | Regeneron Pharmaceuticals, Inc. | Universelle, leichtkettige, humanisierte mäuse |
EP4091442A1 (de) | 2011-09-19 | 2022-11-23 | Kymab Limited | Manipulation der immunglobulin-gen-vielfalt und therapeutika mit mehreren antikörpern |
WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
RU2014120694A (ru) | 2011-10-27 | 2015-12-10 | Нкт Терапьютикс Инк. | ГУМАНИЗИРОВАННЫЕ АНТИТЕЛА К iNKT |
GB2496375A (en) * | 2011-10-28 | 2013-05-15 | Kymab Ltd | A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof |
US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
AR095199A1 (es) | 2013-03-15 | 2015-09-30 | Genzyme Corp | Anticuerpos anti-cd52 |
US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
US20140331339A1 (en) * | 2013-05-03 | 2014-11-06 | Kymab Limited | Transgenic Non-Human Assay Vertebrates, Assays and Kits |
JP7133902B2 (ja) | 2013-10-01 | 2022-09-09 | カイマブ・リミテッド | 動物モデル及び治療用分子 |
EP3119194B1 (de) | 2014-03-21 | 2021-04-28 | Regeneron Pharmaceuticals, Inc. | Einzeldomänenbindende proteine produzierende nichtmenschliche tiere |
AU2016232715A1 (en) | 2015-03-19 | 2017-09-28 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
CN109195443A (zh) | 2016-02-16 | 2019-01-11 | 雷杰纳荣制药公司 | 具有突变型犬尿氨酸酶基因的非人动物 |
EP3457840B1 (de) | 2016-05-20 | 2024-04-10 | Regeneron Pharmaceuticals, Inc. | Verfahren zur durchbrechung einer immunologischen toleranz unter verwendung mehrerer guide-rnas |
CN113361141B (zh) * | 2021-07-11 | 2022-02-18 | 西南石油大学 | 一种dna图谱算法的改进试验方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0435928A1 (de) | 1988-09-21 | 1991-07-10 | Animal Biotechnology Cambridge Limited | Herleitung pluripotenter embryonaler zellinien von nutztieren |
EP1324040A3 (de) | 1992-10-21 | 2007-06-20 | MILTENYI, Stefan | Direkte Auswahl von Zellen durch ein Ausscheidungsprodukt |
GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
US7119248B1 (en) * | 1994-04-12 | 2006-10-10 | Miltenyi Biotec Gmbh | Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof |
-
1994
- 1994-04-12 US US08/226,168 patent/US7119248B1/en not_active Expired - Fee Related
-
1995
- 1995-04-10 CA CA2146693A patent/CA2146693C/en not_active Expired - Fee Related
- 1995-04-12 ES ES95302440T patent/ES2236698T3/es not_active Expired - Lifetime
- 1995-04-12 AT AT95302440T patent/ATE286913T1/de active
- 1995-04-12 DE DE69533912T patent/DE69533912T2/de not_active Expired - Lifetime
- 1995-04-12 JP JP08726995A patent/JP3797680B2/ja not_active Expired - Fee Related
- 1995-04-12 EP EP95302440A patent/EP0677533B1/de not_active Expired - Lifetime
- 1995-04-12 DK DK95302440T patent/DK0677533T3/da active
-
2005
- 2005-09-09 JP JP2005263046A patent/JP2006061158A/ja not_active Withdrawn
-
2006
- 2006-01-11 JP JP2006004229A patent/JP4362121B2/ja not_active Expired - Fee Related
- 2006-10-10 US US11/546,539 patent/US20070101446A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0677533A2 (de) | 1995-10-18 |
JP2006061158A (ja) | 2006-03-09 |
US20070101446A1 (en) | 2007-05-03 |
CA2146693C (en) | 2010-09-14 |
ES2236698T3 (es) | 2005-07-16 |
DE69533912D1 (de) | 2005-02-17 |
EP0677533B1 (de) | 2005-01-12 |
DK0677533T3 (da) | 2005-05-30 |
CA2146693A1 (en) | 1995-10-13 |
US7119248B1 (en) | 2006-10-10 |
JP2006151991A (ja) | 2006-06-15 |
EP0677533A3 (de) | 2000-04-12 |
JPH0856692A (ja) | 1996-03-05 |
JP4362121B2 (ja) | 2009-11-11 |
JP3797680B2 (ja) | 2006-07-19 |
DE69533912T2 (de) | 2005-12-08 |
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