ATE277058T1 - Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel - Google Patents
Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittelInfo
- Publication number
- ATE277058T1 ATE277058T1 AT97908699T AT97908699T ATE277058T1 AT E277058 T1 ATE277058 T1 AT E277058T1 AT 97908699 T AT97908699 T AT 97908699T AT 97908699 T AT97908699 T AT 97908699T AT E277058 T1 ATE277058 T1 AT E277058T1
- Authority
- AT
- Austria
- Prior art keywords
- complexes
- contrast agents
- acid
- polyazomacrocyclofluoromonoalkylphosphenic
- polyazamacrocyclofluoromonoalkylphosphonic
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000002872 contrast media Substances 0.000 title abstract 2
- 229910052688 Gadolinium Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 229910052746 lanthanum Inorganic materials 0.000 abstract 1
- 229910052748 manganese Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/606,162 US5834456A (en) | 1996-02-23 | 1996-02-23 | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents |
PCT/US1997/002799 WO1997031005A1 (en) | 1996-02-23 | 1997-02-21 | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE277058T1 true ATE277058T1 (de) | 2004-10-15 |
Family
ID=24426818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97908699T ATE277058T1 (de) | 1996-02-23 | 1997-02-21 | Polyazomacrocyclofluoromonoalkylphosphensäure, ihre komplexe zur verwendung als kontrastmittel |
Country Status (6)
Country | Link |
---|---|
US (1) | US5834456A (de) |
EP (1) | EP0882055B1 (de) |
AT (1) | ATE277058T1 (de) |
AU (1) | AU2054097A (de) |
DE (1) | DE69730820T2 (de) |
WO (1) | WO1997031005A1 (de) |
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US6565828B2 (en) * | 2000-04-07 | 2003-05-20 | Bristol-Myers Squibb Company | Macrocyclic chelants for metallopharmaceuticals |
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US7048907B2 (en) * | 2001-02-05 | 2006-05-23 | Biophysics Assay Laboratory, Inc. | Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products |
US6670456B2 (en) * | 2001-02-28 | 2003-12-30 | Dow Global Technologies Inc. | Actinium-225 complexes and conjugates for targeted radiotherapy |
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US20040115822A1 (en) * | 2002-09-12 | 2004-06-17 | Schapaugh Randal Lee | Methods of measuring the dissolution rate of an analyte in a non-aqueous liquid composition |
US20060210479A1 (en) * | 2004-08-10 | 2006-09-21 | Dow Global Technologies Inc. | Targeting chelants and chelates |
TR201808537T4 (tr) | 2004-09-23 | 2018-07-23 | Genentech Inc | Sistein değiştirilmiş antikorlar ve konjugatlar. |
US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
RS53168B (en) | 2006-05-30 | 2014-06-30 | Genentech Inc. | Antibodies and Immunoconjugates and Their Use |
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KR20090114443A (ko) | 2007-02-09 | 2009-11-03 | 제넨테크, 인크. | 항-Robo4 항체 및 그의 용도 |
AU2008276128B2 (en) | 2007-07-16 | 2013-10-10 | Genentech, Inc. | Humanized anti-CD79b antibodies and immunoconjugates and methods of use |
ES2381788T3 (es) | 2007-07-16 | 2012-05-31 | Genentech, Inc. | Anticuerpos anti-CD79b e inmunoconjugados y métodos de uso |
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US20110166444A1 (en) * | 2008-09-22 | 2011-07-07 | Koninklijke Philips Electronics N.V. | Mri-visible sutures for minimally invasive image-guided anastomosis |
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MX338775B (es) | 2009-06-04 | 2016-05-02 | Novartis Ag | Metodos para identificacion de sitios para conjugacion de igg. |
CA2781682A1 (en) | 2009-12-04 | 2011-06-09 | Genentech, Inc. | Multispecific antibodies, antibody analogs, compositions, and methods |
US8765977B2 (en) | 2010-03-31 | 2014-07-01 | General Electric Company | Hydroxylated contrast enhancement agents and imaging method |
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US8362281B2 (en) | 2010-03-31 | 2013-01-29 | General Electric Company | Intermediates for hydroxylated contrast enhancement agents |
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RU2630296C2 (ru) | 2012-07-04 | 2017-09-06 | Ф. Хоффманн-Ля Рош Аг | Антитела к биотину и способы их применения |
SI2869837T1 (sl) | 2012-07-04 | 2016-12-30 | F. Hoffmann-La Roche Ag | Protitelesa proti teofilinu in postopki uporabe |
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EP3960768A1 (de) | 2014-01-03 | 2022-03-02 | F. Hoffmann-La Roche AG | Bispezifische anti-hapten-/anti-blut-hirn-schranke-rezeptor-antikörper, komplexe davon und deren verwendung als blut-hirn-schranke-shuttles |
CA2930046A1 (en) | 2014-01-03 | 2015-07-09 | F. Hoffmann-La Roche Ag | Covalently linked polypeptide toxin-antibody conjugates |
CA2930154A1 (en) | 2014-01-03 | 2015-07-09 | F. Hoffmann-La Roche Ag | Covalently linked helicar-anti-helicar antibody conjugates and uses thereof |
SG11201701128YA (en) | 2014-09-12 | 2017-03-30 | Genentech Inc | Cysteine engineered antibodies and conjugates |
BR112017010775A2 (pt) | 2014-12-17 | 2018-02-27 | Hoffmann La Roche | ?método para produzir um produto de conjugação enzimática? |
CN104945312A (zh) * | 2015-06-24 | 2015-09-30 | 黄荣辉 | 一种2,6-二氯甲基吡啶盐酸盐的制备方法 |
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CN108138158B (zh) | 2015-09-25 | 2021-11-09 | 豪夫迈·罗氏有限公司 | 可溶性分选酶a |
EP3436578B1 (de) | 2016-03-30 | 2022-01-19 | F. Hoffmann-La Roche AG | Verbesserte sortase |
CN110709523B (zh) | 2017-04-12 | 2023-07-11 | 豪夫迈·罗氏有限公司 | 使用经pictet spengler反应获得的加标签的核苷的测序反应方法 |
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WO2019077113A1 (en) | 2017-10-20 | 2019-04-25 | F. Hoffmann-La Roche Ag | COPY PROTECTION FOR ANTIBODIES |
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WO2019175131A1 (en) | 2018-03-14 | 2019-09-19 | F. Hoffmann-La Roche Ag | Method for affinity maturation of antibodies |
CN111936522A (zh) | 2018-04-18 | 2020-11-13 | 豪夫迈·罗氏有限公司 | 新型抗胸苷激酶抗体 |
EP3844503B1 (de) | 2018-08-31 | 2024-05-29 | F. Hoffmann-La Roche AG | Thymidinkinase (tk-1) in prognostischen indizes für dlbcl |
CN116271117A (zh) | 2018-09-28 | 2023-06-23 | 伊麦吉纳博公司 | Cd8成像构建体及其使用方法 |
JP2023550278A (ja) | 2020-10-30 | 2023-12-01 | エフ. ホフマン-ラ ロシュ アーゲー | 胆管癌のマーカーとしてのtimp1 |
WO2023111168A1 (en) | 2021-12-17 | 2023-06-22 | F. Hoffmann-La Roche Ag | A novel antibody for detection of amyloid beta 42 (aβ42) |
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US5385893A (en) * | 1993-05-06 | 1995-01-31 | The Dow Chemical Company | Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
DE4317588C2 (de) * | 1993-05-24 | 1998-04-16 | Schering Ag | Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung |
WO1994027644A1 (en) * | 1993-06-02 | 1994-12-08 | Bracco S.P.A. | Iodinated paramagnetic chelates, and their use as contrast agents |
JPH0797340A (ja) * | 1993-06-03 | 1995-04-11 | Terumo Corp | Mri造影剤組成物 |
EP0730616B1 (de) * | 1993-11-26 | 2003-02-05 | Dow Global Technologies Inc. | Verfahren zur herstellung von polyazamacrocylen |
IT1265440B1 (it) * | 1993-12-24 | 1996-11-22 | Bracco Spa | Formulazioni diagnostiche paramagnetiche e metodo d'uso delle stesse |
-
1996
- 1996-02-23 US US08/606,162 patent/US5834456A/en not_active Expired - Fee Related
-
1997
- 1997-02-21 AU AU20540/97A patent/AU2054097A/en not_active Abandoned
- 1997-02-21 WO PCT/US1997/002799 patent/WO1997031005A1/en active IP Right Grant
- 1997-02-21 AT AT97908699T patent/ATE277058T1/de not_active IP Right Cessation
- 1997-02-21 DE DE69730820T patent/DE69730820T2/de not_active Expired - Fee Related
- 1997-02-21 EP EP97908699A patent/EP0882055B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU2054097A (en) | 1997-09-10 |
EP0882055A1 (de) | 1998-12-09 |
EP0882055B1 (de) | 2004-09-22 |
WO1997031005A1 (en) | 1997-08-28 |
DE69730820D1 (de) | 2004-10-28 |
US5834456A (en) | 1998-11-10 |
DE69730820T2 (de) | 2005-09-29 |
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Legal Events
Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |