BR9713176A - Benzotiofenos amorfos,métodos de preparação e métodos de uso - Google Patents

Benzotiofenos amorfos,métodos de preparação e métodos de uso

Info

Publication number
BR9713176A
BR9713176A BR9713176-8A BR9713176A BR9713176A BR 9713176 A BR9713176 A BR 9713176A BR 9713176 A BR9713176 A BR 9713176A BR 9713176 A BR9713176 A BR 9713176A
Authority
BR
Brazil
Prior art keywords
methods
preparation
amorphous
benzothiophenes
processes
Prior art date
Application number
BR9713176-8A
Other languages
English (en)
Inventor
George W Cuff
Arvind L Thakkar
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9713176A publication Critical patent/BR9713176A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Patente de Invenção: <B>"BENZOTIOFENOS AMORFOS, MéTODOS DE PREPARAçãO E MéTODOS DE USO''<D>. A presente invenção fornece uma forma amorfa de um composto de fórmula (I). São também fornecidos processos de preparação do material, assim como processos de uso do mesmo.
BR9713176-8A 1996-08-28 1997-08-22 Benzotiofenos amorfos,métodos de preparação e métodos de uso BR9713176A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2483196P 1996-08-28 1996-08-28
PCT/US1997/014768 WO1998008513A1 (en) 1996-08-28 1997-08-22 Amorphous benzothiophenes, methods of preparation, and methods of use

Publications (1)

Publication Number Publication Date
BR9713176A true BR9713176A (pt) 2000-02-08

Family

ID=21822611

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9713176-8A BR9713176A (pt) 1996-08-28 1997-08-22 Benzotiofenos amorfos,métodos de preparação e métodos de uso

Country Status (25)

Country Link
EP (1) EP0826682B1 (pt)
JP (1) JP2002514174A (pt)
KR (1) KR20000035941A (pt)
CN (1) CN1244124A (pt)
AR (2) AR009333A1 (pt)
AT (1) ATE234295T1 (pt)
AU (1) AU723987B2 (pt)
BR (1) BR9713176A (pt)
CA (1) CA2263175A1 (pt)
CO (1) CO4650039A1 (pt)
CZ (1) CZ64399A3 (pt)
DE (1) DE69719640T2 (pt)
EA (1) EA002022B1 (pt)
ES (1) ES2195089T3 (pt)
HU (1) HUP0001172A3 (pt)
IL (1) IL128641A (pt)
IN (1) IN182940B (pt)
NO (1) NO990914L (pt)
NZ (1) NZ333839A (pt)
PE (1) PE108598A1 (pt)
PL (1) PL333356A1 (pt)
TR (1) TR199900403T2 (pt)
WO (1) WO1998008513A1 (pt)
YU (1) YU10599A (pt)
ZA (1) ZA977617B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19980033284A (ko) * 1996-10-30 1998-07-25 피터지.스트링거 개선된 유방암 예방법
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
FI982733A (fi) 1998-12-17 2000-06-18 Orion Yhtymae Oyj Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia
EP1832582A1 (en) * 2002-09-30 2007-09-12 A/S GEA Farmaceutisk Fabrik Novel raloxifene malonic acid addition salts and/or solvates thereof, and pharmaceutical compositions comprising these
US20050008704A1 (en) * 2003-07-11 2005-01-13 Ray Anup Kumar Pharmaceutical composition for solubility enhancement of hydrophobic drugs
CA2634056C (en) * 2005-12-21 2014-06-10 Eisai R&D Management Co., Ltd. Amorphous form of 1,2-dihydropyridine compound
GB2456096B (en) 2006-10-17 2011-08-17 Cipla Ltd Crystalline form of benzothiophene compound and process for preparation thereof
ES2437916T3 (es) 2009-07-02 2014-01-15 Synthon B.V. Composición de raloxifeno
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy
ITMI20121821A1 (it) * 2012-10-25 2014-04-26 Erregierre Spa Composizione farmaceutica solubile in acqua a base di un sale di raloxifene

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230862A (en) * 1975-10-28 1980-10-28 Eli Lilly And Company Antifertility compounds
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5631369A (en) * 1994-08-31 1997-05-20 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents

Also Published As

Publication number Publication date
AR009334A1 (es) 2000-04-12
EP0826682A1 (en) 1998-03-04
IL128641A (en) 2001-10-31
HUP0001172A3 (en) 2002-01-28
WO1998008513A1 (en) 1998-03-05
ATE234295T1 (de) 2003-03-15
NO990914D0 (no) 1999-02-25
EA199900235A1 (ru) 1999-08-26
NO990914L (no) 1999-02-25
CO4650039A1 (es) 1998-09-03
KR20000035941A (ko) 2000-06-26
EA002022B1 (ru) 2001-12-24
TR199900403T2 (xx) 2002-01-21
NZ333839A (en) 2001-06-29
ES2195089T3 (es) 2003-12-01
DE69719640T2 (de) 2003-11-06
ZA977617B (en) 1999-02-25
YU10599A (sh) 2001-07-10
HUP0001172A2 (hu) 2001-06-28
IL128641A0 (en) 2000-01-31
DE69719640D1 (de) 2003-04-17
CZ64399A3 (cs) 1999-05-12
PL333356A1 (en) 1999-12-06
AR009333A1 (es) 2000-04-12
AU4233597A (en) 1998-03-19
PE108598A1 (es) 1999-01-13
JP2002514174A (ja) 2002-05-14
EP0826682B1 (en) 2003-03-12
CN1244124A (zh) 2000-02-09
CA2263175A1 (en) 1998-03-05
AU723987B2 (en) 2000-09-07
IN182940B (pt) 1999-08-14

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A , 7A E 8A ANUIDADES.