ZA991572B - New salt forms of (2E)-5-amino-5-methylhex-2-enoic acid N-methyl-N-((1R)-1-(N-methyl-N-((1R)-1-(methylcarbamoyl)-2-phenylethyl)carbamoy L)-2-(2-naphthyl)ethyl)amide. - Google Patents
New salt forms of (2E)-5-amino-5-methylhex-2-enoic acid N-methyl-N-((1R)-1-(N-methyl-N-((1R)-1-(methylcarbamoyl)-2-phenylethyl)carbamoy L)-2-(2-naphthyl)ethyl)amide.Info
- Publication number
- ZA991572B ZA991572B ZA9901572A ZA991572A ZA991572B ZA 991572 B ZA991572 B ZA 991572B ZA 9901572 A ZA9901572 A ZA 9901572A ZA 991572 A ZA991572 A ZA 991572A ZA 991572 B ZA991572 B ZA 991572B
- Authority
- ZA
- South Africa
- Prior art keywords
- methyl
- methylcarbamoyl
- phenylethyl
- naphthyl
- amide
- Prior art date
Links
- WURGZWOTGMLDJP-ZCYANPAGSA-N (e)-5-amino-n,5-dimethyl-n-[(2r)-1-[methyl-[(2r)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]hex-2-enamide Chemical compound C([C@H](C(=O)NC)N(C)C(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)\C=C\CC(C)(C)N)C1=CC=CC=C1 WURGZWOTGMLDJP-ZCYANPAGSA-N 0.000 title abstract 2
- 150000003839 salts Chemical group 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK28298 | 1998-03-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA991572B true ZA991572B (en) | 1999-09-03 |
Family
ID=8091813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9901572A ZA991572B (en) | 1998-03-03 | 1999-02-26 | New salt forms of (2E)-5-amino-5-methylhex-2-enoic acid N-methyl-N-((1R)-1-(N-methyl-N-((1R)-1-(methylcarbamoyl)-2-phenylethyl)carbamoy L)-2-(2-naphthyl)ethyl)amide. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP1060190B1 (xx) |
JP (1) | JP2002505340A (xx) |
KR (1) | KR20010041533A (xx) |
CN (1) | CN1291994A (xx) |
AT (1) | ATE254632T1 (xx) |
AU (1) | AU3247899A (xx) |
BR (1) | BR9908399A (xx) |
CA (1) | CA2322051A1 (xx) |
DE (1) | DE69912930D1 (xx) |
HU (1) | HUP0100998A3 (xx) |
IL (1) | IL137353A0 (xx) |
PL (1) | PL342706A1 (xx) |
TW (1) | TW538047B (xx) |
WO (1) | WO1999045029A1 (xx) |
ZA (1) | ZA991572B (xx) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1407779A1 (en) | 2002-10-10 | 2004-04-14 | Gastrotech A/S | Use of ghrelin for treating low body weight and body fat in gastrectomized individuals |
US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
AR059066A1 (es) | 2006-01-27 | 2008-03-12 | Amgen Inc | Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf) |
CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
AU2008241532A1 (en) | 2007-02-09 | 2008-10-30 | Tranzyme Pharma, Inc. | Macrocyclic ghrelin receptor modulators and methods of using the same |
JP5767643B2 (ja) | 2009-09-21 | 2015-08-19 | ギリード・サイエンシズ・インコーポレーテッド | 1’−置換カルバヌクレオシド類似体の調製のためのプロセスおよび中間体 |
US9090642B2 (en) | 2010-07-19 | 2015-07-28 | Gilead Sciences, Inc. | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
BR122020020745B8 (pt) | 2010-07-22 | 2023-10-31 | Gilead Sciences Inc | Composto antiviral para o tratamento de infecções por paramyxoviridae e composição farmacêutica que o compreende |
TWI698444B (zh) | 2014-10-29 | 2020-07-11 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
AU2016205311B2 (en) | 2015-01-08 | 2022-02-17 | The Board Of Trustees Of The Leland Stanford Junior University | Factors and cells that provide for induction of bone, bone marrow, and cartilage |
LT3785717T (lt) | 2015-09-16 | 2022-04-11 | Gilead Sciences, Inc. | Coronaviridae infekcijų gydymo būdai |
ES2961460T3 (es) | 2017-03-14 | 2024-03-12 | Gilead Sciences Inc | Métodos para tratar las infecciones por coronavirus felinas |
AU2018262501B2 (en) | 2017-05-01 | 2020-12-10 | Gilead Sciences, Inc. | Crystalline forms of (S) 2 ethylbutyl 2 (((S) (((2R,3S,4R,5R) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
CN111093627B (zh) | 2017-07-11 | 2024-03-08 | 吉利德科学公司 | 用于治疗病毒感染的包含rna聚合酶抑制剂和环糊精的组合物 |
CA3163424A1 (en) | 2020-01-27 | 2021-08-05 | Gilead Sciences, Inc. | Methods for treating sars cov-2 infections |
JP2023516087A (ja) | 2020-03-12 | 2023-04-17 | ギリアード サイエンシーズ, インコーポレイテッド | 1’-シアノヌクレオシドを調製する方法 |
AU2021251689A1 (en) | 2020-04-06 | 2022-11-17 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
US11975012B2 (en) | 2020-05-29 | 2024-05-07 | Gilead Sciences, Inc. | Remdesivir treatment methods |
WO2021262826A2 (en) | 2020-06-24 | 2021-12-30 | Gilead Sciences, Inc. | 1'-cyano nucleoside analogs and uses thereof |
TW202228722A (zh) | 2020-08-27 | 2022-08-01 | 美商基利科學股份有限公司 | 用於治療病毒感染之化合物及方法 |
TW202400185A (zh) | 2022-03-02 | 2024-01-01 | 美商基利科學股份有限公司 | 用於治療病毒感染的化合物及方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0869974B1 (en) * | 1995-12-22 | 2009-03-04 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
-
1999
- 1999-02-26 DE DE69912930T patent/DE69912930D1/de not_active Expired - Lifetime
- 1999-02-26 CA CA002322051A patent/CA2322051A1/en not_active Abandoned
- 1999-02-26 CN CN99803429A patent/CN1291994A/zh active Pending
- 1999-02-26 AT AT99937933T patent/ATE254632T1/de not_active IP Right Cessation
- 1999-02-26 KR KR1020007009706A patent/KR20010041533A/ko not_active Application Discontinuation
- 1999-02-26 WO PCT/DK1999/000089 patent/WO1999045029A1/en not_active Application Discontinuation
- 1999-02-26 EP EP99937933A patent/EP1060190B1/en not_active Expired - Lifetime
- 1999-02-26 IL IL13735399A patent/IL137353A0/xx unknown
- 1999-02-26 HU HU0100998A patent/HUP0100998A3/hu unknown
- 1999-02-26 ZA ZA9901572A patent/ZA991572B/xx unknown
- 1999-02-26 BR BR9908399-0A patent/BR9908399A/pt not_active IP Right Cessation
- 1999-02-26 PL PL99342706A patent/PL342706A1/xx not_active Application Discontinuation
- 1999-02-26 JP JP2000534571A patent/JP2002505340A/ja active Pending
- 1999-02-26 AU AU32478/99A patent/AU3247899A/en not_active Abandoned
- 1999-03-30 TW TW088105002A patent/TW538047B/zh active
Also Published As
Publication number | Publication date |
---|---|
EP1060190A1 (en) | 2000-12-20 |
CA2322051A1 (en) | 1999-09-10 |
HUP0100998A2 (hu) | 2001-08-28 |
BR9908399A (pt) | 2000-10-31 |
EP1060190B1 (en) | 2003-11-19 |
AU3247899A (en) | 1999-09-20 |
IL137353A0 (en) | 2001-07-24 |
JP2002505340A (ja) | 2002-02-19 |
HUP0100998A3 (en) | 2001-12-28 |
PL342706A1 (en) | 2001-07-02 |
DE69912930D1 (de) | 2003-12-24 |
WO1999045029A1 (en) | 1999-09-10 |
ATE254632T1 (de) | 2003-12-15 |
KR20010041533A (ko) | 2001-05-25 |
TW538047B (en) | 2003-06-21 |
CN1291994A (zh) | 2001-04-18 |
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