ATE214049T1 - Analgetische 4-arylisoindolen - Google Patents

Analgetische 4-arylisoindolen

Info

Publication number
ATE214049T1
ATE214049T1 AT95904262T AT95904262T ATE214049T1 AT E214049 T1 ATE214049 T1 AT E214049T1 AT 95904262 T AT95904262 T AT 95904262T AT 95904262 T AT95904262 T AT 95904262T AT E214049 T1 ATE214049 T1 AT E214049T1
Authority
AT
Austria
Prior art keywords
image
arylisoindole
analgesic
arylisoindoles
alkylcarbonyloxy
Prior art date
Application number
AT95904262T
Other languages
English (en)
Inventor
Richard J Carmosin
John R Carson
Philip Pitis
Robert B Raffa
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Application granted granted Critical
Publication of ATE214049T1 publication Critical patent/ATE214049T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
AT95904262T 1993-12-23 1994-12-02 Analgetische 4-arylisoindolen ATE214049T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/173,326 US5543530A (en) 1993-12-23 1993-12-23 4-arylisoindole analgesics
PCT/US1994/014050 WO1995017384A1 (en) 1993-12-23 1994-12-02 4-arylisoindole analgesics

Publications (1)

Publication Number Publication Date
ATE214049T1 true ATE214049T1 (de) 2002-03-15

Family

ID=22631518

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95904262T ATE214049T1 (de) 1993-12-23 1994-12-02 Analgetische 4-arylisoindolen

Country Status (14)

Country Link
US (1) US5543530A (de)
EP (1) EP0740657B1 (de)
JP (1) JP3541952B2 (de)
AT (1) ATE214049T1 (de)
AU (1) AU700505B2 (de)
CA (1) CA2179634C (de)
DE (1) DE69430074T2 (de)
DK (1) DK0740657T3 (de)
ES (1) ES2173169T3 (de)
IL (1) IL112110A0 (de)
MX (1) MX9500231A (de)
PT (1) PT740657E (de)
WO (1) WO1995017384A1 (de)
ZA (1) ZA9410280B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602167A (en) * 1995-05-17 1997-02-11 Ortho Pharmaceutical Corporation 4-arylcyclohepta[c] pyrrole analgesics
US5541217A (en) * 1995-05-17 1996-07-30 Ortho Pharmaceutical Corporation 4-arylcyclopenta[c]pyrrole analgesics
US7135484B2 (en) 2002-08-14 2006-11-14 Abbott Laboratories Azabicyclic compounds are central nervous system active agents
WO2004016604A2 (en) * 2002-08-14 2004-02-26 Abbott Laboratories Azabicyclic compounds are central nervous system active agents
CN102911108A (zh) * 2012-11-16 2013-02-06 葛长乐 一种反式全氢异吲哚及其盐的制备方法
EP3978497A4 (de) * 2019-05-30 2022-07-13 Shanghai Institute of Materia Medica, Chinese Academy of Sciences Kondensierte ringverbindung, herstellungsverfahren dafür und verwendung davon

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042707A (en) * 1976-02-19 1977-08-16 E. I. Du Pont De Nemours And Company 3α-Arylhydroisoindoles
US4689329A (en) * 1986-02-04 1987-08-25 Mcneilab, Inc. 5-substituted octahydroindolizine analgesics compounds and 7-keto intermediates
FR2654726B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone et leur preparation.
US5216018A (en) * 1992-02-14 1993-06-01 Du Pont Merck Pharmaceutical Company Hydroisoindolines and hydroisoquinolines as psychotropic
US5508424A (en) * 1993-03-26 1996-04-16 Ortho Pharmaceutical Corporation 4-arylisoindole analgesics

Also Published As

Publication number Publication date
PT740657E (pt) 2002-07-31
CA2179634C (en) 2005-09-13
AU700505B2 (en) 1999-01-07
ES2173169T3 (es) 2002-10-16
WO1995017384A1 (en) 1995-06-29
CA2179634A1 (en) 1995-06-29
JP3541952B2 (ja) 2004-07-14
AU1301895A (en) 1995-07-10
IL112110A0 (en) 1995-03-15
ZA9410280B (en) 1996-06-24
EP0740657B1 (de) 2002-03-06
US5543530A (en) 1996-08-06
EP0740657A1 (de) 1996-11-06
JPH09507064A (ja) 1997-07-15
DK0740657T3 (da) 2002-06-24
DE69430074T2 (de) 2002-09-05
MX9500231A (es) 1997-02-28
DE69430074D1 (de) 2002-04-11

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification