ATE254632T1 - Neue salzformn von (2e)-5-amino-5-methylhex-2- enolsäure n-methyl-n-((1r)-1-(methylcarbamoyl)-2- phruylrthyl) carbamoyl)-2-(2-naphtyl)ethyl)amid - Google Patents

Neue salzformn von (2e)-5-amino-5-methylhex-2- enolsäure n-methyl-n-((1r)-1-(methylcarbamoyl)-2- phruylrthyl) carbamoyl)-2-(2-naphtyl)ethyl)amid

Info

Publication number
ATE254632T1
ATE254632T1 AT99937933T AT99937933T ATE254632T1 AT E254632 T1 ATE254632 T1 AT E254632T1 AT 99937933 T AT99937933 T AT 99937933T AT 99937933 T AT99937933 T AT 99937933T AT E254632 T1 ATE254632 T1 AT E254632T1
Authority
AT
Austria
Prior art keywords
methyl
methylcarbamoyl
carbamoyl
ethyl
amino
Prior art date
Application number
AT99937933T
Other languages
English (en)
Inventor
Claus Ulrik Jessen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE254632T1 publication Critical patent/ATE254632T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth-hormone releasing factors (GH-RF) (Somatoliberin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
AT99937933T 1998-03-03 1999-02-26 Neue salzformn von (2e)-5-amino-5-methylhex-2- enolsäure n-methyl-n-((1r)-1-(methylcarbamoyl)-2- phruylrthyl) carbamoyl)-2-(2-naphtyl)ethyl)amid ATE254632T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK28298 1998-03-03
PCT/DK1999/000089 WO1999045029A1 (en) 1998-03-03 1999-02-26 New salt forms of (2e)- 5-amino-5- methylhex-2- enoic acid n-methyl-n-((1r)-1-(n- methyl-n-((1r)-1-(methylcarbamoyl)-2- phenylethyl)carbamoyl)-2- (2-naphtyl)ethyl)amide

Publications (1)

Publication Number Publication Date
ATE254632T1 true ATE254632T1 (de) 2003-12-15

Family

ID=8091813

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99937933T ATE254632T1 (de) 1998-03-03 1999-02-26 Neue salzformn von (2e)-5-amino-5-methylhex-2- enolsäure n-methyl-n-((1r)-1-(methylcarbamoyl)-2- phruylrthyl) carbamoyl)-2-(2-naphtyl)ethyl)amid

Country Status (15)

Country Link
EP (1) EP1060190B1 (de)
JP (1) JP2002505340A (de)
KR (1) KR20010041533A (de)
CN (1) CN1291994A (de)
AT (1) ATE254632T1 (de)
AU (1) AU3247899A (de)
BR (1) BR9908399A (de)
CA (1) CA2322051A1 (de)
DE (1) DE69912930D1 (de)
HU (1) HUP0100998A3 (de)
IL (1) IL137353A0 (de)
PL (1) PL342706A1 (de)
TW (1) TW538047B (de)
WO (1) WO1999045029A1 (de)
ZA (1) ZA991572B (de)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1407779A1 (de) 2002-10-10 2004-04-14 Gastrotech A/S Verwendung von Ghrelin zur Behandlung von vermindertem Körpergewicht und Körperfett in Individuen mit Gastrektomie
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
AR059066A1 (es) 2006-01-27 2008-03-12 Amgen Inc Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf)
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
EP2118080B1 (de) 2007-02-09 2016-08-31 Ocera Therapeutics, Inc. Makrocyclische ghrelin-rezeptormodulatoren und verwendungsverfahren dafür
SI2480559T1 (sl) 2009-09-21 2013-10-30 Gilead Sciences, Inc. Postopki in intermediati za pripravo 1'-ciano-karbanukleozidnih analogov
KR20200052384A (ko) 2010-07-19 2020-05-14 길리애드 사이언시즈, 인코포레이티드 부분입체 이성질성으로 순수한 포스포라미데이트 전구약물의 제조 방법
PT2595980E (pt) 2010-07-22 2014-11-27 Gilead Sciences Inc Métodos e compostos para tratar infeções pelo vírus da família paramyxoviridae
TWI698444B (zh) 2014-10-29 2020-07-11 美商基利科學股份有限公司 製備核糖苷的方法
EP3242934B1 (de) 2015-01-08 2021-08-18 The Board of Trustees of the Leland Stanford Junior University Faktoren und zellen zur bereitstellung der induktion von knochen, knochenmark und knorpel
CA2998189C (en) 2015-09-16 2021-08-03 Gilead Sciences, Inc. Methods for treating arenaviridae and coronaviridae virus infections
CN110869028B (zh) 2017-03-14 2023-01-20 吉利德科学公司 治疗猫冠状病毒感染的方法
CN115403626A (zh) 2017-05-01 2022-11-29 吉利德科学公司 新结晶形式
US10675296B2 (en) 2017-07-11 2020-06-09 Gilead Sciences, Inc. Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections
WO2021154687A1 (en) 2020-01-27 2021-08-05 Gilead Sciences, Inc. Methods for treating sars cov-2 infections
CN115298181A (zh) 2020-03-12 2022-11-04 吉利德科学公司 制备1’-氰基核苷的方法
EP4132651A1 (de) 2020-04-06 2023-02-15 Gilead Sciences, Inc. Inhalationsformulierungen von 1'-cyansubstituierten carbanukleosidanaloga
CA3179226A1 (en) 2020-05-29 2021-12-02 Tomas Cihlar Remdesivir treatment methods
CN115996928A (zh) 2020-06-24 2023-04-21 吉利德科学公司 1’-氰基核苷类似物及其用途
PE20231983A1 (es) 2020-08-27 2023-12-12 Gilead Sciences Inc Compuestos y metodos para el tratamiento de infecciones virales
WO2023167944A1 (en) 2022-03-02 2023-09-07 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2323159T3 (es) * 1995-12-22 2009-07-07 Novo Nordisk A/S Compuestos con propiedades de liberacion de la hormona del crecimiento.

Also Published As

Publication number Publication date
EP1060190A1 (de) 2000-12-20
KR20010041533A (ko) 2001-05-25
EP1060190B1 (de) 2003-11-19
HUP0100998A2 (hu) 2001-08-28
WO1999045029A1 (en) 1999-09-10
PL342706A1 (en) 2001-07-02
TW538047B (en) 2003-06-21
CA2322051A1 (en) 1999-09-10
CN1291994A (zh) 2001-04-18
ZA991572B (en) 1999-09-03
BR9908399A (pt) 2000-10-31
DE69912930D1 (de) 2003-12-24
JP2002505340A (ja) 2002-02-19
AU3247899A (en) 1999-09-20
IL137353A0 (en) 2001-07-24
HUP0100998A3 (en) 2001-12-28

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