ATE237682T1 - Universale spenderzellen - Google Patents

Universale spenderzellen

Info

Publication number: ATE237682T1
Authority: AT; Austria
Prior art keywords: cells; cell; class; universal donor; donor cells
Prior art date: 1991-07-15

Application number

AT92915715T

Other languages

English (en)

Inventor

Peter J Simms

Alfred L M Bothwell

Eileen A Elliot

Richard A Flavell

Joseph Madri

Scott Rollins

Leonard Bell

Stephen Squinto

Original Assignee

Oklahoma Med Res Found

Univ Yale

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-15

Filing date

1992-07-14

Publication date

2003-05-15

1992-07-14 Application filed by Oklahoma Med Res Found, Univ Yale filed Critical Oklahoma Med Res Found

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE237682T1 publication Critical patent/ATE237682T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Cell Biology (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Public Health (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Environmental Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Wood Science & Technology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Biotechnology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Animal Husbandry (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Biodiversity & Conservation Biology (AREA)
Transplantation (AREA)
Oral & Maxillofacial Surgery (AREA)

AT92915715T 1991-07-15 1992-07-14 Universale spenderzellen ATE237682T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US72992691A	1991-07-15	1991-07-15
US90639492A	1992-06-29	1992-06-29
PCT/US1992/005920 WO1993002188A1 (en)	1991-07-15	1992-07-14	Universal donor cells

Publications (1)

Publication Number	Publication Date
ATE237682T1 true ATE237682T1 (de)	2003-05-15

Family

ID=27111956

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92915715T ATE237682T1 (de)	1991-07-15	1992-07-14	Universale spenderzellen

Country Status (6)

Country	Link
EP (2)	EP1041142A3 (de)
JP (2)	JPH06506604A (de)
AT (1)	ATE237682T1 (de)
CA (1)	CA2113089C (de)
DE (1)	DE69233010T2 (de)
WO (1)	WO1993002188A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9100481D0 (en) *	1991-01-10	1991-02-20	Inst Nat Sante Rech Med	Genetically engineered mice
AU2883192A (en) *	1991-10-21	1993-05-21	Cell Genesys, Inc.	Combined cellular and immunosuppressive therapies
AU5965294A (en) *	1993-01-08	1994-08-15	Exemplar Corporation	An (in vitro)/(in vivo) method for identifying anti-neoplastic drugs
US5859226A (en) *	1993-07-29	1999-01-12	Regents Of The University Of California, The	Polynucleotide decoys that inhibit MHC-II expression and uses thereof
AU7518194A (en)	1993-07-29	1995-02-28	Regents Of The University Of California, The	Polynucleotide decoys that ihnibit mhc-ii expression and uses thereof
WO1995004756A1 (en) *	1993-08-11	1995-02-16	Alexion Pharmaceuticals, Inc.	Complement inhibitor proteins of non-human primates
DE69532976T2 (de) *	1994-03-14	2005-05-04	Cryolife, Inc.	Herstellungsverfahren von gewebe zur implantation
US6156306A (en) *	1994-08-17	2000-12-05	Albert Einstein College Of Medicine Of Yeshiva University	Pancreatic β-cells for allogeneic transplantation without immunosuppression
US5629194A (en) *	1994-10-21	1997-05-13	Diacrin, Inc.	Isolated porcine pancreatic cells for use in treatment of diseases characterized by insufficient insulin activity
US6610288B1 (en) *	1995-05-26	2003-08-26	Diacrin, Inc.	Porcine hepatocytes for use in treatment of disorders characterized by insufficient liver function
US5766584A (en) *	1995-06-02	1998-06-16	Massachusetts Institute Of Technology	Inhibition of vascular smooth muscle cell proliferation with implanted matrix containing vascular endothelial cells
WO1997004087A1 (de) *	1995-07-18	1997-02-06	Guido Krupp	Ribozyme zur selektiven hemmung der expression von genen von mhc-allelen und diese enthaltende arzneimittel
US6030833A (en) *	1995-08-04	2000-02-29	The General Hospital	Transgenic swine and swine cells having human HLA genes
US6166288A (en) *	1995-09-27	2000-12-26	Nextran Inc.	Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
AU1933897A (en) *	1996-03-22	1997-10-17	Imutran Limited	Surfaces which prevent or reduce complement activation
US6022863A (en) *	1996-05-21	2000-02-08	Yale University	Regulation of gene expression
AU7935598A (en) *	1997-07-14	1999-02-10	Nippon Meat Packers, Inc.	Transgenic mammals
ATE470701T1 (de)	2005-04-21	2010-06-15	Massachusetts Inst Technology	Materialien und verfahren zur änderung einer immunreaktion auf exogene und endogene immunogene,einschliesslich genidentischer und nicht- genidentischer zellen, gewebe oder organe
SG161258A1 (en)	2005-06-21	2010-05-27	Pervasis Therapeutics Inc	Methods and compositions for enhancing vascular access
CA2664093A1 (en) *	2006-09-21	2008-03-27	Tissue Genesis, Inc.	Cell delivery matrices
JP2011069570A (ja) *	2009-09-28	2011-04-07	Fujitsu General Ltd	ヒートポンプサイクル装置
PL3116902T3 (pl)	2014-03-11	2020-07-27	Cellectis	Sposób wytwarzania limfocytów T kompatybilnych do przeszczepienia alogenicznego
AU2017283470B2 (en)	2016-06-14	2024-03-21	Regeneron Pharmaceuticals, Inc.	Anti-C5 antibodies and uses thereof
US11834680B2 (en)	2017-06-28	2023-12-05	Rutgers, The State University Of New Jersey	Single kidney cell-derived organoids
US20210155896A1 (en) *	2017-06-28	2021-05-27	Rutgers, The State University Of New Jersey	Single brain cell-derived organoids
JP2021506241A (ja)	2017-12-13	2021-02-22	リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	抗ｃ５抗体組み合わせ物およびその使用
WO2020131717A1 (en) *	2018-12-16	2020-06-25	Figene, Llc	Therapeutic uses of gene edited fibroblasts

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL82390A0 (en) *	1986-05-02	1987-10-30	Genentech Inc	Nucleic acid and methods for the synthesis of novel daf compositions
US4883755A (en) *	1987-10-28	1989-11-28	Thomas Jefferson University	Method of reendothelializing vascular linings
IT1230047B (it) *	1989-07-04	1991-09-27	Giovanni Brotzu	Protesi vascolare contenente nella parete microcapsule inglobanti cellule produttrici di ormoni.
CA2062969C (en) *	1989-07-21	2000-10-10	John P. Atkinson	Recombinantly produced human membrane cofactor protein (mcp)
EP0437576B1 (de) *	1989-07-25	2002-07-03	Cell Genesys, Inc.	Homologe rekombination für universelle donorzellen und chimerische säugetierzellen
IE75345B1 (en) *	1989-10-12	1997-08-27	Imutran Ltd	Modified biological material
EP0537171B1 (de) *	1990-05-11	2002-09-18	The Austin Research Institute	CD46 Isoformen
AU9076191A (en) *	1990-11-21	1992-06-25	Massachusetts Institute Of Technology	Mice having beta 2 microglobulin gene disruption

1992
- 1992-07-14 WO PCT/US1992/005920 patent/WO1993002188A1/en active IP Right Grant
- 1992-07-14 EP EP00114262A patent/EP1041142A3/de not_active Withdrawn
- 1992-07-14 CA CA002113089A patent/CA2113089C/en not_active Expired - Fee Related
- 1992-07-14 EP EP92915715A patent/EP0591462B1/de not_active Expired - Lifetime
- 1992-07-14 JP JP5502933A patent/JPH06506604A/ja not_active Withdrawn
- 1992-07-14 AT AT92915715T patent/ATE237682T1/de not_active IP Right Cessation
- 1992-07-14 DE DE69233010T patent/DE69233010T2/de not_active Expired - Fee Related
1997
- 1997-06-18 JP JP9161718A patent/JPH1057054A/ja active Pending

Also Published As

Publication number	Publication date
DE69233010D1 (de)	2003-05-22
WO1993002188A1 (en)	1993-02-04
JPH06506604A (ja)	1994-07-28
EP1041142A3 (de)	2007-10-24
CA2113089C (en)	2007-11-06
EP0591462B1 (de)	2003-04-16
JPH1057054A (ja)	1998-03-03
EP1041142A2 (de)	2000-10-04
CA2113089A1 (en)	1993-02-04
EP0591462A1 (de)	1994-04-13
DE69233010T2 (de)	2004-02-19

Legal Events

Date	Code	Title	Description
2003-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE237682T1 (de)	2003-05-15	Universale spenderzellen
ATE123806T1 (de)	1995-06-15	Genetisch geformte neue pflanzenphenotypen.
NO173741C (no)	1994-01-26	DNA-sekvens for modifisert protein C, vektor inneholdende denne, patte-dyrceller transfektert med vektorer, og fremgangsmaate for fremstilling av nevnte protein
DK288183A (da)	1983-06-22	Fremgangsmaade til fremstilling af et oligonucleotidt terapeutisk middel
DE69229476D1 (de)	1999-07-29	Ospa proteine von borrelia burgdorferi untergruppen, dafür kodierende gene sowie impfstoffe
FI881185A (fi)	1988-09-15	Human mangan-superoxiddismutas (hmn-sod).
NO950939D0 (no)	1995-03-10	Defektive adenovirusvektorer og deres anvendelse i gene-terapien
DE3688900D1 (de)	1993-09-23	Expression von protein c.
DE69434328D1 (de)	2005-05-19	TAT transdominante Variante aus Human Immunodeficiency Virus
ATE215988T1 (de)	2002-04-15	Vitamin-k-abhängige carboxylase
DE50010519D1 (de)	2005-07-14	Pharmazeutische Zusammensetzungen zur Therapie der Herzinsuffizienz
WO1994013812A3 (en)	1994-11-10	Novel entomopoxvirus genes, proteins and methods of use thereof
ES2171563T3 (es)	2002-09-16	Nueva familia de inhibidores de proteasas, y otras sustancias de actividad biologica.
WO2004035799A3 (de)	2004-06-10	Virale vektoren und deren verwendung für die gentherapie
DK349688D0 (da)	1988-06-24	Bomologe af humant aprotinin, vaertsstamme samt ekspressionsvektorer til deres fremstilling og deres anvendelse som laegemidler
DK0781344T3 (da)	2006-02-13	Hidtil ukendt implantat og hidtil ukendt vektor til behandling af erhvervede sygdomme
ATE103980T1 (de)	1994-04-15	Das f-protein vom aids-virus enthaltender impfstoff.
DE69332652D1 (de)	2003-02-27	Verbesserungen in bezug auf die herstellung von malariaimpstoffen
BR9915970A (pt)	2001-12-04	Vìrus recombinante expressando dna exógenocodificando cd80 felino, ctla-4 felino ou cd86 felinoe usos do mesmo
AU3964189A (en)	1990-01-05	Complete nucleotidic sequence of the complementary dna of the genomic rna of the potyvirus, genes coding for the potyvirus capside protein and application of said genes to the creation of potyvirus-resistant transgenic plants
Meerovitch	1986	Effects of cyclosporins on lymphokine gene expression
WO2000063402A8 (fr)	2000-12-07	Cassette de regulation de l'expression d'un acide nucleique heterologue dans une cellule eucaryote, en particulier musculaire
EP0808902A3 (de)	1998-02-04	Für antivirale Proteine aus Phytolacca insularis Nakai kodierende Gene und diese Proteine exprimierende rekombinante Mikroorganismen