ATE241633T1 - Phosphoramidat-, mono-, di-, und triphosphatester von (1r, cis)-4-(6-amino-9h-purin-9-yl)-2- cyclopentene-1-methanol als antivirale mittel - Google Patents

Phosphoramidat-, mono-, di-, und triphosphatester von (1r, cis)-4-(6-amino-9h-purin-9-yl)-2- cyclopentene-1-methanol als antivirale mittel

Info

Publication number: ATE241633T1
Authority: AT; Austria
Prior art keywords: phosphoramidate; cyclopentene; purine; cis; mono
Prior art date: 1999-02-12

Application number

AT00905043T

Other languages

English (en)

Inventor

Susan Mary Daluge

Christopher Mcguigan

Original Assignee

Glaxo Group Ltd

Univ Cardiff

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-12

Filing date

2000-02-10

Publication date

2003-06-15

1999-02-12 Priority claimed from GBGB9903090.0A external-priority patent/GB9903090D0/en

2000-02-10 Application filed by Glaxo Group Ltd, Univ Cardiff filed Critical Glaxo Group Ltd

2003-06-15 Application granted granted Critical

2003-06-15 Publication of ATE241633T1 publication Critical patent/ATE241633T1/de

Links

COZAZKCWQGBJDE-JGVFFNPUSA-N [(1r,4s)-4-(6-aminopurin-9-yl)cyclopent-2-en-1-yl]methanol Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@@H](CO)C=C1 COZAZKCWQGBJDE-JGVFFNPUSA-N 0.000 title 1
239000003443 antiviral agent Substances 0.000 title 1
PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 title 1
UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical class OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Biochemistry (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

AT00905043T 1999-02-12 2000-02-10 Phosphoramidat-, mono-, di-, und triphosphatester von (1r, cis)-4-(6-amino-9h-purin-9-yl)-2- cyclopentene-1-methanol als antivirale mittel ATE241633T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9903090.0A GB9903090D0 (en)	1999-02-12	1999-02-12	Therapeutic compounds
US17020599P	1999-12-10	1999-12-10
PCT/EP2000/001045 WO2000047591A1 (en)	1999-02-12	2000-02-10	Phosphoramidate, and mono-, di-, and tri-phosphate esters of (1r, cis)-4-(6-amino-9h-purin-9-yl)-2-cyclopentene-1-methanol as antiviral agents

Publications (1)

Publication Number	Publication Date
ATE241633T1 true ATE241633T1 (de)	2003-06-15

Family

ID=26315118

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00905043T ATE241633T1 (de)	1999-02-12	2000-02-10	Phosphoramidat-, mono-, di-, und triphosphatester von (1r, cis)-4-(6-amino-9h-purin-9-yl)-2- cyclopentene-1-methanol als antivirale mittel

Country Status (24)

Country	Link
US (1)	US7115590B1 (de)
EP (1)	EP1150988B1 (de)
JP (1)	JP2002536452A (de)
KR (1)	KR20010102082A (de)
CN (1)	CN1346360A (de)
AR (1)	AR031975A1 (de)
AT (1)	ATE241633T1 (de)
AU (1)	AU772478B2 (de)
BR (1)	BR0008135A (de)
CA (1)	CA2362662A1 (de)
CZ (1)	CZ20012908A3 (de)
DE (1)	DE60002986T2 (de)
DK (1)	DK1150988T3 (de)
DZ (1)	DZ3007A1 (de)
ES (1)	ES2200820T3 (de)
HK (1)	HK1039337B (de)
HU (1)	HUP0105476A3 (de)
IL (1)	IL144647A0 (de)
NO (1)	NO20013910L (de)
NZ (1)	NZ513450A (de)
PL (1)	PL204458B1 (de)
PT (1)	PT1150988E (de)
TR (1)	TR200102313T2 (de)
WO (1)	WO2000047591A1 (de)

Families Citing this family (29)

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WO2001042255A1 (en) *	1999-12-10	2001-06-14	Glaxo Group Limited	(1R,CIS)-4-(4-AMINO-7H-PYRROLO'2,3-I(D) &excl; PYRIMIDINE-7-YL)-2-CYCLOPENTENE-1-METHANOL DERIVATIVES AS ANTIVIRAL
PE20010915A1 (es) *	1999-12-10	2001-09-29	Glaxo Group Ltd	Analogos de (1s, cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol para uso en el tratamiento de infecciones virales
NZ547204A (en)	2000-05-26	2008-01-31	Idenix Cayman Ltd	Methods and compositions for treating flaviviruses and pestiviruses
KR100767432B1 (ko) †	2000-07-21	2007-10-17	길리애드 사이언시즈, 인코포레이티드	포스포네이트 뉴클레오티드 유사체의 전구 약물과 그것의 선택 및 제조 방법
GB0129945D0 (en) *	2001-12-13	2002-02-06	Mrc Technology Ltd	Chemical compounds
GB0401088D0 (en)	2004-01-19	2004-02-18	Univ Cardiff	Phosphoramidate derivatives
US9243025B2 (en)	2011-03-31	2016-01-26	Idenix Pharmaceuticals, Llc	Compounds and pharmaceutical compositions for the treatment of viral infections
WO2013039920A1 (en)	2011-09-12	2013-03-21	Idenix Pharmaceuticals, Inc.	Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
TW201331221A (zh)	2011-10-14	2013-08-01	Idenix Pharmaceuticals Inc	嘌呤核苷酸化合物類之經取代的３’，５’－環磷酸酯及用於治療病毒感染之醫藥組成物
EP2852605B1 (de)	2012-05-22	2018-01-31	Idenix Pharmaceuticals LLC	3',5'-cyclische phosphat-prodrugs für hcv-infektion
WO2013177188A1 (en)	2012-05-22	2013-11-28	Idenix Pharmaceuticals, Inc.	3',5'-cyclic phosphoramidate prodrugs for hcv infection
AU2013266393B2 (en)	2012-05-22	2017-09-28	Idenix Pharmaceuticals Llc	D-amino acid compounds for liver disease
SG11201407336PA (en)	2012-05-25	2015-03-30	Janssen Sciences Ireland Uc	Uracyl spirooxetane nucleosides
US9192621B2 (en)	2012-09-27	2015-11-24	Idenix Pharmaceuticals Llc	Esters and malonates of SATE prodrugs
GEP201706723B (en)	2012-10-08	2017-08-25	Idenix Pharmaceuticals Llk	2'-chloro nucleoside analogs for hcv infection
WO2014066239A1 (en)	2012-10-22	2014-05-01	Idenix Pharmaceuticals, Inc.	2',4'-bridged nucleosides for hcv infection
WO2014099941A1 (en)	2012-12-19	2014-06-26	Idenix Pharmaceuticals, Inc.	4'-fluoro nucleosides for the treatment of hcv
US9339541B2 (en)	2013-03-04	2016-05-17	Merck Sharp & Dohme Corp.	Thiophosphate nucleosides for the treatment of HCV
WO2014137926A1 (en)	2013-03-04	2014-09-12	Idenix Pharmaceuticals, Inc.	3'-deoxy nucleosides for the treatment of hcv
WO2014160484A1 (en)	2013-03-13	2014-10-02	Idenix Pharmaceuticals, Inc.	Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
WO2014165542A1 (en)	2013-04-01	2014-10-09	Idenix Pharmaceuticals, Inc.	2',4'-fluoro nucleosides for the treatment of hcv
EP3004130B1 (de)	2013-06-05	2019-08-07	Idenix Pharmaceuticals LLC.	1',4'-thionukleoside zur behandlung von hcv
WO2015017713A1 (en)	2013-08-01	2015-02-05	Idenix Pharmaceuticals, Inc.	D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
US10202411B2 (en)	2014-04-16	2019-02-12	Idenix Pharmaceuticals Llc	3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV
KR102363946B1 (ko)	2015-03-06	2022-02-17	아테아 파마슈티컬즈, 인크.	HCV 치료를 위한 β-D-2'-데옥시-2'-α-플루오로-2'-β-C-치환된-2-변형된-N6-치환된 퓨린 뉴클레오티드
WO2018013937A1 (en)	2016-07-14	2018-01-18	Atea Pharmaceuticals, Inc.	Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
KR20190043602A (ko)	2016-09-07	2019-04-26	아테아 파마슈티컬즈, 인크.	Rna 바이러스 치료를 위한 2'-치환된-n6-치환된 퓨린 뉴클레오티드
WO2021173713A1 (en)	2020-02-27	2021-09-02	Atea Pharmaceuticals, Inc.	Highly active compounds against covid-19
US10874687B1 (en)	2020-02-27	2020-12-29	Atea Pharmaceuticals, Inc.	Highly active compounds against COVID-19

Family Cites Families (6)

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Publication number	Priority date	Publication date	Assignee	Title
US5244896A (en) *	1990-09-14	1993-09-14	Marion Merrell Dow Inc.	Carbocyclic adenosine analogs useful as immunosuppressants
GB9505025D0 (en) *	1995-03-13	1995-05-03	Medical Res Council	Chemical compounds
US6887707B2 (en) *	1996-10-28	2005-05-03	University Of Washington	Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
GB9821058D0 (en) *	1998-09-28	1998-11-18	Univ Cardiff	Chemical compound
WO2001042255A1 (en) *	1999-12-10	2001-06-14	Glaxo Group Limited	(1R,CIS)-4-(4-AMINO-7H-PYRROLO'2,3-I(D) &excl; PYRIMIDINE-7-YL)-2-CYCLOPENTENE-1-METHANOL DERIVATIVES AS ANTIVIRAL
US20030096833A1 (en) *	2001-08-31	2003-05-22	Jagtap Prakash G.	Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof

2000
- 2000-02-10 AT AT00905043T patent/ATE241633T1/de not_active IP Right Cessation
- 2000-02-10 ES ES00905043T patent/ES2200820T3/es not_active Expired - Lifetime
- 2000-02-10 HU HU0105476A patent/HUP0105476A3/hu unknown
- 2000-02-10 CA CA002362662A patent/CA2362662A1/en not_active Abandoned
- 2000-02-10 PL PL350023A patent/PL204458B1/pl not_active IP Right Cessation
- 2000-02-10 AU AU26713/00A patent/AU772478B2/en not_active Ceased
- 2000-02-10 CZ CZ20012908A patent/CZ20012908A3/cs unknown
- 2000-02-10 CN CN00806002A patent/CN1346360A/zh active Pending
- 2000-02-10 KR KR1020017010198A patent/KR20010102082A/ko not_active Application Discontinuation
- 2000-02-10 AR ARP000100596A patent/AR031975A1/es not_active Application Discontinuation
- 2000-02-10 TR TR2001/02313T patent/TR200102313T2/xx unknown
- 2000-02-10 IL IL14464700A patent/IL144647A0/xx unknown
- 2000-02-10 EP EP00905043A patent/EP1150988B1/de not_active Expired - Lifetime
- 2000-02-10 PT PT00905043T patent/PT1150988E/pt unknown
- 2000-02-10 JP JP2000598510A patent/JP2002536452A/ja active Pending
- 2000-02-10 WO PCT/EP2000/001045 patent/WO2000047591A1/en not_active Application Discontinuation
- 2000-02-10 DE DE60002986T patent/DE60002986T2/de not_active Expired - Fee Related
- 2000-02-10 DK DK00905043T patent/DK1150988T3/da active
- 2000-02-10 NZ NZ513450A patent/NZ513450A/xx unknown
- 2000-02-10 BR BR0008135-3A patent/BR0008135A/pt not_active IP Right Cessation
- 2000-02-10 US US09/913,226 patent/US7115590B1/en not_active Expired - Fee Related
- 2000-03-09 DZ DZ000019A patent/DZ3007A1/xx active
2001
- 2001-08-10 NO NO20013910A patent/NO20013910L/no not_active Application Discontinuation
2002
- 2002-02-05 HK HK02100897.2A patent/HK1039337B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2002536452A (ja)	2002-10-29
IL144647A0 (en)	2002-05-23
AR031975A1 (es)	2003-10-22
AU772478B2 (en)	2004-04-29
TR200102313T2 (tr)	2002-03-21
CZ20012908A3 (cs)	2002-10-16
US7115590B1 (en)	2006-10-03
HUP0105476A2 (en)	2002-06-29
PL350023A1 (en)	2002-10-21
HK1039337B (zh)	2003-11-21
NO20013910D0 (no)	2001-08-10
PL204458B1 (pl)	2010-01-29
CA2362662A1 (en)	2000-08-17
DE60002986T2 (de)	2004-05-19
HK1039337A1 (en)	2002-04-19
AU2671300A (en)	2000-08-29
PT1150988E (pt)	2003-10-31
KR20010102082A (ko)	2001-11-15
EP1150988B1 (de)	2003-05-28
WO2000047591A1 (en)	2000-08-17
DE60002986D1 (en)	2003-07-03
NZ513450A (en)	2004-03-26
NO20013910L (no)	2001-10-10
HUP0105476A3 (en)	2002-08-28
DK1150988T3 (da)	2003-09-29
BR0008135A (pt)	2002-02-19
CN1346360A (zh)	2002-04-24
DZ3007A1 (fr)	2003-03-27
EP1150988A1 (de)	2001-11-07
ES2200820T3 (es)	2004-03-16

Legal Events

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2004-01-15

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2010-11-15

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Publication	Publication Date	Title
ATE241633T1 (de)	2003-06-15	Phosphoramidat-, mono-, di-, und triphosphatester von (1r, cis)-4-(6-amino-9h-purin-9-yl)-2- cyclopentene-1-methanol als antivirale mittel
DK1523489T3 (da)	2014-06-16	Modificerede 2'- og 3'-nukleosidprodrugs til behandling af flaviridae-infektioner
AP2005003213A0 (en)	2005-03-31	2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections.
DE60232400D1 (de)	2009-07-02	Mittel zur linderung von hautreizungen
NO996133D0 (no)	1999-12-10	Olje-i-vann-vaksinesammensetninger
EE200300510A (et)	2004-02-16	Keskmise pikkusega ahelaga rasvhapped, glütseriidid ja nende analoogid kui neutrofiilide ellujäämis- ja aktiveerimisfaktorid
DE59910836D1 (de)	2004-11-18	Dermal applizierbare wasserhaltige formulierungen von parasitiziden
IS6698A (is)	2003-01-24	Háhreinsaðar símvastatínblöndur
DE50213477D1 (de)	2009-06-04	Bremsanlage und kraftübertragungsanordnung hierfür
ID29792A (id)	2001-10-11	Formulasi lepas terkendali untuk mengobati corp
IS6933A (is)	2003-08-27	Veirueyðandi samsetningar
ATE374011T1 (de)	2007-10-15	Hautbehandlungsmittel
ATE264305T1 (de)	2004-04-15	Antivirale mittel
DE10084591T1 (de)	2002-03-28	Mittel zur Entfernung keratotischer Pfropfen
FR2819508B1 (fr)	2005-01-21	Derives de 2-arylimino-2, 3-dihydorthiazoles, leurs procedes de preparation et leur utilisation therapeutiques
IT1311568B1 (it)	2002-03-13	Arnese da cucina per agitare, sbattere e smuovere.
DE60220799D1 (de)	2007-08-02	Hypoglykämisches mittel
DE60136966D1 (de)	2009-01-22	Pflanzenstärkendes mittel
SI1150988T1 (en)	2003-12-31	Phosphoramidate, and mono-, di-, and tri-phosphate esters of (1r, cis)-4-(6-amino-9h-purin-9-yl)-2-cyclopentene-1-methanol as antiviral agents
ZA200106551B (en)	2003-01-29	Phosphoramidate, and mono-, di-, and tri-phosphate esters of (1R, cis)-4-(6-amino-9H-purin-9-yl)-2-cyclopentene-1-methanol as antiviral agents.
ES1050591Y (es)	2002-08-16	Cenicero desechable perfeccionado de multiples usos.
DK1105498T3 (da)	2009-08-31	HIV vaccine
DE29815814U1 (de)	1998-12-03	Verbesserungen an Regalen
IT1309805B1 (it)	2002-01-30	Lampione per cimitero montabile rapidamente e semplicemente
ATE260288T1 (de)	2004-03-15	(1s, cis)-4-(2-amino-9h-purin-9-yl)-2-cyclopenten-1- ethanol analogue als antiviral