ATE246188T1 - Substituierte sulfonylphenylheterocyclen als cyclooxygenase-2 und lipoxygenase inhibitoren - Google Patents
Substituierte sulfonylphenylheterocyclen als cyclooxygenase-2 und lipoxygenase inhibitorenInfo
- Publication number
- ATE246188T1 ATE246188T1 AT96917888T AT96917888T ATE246188T1 AT E246188 T1 ATE246188 T1 AT E246188T1 AT 96917888 T AT96917888 T AT 96917888T AT 96917888 T AT96917888 T AT 96917888T AT E246188 T1 ATE246188 T1 AT E246188T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclooxygenase
- lipoxygenase inhibitors
- substituted sulfonylphenylheterocycles
- sulfonylphenylheterocycles
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/460,324 US5643933A (en) | 1995-06-02 | 1995-06-02 | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
PCT/US1996/008183 WO1996038442A1 (en) | 1995-06-02 | 1996-05-31 | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE246188T1 true ATE246188T1 (de) | 2003-08-15 |
Family
ID=23828245
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00100201T ATE221885T1 (de) | 1995-06-02 | 1996-05-31 | Substituierte sulfonylphenylheterocyclen als cyclooxygenase-2 und 5- lipoxygenase inhibitoren |
AT96917888T ATE246188T1 (de) | 1995-06-02 | 1996-05-31 | Substituierte sulfonylphenylheterocyclen als cyclooxygenase-2 und lipoxygenase inhibitoren |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00100201T ATE221885T1 (de) | 1995-06-02 | 1996-05-31 | Substituierte sulfonylphenylheterocyclen als cyclooxygenase-2 und 5- lipoxygenase inhibitoren |
Country Status (11)
Country | Link |
---|---|
US (1) | US5643933A (de) |
EP (2) | EP0828736B1 (de) |
AT (2) | ATE221885T1 (de) |
AU (1) | AU6027996A (de) |
CA (1) | CA2223091A1 (de) |
DE (2) | DE69629290T2 (de) |
DK (2) | DK0828736T3 (de) |
ES (2) | ES2181614T3 (de) |
HK (1) | HK1027802A1 (de) |
PT (2) | PT995747E (de) |
WO (1) | WO1996038442A1 (de) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5633272A (en) * | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
WO1996038418A1 (en) | 1995-06-02 | 1996-12-05 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
US6512121B2 (en) | 1998-09-14 | 2003-01-28 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
DK0888127T3 (da) | 1996-02-13 | 2002-04-08 | Searle & Co | Kombinationer med immunoundertrykkende virkninger indeholdende cyclooxygenase-2-inhibitorer og 5-lipooxygenaseinhibitortorer |
US5908858A (en) | 1996-04-05 | 1999-06-01 | Sankyo Company, Limited | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses |
US6677364B2 (en) * | 1998-04-20 | 2004-01-13 | G.D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
IL128255A (en) | 1996-08-14 | 2004-06-20 | Searle & Co | Crystal form of –4 [–5 methyl –– 3 phenylisoxazole ––4yl] benzenesulfonamide |
FR2753449B1 (fr) * | 1996-09-13 | 1998-12-04 | Union Pharma Scient Appl | Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique |
CA2285434A1 (en) * | 1997-04-03 | 1998-10-08 | Philip Needleman | Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of dementia |
US6130334A (en) * | 1998-04-15 | 2000-10-10 | Merck & Co., Inc. | Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors |
YU53899A (sh) * | 1997-04-18 | 2002-10-18 | G.D. Searle & Co. | Primena inhibitora ciklooksigenaze-2 u prevenciji kardiovaskularnih poremećaja |
US6127545A (en) * | 1997-04-18 | 2000-10-03 | Merck & Co., Inc. | Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors |
TW492959B (en) * | 1997-04-18 | 2002-07-01 | Merck & Co Inc | Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors |
FR2769311B1 (fr) * | 1997-10-07 | 1999-12-24 | Union Pharma Scient Appl | Nouveaux derives 3,4-diarylthiazolin-2-one ou -2-thione, leurs procedes de preparation et leurs utilisations en therapeutique |
US7041694B1 (en) | 1997-12-17 | 2006-05-09 | Cornell Research Foundation, Inc. | Cyclooxygenase-2 inhibition |
EP1085845A2 (de) | 1998-06-08 | 2001-03-28 | Advanced Medicine, Inc. | Mehrfachbindende inhibitoren von cyclooxygenase-2 |
TW477789B (en) | 1998-09-03 | 2002-03-01 | Japan Tobacco Inc | Production method of oxazole compound |
SA99191255B1 (ar) | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
ES2159479B1 (es) * | 1999-10-25 | 2002-05-01 | Menarini Lab | Nuevos indazoles como inhibidores de la ciclooxigenasa-ii |
NZ513960A (en) * | 1999-12-08 | 2004-02-27 | Pharmacia Corp | Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect |
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US20040235925A1 (en) * | 2002-12-17 | 2004-11-25 | Pharmacia Corporation | Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of duloxetine, venlafaxine or atomoxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof |
US20040204411A1 (en) * | 2002-12-17 | 2004-10-14 | Pharmacia Corporation | Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of reboxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof |
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US8119358B2 (en) | 2005-10-11 | 2012-02-21 | Tethys Bioscience, Inc. | Diabetes-related biomarkers and methods of use thereof |
KR20080056288A (ko) * | 2005-11-07 | 2008-06-20 | 아이알엠 엘엘씨 | Ppar 조절제로서의 화합물 및 조성물 |
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JP2022501359A (ja) | 2018-09-19 | 2022-01-06 | モデルナティーエックス, インコーポレイテッド | Peg脂質及びそれらの使用 |
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US20240165148A1 (en) | 2021-03-15 | 2024-05-23 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases |
Family Cites Families (23)
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---|---|---|---|---|
US5242940A (en) * | 1987-05-29 | 1993-09-07 | Ortho Pharmaceutical Corporation | Pharmacologically active N-1 and C-5 heterocyclic pyrazoles and method for synthesizing the same |
GB8927287D0 (en) * | 1988-12-23 | 1990-01-31 | Ici Plc | Cyclic ether derivatives |
US5234950A (en) * | 1988-12-23 | 1993-08-10 | Imperial Chemical Industries Plc | Tetrahydrofuran derivatives |
US5196419A (en) * | 1989-02-28 | 1993-03-23 | Imperial Chemical Industries Plc | Heterocyclic cyclic ethers |
US5234939A (en) * | 1990-03-27 | 1993-08-10 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl imidazolyl methanones and related compounds as antiinflammatory agents |
AU637500B2 (en) * | 1990-06-21 | 1993-05-27 | Zeneca Limited | Bicyclic heterocyclic compounds |
US5179115A (en) * | 1990-06-21 | 1993-01-12 | Imperial Chemical Industries Plc | Bicyclic heterocyclic derivatives as 5-lipoxygenase inhibitors |
GB9113137D0 (en) * | 1990-07-13 | 1991-08-07 | Ici Plc | Thioxo heterocycles |
IE913655A1 (en) * | 1990-11-06 | 1992-05-22 | Zeneca Ltd | Synergistic agents |
EP0569493A4 (en) * | 1991-01-31 | 1993-11-24 | Warner-Lambert Company | Substituted 4,6-di-tertiary-butyl-5-hydroxy-pyrimidines |
US5308852A (en) * | 1992-06-29 | 1994-05-03 | Merck Frosst Canada, Inc. | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis |
US5354865A (en) * | 1992-09-10 | 1994-10-11 | Abbott Laboratories | Phenylmethyl derivatives having lipoxygenase inhibitory activity |
US5604260A (en) * | 1992-12-11 | 1997-02-18 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
CA2243199C (en) * | 1993-01-15 | 2005-08-02 | G.D. Searle & Co. | Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents |
US5409944A (en) * | 1993-03-12 | 1995-04-25 | Merck Frosst Canada, Inc. | Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase |
WO1994026731A1 (en) * | 1993-05-13 | 1994-11-24 | Merck Frosst Canada Inc. | 2-substituted-3,4-diarylthiophene derivatives as inhibitors of cyclooxygenase |
US5380738A (en) * | 1993-05-21 | 1995-01-10 | Monsanto Company | 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents |
US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
US5298521A (en) * | 1993-08-30 | 1994-03-29 | Ortho Pharmaceutical Corporation | 1,5-diphenyl-3-pyrazolylalkyl-N-hydroxydithiocaramates, compositions and use |
US5344991A (en) * | 1993-10-29 | 1994-09-06 | G.D. Searle & Co. | 1,2 diarylcyclopentenyl compounds for the treatment of inflammation |
US5401765A (en) * | 1993-11-30 | 1995-03-28 | G. D. Searle | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders |
US5393790A (en) * | 1994-02-10 | 1995-02-28 | G.D. Searle & Co. | Substituted spiro compounds for the treatment of inflammation |
WO1995030669A1 (en) * | 1994-05-06 | 1995-11-16 | Zeneca Limited | Ether derivatives and pharmaceutical compositions containing them |
-
1995
- 1995-06-02 US US08/460,324 patent/US5643933A/en not_active Expired - Fee Related
-
1996
- 1996-05-31 AT AT00100201T patent/ATE221885T1/de not_active IP Right Cessation
- 1996-05-31 ES ES00100201T patent/ES2181614T3/es not_active Expired - Lifetime
- 1996-05-31 PT PT00100201T patent/PT995747E/pt unknown
- 1996-05-31 PT PT96917888T patent/PT828736E/pt unknown
- 1996-05-31 AU AU60279/96A patent/AU6027996A/en not_active Abandoned
- 1996-05-31 CA CA002223091A patent/CA2223091A1/en not_active Abandoned
- 1996-05-31 EP EP96917888A patent/EP0828736B1/de not_active Expired - Lifetime
- 1996-05-31 ES ES96917888T patent/ES2205035T3/es not_active Expired - Lifetime
- 1996-05-31 DE DE69629290T patent/DE69629290T2/de not_active Expired - Fee Related
- 1996-05-31 WO PCT/US1996/008183 patent/WO1996038442A1/en active IP Right Grant
- 1996-05-31 DK DK96917888T patent/DK0828736T3/da active
- 1996-05-31 AT AT96917888T patent/ATE246188T1/de not_active IP Right Cessation
- 1996-05-31 DE DE69622894T patent/DE69622894T2/de not_active Expired - Fee Related
- 1996-05-31 DK DK00100201T patent/DK0995747T3/da active
- 1996-05-31 EP EP00100201A patent/EP0995747B1/de not_active Expired - Lifetime
-
2000
- 2000-08-21 HK HK00105257A patent/HK1027802A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69622894T2 (de) | 2003-04-30 |
EP0828736A1 (de) | 1998-03-18 |
US5643933A (en) | 1997-07-01 |
ES2181614T3 (es) | 2003-03-01 |
AU6027996A (en) | 1996-12-18 |
EP0828736B1 (de) | 2003-07-30 |
DK0995747T3 (da) | 2002-11-25 |
EP0995747B1 (de) | 2002-08-07 |
CA2223091A1 (en) | 1996-12-05 |
EP0995747A1 (de) | 2000-04-26 |
WO1996038442A1 (en) | 1996-12-05 |
DE69629290D1 (en) | 2003-09-04 |
ATE221885T1 (de) | 2002-08-15 |
DE69629290T2 (de) | 2004-04-22 |
PT995747E (pt) | 2002-12-31 |
DK0828736T3 (da) | 2003-11-24 |
PT828736E (pt) | 2003-12-31 |
ES2205035T3 (es) | 2004-05-01 |
DE69622894D1 (de) | 2002-09-12 |
HK1027802A1 (en) | 2001-01-23 |
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