ATE223902T1 - Chinolinderivate als gnrh antagonisten - Google Patents

Chinolinderivate als gnrh antagonisten

Info

Publication number
ATE223902T1
ATE223902T1 AT96935360T AT96935360T ATE223902T1 AT E223902 T1 ATE223902 T1 AT E223902T1 AT 96935360 T AT96935360 T AT 96935360T AT 96935360 T AT96935360 T AT 96935360T AT E223902 T1 ATE223902 T1 AT E223902T1
Authority
AT
Austria
Prior art keywords
agent
cancer
controlling agent
animals
agents
Prior art date
Application number
AT96935360T
Other languages
English (en)
Inventor
Shuichi Furuya
Nobuo Choh
Satoshi Sasaki
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE223902T1 publication Critical patent/ATE223902T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT96935360T 1995-10-19 1996-10-18 Chinolinderivate als gnrh antagonisten ATE223902T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27164095 1995-10-19
PCT/JP1996/003019 WO1997014682A1 (en) 1995-10-19 1996-10-18 Quinoline derivatives as gnrh antagonists

Publications (1)

Publication Number Publication Date
ATE223902T1 true ATE223902T1 (de) 2002-09-15

Family

ID=17502876

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96935360T ATE223902T1 (de) 1995-10-19 1996-10-18 Chinolinderivate als gnrh antagonisten

Country Status (8)

Country Link
US (2) US5807869A (de)
EP (1) EP0876349B1 (de)
CN (1) CN1200114A (de)
AT (1) ATE223902T1 (de)
AU (1) AU7333496A (de)
CA (1) CA2229201A1 (de)
DE (1) DE69623655T2 (de)
WO (1) WO1997014682A1 (de)

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AU3368299A (en) * 1998-04-02 1999-10-25 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
AU3118399A (en) * 1998-04-02 1999-10-25 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
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WO2001012600A1 (en) * 1999-08-12 2001-02-22 Cor Therapeutics, Inc. INHIBITORS OF FACTOR Xa
US6537998B1 (en) 1999-10-15 2003-03-25 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
ES2383954T3 (es) 2000-01-25 2012-06-27 Neurocrine Biosciences, Inc Antagonistas del receptor de la hormona liberadora de ganodotropina y métodos relacionados con ellos
US6583153B2 (en) 2000-12-12 2003-06-24 Ortho-Mcneil Pharmaceutical, Inc. 7-heterocyclyl quinoline and thieno[2,3-b]yridine derivatives useful as antagonists of gonadotropin releasing hormone
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
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JP2005504034A (ja) 2001-08-02 2005-02-10 ニューロクライン バイオサイエンシーズ， インコーポレイテッド ゴナドトロピン放出性ホルモンレセプターアンタゴニストとしてのピリジノン誘導体およびピリダジノン誘導体
AU2002324586B2 (en) 2001-08-02 2008-04-24 Neurocrine Biosciences, Inc. 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists
CA2455235A1 (en) 2001-08-02 2003-02-13 Joseph Pontillo 1,2,4-triazin-3,5-diones as gonadotropin-releasing hormone receptor (gnrh) antagonists
WO2003013528A1 (en) 2001-08-02 2003-02-20 Neurocrine Biosciences, Inc. Substituted pyridin-4-ones and their use as gonadotropin-releasing hormone receptor antagonists.
WO2003064429A1 (fr) 2002-01-30 2003-08-07 Takeda Chemical Industries, Ltd. Thienopyrimidines, procedes de fabrication et d'utilisation correspondants
EP1495768A4 (de) * 2002-04-12 2007-12-05 Takeda Pharmaceutical Mittel zur prävention/behandlung von hitzewallungen
ATE557007T1 (de) 2003-07-07 2012-05-15 Neurocrine Biosciences Inc Arylpyrimidine geeignet zur behandlung von sexualhormonbedingten zuständen wie endometriose, prostatakrebs und dergleichen
CA2531507C (en) 2003-07-07 2013-10-01 Neurocrine Biosciences, Inc. Pyrimidine-2,4-dione derivatives as gonadotropin-releasing hormone receptor antagonists
EP1646389B1 (de) 2003-07-07 2008-09-10 Neurocrine Biosciences, Inc. Pyrimidin-2,4-dion-derivate als gonadotropin freisetzende hormon-rezeptor-antagonisten
WO2005118556A1 (ja) * 2004-06-04 2005-12-15 Astellas Pharma Inc. プロパン－１，３－ジオン誘導体又はその塩
DK1773816T3 (en) 2004-06-24 2015-01-26 Vertex Pharma Modulators of ATP-binding cassette transporters
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
CN101863971A (zh) 2004-06-25 2010-10-20 武田药品工业株式会社 转移素衍生物及其用途
DE102004033902A1 (de) 2004-07-14 2006-02-16 Zentaris Gmbh Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's)
CA2603185C (en) * 2005-03-31 2011-07-26 Astellas Pharma Inc. Propane-1,3-dione derivative or salt thereof
UA92007C2 (ru) * 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
UA92008C2 (en) * 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
UA92009C2 (ru) * 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
WO2006117023A1 (en) * 2005-05-04 2006-11-09 N.V. Organon Dihydropyridine derivatives
US8404643B2 (en) 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
TWI386417B (zh) 2005-12-22 2013-02-21 Takeda Pharmaceutical 轉移抑素衍生物及其用途
US20090105272A1 (en) * 2005-12-24 2009-04-23 Grootenhuis Peter D J Prodrugs of modulators of ABC transporters
JP5409010B2 (ja) 2005-12-28 2014-02-05 バーテックス ファーマシューティカルズ インコーポレイテッド Ｎ−［２，４−ビス（１，１−ジメチルエチル）−５−ヒドロキシフェニル］−１，４−ジヒドロ−４−オキソキノリン−３−カルボキサミドの固体形態
TWI404726B (zh) 2006-10-25 2013-08-11 Takeda Pharmaceutical 腫瘤轉移抑制素衍生物及其用途
EP2095818A1 (de) 2008-02-29 2009-09-02 AEterna Zentaris GmbH Verwendung von LHRH-Antagonisten in nicht-kastrierenden Dosen
NZ624460A (en) 2009-03-20 2015-12-24 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
TW201130854A (en) 2009-12-22 2011-09-16 Bayer Schering Pharma Ag Pyridinone derivatives and pharmaceutical compositions thereof
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
WO2012175514A1 (en) 2011-06-21 2012-12-27 Bayer Intellectual Property Gmbh Pyridinone derivatives and pharmaceutical compositions thereof
CN104470518A (zh) 2012-02-27 2015-03-25 沃泰克斯药物股份有限公司 药物组合物及其施用
CA2963945C (en) 2014-10-07 2023-01-10 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
US10299702B2 (en) 2015-11-11 2019-05-28 Zwift, Inc. Devices and methods for determining step characteristics

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JPS5488276A (en) * 1977-12-21 1979-07-13 Grelan Pharmaceut Co Ltd 6- and 7-carbamoylquinoline derivative
US4659691A (en) * 1985-02-08 1987-04-21 Merck & Co., Inc. Novel cyclic Hexapeptide LHRH antagonists
US5140009A (en) * 1988-02-10 1992-08-18 Tap Pharmaceuticals, Inc. Octapeptide LHRH antagonists
US5171835A (en) * 1988-10-21 1992-12-15 The Administrators Of The Tulane Educational Fund LHRH antagonists
WO1994020460A1 (en) * 1993-03-11 1994-09-15 Smithkline Beecham Corporation Chemical compounds
TW449600B (en) * 1994-04-19 2001-08-11 Takeda Chemical Industries Ltd Condensed-ring thiophene derivatives, their production and use

Also Published As

Publication number Publication date
CA2229201A1 (en) 1997-04-24
CN1200114A (zh) 1998-11-25
US6087503A (en) 2000-07-11
WO1997014682A1 (en) 1997-04-24
US5807869A (en) 1998-09-15
EP0876349A1 (de) 1998-11-11
DE69623655D1 (de) 2002-10-17
EP0876349B1 (de) 2002-09-11
DE69623655T2 (de) 2003-04-24
AU7333496A (en) 1997-05-07

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