ATE251608T1 - Neue trizyklische verbindungen und arzneimittelzusammensetzungen die diese enthalten - Google Patents

Neue trizyklische verbindungen und arzneimittelzusammensetzungen die diese enthalten

Info

Publication number
ATE251608T1
ATE251608T1 AT96942564T AT96942564T ATE251608T1 AT E251608 T1 ATE251608 T1 AT E251608T1 AT 96942564 T AT96942564 T AT 96942564T AT 96942564 T AT96942564 T AT 96942564T AT E251608 T1 ATE251608 T1 AT E251608T1
Authority
AT
Austria
Prior art keywords
represents hydrogen
compositions containing
amino
containing same
medicinal compositions
Prior art date
Application number
AT96942564T
Other languages
English (en)
Inventor
Shiro Miyoshi
Kohei Ogawa
Original Assignee
Asahi Chemical Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Ind filed Critical Asahi Chemical Ind
Application granted granted Critical
Publication of ATE251608T1 publication Critical patent/ATE251608T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/10—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/76—Dibenzothiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT96942564T 1996-01-10 1996-12-18 Neue trizyklische verbindungen und arzneimittelzusammensetzungen die diese enthalten ATE251608T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP257696 1996-01-10
PCT/JP1996/003689 WO1997025311A1 (fr) 1996-01-10 1996-12-18 Nouveaux composes tricycliques et compositions medicamenteuses contenant ces composes

Publications (1)

Publication Number Publication Date
ATE251608T1 true ATE251608T1 (de) 2003-10-15

Family

ID=11533209

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96942564T ATE251608T1 (de) 1996-01-10 1996-12-18 Neue trizyklische verbindungen und arzneimittelzusammensetzungen die diese enthalten

Country Status (14)

Country Link
US (4) US6037362A (de)
EP (1) EP0882707B1 (de)
JP (1) JP2000239255A (de)
KR (1) KR100395280B1 (de)
CN (2) CN1083831C (de)
AT (1) ATE251608T1 (de)
AU (1) AU715233B2 (de)
CA (1) CA2242351C (de)
DE (1) DE69630319T2 (de)
ES (1) ES2208772T3 (de)
HK (1) HK1017669A1 (de)
NO (2) NO312159B1 (de)
PT (1) PT882707E (de)
WO (1) WO1997025311A1 (de)

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ES2149742T1 (es) 1997-07-03 2000-11-16 Asahi Chemical Ind Nuevos compuestos triciclicos que tienen anillos saturados y composiciones medicinales que contienen los mismos.
WO1999051564A1 (en) * 1998-04-06 1999-10-14 Fujisawa Pharmaceutical Co., Ltd. Propanolamine derivatives
US20030073644A1 (en) * 1998-11-11 2003-04-17 Smithkline Beecham P.L.C. Combinations comprising a beta-agonist and a further antidiabetic agent
EP1128845A1 (de) * 1998-11-11 2001-09-05 Smithkline Beecham Plc Kombinationen enthaltend einen beta-agonist und weiter antidiabetische substanzen
AU751833B2 (en) * 1998-12-15 2002-08-29 Asahi Kasei Kabushiki Kaisha Novel heterocyclic compounds and drug compositions containing the same
TW519537B (en) * 1999-03-26 2003-02-01 Asahi Chemical Ind Process for the preparation of tricylic amino-alcohol derivatives
EP1174426A1 (de) * 1999-04-01 2002-01-23 Asahi Kasei Kabushiki Kaisha Methoden zur herstellung eines trizyklischen aminoalkoholes durch azide
CN1360574A (zh) * 1999-07-09 2002-07-24 旭化成株式会社 制备三环氨基醇衍生物的方法
KR20020030802A (ko) * 1999-09-03 2002-04-25 야마모토 카즈모토 삼환식 아미노 알코올 유도체의 제조 방법
US20030220329A1 (en) * 1999-09-17 2003-11-27 Duke University Method of improving beta-adrenergic receptor function
AU7447900A (en) * 1999-10-04 2001-05-10 Asahi Kasei Kabushiki Kaisha Method for improving the solubility of tricyclic amino alcohol derivatives
WO2001044187A1 (fr) * 1999-12-16 2001-06-21 Asahi Kasei Kabushiki Kaisha Nouveaux composes tricycliques substitues
US20030018061A1 (en) * 2000-01-28 2003-01-23 Kohei Ogawa Novel remedies with the use of beta 3 agonist
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WO2001083453A1 (fr) * 2000-04-28 2001-11-08 Asahi Kasei Kabushiki Kaisha Nouveaux composes tricycliques substitues
WO2001083452A1 (fr) * 2000-04-28 2001-11-08 Asahi Kasei Kabushiki Kaisha Nouveaux composes tricycliques
GB0010757D0 (en) * 2000-05-05 2000-06-28 Astrazeneca Ab Chemical compounds
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JPWO2002074306A1 (ja) * 2001-03-19 2004-07-08 旭化成ファーマ株式会社 脂肪肝治療薬
GB0121941D0 (en) * 2001-09-11 2001-10-31 Astrazeneca Ab Chemical compounds
KR100816527B1 (ko) * 2001-09-12 2008-04-10 한국화학연구원 페닐테트라졸 유도체로 치환된 β-아미노알코올 화합물
ATE497948T1 (de) 2001-10-25 2011-02-15 Asahi Kasei Pharma Corp Bicyclische verbindungen
WO2003072573A1 (en) 2002-02-27 2003-09-04 Pfizer Products Inc. Crystal forms of (r)-2-(2-(4-oxazol-4-yl-phenoxy)-ethylamino)-1-pyridin-3-yl-ethanol
US6864268B2 (en) 2002-02-27 2005-03-08 Pfizer Inc. β3 adrenergic receptor agonists
CA2471646A1 (en) 2002-02-27 2003-09-04 Yong Tao Processes and intermediates useful in preparing .beta.3-adrenergic receptor agonists
EP1424079A1 (de) * 2002-11-27 2004-06-02 Boehringer Ingelheim International GmbH Kombination eines beta-3-Rezeptoragonisten und eines Serotonin und/oder Norepinephrin-Wiederaufnahmeinhibitors
EP1593666B1 (de) * 2003-02-14 2008-07-02 Kissei Pharmaceutical Co., Ltd. Aminoalkoholderivate, pharmazeutische zusammensetzungen, die diese enthalten, und verwendung davon
CA2541894A1 (en) * 2003-10-24 2005-05-06 Kissei Pharmaceutical Co., Ltd. Amino alcohol derivative, medicinal composition containing the same, and use of these
US8501994B2 (en) 2007-08-28 2013-08-06 Sunovion Pharmaceuticals Inc. Acetamide stereoisomer
US7718822B2 (en) 2007-08-28 2010-05-18 Sepracor Inc. Carbamate Stereoisomer
CN102171191A (zh) 2008-10-09 2011-08-31 旭化成制药株式会社 吲唑衍生物
AU2009301798B2 (en) 2008-10-09 2012-03-01 Asahi Kasei Pharma Corporation Indazole compound
US20100222404A1 (en) * 2008-11-04 2010-09-02 Asahi Kasei Pharma Corporation Indazole derivative dihydrochloride
EP2484668A4 (de) * 2009-09-30 2013-03-27 Asahi Kasei Pharma Corp Indazol-analogon
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US11053255B2 (en) 2015-06-22 2021-07-06 Georgetown University Synthesis of mahanine and related compounds
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Also Published As

Publication number Publication date
US6187809B1 (en) 2001-02-13
CA2242351C (en) 2003-03-11
KR19990077162A (ko) 1999-10-25
EP0882707A1 (de) 1998-12-09
US6037362A (en) 2000-03-14
DE69630319D1 (de) 2003-11-13
KR100395280B1 (ko) 2004-06-04
JP2000239255A (ja) 2000-09-05
NO312159B1 (no) 2002-04-02
CN1209119A (zh) 1999-02-24
CN1295064A (zh) 2001-05-16
DE69630319T2 (de) 2004-07-29
AU1170897A (en) 1997-08-01
ES2208772T3 (es) 2004-06-16
CA2242351A1 (en) 1997-07-17
EP0882707A4 (de) 2001-04-11
HK1017669A1 (en) 1999-11-26
NO20012876L (no) 1998-09-10
WO1997025311A1 (fr) 1997-07-17
US20030139475A1 (en) 2003-07-24
NO983197L (no) 1998-09-10
PT882707E (pt) 2004-02-27
EP0882707B1 (de) 2003-10-08
AU715233B2 (en) 2000-01-20
US6545053B1 (en) 2003-04-08
CN1083831C (zh) 2002-05-01
NO20012876D0 (no) 2001-06-11

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