ATE206432T1 - A3 -adenosin -rezeptor agonisten - Google Patents

A3 -adenosin -rezeptor agonisten

Info

Publication number
ATE206432T1
ATE206432T1 AT94923445T AT94923445T ATE206432T1 AT E206432 T1 ATE206432 T1 AT E206432T1 AT 94923445 T AT94923445 T AT 94923445T AT 94923445 T AT94923445 T AT 94923445T AT E206432 T1 ATE206432 T1 AT E206432T1
Authority
AT
Austria
Prior art keywords
receptor
adenosine receptor
mammal
uronamide
provides
Prior art date
Application number
AT94923445T
Other languages
English (en)
Inventor
Kenneth A Jacobson
Carola Gallo-Rodriguez
Galen Philip J M Van
Lubitz Dag K J E Von
Heaok Kim Jeong
Seodaemun-Ku College Of P Dong
Original Assignee
Nasa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nasa filed Critical Nasa
Application granted granted Critical
Publication of ATE206432T1 publication Critical patent/ATE206432T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
AT94923445T 1993-07-13 1994-07-13 A3 -adenosin -rezeptor agonisten ATE206432T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9110993A 1993-07-13 1993-07-13
US16332493A 1993-12-06 1993-12-06
PCT/US1994/007835 WO1995002604A1 (en) 1993-07-13 1994-07-13 A3 adenosine receptor agonists

Publications (1)

Publication Number Publication Date
ATE206432T1 true ATE206432T1 (de) 2001-10-15

Family

ID=26783598

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94923445T ATE206432T1 (de) 1993-07-13 1994-07-13 A3 -adenosin -rezeptor agonisten

Country Status (6)

Country Link
US (1) US5773423A (de)
EP (1) EP0708781B1 (de)
AT (1) ATE206432T1 (de)
AU (1) AU7331094A (de)
DE (1) DE69428536T2 (de)
WO (1) WO1995002604A1 (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9301000D0 (en) * 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
WO1997037667A1 (en) 1996-04-10 1997-10-16 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Use of an a1 adenosine receptor agonist to treat cerebral ischaemia
GB9610031D0 (en) * 1996-05-14 1996-07-17 Glaxo Group Ltd Chemical compounds
CA2264953C (en) * 1996-08-16 2008-09-30 The Texas A & M University System Modifying insect cell gylcosylation pathways with baculovirus expression vectors
TW528755B (en) 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
EP1014995A4 (de) 1997-06-18 2005-02-16 Aderis Pharmaceuticals Inc Zusammensetzungen und verfahren zur verhütung von restenosis nach wiedergefässbildung
US6110902A (en) * 1997-06-23 2000-08-29 Moehler; Hanns Method for the inhibition of neuronal activity leading to a focal epileptic seizure by local delivery of adenosine
YU44900A (sh) 1998-01-31 2003-01-31 Glaxo Group Limited Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
CN1301167A (zh) * 1998-06-15 2001-06-27 荷兰应用科学研究会(Tno) 一种治疗有机磷酸盐中毒的方法
ATE246701T1 (de) 1998-06-23 2003-08-15 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivate
CA2336967C (en) 1998-07-10 2010-06-29 The United States Of America, Represented By The Secretary, Department Of Health And Human Services A3 adenosine receptor antagonists
US6576619B2 (en) * 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
IL133680A0 (en) * 1999-09-10 2001-04-30 Can Fite Technologies Ltd Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
CO5180581A1 (es) * 1999-09-30 2002-07-30 Pfizer Prod Inc Compuestos para el tratamiento de la isquemia ciones farmaceuticas que los contienen para el tratamiento de la isquemia
US6803457B1 (en) 1999-09-30 2004-10-12 Pfizer, Inc. Compounds for the treatment of ischemia
WO2001051490A1 (en) * 2000-01-14 2001-07-19 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methanocarba cycloalkyl nucleoside analogues
US20010051348A1 (en) 2000-01-28 2001-12-13 Lee Chee Wee Novel ligands and methods for preparing same
IL156704A0 (en) * 2001-01-16 2004-01-04 Can Fite Biopharma Ltd Use of an adenosine a3 receptor agonist for inhibition of viral replication
US20020115635A1 (en) * 2001-02-21 2002-08-22 Pnina Fishman Modulation of GSK-3beta activity and its different uses
EP1241176A1 (de) * 2001-03-16 2002-09-18 Pfizer Products Inc. Purinderivate zur Behandlung von Ischämie
JP2002338593A (ja) * 2001-05-22 2002-11-27 Ajinomoto Co Inc β−D−リボフラノース誘導体又はその光学異性体の製造方法
US6921594B2 (en) * 2001-12-19 2005-07-26 Sud-Chemie Inc. Exhaust treatment and filtration system for molten carbonate fuel cells
US6846988B2 (en) * 2002-01-18 2005-01-25 Adc Telecommunications, Inc. Triaxial connector including cable clamp
US7414036B2 (en) 2002-01-25 2008-08-19 Muscagen Limited Compounds useful as A3 adenosine receptor agonists
AU2003282359A1 (en) * 2002-11-19 2004-06-15 Can-Fite Biopharma Ltd. A3ar agonists for the treatment of inflammatory arthritis
CZ294538B6 (cs) * 2002-12-30 2005-01-12 Ústav Experimentální Botaniky Akademie Vědčeské Re Substituční deriváty N6-benzyladenosinu, způsob jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
US20050101560A1 (en) * 2003-11-12 2005-05-12 Can-Fite Biopharma Ltd. Method of treating an individual with methyl 1-[N6-(3-iodobenzyl)-adenin-9-yl] beta-D-ibofuronamide
PL1699459T3 (pl) * 2003-12-29 2007-12-31 Can Fite Biopharma Ltd Sposób leczenia stwardnienia rozsianego
PE20060272A1 (es) 2004-05-24 2006-05-22 Glaxo Group Ltd (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
ME01072B (de) 2004-05-26 2012-10-20 Inotek Pharmaceuticals Corp Purinderivate als adenosin a 1 rezeptoragonisten und anwendungsverfahren dafür
US7825102B2 (en) * 2004-07-28 2010-11-02 Can-Fite Biopharma Ltd. Treatment of dry eye conditions
DK1778239T3 (da) * 2004-07-28 2013-12-02 Can Fite Biopharma Ltd Adenosin-a3-receptor-agonister til behandling af sygdomme forbundet medtørre øjne, herunder sjögrens syndrom
WO2006031505A1 (en) * 2004-09-09 2006-03-23 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Purine derivatives as a3 and a1 adenosine receptor agonists
US7863253B2 (en) 2004-09-20 2011-01-04 Inotek Pharmaceuticals Corporation Purine Derivatives and methods of use thereof
US20080051364A1 (en) * 2004-11-08 2008-02-28 Pninna Fishman Therapeutic Treatment of Accelerated Bone Resorption
US20080070860A1 (en) * 2005-02-04 2008-03-20 Uti Limited Partnership Adenosine Analogs Useful as Anti-Bacterial and Anti Protozoan Agents
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
CN101330909B (zh) 2005-11-30 2012-09-26 坎-菲特生物药物有限公司 A3腺苷受体激动剂在制备治疗骨关节炎的药物中的应用
BRPI0619261A2 (pt) 2005-11-30 2011-09-27 Inotek Pharmaceuticals Corp derivados de purina e métodos de uso desses
US20090286813A1 (en) * 2006-04-13 2009-11-19 Astrazeneca Ab Thioxanthine Derivatives and Their Use as Inhibitors of MPO
UY30267A1 (es) * 2006-04-13 2007-11-30 Astrazeneca Ab Nuevos derivados de la tioxantina , composiciones farmacéuticas que los contienen, procedimientos de preparacion y aplicaciones
US7897737B2 (en) * 2006-12-05 2011-03-01 Lasergen, Inc. 3′-OH unblocked, nucleotides and nucleosides, base modified with photocleavable, terminating groups and methods for their use in DNA sequencing
US7893227B2 (en) * 2006-12-05 2011-02-22 Lasergen, Inc. 3′-OH unblocked nucleotides and nucleosides base modified with non-cleavable, terminating groups and methods for their use in DNA sequencing
EP2137202B1 (de) * 2007-03-14 2017-06-21 Can-Fite Biopharma Ltd. Verfahren zur herstellung von ib-meca
EP2170401A1 (de) 2007-06-29 2010-04-07 Government of the United States of America, Represented by the Secretary, Department of Health and Human Services Dendrimer-konjugate von agonisten und antagonisten der gpcr-superfamilie
JP5592262B2 (ja) * 2007-10-15 2014-09-17 キャン−ファイト・バイオファーマ・リミテッド 肝細胞の増殖を誘導する方法及びその使用
AU2009231978C1 (en) 2008-03-31 2014-01-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Purine derivatives as A3 adenosine receptor- selective agonists
US8916570B2 (en) 2008-03-31 2014-12-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A3 adenosine receptor agonists and antagonists
AU2009257369B2 (en) 2008-06-11 2015-03-26 Agilent Technologies, Inc. Nucleotides and nucleosides and methods for their use in DNA sequencing
US9181253B2 (en) 2008-08-01 2015-11-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adenosine receptor agonists, partial agonists, and antagonists
AU2009276411B2 (en) * 2008-08-01 2014-08-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A3 adenosine receptor antagonists and partial agonists
JP5849044B2 (ja) 2009-05-17 2016-01-27 キャン−ファイト バイオファーマ リミテッド 眼圧低下のためのa3アデノシン受容体作動薬
US9199102B2 (en) 2009-07-21 2015-12-01 Oradin Pharmaceutical Ltd. A3 adenosine receptor ligands for modulation of pigmentation
EP2507241A1 (de) 2009-12-02 2012-10-10 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Methanocarba adenosin-derivate und dendrimerkonjugate daraus
ES2613698T3 (es) 2010-01-11 2017-05-25 Inotek Pharmaceuticals Corporation Combinación, kit y método de reducción de la presión intraocular
MX2012010006A (es) 2010-03-03 2013-01-17 Us Gov Health & Human Serv Agonistas de a3ar para el tratamiento de uveitis.
SG184221A1 (en) 2010-03-26 2012-10-30 Inotek Pharmaceuticals Corp Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof
US20130109645A1 (en) 2010-03-31 2013-05-02 The united States of America,as represented by Secretary,Dept.,of Health and Human Services Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders
JP5576484B2 (ja) * 2010-06-18 2014-08-20 株式会社林原 アデノシンn1−オキシドを有効成分として含有する炎症性疾患治療剤
US9493502B2 (en) 2011-01-26 2016-11-15 Beijing Kbd Pharmaceuticals Co., Ltd. Ribofuranosyl purine compounds, methods for preparing the same and use thereof
CN102617680B (zh) * 2011-02-01 2014-04-02 复旦大学 一种双功能抗血小板聚集药物及其用途
DE102011005232A1 (de) 2011-03-08 2012-09-13 AristoCon GmbH & Co. KG Adenosin und seine Derivate zur Verwendung in der Schmerztherapie
MX342195B (es) 2011-09-13 2016-09-20 Lasergen Inc Nucleótidos de terminación de rápida fotodescomposición 5-metoxi, 3' -oh no bloqueados y métodos para secuenciación de ácido nucleico.
KR20140128974A (ko) 2012-01-26 2014-11-06 이노텍 파마슈티컬스 코포레이션 ((2r,3s,4r,5r)-5-(6-(시클로펜틸아미노)-9h-퓨린-9-일)-3,4-디히드록시테트라히드로푸란-2-일) 메틸 니트레이트의 무수 다형체들 및 이들의 제조 방법들
CN103421067A (zh) * 2012-05-18 2013-12-04 复旦大学 一种双靶点抗血小板聚集药物及其用途
CN104619323B (zh) 2012-08-09 2018-03-09 坎-菲特生物药物有限公司 用于在治疗性功能障碍中使用的a3腺苷受体配体
NZ630759A (en) 2013-03-15 2017-07-28 Inotek Pharmaceuticals Corp Ophthalmic formulations comprising an a1 agonist
JP2015172077A (ja) * 2015-06-24 2015-10-01 中国医学科学院葯物研究所 N6−置換アデノシン誘導体とn6−置換アデニン誘導体の鎮静、催眠、抗うつ、抗痙攣、抗てんかん、抗パーキンソン病と認知証予防・治療の用途
IL242723B (en) 2015-11-23 2019-12-31 Can Fite Biopharma Ltd A3 adenosine receptor ligand for the treatment of ectopic fat accumulation
CN109310695B (zh) 2016-04-21 2022-04-01 阿斯特罗赛特制药公司 治疗神经和心血管病况的化合物和方法
CN106632333A (zh) * 2016-11-30 2017-05-10 湖州恒远生物化学技术有限公司 一种低成本8‑氯茶碱的制备方法
IL254535A0 (en) 2017-09-17 2017-11-30 Can Fite Biopharma Ltd Adenosine a3 receptor ligand for use in the management of cytokine release syndrome
CN109666053A (zh) * 2017-10-16 2019-04-23 张家口华健致远生物科技有限公司 一种a3腺苷受体激动剂及其用途
WO2019105388A1 (zh) * 2017-11-29 2019-06-06 苏州科睿思制药有限公司 一种a3腺苷受体激动剂药物的晶型及其制备方法和用途
WO2019157317A1 (en) 2018-02-09 2019-08-15 Astrocyte Pharmaceuticals, Inc. Compounds and methods for treating addiction and related disorders
US10765693B2 (en) 2018-09-26 2020-09-08 Astrocyte Pharmaceuticals, Inc. Polymorphic compounds and uses thereof
IL264112A (en) 2019-01-06 2020-07-30 Fishman Pnina Adenosine a3 receptor ligand for use in lowering adipocyte levels
US20240116975A1 (en) * 2020-12-29 2024-04-11 Zhejiang Vimgreen Pharmaceuticals, Ltd. Adenosine a3 receptor agonists, preparation methods and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2524284A1 (de) * 1966-12-21 1976-10-28 Boehringer Mannheim Gmbh Adenosin-derivate und verfahren zu ihrer herstellung
NL6717061A (de) * 1966-12-21 1968-06-24
US5310731A (en) * 1984-06-28 1994-05-10 Whitby Research, Inc. N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents
US5140015A (en) * 1990-02-20 1992-08-18 Whitby Research, Inc. 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents
US5443836A (en) * 1993-03-15 1995-08-22 Gensia, Inc. Methods for protecting tissues and organs from ischemic damage

Also Published As

Publication number Publication date
AU7331094A (en) 1995-02-13
EP0708781B1 (de) 2001-10-04
US5773423A (en) 1998-06-30
EP0708781A1 (de) 1996-05-01
WO1995002604A1 (en) 1995-01-26
DE69428536T2 (de) 2002-06-06
DE69428536D1 (de) 2001-11-08

Similar Documents

Publication Publication Date Title
DE69428536T2 (de) A3 -adenosin -rezeptor agonisten
DK0725782T3 (da) A1-adenosin-receptor-agonister og antiagonister
SE0003984D0 (sv) Adenosin A3-receptormodulatorer
IT8621358A0 (it) Composizione farmaceutica adattivita' analgesica.
DE3880047D1 (de) Zusammensetzung eines zusatzes.
BR9612324A (pt) "agonistas e antagonistas receptores de adenosina a"
DE69004256D1 (de) Dihydropyrimidin-antiallergie-mittel.
DE3852988T2 (de) Propylen-Ethylen-Blockcopolymer Zusammensetzung.
DE68918201T2 (de) Grundierungszusammensetzungen.
DE3876490D1 (de) Korrosionsinhibierende zusammensetzung.
NO943846L (no) Angiotensin II antagonister mot forstyrrelser knyttet til svekket nerveledningshastighet, særlig diabetisk nevropati
DK630589D0 (da) 2',3'-dideoxypurinnucleosid/purinnucleosid-phosphorylase-inhibitor-sammensaetning
EA200000198A1 (ru) 2-ациламинопропанамины в качестве антагонистов рецепторов тахикининов
ES2106025T3 (es) Analogos de gangliosidos semisinteticos.
ES2072869T3 (es) Uso de derivados de la 1,4-dihidropiridina en el tratamiento del alcoholismo.
UA26443A (uk) Похідhі 20,21-диhоребурhамеhіhу, їх рацемати або оптичhі ізомери, або їх адитивhі солі з оргаhічhими кислотами, що мають hоотропhі та аhтидепресивhі властивості
DE69001580D1 (de) Perkutane verabreichung von 3'-azido-3'-deoxythymidin.
IT8821570A0 (it) Impiego di derivati adenosinici per la preparazione di composizioni farmaceutiche aventi attivita' immunostimolante.
NO985079L (no) Eksplosiv formulering
DK316188D0 (da) Sulfolipopolysaccharider som stimolatorer for den ikke specifikke forsvarsmekanisme
FI955257A0 (fi) 8-substituoidut-ksantiinit valikoivina adenosiinireseptoriaineina
DE69012388T2 (de) Selektive Adenosinrezeptor-Verbindungen.
ATE114310T1 (de) Alpha-adrenergische rezeptorantagonisten.
NO892727L (no) Eterholdige n-terminale aminodiolaminosyre derivater som anti-hypertensive midler.
ATE109483T1 (de) Alpha-adrenergische rezeptorantagonisten.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties