ATE266663T1 - Acrylamid-derivate und verfahren zu deren herstellung - Google Patents

Acrylamid-derivate und verfahren zu deren herstellung

Info

Publication number: ATE266663T1
Authority: AT; Austria
Prior art keywords: acrylamide derivatives; general formula; production; derivatives represented; eüindole
Prior art date: 1994-11-29

Application number

AT95937194T

Other languages

English (en)

Inventor

Yasumichi Fukuda

Shigeki Seto

Yasuo Oomori

Hiroyuki Ebisu

Shiro Terashima

Original Assignee

Kyorin Seiyaku Kk

Sagami Chem Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-29

Filing date

1995-11-28

Publication date

2004-05-15

1995-11-28 Application filed by Kyorin Seiyaku Kk, Sagami Chem Res filed Critical Kyorin Seiyaku Kk

2004-05-15 Application granted granted Critical

2004-05-15 Publication of ATE266663T1 publication Critical patent/ATE266663T1/de

Links

HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical class NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 2
150000003926 acrylamides Chemical class 0.000 abstract 2
201000011510 cancer Diseases 0.000 abstract 1
231100001231 less toxic Toxicity 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Fertilizers (AREA)

AT95937194T 1994-11-29 1995-11-28 Acrylamid-derivate und verfahren zu deren herstellung ATE266663T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP29527494		1994-11-29
PCT/JP1995/002413 WO1996016965A1 (fr)	1994-11-29	1995-11-28	Derives d'acrylamide et leur procede de production

Publications (1)

Publication Number	Publication Date
ATE266663T1 true ATE266663T1 (de)	2004-05-15

Family

ID=17818480

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95937194T ATE266663T1 (de)	1994-11-29	1995-11-28	Acrylamid-derivate und verfahren zu deren herstellung

Country Status (12)

Country	Link
US (1)	US5786486A (de)
EP (1)	EP0799827B1 (de)
KR (1)	KR100395083B1 (de)
CN (1)	CN1051552C (de)
AT (1)	ATE266663T1 (de)
AU (1)	AU693283B2 (de)
CA (1)	CA2205872A1 (de)
DE (1)	DE69533043T2 (de)
FI (1)	FI972074A0 (de)
HU (1)	HUT77654A (de)
MX (1)	MX9703917A (de)
WO (1)	WO1996016965A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU742641B2 (en)	1998-01-28	2002-01-10	Shionogi & Co., Ltd.	Novel tricyclic compound
IL154183A0 (en) *	2001-05-31	2003-07-31	Medarex Inc	Cytotoxins, prodrugs, linkers and stabilizers useful therefor
US7691962B2 (en) *	2004-05-19	2010-04-06	Medarex, Inc.	Chemical linkers and conjugates thereof
US7517903B2 (en) *	2004-05-19	2009-04-14	Medarex, Inc.	Cytotoxic compounds and conjugates
WO2006089230A2 (en) *	2005-02-18	2006-08-24	Medarex, Inc.	Human monoclonal antibodies to prostate specific membrane antigen (psma)
US7714016B2 (en) *	2005-04-08	2010-05-11	Medarex, Inc.	Cytotoxic compounds and conjugates with cleavable substrates
WO2007051081A1 (en)	2005-10-26	2007-05-03	Medarex, Inc.	Methods and compounds for preparing cc-1065 analogs
WO2007059404A2 (en)	2005-11-10	2007-05-24	Medarex, Inc.	Duocarmycin derivatives as novel cytotoxic compounds and conjugates
TWI412367B (zh)	2006-12-28	2013-10-21	Medarex Llc	化學鏈接劑與可裂解基質以及其之綴合物
JP2010519310A (ja)	2007-02-21	2010-06-03	メダレックスインコーポレイテッド	単一のアミノ酸を有する化学リンカーおよびその複合体
EP2922818B1 (de)	2012-11-24	2018-09-05	Hangzhou Dac Biotech Co., Ltd	Hydrophile binder und deren verwendung zur konjugation von wirkstoffen an zellbindende moleküle
ES2960619T3 (es)	2014-02-28	2024-03-05	Hangzhou Dac Biotech Co Ltd	Enlazadores cargados y sus usos para la conjugación
AU2015242213A1 (en)	2015-07-12	2018-03-08	Hangzhou Dac Biotech Co., Ltd	Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en)	2015-07-15	2017-12-12	Suzhou M-Conj Biotech Co., Ltd.	Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
CN110099682B (zh)	2016-11-14	2023-03-31	杭州多禧生物科技有限公司	偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1238907A (en) *	1984-02-21	1988-07-05	Robert C. Kelly	1,2,8,8a-tetrahydrocyclopropa¬c\|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
JP2598819B2 (ja) *	1986-12-19	1997-04-09	ジ・アップジョン・カンパニー	新規なｃｃ‐１０６５同族体
US5258383A (en) *	1991-06-28	1993-11-02	Kyowa Hakko Kogyo Co., Ltd.	DC-89 derivatives
JP2502005B2 (ja)	1992-04-27	1996-05-29	オンキヨー株式会社	バイオフィ―ドバックシステム
JP3514490B2 (ja) *	1992-08-21	2004-03-31	杏林製薬株式会社	トリフルオロメチルピロロインドールカルボン酸エステル誘導体及びその製造方法

1995
- 1995-11-28 WO PCT/JP1995/002413 patent/WO1996016965A1/ja active IP Right Grant
- 1995-11-28 US US08/849,160 patent/US5786486A/en not_active Expired - Fee Related
- 1995-11-28 MX MX9703917A patent/MX9703917A/es not_active IP Right Cessation
- 1995-11-28 CA CA002205872A patent/CA2205872A1/en not_active Abandoned
- 1995-11-28 KR KR1019970703468A patent/KR100395083B1/ko not_active IP Right Cessation
- 1995-11-28 AT AT95937194T patent/ATE266663T1/de not_active IP Right Cessation
- 1995-11-28 DE DE69533043T patent/DE69533043T2/de not_active Expired - Fee Related
- 1995-11-28 HU HU9800067A patent/HUT77654A/hu not_active Application Discontinuation
- 1995-11-28 AU AU39370/95A patent/AU693283B2/en not_active Ceased
- 1995-11-28 EP EP95937194A patent/EP0799827B1/de not_active Expired - Lifetime
- 1995-11-28 CN CN95197472A patent/CN1051552C/zh not_active Expired - Fee Related
1997
- 1997-05-14 FI FI972074A patent/FI972074A0/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1174553A (zh)	1998-02-25
KR100395083B1 (ko)	2004-02-05
AU693283B2 (en)	1998-06-25
FI972074A0 (fi)	1997-05-14
EP0799827A1 (de)	1997-10-08
WO1996016965A1 (fr)	1996-06-06
DE69533043T2 (de)	2005-04-07
DE69533043D1 (de)	2004-06-17
CA2205872A1 (en)	1996-06-06
HUT77654A (hu)	1998-07-28
EP0799827A4 (de)	1998-01-28
US5786486A (en)	1998-07-28
AU3937095A (en)	1996-06-19
MX9703917A (es)	1998-05-31
EP0799827B1 (de)	2004-05-12
CN1051552C (zh)	2000-04-19

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Legal Events

Date	Code	Title	Description
2004-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties